This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published May 16-23.

Biomedical Sciences

Stomach Cancer Prediction Model (SCoPM): An Approach to Risk Stratification in a Diverse U.S. Population. Wu, Bechien U., Elizabeth Y. Dong, Qiaoling Chen, Tiffany Q. Luong, Eva Lustigova, Christie Y. Jeon, and Wansu Chen. PloS One 19 (5): e0303153.

The Role of ??T Lymphocytes in Atherosclerosis. Xu, LiMin, Fanfan Chen, Wei Fan, Suguru Saito, and DuoYao Cao. Frontiers in Immunology 15: 1369202.

The Glucocorticoid Receptor Acts Locally to Protect Dystrophic Muscle and Heart During Disease. Oliver, Trinitee, Nhu Y. Nguyen, Christopher B. Tully, Nikki M. McCormack, Christina M. Sun, Alyson A. Fiorillo, and Christopher R. Heier. Disease Models & Mechanisms 17 (5): dmm050397.

Cardiac Surgery

Pediatric Heart Transplantation Over 36 Years and Contemporary Volume-Outcome Analysis of UNOS. Sharaf, Omar M., Ahmet Bilgili, Zachary Brennan, John A. Treffalls, Giles J. Peek, Mark S. Bleiweis, and Jeffrey P. Jacobs. The Annals of Thoracic Surgery, May, S0003-4975(24)00377-1.

Cardiology

Extravascular Implantable Cardioverter-Defibrillator Sensing and Detection in a Large Global Population. Swerdlow, Charles, Jeff Gillberg, Lucas V. A. Boersma, Jaimie Manlucu, Xusheng Zhang, Yan Zhang, Alfonso Aranda Hernandez, Varun Bhatia, and Francis Murgatroyd. JACC. Clinical Electrophysiology, April, S2405-500X(24)00181-6.

Hypokalemic Paralysis Following Intramuscular Betamethasone Injection: A Case Report and Review of Literature. Ebrahimi, Pouya, Homa Taheri, Seyed Ali Mousavinejad, and Pedram Nazari. Clinical Case Reports 12 (5): e8923.

Iatrogenic Combined Common Iliac and Lateral Sacral Artery Perforation During Coronary Angiography: A Case Report and Review of Literature. Mehrpooya, Maryam, Massoud Ghasemi, Pouya Ebrahimi, Homa Taheri, and Parnian Soltani. Clinical Case Reports 12 (5): e8903.

High- Versus Low-Gradient Aortic Stenosis: Is Our Evaluation Limited by Aorto-Mitral Angle on Cardiovascular CT? See, Claudia, Yekaterina Kim, Jakob Park, Yanting Wang, Samuel W. Reinhardt, Evgeny Shkolnik, Kamil F. Faridi, Bernardo Lombo, Lavanya Bellumkonda, Robert L. McNamara, Lissa Sugeng, and David J. Hur. International Journal of Cardiology, May, 132174.

The Significance of Non-Sustained Ventricular Tachycardia on Life-Threatening Ventricular Arrhythmia Events in Patients With Non-Ischemic Cardiomyopathy in the Contemporary Era: A Systematic Review and Meta-Analysis. Kuroda, Shunsuke, Iwanari Kawamura, Yuki Sahashi, and Toshiki Kuno. Journal of Cardiology, May, S0914-5087(24)00086-8.

Socioeconomic Disadvantage in Pregnancy and Postpartum Risk of Cardiovascular Disease. Venkatesh, Kartik K., Sadiya S. Khan, Janet Catov, Jiqiang Wu, Rebecca McNeil, Philip Greenland, Jun Wu, Lisa D. Levine, Lynn M. Yee, Hyagriv N. Simhan, David M. Haas, Uma M. Reddy, George Saade, Robert M. Silver, C. Noel Bairey Merz, and William A. Grobman. American Journal of Obstetrics and Gynecology, May, S0002-9378(24)00589-1.

DCM-Spheroid Morphs Express PADs and Citrullinated Cytoskeletal Proteins. Sadiq, Alia, and Justyna Fert-Bober. The Journal of Histochemistry and Cytochemistry, May, 221554241252862.

Sympathetic Toggled Paroxysmal Atrial Fibrillation and Recurrent Premature Atrial Contractions in Ambulatory Patients. Hwang, Daerin, Xiao Liu, Anxhela Kote, Jewel Reaso, Taiga Andersson, Michael M. Shehata, Ashkan Ehdaie, Xunzhang Wang, Eugenio Cingolani, Archana Ramireddy, Eric D. Braunstein, Lan S. Chen, Xiaochun Li, Joshua Goldhaber, and Peng-Sheng Chen. Heart Rhythm, May, S1547-5271(24)02571-2.

Development and Validation of Machine Learning Algorithms Based on Electrocardiograms for Cardiovascular Diagnoses at the Population Level. Kalmady, Sunil Vasu, Amir Salimi, Weijie Sun, Nariman Sepehrvand, Yousef Nademi, Kevin Bainey, Justin Ezekowitz, Abram Hindle, Finlay McAlister, Russel Greiner, Roopinder Sandhu, and Padma Kaul. NPJ Digital Medicine 7 (1): 133.

Diagnostic Pitfall and Clinical Characteristics of Variant Versus Wild-Type Transthyretin Amyloid Cardiomyopathy in Asian Population: The Korean Nationwide Cohort Study. Kim, Darae, Jong-Chan Youn, Hye Won Lee, Jaewon Oh, Jung-Woo Son, Hyun-Jai Cho, Seul Lee, Nishant R. Shah, Michelle M. Kittleson, and Eun-Seok Jeon. Journal of Korean Medical Science 39 (19): e163.

One- Versus Three-Month Dual Antiplatelet Therapy in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention for Non-ST-Segment Elevation Acute Coronary Syndromes. Cao, Davide, Pascal Vranckx, Marco Valgimigli, Samantha Sartori, Dominick J. Angiolillo, Sripal Bangalore, Deepak L. Bhatt, Yihan Feng, Junbo Ge, James Hermiller, Raj R. Makkar, Franz-Josef Neumann, Shigeru Saito, Hector Picon, Ralph Toelg, Aziz Maksoud, Bassem M. Chehab, James W. Choi, Gianluca Campo, José M. De la Torre Hernandez, Mitchell W. Krucoff, Vijay Kunadian, Gennaro Sardella, Alessandro Spirito, Holger Thiele, Olivier Varenne, Birgit Vogel, Yujie Zhou, Stephan Windecker, and Roxana Mehran. EuroIntervention: Journal of EuroPCR in Collaboration With the Working Group on Interventional Cardiology of the European Society of Cardiology 20 (10): e630–42.

In Vivo Fluid Dynamics of the Ventura Interatrial Shunt Device in Patients With Heart Failure. Pfeiffer, Michael, John Boehmer, John Gorcsan, Shunsuke Eguchi, Yoshiyuki Orihara, Michal Laufer Perl, Neal Eigler, William T. Abraham, Julio Nuñez Villota, Elizabeth Lee, Antoni Bayés-Genís, Gil Moravsky, Saibal Kar, Michael R. Zile, Richard Holcomb, Stefan D. Anker, Gregg W. Stone, Josep Rodés-Cabau, JoAnn Lindenfeld, and Jeroen J. Bax. ESC Heart Failure, May.

Cardiovascular and Renal Outcomes of Glucagon-Like Peptide 1 Receptor Agonists Among Patients With and Without Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Placebo-Controlled Trials. Rivera, Frederick Berro, Linnaeus Louisse A. Cruz, John Vincent Magalong, Jade Monica Marie J. Ruyeras, John Paul Aparece, Nathan Ross B. Bantayan, Kyla Lara-Breitinger, and Martha Gulati. American Journal of Preventive Cardiology 18 (June): 100679.

Sex-Based Utilization of Guideline Recommended Statin Therapy and Cardiovascular Disease Outcomes: Data From a Multisite Healthcare Network Primary Prevention Cohort. Koczo, Agnes, Adipong Brickshawana, Jianhui Zhu, Floyd Thoma, Malamo Countouris, Kathryn Berlacher, Martha Gulati, Erin D. Michos, Steven Reis, Suresh Mulukutla, and Anum Saeed. American Journal of Preventive Cardiology 18 (June): 100667.

Targeting Arrhythmogenic Macrophages: Lessons Learned From Arrhythmogenic Cardiomyopathy. Mesquita, Thassio, and Eugenio Cingolani. The Journal of Clinical Investigation 134 (10).

Medicine

Remission and Low Disease Activity Are Associated With Lower Healthcare Costs: Results From the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Barber, Megan R. W., Manuel Francisco Ugarte-Gil, John G. Hanly, Murray B. Urowitz, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Søren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Bernardo A. Pons-Estel, Francesca S. Cardwell, Graciela S. Alarcón, and Ann E. Clarke. Annals of the Rheumatic Diseases, May, ard-2024-225613.

A Novel Gain-of-Function Phosphorylation Site Modulates PTPN22 Inhibition of TCR Signaling. Zhuang, Chuling, Shen Yang, Carlos G. Gonzalez, Richard I. Ainsworth, Sheng Li, Masumi Takayama Kobayashi, Igor Wierzbicki, Leigh-Ana M. Rossitto, Yutao Wen, Wolfgang Peti, Stephanie M. Stanford, David J. Gonzalez, Ramachandran Murali, Eugenio Santelli, and Nunzio Bottini. The Journal of Biological Chemistry, May, 107393.

HIV and Prior Exposure to Antiretroviral Therapy Alter Tumour Composition and Tumour: T-Cell Associations in Diffuse Large B-Cell Lymphoma. Coelho, Jenny, Sophia M. Roush, Alexander M. Xu, Kaushik Puranam, Marriam Mponda, Edwards Kasonkanji, Maurice Mulenga, Tamiwe Tomoka, Jonathan Galeotti, Amy Brownlee, Hormas Ghadially, Blossom Damania, Matthew Painschab, Akil Merchant, Satish Gopal, and Yuri Fedoriw. British Journal of Haematology, May.

CXCR3-Independent Role of CXCL10 in Alveolar Epithelial Repair. Zhang, Yanli, Jiurong Liang, Jun Ye, Ningshan Liu, Paul W. Noble, and Dianhua Jiang. American Journal of Physiology. Lung Cellular and Molecular Physiology, May.

Predictive Factors of Inactive Patient Participation in an Inflammatory Bowel Disease Learning Health System: A Longitudinal Cohort Study. Dang, Nhu, Soryan Kumar, Michelle Kwon, Michael Cradeur, Katherine Zeven, Mihir Khunte, Daniel Marino, Chung Sang Tse, Welmoed K. van Deen, Adrian Lee, Kendra Kamp, Ridhima Oberai, Gil Y. Melmed, Corey A. Siegel, S. Alandra Weaver, and Samir A. Shah. Inflammatory Bowel Diseases, May, izae099. https://doi.org/10.1093/ibd/izae099.

Long-Term Safety in Epstein-Barr Virus-Seropositive Kidney-Only Transplant Recipients Treated With Belatacept in Clinical Practice: Final Study Results From the ENLiST Registry. Larsen, Christian P., Flavio Vincenti, Tzuyung D Kou, Craig A. Shadur, Barbara Bresnahan, Stanley C. Jordan, E. Steve Woodle, Nelson Goes, John Vella, David Wojciechowski, Martin S. Polinsky, and Andres Gomez-Caminero. Transplantation Direct 10 (6): e1644.

Pragmaticism in Cancer Clinical Trials. Sankar, Kamya, Mary W. Redman, Konstantin H. Dragnev, Brian S. Henick, Wade T. Iams, Charles D. Blanke, Roy S. Herbst, Jhanelle E. Gray, and Karen L. Reckamp. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting 44 (3): e100040.

Neurology

Tocilizumab Is Associated With Reduced Delirium and Coma in Critically Ill Patients With COVID-19. Alkhateeb, Tuqa, Joanna L. Stollings, Ine Sohn, Dandan Liu, L. Montana Fleenor, E. Wesley Ely, and Shouri Lahiri. Scientific Reports 14 (1): 11738.

Neurosurgery

Alzheimer’s Disease Pathophysiology in the Retina. Gaire, Bhakta Prasad, Yosef Koronyo, Dieu-Trang Fuchs, Haoshen Shi, Altan Rentsendorj, Ron Danziger, Jean-Philippe S. Vit, Nazanin Mirzaei, Jonah Doustar, Julia Sheyn, Harald Hampel, Andrea Vergallo, Miyah R. Davis, Ousman Jallow, Filippo Baldacci, Steven R. Verdooner, Ernesto Barron, Mehdi Mirzaei, Vivek K. Gupta, Stuart L. Graham, Mourad Tayebi, Roxana O. Carare, Alfredo A. Sadun, Carol A. Miller, Oana M. Dumitrascu, Shouri Lahiri, Liang Gao, Keith L. Black, and Maya Koronyo-Hamaoui. Progress in Retinal and Eye Research, May, 101273.

OBGYN

Race, Ethnicity, and Sex Representation Trends Among Minimally Invasive Gynecologic Surgery Fellowship Trainees and Graduates. Hamilton, Kacey M., Rhiana Bakhit, Rebecca Schneyer, Gabriel Levin, Magdy Milad, Mireille Truong, Kelly N. Wright, Matthew T. Siedhoff, and Raanan Meyer. Journal of Minimally Invasive Gynecology, May, S1553-4650(24)00219-X.

24-Hour Compared With 12-Hour Mifepristone–Misoprostol Interval for Second-Trimester Abortion: A Randomized Controlled Trial [ID 2683386]. Meyer, Raanan, Shlomi Toussia-Cohen, Maya Shats, Omri Segal, Paul D. Blumenthal, and Roy Mashiach. Obstetrics & Gynecology 143 (5S): 2S.

Pathology and Laboratory Medicine

Classical and Non-Classical Effects of Angiotensin Converting Enzyme: How Increased ACE Enhances Myeloid Immune Function. Bernstein, Kenneth E., DuoYao Cao, Tomohiro Shibata, Suguru Saito, Ellen A. Bernstein, Erika Nishi, Michifumi Yamashita, Warren G. Tourtellotte, Tuantuan V. Zhao, and Zakir Khan. The Journal of Biological Chemistry, May, 107388.

Parental Legal System Involvement, Positive Childhood Experiences, and Suicide Risk. Bravo, Lilian G., Jocelyn Meza, Sara J. Schiff, Charisse Ahmed, Thomas Elliot, Jaime La Charite, and Kristen Choi. Pediatrics, May, e2023062566.

Podocyte Injury as a Potential Therapeutic Target in IgA Nephropathy: Should Pathology Guide Us? Haas, Mark. Kidney International 105 (6): 1165–67.

Pediatrics

Chlamydia Pneumoniae in Alzheimer’s Disease Pathology. Subedi, Lalita, Bhakta Prasad Gaire, Yosef Koronyo, Maya Koronyo-Hamaoui, and Timothy R. Crother. Frontiers in Neuroscience 18: 1393293.

Safety and Infectious Outcomes in Pediatric Kidney Transplant Recipients After COVID-19 Vaccination: A Pediatric Nephrology Research Consortium Study. Churilla, Travis, Clarkson Crane, Rajasree Sreedharan, Bakri J. Alzarka, Olga Charnaya, Namrata G. Jain, Helen Pizzo, Asifhusen Mansuri, Amrish Jain, Manpreet Grewal, Joseph D. Fishbein, Alexander J. Kula, Taylor Heald-Sargent, Debora Matossian, and Priya S. Verghese. Pediatric Transplantation 28 (4): e14786.

Physical Medicine & Rehabilitation

In Memorium: Kenneth J. Ottenbacher - Advancing Science in Medical Rehabilitation as an Academic, Program Developer and Mentor. Deutsch, Anne, Pamela Roberts, and James E. Graham. Archives of Physical Medicine and Rehabilitation, May, S0003-9993(24)00992-4.

Radiation Oncology

Long-Term Analysis of NRG Oncology RTOG 0415: A Randomized Phase III Noninferiority Study Comparing Two Fractionation Schedules in Patients With Low-Risk Prostate Cancer. Lee, W. Robert, James J. Dignam, Mahul B. Amin, Deborah W. Bruner, Daniel Low, Gregory P. Swanson, Amit B. Shah, David D’Souza, Jeff M. Michalski, Ian S. Dayes, Samantha A. Seaward, William A. Hall, Paul L. Nguyen, Thomas M. Pisansky, Sergio L. Faria, Yuhchyau Chen, Joseph P. Rodgers, and Howard M. Sandler. Journal of Clinical Oncology, May, JCO2302445.

Association Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance: An Analysis From a Population-Based Screening Study. Sverrisdottir, Ingigerdur, Sigrun Thorsteinsdottir, Sæmundur Rognvaldsson, Thor Aspelund, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni A. Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdóttir, Signy Vala Sveinsdottir, Robert Palmason, Isleifur Olafsson, Fridbjorn Sigurdsson, Asdis Rosa Thordardóttir, Elias Eythorsson, Asbjorn Jonsson, Runolfur Palsson, Olafur Skuli Indridason, Gauti Kjartan Gislason, Andri Olafsson, Jon Sigurdsson, Hlif Steingrímsdóttir, Thorir Einarsson Long, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Ola Landgren, Sigurdur Yngvi Kristinsson, and Thorvardur Jon Love. Annals of Internal Medicine, May.

Refining Risk Stratification of High-Risk and Locoregional Prostate Cancer: A Pooled Analysis of Randomized Trials. Ravi, Praful, Wanling Xie, Marc Buyse, Susan Halabi, Philip W. Kantoff, Oliver Sartor, Gert Attard, Noel Clarke, Anthony D’Amico, James Dignam, Nicholas James, Karim Fizazi, Silke Gillessen, Wendy Parulekar, Howard Sandler, Daniel E. Spratt, Matthew R. Sydes, Bertrand Tombal, Scott Williams, and Christopher J. Sweeney. European Urology, May, S0302-2838(24)02380-7.

Surgery

Impact of Primary Tumor Resection in the Management of Metastatic Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Pancreas. Russo, Ashley, Timothy DiPeri, Teodora Dumitra, Joshua Tseng, Eric Pletcher, Monica Justo, Courtney Chen, Nicholas Nissen, Farin Amersi, Jun Gong, Andrew Hendifar, and Alexandra Gangi. Journal of Neuroendocrinology, May, e13399.

Chimeric Antigen Receptor T Cell With an Inducible Caspase 9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting. Ventin, Marco, Giulia Cattaneo, Shahrzad Arya, Jingyu Jia, Maria Chiara Gelmi, Yi Sun, Luke Maggs, Bruce R. Ksander, Robert M. Verdijk, Genevieve M. Boland, Russell W. Jenkins, Rizwan Haq, Martine J. Jager, Xinhui Wang, Sandra Ryeom, and Cristina R. Ferrone. Clinical Cancer Research, May.

Multi-Center Experience With Intravascular Lithotripsy for Treatment of Severe Calcification During TCAR for High-Risk Patients. DiLosa, Kathryn, Sally Schonefeld, Rym El-Khoury, Charles Eichler, Alexander DiBartolomeo, Gregory A. Magee, Jeniann Yi, Andrea Simioni, Dennis Gable, Robert Barghout, Micheal Ayad, Nicolas J. Mouawad, Steven Maximus, Donald Baril, Nathan Aranson, Ali Azizzadeh, and Misty Humphries. Journal of Vascular Surgery, May, S0741-5214(24)01075-9.

An Abdominal Seat Belt Sign Is Associated With Similar Incidence of Hollow Viscus Injury but Increased In-Hospital Mortality in Older Adult Trauma Patients: A PCSA Multicenter Study. Sullivan, Brittany G., Patrick T. Delaplain, Morgan Manasa, Erika Tay-Lasso, Walter L. Biffl, Kathryn B. Schaffer, Margaret Sundel, Samar Behdin, Mira Ghneim, Todd W. Costantini, Jarrett E. Santorelli, Emily Switzer, Morgan Schellenberg, Jessica A. Keeley, Dennis Y. Kim, Andrew Wang, Navpreet K. Dhillon, Deven Patel, Eric M. Campion, Caitlin K. Robinson, Susan Kartiko, Megan T. Quintana, Jordan M. Estroff, Katharine A. Kirby, and Jeffry Nahmias. The American Surgeon, May, 31348241256084.

Correction of Age-Related Changes in the Skin at the Dermal and Subdermal Level Using Radiofrequency Macroneedling Therapy. Flegontova, Elena, Michael Kreindel, Neil M. Vranis, and R. Stephen Mulholland. Journal of Cosmetic Dermatology, May.

Urology

Challenges and Opportunities in Establishing Appropriate Intermediate Endpoints Reflecting Patient Benefit: A Roadmap for Research and Clinical Application in Nonmetastatic Prostate Cancer. Brookman-May, Sabine D., Marc Buyse, Stephen J. Freedland, Branko Miladinovic, Ke Zhang, Wolfgang P. Fendler, Felix Feng, Oliver Sartor, and Christopher J. Sweeney. European Urology, May, S0302-2838(24)02348-0.

Variation in Content Discussed by Specialty in Consultations for Clinically Localized Prostate Cancer. Friedrich, Nadine A., Michael Luu, Rebecca Gale, Antwon Chaplin, Leslie Ballas, Howard M. Sandler, Edwin M. Posadas, Stephen J. Freedland, Brennan Spiegel, Paul Kokorowski, and Timothy J. Daskivich. Urologic Oncology, May, S1078-1439(24)00432-0.