A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published May 4-11.

Biomedical Sciences

Chemically Defined Production of Tri-Lineage Human IPSC-Derived Cardiac Spheroids. Arzt, Madelyn, Stephany Pohlman, Maedeh Mozneb, and Arun Sharma. Current Protocols 3 (5): e767.

Beyond the Rainbow: A Review of Advanced Lineage Tracing Methodologies for Interrogating the Initiation, Evolution, and Recurrence of Brain Tumors. Sabet, Sara, and Joshua J. Breunig. Developmental Neuroscience, April, 1.

Cancer

Reprogramming of TAMs via the STAT3/CD47-SIRP? Axis Promotes Acquired Resistance to EGFR-TKIs in Lung Cancer. Lu, Jiaye, Jingwei Li, Ziyou Lin, Huaxuan Li, Linlin Lou, Wen Ding, Shumin Ouyang, Yonghui Wu, Yuanzhen Wen, Xiaobing Chen, Peibin Yue, Yuanxiang Wang, Peiqing Liu, Jinjian Lu, Jian Zhang, Weineng Feng, and Xiaolei Zhang. Cancer Letters 564 (May): 216205.

Cardiac Surgery

Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease. Young Jang, Min, Parth N. Patel, Alexandre C. Pereira, Jon A. L. Willcox, Alireza Haghighi, Angela C. Tai, Kaoru Ito, Sarah U. Morton, Joshua M. Gorham, David M. McKean, Steven R. DePalma, Daniel Bernstein, Martina Brueckner, Wendy K. Chung, Alessandro Giardini, Elizabeth Goldmuntz, Jonathan R. Kaltman, Richard Kim, Jane W. Newburger, Yufeng Shen, Deepak Srivastava, Martin Tristani-Firouzi, Bruce D. Gelb, George A. Porter, Christine E. Seidman, and Jonathan G. Seidman. Circulation. Genomic and Precision Medicine, May, e003924.

Successful Reuse of a Donor Heart. Esmailian, Gabriel, Qiudong Chen, Danny Ramzy, Jon A. Kobashigawa, Joanna Chikwe, and Fardad Esmailian. Texas Heart Institute Journal 50 (3): e217726.

Limited Cumulative Experience With Ex-Vivo Lung Perfusion Is Associated With Inferior Outcomes After Lung Transplantation. Chen, Qiudong, Jad Malas, Aasha Krishnan, Jason Thomas, Dominick Megna, Natalia Egorova, Joanna Chikwe, Michael E. Bowdish, and Pedro Catarino. The Journal of Thoracic and Cardiovascular Surgery, April, S0022-5223(23)00332-X.

Cardiology

Economic Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Low Surgical Risk: Results from the PARTNER 3 Trial. Galper, Benjamin Z., Khaja M. Chinnakondepalli, Kaijun Wang, Elizabeth A. Magnuson, Michael Lu, Vinod H. Thourani, Susheel Kodali, Raj Makkar, Howard C. Herrmann, Samir Kapadia, Mathew Williams, John Webb, Craig R. Smith, Michael J. Mack, Martin B. Leon, David J. Cohen, and PARTNER Investigators. Circulation, May.

Three Year Post Heart Transplant Outcomes of Desensitized Durable Mechanical Circulatory Support Patients. Youn, Jong-Chan, Darae Kim, Mi-Hyang Jung, Jin-Jin Kim, In-Cheol Kim, Hye Sun Lee, Jin-Oh Choi, Eun-Seok Jeon, Keith Nishihara, Osamu Seguchi, Evan P. Kransdorf, David H. Chang, Michelle M. Kittleson, Jignesh K. Patel, Robert M. Cole, Jaime D. Moriguchi, Danny Ramzy, Fardad Esmailian, and Jon A. Kobashigawa. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation, May, S1053-2498(23)01851-X.

Medicine

Time and Event-Specific Deep Learning for Personalized Risk Assessment After Cardiac Perfusion Imaging. Pieszko, Konrad, Aakash D. Shanbhag, Ananya Singh, M. Timothy Hauser, Robert J. H. Miller, Joanna X. Liang, Manish Motwani, Jacek Kwieci?ski, Tali Sharir, Andrew J. Einstein, Mathews B. Fish, Terrence D. Ruddy, Philipp A. Kaufmann, Albert J. Sinusas, Edward J. Miller, Timothy M. Bateman, Sharmila Dorbala, Marcelo Di Carli, Daniel S. Berman, Damini Dey, and Piotr J. Slomka. NPJ Digital Medicine 6 (1): 78.

Latent Coronary Plaque Morphology From Computed Tomography Angiography, Molecular Disease Activity on Positron Emission Tomography, and Clinical Outcomes. Kwiecinski, Jacek, Márton Kolossváry, Evangelos Tzolos, Mohammed N. Meah, Philip D. Adamson, Nikhil V. Joshi, Michelle C. Williams, Edwin J. R. van Beek, Daniel S. Berman, Pál Maurovich-Horvat, David E. Newby, Marc R. Dweck, Damini Dey, and Piotr J. Slomka. Arteriosclerosis, Thrombosis, and Vascular Biology, May.

‘I Need My Granddaughter to Know Who I Am!’ A Case Study of a 67-Year-Old African American Man and His Spiritual Legacy. Shu, Christina. Journal of Health Care Chaplaincy, May, 1–13.

Genetic Architecture of the Inflammatory Bowel Diseases Across East Asian and European Ancestries. Liu, Zhanju, Ruize Liu, Han Gao, Seulgi Jung, Xiang Gao, Ruicong Sun, Xiaoming Liu, Yongjae Kim, Ho-Su Lee, Yosuke Kawai, Masao Nagasaki, Junji Umeno, Katsushi Tokunaga, Yoshitaka Kinouchi, Atsushi Masamune, Wenzhao Shi, Chengguo Shen, Zhenglin Guo, Kai Yuan, FinnGen, International Inflammatory Bowel Disease Genetics Consortium, Chinese Inflammatory Bowel Disease Genetics Consortium, Shu Zhu, Dalin Li, Jianjun Liu, Tian Ge, Judy Cho, Mark J. Daly, Dermot P. B. McGovern, Byong Duk Ye, Kyuyoung Song, Yoichi Kakuta, Mingsong Li, and Hailiang Huang. Nature Genetics, May.

Patient and Researcher Stakeholder Preferences for Use of Electronic Health Record Data: A Qualitative Study to Guide the Design and Development of a Platform to Honor Patient Preferences. Morse, Brad, Katherine K. Kim, Zixuan Xu, Cynthia G. Matsumoto, Lisa M. Schilling, Lucila Ohno-Machado, Selene S. Mak, and Michelle S. Keller. Journal of the American Medical Informatics Association: JAMIA, May, ocad058.

The Role of Internal Medicine-Pediatric Programs and Transition Champions in Graduate Medical Trainee Health Care Transition Development. Liu, Allison, Jay Patel, Jessica I. Gold, Nabil Abou Baker, and Rita Rossi Foulkes. The Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine, May, S1054-139X(23)00147-7.

Increased Accuracy in Identifying NAFLD with Advanced Fibrosis and Cirrhosis: Independent Validation of the Agile 3+ and 4 Scores. Noureddin, Mazen, Edward Mena, Raj Vuppalanchi, Niharika Samala, Micaela Wong, Fabiana Pacheco, Prido Polanco, Celine Sakkal, Ani Antaramian, Devon Chang, Nabil Noureddin, Anita Kohli, Stephen A. Harrison, Samer Gwarieh, Naim Alkhouri, and Emily Truong. Hepatology Communications 7 (5): e0055.

Talimogene Laherparepvec in Combination with Ipilimumab versus Ipilimumab Alone for Advanced Melanoma: 5-Year Final Analysis of a Multicenter, Randomized, Open-Label, Phase II Trial. Chesney, Jason A., Igor Puzanov, Frances A. Collichio, Parminder Singh, Mohammed M. Milhem, John Glaspy, Omid Hamid, Merrick Ross, Philip Friedlander, Claus Garbe, Theodore Logan, Axel Hauschild, Celeste Lebbé, Harshada Joshi, Wendy Snyder, and Janice M. Mehnert. Journal for Immunotherapy of Cancer 11 (5): e006270.

Editorial: Targeting the Microbiota to Attenuate Chronic Inflammation. Moreno, Elena, Marius Trøseid, Ivan Vujkovic-Cvijin, Giulia Marchetti, Laura Martín-Pedraza, and Sergio Serrano-Villar. Frontiers in Immunology 14: 1202222.

Barriers to Optimizing Inflammatory Bowel Disease Care in the United States. Spencer, Elizabeth A., Sadeea Abbasi, and Maia Kayal. Therapeutic Advances in Gastroenterology 16: 17562848231169652.

Neurosurgery

Glioma Immunotherapy Enhancement and CD8-Specific Sialic Acid Cleavage by Isocitrate Dehydrogenase (IDH)-1. Cordner, Ryan, Michelle Jhun, Akanksha Panwar, HongQiang Wang, Nicole Gull, Ramachandran Murali, Joseph H. McAbee, Armen Mardiros, Akane Sanchez-Takei, Mia W. Mazer, Xuemo Fan, Emmanuel Jouanneau, John S. Yu, Keith L. Black, and Christopher J. Wheeler. Oncogene, May.

Multidisciplinary Consensus Guideline for the Diagnosis and Management of Spontaneous Intracranial Hypotension. Cheema, Sanjay, Jane Anderson, Heather Angus-Leppan, Paul Armstrong, David Butteriss, Lalani Carlton Jones, David Choi, Amar Chotai, Linda D’Antona, Indran Davagnanam, Brendan Davies, Paul J. Dorman, Callum Duncan, Simon Ellis, Valeria Iodice, Clare Joy, Susie Lagrata, Sarah Mead, Danny Morland, Justin Nissen, Jenny Pople, Nancy Redfern, Parag P. Sayal, Daniel Scoffings, Russell Secker, Ahmed K. Toma, Tamsin Trevarthen, James Walkden, Jürgen Beck, Peter George Kranz, Wouter Schievink, Shuu-Jiun Wang, and Manjit Singh Matharu. Journal of Neurology, Neurosurgery, and Psychiatry, May, jnnp-2023-331166.

Safety and Efficacy of High-Dose Tranexamic Acid in Spine Surgery: A Retrospective Single-Institution Series. Brown, Nolan J., Zach Pennington, Alexander S. Himstead, Chen Yi Yang, Sachiv Chakravarti, Julian Gendreau, Joshua Kurtz, Shane Shahrestani, Martin H. Pham, and Joseph A. Osorio. World Neurosurgery, May, S1878-8750(23)00543-0.

OBGYN

Identification of Complement Factor H Variants That Predispose to Pre-Eclampsia: A Genetic and Functional Study. Lokki, A. I., Z. Ren, M. Triebwasser, E. Daly, FINNPEC, M. Perola, K. Auro, R. Burwick, J. E. Salmon, M. Daly, H. Laivuori, J. P. Atkinson, A. Java, and S. Meri. BJOG: An International Journal of Obstetrics and Gynaecology, May.

‘Vagina’ Is Not a Bad Word: Historical and Contemporary Censorship of the Word ‘Vagina.’ Popat, Shreeya, Rainey Horwitz, Karyn S. Eilber, and Una J. Lee. Urology, May, S0090-4295(23)00372-2.

Surgical Management of Endometriosis to Optimize Fertility. Hamilton, Kacey M., Katherine VanHise, Mireille D. Truong, Kelly N. Wright, and Matthew T. Siedhoff. Current Opinion in Obstetrics & Gynecology, April.

Orthopaedics

Serum CD64 as a Marker for Chronic Periprosthetic Joint Infection. Yalamanchili, Dheeraj R., Zachary A. Rockov, Landon S. Polakof, Eytan M. Debbi, Sumire K. Kitahara, and Guy D. Paiement. Arthroplasty Today 21 (June): 101138.

Pathology

Lymphoid Cell Rich Fine-Needle Aspirations of the Salivary Gland: What Is the Risk of Malignancy? Krishnan, Vimal, Aaron R. Victor, Shikha Bose, and Rania Bakkar. Cytojournal 20 (May).

An Automated Histological Classification System for Precision Diagnostics of Kidney Allografts. Yoo, Daniel, Valentin Goutaudier, Gillian Divard, Juliette Gueguen, Brad C. Astor, Olivier Aubert, Marc Raynaud, Zeynep Demir, Julien Hogan, Patricia Weng, Jodi Smith, Rouba Garro, Bradley A. Warady, Rima S. Zahr, Marta Sablik, Katherine Twombley, Lionel Couzi, Thierry Berney, Olivia Boyer, Jean-Paul Duong-Van-Huyen, Magali Giral, Alaa Alsadi, Pierre A. Gourraud, Emmanuel Morelon, Moglie Le Quintrec, Sophie Brouard, Christophe Legendre, Dany Anglicheau, Jean Villard, Weixiong Zhong, Nassim Kamar, Oriol Bestard, Arjang Djamali, Klemens Budde, Mark Haas, Carmen Lefaucheur, Marion Rabant, and Alexandre Loupy. Nature Medicine, May.

Pediatrics

Outcomes Based on Induction Regimens in Pediatric Kidney Transplantation: A NAPRTCS and PHIS Collaborative Study. Erez, Daniella Levy, Helen Pizzo, Nancy Rodig, Troy Richardson, Michael Somers, and NAPRTCS investigators. Pediatric Nephrology (Berlin, Germany), May.

Psychiatry

Pilot Randomized Controlled Trial of a Hospital-Based Substance Use Treatment and Recovery Team (START) to Improve Initiation of Medication for Alcohol or Opioid Use Disorder and Linkage to Follow-up Care. Ober, Allison J., Karen C. Osilla, David J. Klein, Lane F. Burgette, I. Leamon, Mia W. Mazer, Gabrielle Messineo, Stacy Collier, Samuel Korouri, Katherine E. Watkins, Waghui IsHak, Teryl Nuckols, and Itai Danovitch. Journal of Substance Use and Addiction Treatment, May, 209063.

Surgery

Initial Experience with a Modified ‘Candy-Plug’ Technique for False Lumen Embolization in Chronic Type B Aortic Dissection. Miles, Daniel, Cassra Arbabi, Katherine McMackin, Bruce Tjaden, Sally Schonefeld, Donald Baril, NavYash Gupta, Bruce Gewertz, and Ali Azizzadeh. Journal of Vascular Surgery Cases and Innovative Techniques 9 (2): 101075.

Synchronous Undetected HPV+ Cancer in a HPV- Tongue Cancer Patient. Ershadifar, Soroush, Sarah Ustrell, Morgan Angus Darrow, and Andrew Birkeland. Ear, Nose, & Throat Journal, May, 1455613231173456.

Medication Safety Event Reporting: Factors That Contribute to Safety Events During Times of Organizational Stress. Cohen, Tara N., Carl T. Berdahl, Bernice L. Coleman, Edward G. Seferian, Andrew J. Henreid, Donna W. Leang, and Teryl K. Nuckols. Journal of Nursing Care Quality, May.

Regarding: Predicting Regional Lymph Node Recurrence in The Modern Age of Tumor-Positive Sentinel Node Melanoma. Thompson, John F., John Hyngstrom, Corrado Caracò, Jonathan S. Zager, Tiina Jahkola, Tawnya L. Bowles, Elisabetta Pennacchioli, Harald J. Hoekstra, Marc Moncrieff, Christian Ingvar, Alexander van Akkooi, Michael S. Sabel, Edward A. Levine, Michael Henderson, Reinhard Dummer, Carlo Riccardo Rossi, John M. Kane, Steven Trocha, Frances Wright, David R. Byrd, Maurice Matter, Alastair MacKenzie-Ross, Mark C. Kelley, Patrick Terheyden, Tara L. Huston, Jeffrey D. Wayne, Heather Neuman, B. Mark Smithers, Darius Desai, Jeffrey E. Gershenwald, Shlomo Schneebaum, Anja Gesierich, Lisa K. Jacobs, James M. Lewis, Cristina O’Donoghue, Armando Sardi, J. Greg McKinnon, Craig L. Slingluff, Jeffrey M. Farma, Erwin Schultz, Randall P. Scheri, Sergi Vidal-Sicart, Alessandro A. E. Testori, Richard A. Scolyer, David E. Elashoff, Alistair J. Cochran, and Mark B. Faries. Annals of Surgical Oncology, May.

Identifying Workflow Disruptions in Robotic-Assisted Bariatric Surgery: Elucidating Challenges Experienced by Surgical Teams. Zamudio, Jennifer, Falisha F. Kanji, Connor Lusk, Daniel Shouhed, Barry R. Sanchez, Ken Catchpole, Jennifer T. Anger, and Tara N. Cohen. Obesity Surgery, May, 1–7.

Mediators of the Association between Childhood Trauma and Pain Sensitivity in Adulthood: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Analysis. Pierce, Jennifer, Steven E. Harte, Niloofar Afari, Catherine S. Bradley, James W. Griffith, Jayoung Kim, Susan Lutgendorf, Bruce D. Naliboff, Larissa V. Rodriguez, Bayley J. Taple, David Williams, Richard E. Harris, Andrew Schrepf, and MAPP Research Network. Pain, May.

A Unique Apparatus to Treat Dehiscence Following Bilateral Cleft Lip Repair: A Case Report. Henkle, Garrett, Sarah Ustrell, Jordan K. Simmons, and Rajanya S. Petersson. Ear, Nose, & Throat Journal, May, 1455613231173457.

Postoperative Obstructive Sleep Apnea Management Following Endoscopic Pituitary Surgery: A Systematic Review. Risbud, Adwight, Edward C. Kuan, Arthur W. Wu, Adam N. Mamelak, and Dennis M. Tang. World Neurosurgery, May, S1878-8750(23)00601-0.

Editorial: Use of Smartphone Applications to Increase Physical Activity and Fitness, Volume II. Dourado, Victor Zuniga, and Jayoung Kim. Frontiers in Public Health 11: 1190566.

Urology

Radium-223 Utilization Patterns and Outcomes in Clinical Practice. Taich, Lior, Hanson Zhao, Shannon R. Stock, Lauren E. Howard, Amanda M. De Hoedt, Martha K. Terris, Christopher L. Amling, Christopher J. Kane, Matthew R. Cooperberg, William J. Aronson, Zachary Klaassen, Thomas J. Polascik, Adriana C. Vidal, and Stephen J. Freedland. Urology Practice 9 (5): 405–13.

Key Takeaways for Knowledge Expansion of Early-Career Scientists Conducting Transdisciplinary Research in Energetics and Cancer (TREC): A Report From the TREC Training Workshop 2022. Kung, Che-Pei, Meghan B. Skiba, Erika J. Crosby, Jessica Gorzelitz, Mary A. Kennedy, Bethany A. Kerr, Yun Rose Li, Sarah Nash, Melanie Potiaumpai, Amber S. Kleckner, Dara L. James, Michael F. Coleman, Ciaran M. Fairman, Gloria C. Galván, David O. Garcia, Max J. Gordon, Mathilde His, Lyndsey M. Hornbuckle, So-Youn Kim, Tae-Hyung Kim, Amanika Kumar, Mélanie Mahé, Karen K. McDonnell, Jade Moore, Sangphil Oh, Xinghui Sun, and Melinda L. Irwin. Journal of the National Cancer Institute. Monographs 2023 (61): 149–57.

Reply by Authors. Taich, Lior, Hanson Zhao, Shannon R. Stock, Lauren E. Howard, Amanda M. De Hoedt, Martha K. Terris, Christopher L. Amling, Christopher J. Kane, Matthew R. Cooperberg, William J. Aronson, Zachary Klaassen, Thomas J. Polascik, Adriana C. Vidal, and Stephen J. Freedland. Urology Practice 9 (5): 413.