This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published May 2-9.

Biomedical Sciences

Atypical Functional Connectivity Between the Amygdala and Visual, Salience Regions in Infants With Genetic Liability for Autism. Liu, Janelle, Jessica B. Girault, Tomoyuki Nishino, Mark D. Shen, Sun Hyung Kim, Catherine A. Burrows, Jed T. Elison, Natasha Marrus, Jason J. Wolff, Kelly N. Botteron, Annette M. Estes, Stephen R. Dager, Heather C. Hazlett, Robert C. McKinstry, Robert T. Schultz, Abraham Z. Snyder, Martin Styner, Lonnie Zwaigenbaum, John R. Pruett, Joseph Piven, and Wei Gao. Cerebral Cortex (New York, N.Y.: 1991) 34 (13): 30–39.

Disease Related Changes in ATAC-Seq of iPSC-Derived Motor Neuron Lines From ALS Patients and Controls. Tsitkov, Stanislav, Kelsey Valentine, Velina Kozareva, Aneesh Donde, Aaron Frank, Susan Lei, Answer ALS Consortium, Jennifer E Van Eyk, Steve Finkbeiner, Jeffrey D. Rothstein, Leslie M. Thompson, Dhruv Sareen, Clive N. Svendsen, and Ernest Fraenkel. Nature Communications 15 (1): 3606.

Editorial for ‘Adolescent Reference Values for MR-Derived Biventricular Strain Obtained Using Feature-Tracking and Myocardial Tagging.’ Yang, Hsin-Jung, Christopher Nguyen, and Li-Ting Huang. Journal of Magnetic Resonance Imaging: JMRI, May.

Association Between Diabetes and Subsequent Malignancy Risk Among Older Breast Cancer Survivors. Hardell, Kaitlyn N. Lewis, Sara J. Schonfeld, Cody Ramin, Jacqueline B. Vo, and Lindsay M. Morton. JNCI Cancer Spectrum, May, pkae036.

Long-Term Cardiovascular Disease Risk After Anthracycline and Trastuzumab Treatments in U.S. Breast Cancer Survivors. Vo, Jacqueline B., Cody Ramin, Lene H. S. Veiga, Carolyn Brandt, Rochelle E. Curtis, Clara Bodelon, Ana Barac, Véronique L. Roger, Heather Spencer Feigelson, Diana S. M. Buist, Erin J. Aiello Bowles, Gretchen L. Gierach, and Amy Berrington de González. Journal of the National Cancer Institute, May, djae107.

Phenformin Activates ER Stress to Promote Autophagic Cell Death via NIBAN1 and DDIT4 in Oral Squamous Cell Carcinoma Independent of AMPK. Zhuang, Dexuan, Shuangshuang Wang, Huiting Deng, Yuxin Shi, Chang Liu, Xue Leng, Qun Zhang, Fuxiang Bai, Bin Zheng, Jing Guo, and Xunwei Wu. International Journal of Oral Science 16 (1): 35.

Cardiology

Targeting Low Levels of MIF Expression as a Potential Therapeutic Strategy for ALS. Alfahel, Leenor, Thomas Gschwendtberger, Velina Kozareva, Laura Dumas, Rachel Gibbs, Alexander Kertser, Kuti Baruch, Shir Zaccai, Joy Kahn, Nadine Thau-Habermann, Reto Eggenschwiler, Jared Sterneckert, Andreas Hermann, Niveda Sundararaman, Vineet Vaibhav, Jennifer E. Van Eyk, Victor F. Rafuse, Ernest Fraenkel, Tobias Cantz, Susanne Petri, and Adrian Israelson. Cell Reports. Medicine, April, 101546.

Discovering the Limits of the Possible: Two Can Play That Game. Peled, Yael, and Michelle M. Kittleson. The Journal of Heart and Lung Transplantation, May, S1053-2498(24)01643-7.

Competing Risks for Monomorphic Versus Non-Monomorphic Ventricular Arrhythmias in Primary Prevention Implantable Cardioverter Defibrillator Recipients: Global Electrical Heterogeneity and Clinical Outcomes (GEHCO) Study. Tereshchenko, Larisa G., Jonathan W. Waks, Christine Tompkins, Albert J. Rogers, Ashkan Ehdaie, Charles A. Henrikson, Khidir Dalouk, Merritt Raitt, Shivangi Kewalramani, Michael W. Kattan, Pasquale Santangeli, Bruce W. Wilkoff, Samir R. Kapadia, Sanjiv M. Narayan, and Sumeet S. Chugh. Europace, May, euae127.

Cardiac Function is Regulated by the Sodium-Dependent Inhibition of the Sodium-Calcium Exchanger NCX1. Scranton, Kyle, Scott John, Marina Angelini, Federica Steccanella, Soban Umar, Rui Zhang, Joshua I. Goldhaber, Riccardo Olcese, and Michela Ottolia. Nature Communications 15 (1): 3831.

Autopsy of All Young Sudden Death Cases Is Important to Increase Survival in Family Members Left Behind. Lynge, Thomas H., Christine M. Albert, Cristina Basso, Rodrigue Garcia, Andrew D. Krahn, Christopher Semsarian, Mary N. Sheppard, Elijah R. Behr, and Jacob Tfelt-Hansen. Europace, May, euae128.

Left Ventricular Global Longitudinal Strain Is Worse in BRCA Mutation Positive Breast Cancer Patients Prior to Cancer Treatment and Premature Menopause. Lin, Billy, Alexis LeVee, Louie Cao, Reva Basho, Balaji Tamarappoo, Janet Wei, and Chrisandra Shufelt. Breast Cancer Research and Treatment, May.

Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Following Prior Infection or Vaccination. Ebinger, Joseph E., Nancy Sun, Sandy Y. Joung, John Michael S. Sanchez, Minhao Wang, Yunxian Liu, John C. Prostko, Edwin C. Frias, James L. Stewart, Mallory Heath, Brian L. Claggett, Susan Cheng, and Kimia Sobhani. The Journal of Infectious Diseases, May, jiae130.

Editorial: Polycystic Ovary Syndrome and Cardiovascular Risk: Asking the Right Questions. Safwan, Nancy, Mariam Saadedine, C. Noel Bairey Merz, and Chrisandra L. Shufelt. European Journal of Preventive Cardiology, May, zwae159.

Anticoagulation for Atrial Fibrillation in Patients With Surgically Occluded Left Atrial Appendage. Chakravarty, Tarun, Aum Solanki, Neel Bhardwaj, Vivek Patel, Joanna Chikwe, and Raj R. Makkar. Journal of the American College of Cardiology 83 (19): 1936–38.

Computational Biomedicine

Current Status of Artificial Intelligence Methods for Skin Cancer Survival Analysis: A Scoping Review. Schreidah, Celine M., Emily R. Gordon, Oluwaseyi Adeuyan, Caroline Chen, Brigit A. Lapolla, Joshua A. Kent, George Bingham Reynolds, Lauren M. Fahmy, Chunhua Weng, Nicholas P. Tatonetti, Herbert S. Chase, Itsik Pe’er, and Larisa J. Geskin. Frontiers in Medicine 11: 1243659.

Elucidating Immunological Characteristics of the Adenoma-Carcinoma Sequence in Colorectal Cancer Patients in South Korea Using a Bioinformatics Approach. Song, Jaeseung, Daeun Kim, Junghyun Jung, Eunyoung Choi, Yubin Lee, Yeonbin Jeong, Byungjo Lee, Sora Lee, Yujeong Shim, Youngtae Won, Hyeki Cho, Dong Kee Jang, Hyoun Woo Kang, Jong Wha J. Joo, and Wonhee Jang. Scientific Reports 14 (1): 10105.

Evaluating Site-of-Care-Related Racial Disparities in Kidney Graft Failure Using a Novel Federated Learning Framework. Tong, Jiayi, Yishan Shen, Alice Xu, Xing He, Chongliang Luo, Mackenzie Edmondson, Dazheng Zhang, Yiwen Lu, Chao Yan, Ruowang Li, Lianne Siegel, Lichao Sun, Elizabeth A. Shenkman, Sally C. Morton, Bradley A. Malin, Jiang Bian, David A. Asch, and Yong Chen. Journal of the American Medical Informatics Association: JAMIA, May, ocae075.

The Future of Proteomics Is Up in the Air: Can Ion Mobility Replace Liquid Chromatography for High Throughput Proteomics? Jiang, Yuming, Daniel DeBord, Heidi Vitrac, Jordan Stewart, Ali Haghani, Jennifer E. Van Eyk, Justyna Fert-Bober, and Jesse G. Meyer. Journal of Proteome Research, May.

Medicine

Temporal Dynamics of the Multi-Omic Response to Endurance Exercise Training. MoTrPAC Study Group, Lead Analysts, and MoTrPAC Study Group. Nature 629 (8010): 174–83.

Predictive Factors of Non-Inflammatory Small Bowel Obstruction After Bowel Resection in Crohn’s Patients. Zulqarnain, Mir, Fouad Jaber, Vinay Jahagirdar, Saqr Alsakarneh, Jose Gomez, Aditi Stanton, Nedhi Patel, Poonam Beniwal-Patel, Daniel Stein, Mary Otterson, and Andres J. Yarur. Gastroenterology Research 17 (2): 64–71.

Is Hepatic Encephalopathy the First True Disorder of Gut-Brain Interaction? Bajaj, Jasmohan S., and Mark Pimentel. The American Journal of Gastroenterology, April.

Prevalence, Incidence, and Treatment Patterns of Fistulizing Crohn Disease: A US Population-Based Cohort Study. Fan, Yanni, Ling Zhang, and Gil Y. Melmed. Journal of Managed Care & Specialty Pharmacy 30 (5): 420–29.

Complement Proteins and Liver Diseases: A Response to the Correspondence. Rezaee-Zavareh, Mohammad Saeid, Naomy Kim, and Ju Dong Yang. Clinical and Molecular Hepatology, May.

Final Outcomes Analysis of the Cell Product SQZ-PBMC-HPV Phase 1 Trial in Incurable HPV16+ Solid Tumors Shows Improved Overall Survival in Patients With Increased CD8+ T Cell Tumor Infiltration. Weaver, Alice N., Wade T. Iams, Jong Chul Park, Monica Mita, Udo Holtick, Michael S. Gordon, Kerry J. Rodabaugh, Neesha Dhani, Prakash Neupane, Matthew Taylor, E. Amanda Duvall, Julia Jennings, Nathan R. Miselis, Scott Loughhead, Marshelle S. Warren, Howard Bernstein, Jens P. Klussmann, Joaquina Baranda, and Antonio Jimeno. Molecular Carcinogenesis, May.

A PD-1highCD4+ T Cell Population With a Cytotoxic Phenotype Is Associated With Interstitial Lung Disease in Systemic Sclerosis. Elahee, Mehreen, Alisa A. Mueller, Runci Wang, Kathryne E. Marks, Takanori Sasaki, Ye Cao, Andrea Fava, Paul F. Dellaripa, Francesco Boin, and Deepak A. Rao. ACR Open Rheumatology, May.

Etrasimod for the Treatment of Ulcerative Colitis: Analysis of Infection Events From the ELEVATE UC Clinical Program. Regueiro, Miguel, Britta Siegmund, Andres J. Yarur, Flavio Steinwurz, Krisztina B. Gecse, Martina Goetsch, Abhishek Bhattacharjee, Joseph Wu, Jesse Green, Aoibhinn McDonnell, Catherine Crosby, Krisztina Lazin, Diogo Branquinho, Irene Modesto, and Maria T. Abreu. Journal of Crohn’s & Colitis, May, jjae060.

Painful Raynaud’s Mimics. Zahn, Carleigh, Cindy Puga, Aroosa Malik, and Dinesh Khanna. Best Practice & Research. Clinical Rheumatology, May, 101948.

Response to ‘ChatGPT’s Ability to Comprehend and Answer Cirrhosis Related Questions: Comment.’ Samaan, Jamil S., Yee Hui Yeo, and Walid S. Ayoub. Arab Journal of Gastroenterology, May, S1687-1979(24)00032-7.

Neurosurgery

Compulsive Repetitive Flexion With Breath-Holding in Sagging Brain Syndrome. Schmahmann, Jeremy D., and Wouter I. Schievink. Neurology. Clinical Practice 14 (2): e200261.

A Proposed Stratification System to Address the Heterogeneity of Subdural Hematoma Outcome Reporting in the Literature. Nisson, Peyton L., John Francis, Michelot Michel, Takuma Maeda, and Chirag Patil. Neurosurgical Review 47 (1): 207.

Diagnosis and Treatment of Spontaneous Intracranial Hypotension: Role of Epidural Blood Patching. Callen, Andrew L., Deborah I. Friedman, Simy Parikh, Jill C. Rau, Wouter I. Schievink, Jeremy K. Cutsforth-Gregory, Timothy J. Amrhein, Elena Haight, Robert P. Cowan, Meredith J. Barad, Jennifer M. Hah, Tracy Jackson, Connie Deline, Andrea J. Buchanan, and Ian Carroll. Neurology. Clinical Practice 14 (3): e200290.

OBGYN

Surgical Field Separation in Total Laparoscopic Hysterectomy. Meyer, Raanan, Clarissa Niino, Rebecca Schneyer, Kacey Hamilton, Matthew T. Siedhoff, and Kelly N. Wright. Obstetrics and Gynecology, May.

Orthopaedics

Accuracy of Machine Learning to Predict the Outcomes of Shoulder Arthroplasty: A Systematic Review. Karimi, Amir H., Joshua Langberg, Ajith Malige, Omar Rahman, Joseph A. Abboud, and Michael A. Stone. Arthroplasty (London, England) 6 (1): 26.

Chondrosarcoma of the Mobile Spine: An Update on Patients Treated at a Single Institution. Tobert, Daniel G., Sidney Messier, Andrew J. Schoenfeld, Chinmay Bakshi, Shannon M. MacDonald, and Joseph H. Schwab. Spine, May.

Subchondral Rafting Wires Reduce Tibial Plateau Fracture Subsidence. Patterson, Joseph T., Daniel Rusu, Andrew M. Duong, Vivek Satish, Max Yang, Lucas Mayer, Michael Allen, and Geoffrey S. Marecek. European Journal of Orthopaedic Surgery & Traumatology: Orthopedie Traumatologie, May.

Surgery

Common Hepatic Artery Lymph Node Metastasis in Pancreatic Ductal Adenocarcinoma: An Analysis of Actual Survival. Kuo, Susan, Marco Ventin, Hiroki Sato, Jon M. Harrison, Yusuke Okuda, Motaz Qadan, Cristina R. Ferrone, Keith D. Lillemoe, and Carlos Fernandez-Del Castillo. Journal of Gastrointestinal Surgery 28 (5): 672–78.

Benign Paroxysmal Positional Vertigo After Use of Handheld Massage Gun. Elisha, David, and Ronen Nazarian. JAMA Otolaryngology-- Head & Neck Surgery, May.

Ample Evidence for the Presence of HSV-1 LAT in Non-Neuronal Ganglionic Cells of Mice and Humans. Wang, Shaohui, Xueying Song, Alex Rajewski, Chintda Santiskulvong, and Homayon Ghiasi. Journal of Virology, May, e0044124.

Racial Disparities in Access to Minimally Invasive Proctectomy for Rectal Cancer-a National Surgical Quality Improvement Program Study. Nasseri, Yosef Y., Kristina H.-T. La, Kimberly Oka, Paola Solis-Pazmino, Abbas Smiley, Sean Langenfeld, Jason Cohen, and Moshe Barnajian. Colorectal Disease, May.

Enhancing Lymph Node Yield in Gastric Cancer Resection: Impact of Back Table Dissection on Number of Lymph Node Examined. Wong, Harry J., Rushil Rawal, Joshua Tseng, Edward Phillips, Alexandra Gangi, and Miguel Burch. The American Surgeon, May, 31348241250038.

Reappraising the Role of Intraoperative Neck Margin Revision in Post-Neoadjuvant Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma: A Multi-Institutional Analysis. Malleo, Giuseppe, Gabriella Lionetto, Stefano Crippa, Motaz Qadan, Giada Moser, Giulio Belfiori, Aldo Scarpa, Marco Schiavo-Lena, Fabio Casciani, Paola Mattiolo, Salvatore Paiella, Alessandro Esposito, Claudio Luchini, Cristina R. Ferrone, Keith D. Lillemoe, Carlos Fernández-Del Castillo, Massimo Falconi, and Roberto Salvia. Annals of Surgery, May.