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Faculty Publications March 7-14


A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published March 7-14.


Overview and Clinical Applications of Artificial Intelligence and Machine Learning in Cardiac Anesthesiology. Mathis, Michael, Kirsten R. Steffner, Harikesh Subramanian, George P. Gill, Natalia I. Girardi, Sagar Bansal, Karsten Bartels, Ashish K. Khanna, and Jiapeng Huang. Journal of Cardiothoracic and Vascular Anesthesia, February, S1053-0770(24)00098-3.

Biomedical Sciences

In Vitro and in Vivo Modeling Systems of Supratentorial Ependymomas. Hatanaka, Emily A., and Joshua J. Breunig. Frontiers in Oncology 14: 1360358.

Association of Epicardial Adipose Tissue With Early Structural and Functional Cardiac Changes in Type 2 Diabetes. Ayton, Sarah L., Jian L. Yeo, Gaurav S. Gulsin, Abhishek Dattani, Joanna Bilak, Aparna Deshpande, J. Ranjit Arnold, Anvesha Singh, Matthew P. M. Graham-Brown, Leong Ng, Donald Jones, Piotr Slomka, Damini Dey, Alastair J. Moss, Emer M. Brady, and Gerry P. McCann. European Journal of Radiology 174 (February): 111400.

Reproducibility of Artificial Intelligence-Enabled Plaque Measurements Between Systolic and Diastolic Phases From Coronary Computed Tomography Angiography. Flores Tomasino, Guadalupe, Donghee Han, Raymond Pimentel, William Paz, Juni Liang, Victor Y. Cheng, Piotr Slomka, Daniel S. Berman, and Damini Dey. European Radiology, March.


Real-World Outcomes for the Fifth-Generation Balloon Expandable Transcatheter Heart Valve in the United States. Stinis, Curtiss T., Amr E. Abbas, Paul Teirstein, Raj R. Makkar, Christine J. Chung, Vijay Iyer, Philippe Généreux, Robert M. Kipperman, John K. Harrison, G. Chad Hughes, Jefferson M. Lyons, Ayaz Rahman, Nikolaos Kakouros, Jennifer Walker, David K. Roberts, Pei-Hsiu Huang, Biswajit Kar, Abhijeet Dhoble, Daniel P. Logsdon, Puneet K. Khanna, Joseph Aragon, and James M. McCabe. JACC. Cardiovascular Interventions, February, S1936-8798(24)00461-8.

Paclitaxel-Coated Balloon vs Uncoated Balloon for Coronary In-Stent Restenosis: The AGENT IDE Randomized Clinical Trial. Yeh, Robert W., Richard Shlofmitz, Jeffrey Moses, William Bachinsky, Suhail Dohad, Steven Rudick, Robert Stoler, Brian K. Jefferson, William Nicholson, John Altman, Cinthia Bateman, Amar Krishnaswamy, J. Aaron Grantham, Frank J. Zidar, Steven P. Marso, Jennifer A. Tremmel, Cindy Grines, Mustafa I. Ahmed, Azeem Latib, Behnam Tehrani, J. Dawn Abbott, Wayne Batchelor, Paul Underwood, Dominic J. Allocco, Ajay J. Kirtane, and AGENT IDE Investigators. JAMA, March, e241361.

Computational Biomedicine

Class-Balanced Deep Learning With Adaptive Vector Scaling Loss for Dementia Stage Detection. Tong, Boning, Zhuoping Zhou, Davoud Ataee Tarzanagh, Bojian Hou, Andrew J. Saykin, Jason Moore, Marylyn Ritchie, and Li Shen. Machine Learning in Medical Imaging. MLMI (Workshop) 14349: 144–54.

Emergency Medicine

Privacy and Confidentiality of Emergency Department Patient Information: Contemporary Considerations and Challenges. Brenner, Jay M., Michele Y. Delpier, Jeremy R. Simon, Joel M. Geiderman, Catherine A. Marco, John C. Moskop, and American College of Emergency Physicians Ethics Committee. Journal of the American College of Emergency Physicians Open 5 (2): e13130.


AI-Defined Cardiac Anatomy Improves Risk Stratification of Hybrid Perfusion Imaging. Miller, Robert J. H., Aakash Shanbhag, Aditya Killekar, Mark Lemley, Bryan Bednarski, Paul B. Kavanagh, Attila Feher, Edward J. Miller, Timothy Bateman, Valerie Builoff, Joanna X. Liang, David E. Newby, Damini Dey, Daniel S. Berman, and Piotr J. Slomka. JACC. Cardiovascular Imaging, March, S1936-878X(24)00038-X.


Opioid-Induced Adrenal Insufficiency: Diagnostic and Management Considerations. Patel, Erica, and Anat Ben-Shlomo. Frontiers in Endocrinology 14: 1280603.

Artificial Intelligence in Liver Cancer Research: A Scientometrics Analysis of Trends and Topics. Rezaee-Zavareh, Mohammad Saeid, Naomy Kim, Yee Hui Yeo, Hyunseok Kim, Jeong Min Lee, Claude B. Sirlin, Bachir Taouli, Rola Saouaf, Ashley M. Wachsman, Mazen Noureddin, Zhiping Wang, Jason Moore, Debiao Li, Amit G. Singal, and Ju Dong Yang. Frontiers in Oncology 14: 1355454.

Corrigendum: Poor Prognostic Factors of Pharmacokinetic Origin Predict Outcomes in Inflammatory Bowel Disease Patients Treated With Anti-Tumor Necrosis Factor-?. Spencer, Elizabeth A., Marla C. Dubinsky, Michael A. Kamm, Maria Chaparro, Paolo Gionchetti, Fernando Rizzello, Javier P. Gisbert, Emily K. Wright, Julien D. Schulberg, Amy L. Hamilton, Dermot P. B. McGovern, and Thierry Dervieux. Frontiers in Immunology 15: 1383704.

Patient Perceptions of Dietary Therapies in Crohn’s Disease: A Dietitian’s Perspective. Scarcello, Christine L. Crohn’s & Colitis 360 6 (1): otae012.

The Importance of Ultrasound-Guided Synovial Biopsy in the Workup of Seronegative Inflammatory Arthritis: A Case Report. Zhi, Cherie S., Julia R. Kesselhaut, Swamy R. Venuturupalli, and Ami Ben-Artzi. Cureus 16 (2): e53805.

Spontaneous Fusion With Transformed Mesenchymal Stromal Cells Results in Complete Heterogeneity in Prostate Cancer Cells. Wang, Ruoxiang, Peizhen Hu, Fubo Wang, Ji Lyu, Yan Ou, Mouad Edderkaoui, Yi Zhang, Michael S. Lewis, Stephen J. Pandol, Haiyen E. Zhau, and Leland W. K. Chung. Cancers 16 (5): 951.

Circulating Immune Signatures in Chronic Pancreatitis With and Without Preceding Acute Pancreatitis: A Pilot Study. Hagn-Meincke, Rasmus, Dhiraj Yadav, Dana K. Andersen, Santhi Swaroop Vege, Evan L. Fogel, Jose Serrano, Melena D. Bellin, Mark D. Topazian, Darwin L. Conwell, Liang Li, Stephen K. Van Den Eeden, Asbjørn M. Drewes, Stephen J. Pandol, Chris E. Forsmark, William E. Fisher, Phil A. Hart, Søren S. Olesen, Walter G. Park, and Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). Pancreatology, February, S1424-3903(24)00056-5.

The Disproportionate Rise in Pancreatic Cancer in Younger Women Is Due to a Rise in Adenocarcinoma and Not Neuroendocrine Tumors: A Nationwide Time-Trend Analysis Using 2001-2018 United States Cancer Statistics Databases. Jiang, Yi, Yazan Abboud, Jeff Liang, Brent Larson, Arsen Osipov, Jun Gong, Andrew E. Hendifar, Katelyn Atkins, Quin Liu, Nicholas N. Nissen, Debiao Li, Stephen J. Pandol, Simon K. Lo, and Srinivas Gaddam. Cancers 16 (5): 971.

Rosuvastatin Effect on Atherosclerotic Plaque Metabolism: A Subclinical Atherosclerosis Imaging Study With 18F-NaF PET-CT. Oliveira-Santos, Manuel, João Borges-Rosa, Rodolfo Silva, Luís Paixão, Cláudio Espírito Santo, Antero Abrunhosa, Miguel Castelo-Branco, Piotr J. Slomka, Lino Gonçalves, and Maria João Ferreira. Atherosclerosis, February, 117481.

Tranexamic Acid in Upper Gastrointestinal Bleeding Is Associated With Venous and Arterial Thromboembolic Events. Fowler, Cosmo, Jason Nasser, Brittany Fera, Lauren Chism, and Stephen M. Pastores. Critical Care Explorations 6 (3): e1060.

Atrial Arrhythmias in Patients With Pulmonary Hypertension. O’Meara, Kyle, Gregory Stone, Eric Buch, Adam Brownstein, Rajan Saggar, Richard Channick, Alexander E. Sherman, and Aron Bender. Chest, March, S0012-3692(24)00291-5.

Glutamine Supplementation as an Anticancer Strategy: A Potential Therapeutic Alternative to the Convention. Muranaka, Hayato, Rasaq Akinsola, Sandrine Billet, Stephen J. Pandol, Andrew E. Hendifar, Neil A. Bhowmick, and Jun Gong. Cancers 16 (5): 1057.

AI-Luminating Artificial Intelligence in Inflammatory Bowel Diseases: A Narrative Review on the Role of AI in Endoscopy, Histology, and Imaging for IBD. Gu, Phillip, Oreen Mendonca, Dan Carter, Shishir Dube, Paul Wang, Xiuzhen Huang, Debiao Li, Jason H. Moore, and Dermot P. B. McGovern. Inflammatory Bowel Diseases, March, izae030.

Home-Based Telemedicine in Rheumatology-A Scoping Review. Venuturupalli, Swamy, Alexander Peck, Yogamanas Jinka, Natalie Fortune, Nikhil Davuluri, William B. Nowell, Kelly Gavigan, John Cush, Neelkamal Soares, Rebecca Grainger, and Jeffrey R. Curtis. ACR Open Rheumatology, March.

Thoracic Aortic Microcalcification Activity in Combined Positron Emission Tomography and Magnetic Resonance Imaging. Nash, Jennifer, Samuel Debono, Beth Whittington, Jakub Kaczynski, Tim Clark, Gillian Macnaught, Scott Semple, Edwin J. R. van Beek, Adriana Tavares, Damini Dey, Michelle C. Williams, Piotr J. Slomka, David E. Newby, Marc R. Dweck, and Alexander J. Fletcher. European Journal of Nuclear Medicine and Molecular Imaging, March.

Long-Term Proton Pump Inhibitor Use: Review of Indications and Special Considerations. Kamboj, Amrit K., Dhyanesh A. Patel, and Rena Yadlapati. Clinical Gastroenterology and Hepatology, March, S1542-3565(24)00195-2.

Factors Associated With the Maintenance of Cost-Effectiveness at 5 Years in Adult Spinal Deformity Corrective Surgery. Passias, Peter G., Jamshaid M. Mir, Pooja Dave, Justin S. Smith, Renaud Lafage, Jeffrey Gum, Breton G. Line, Bassel Diebo, Alan H. Daniels, David Kojo Hamilton, Thomas J. Buell, Justin K. Scheer, Robert K. Eastlack, Jeffrey P. Mullin, Gregory M. Mundis, Naobumi Hosogane, Mitsuru Yagi, Andrew J. Schoenfeld, Juan S. Uribe, Neel Anand, Praveen V. Mummaneni, Dean Chou, Eric O. Klineberg, Khaled M. Kebaish, Stephen J. Lewis, Munish C. Gupta, Han Jo Kim, Robert A. Hart, Lawrence G. Lenke, Christopher P. Ames, Christopher I. Shaffrey, Frank J. Schwab, Virginie Lafage, Richard A. Hostin, Shay Bess, Douglas C. Burton, and International Spine Study Group. Spine, March.

Large Language Models and Bariatric Surgery Patient Education: A Comparative Readability Analysis of GPT-3.5, GPT-4, Bard, and Online Institutional Resources. Srinivasan, Nitin, Jamil S. Samaan, Nithya D. Rajeev, Mmerobasi U. Kanu, Yee Hui Yeo, and Kamran Samakar. Surgical Endoscopy, March.

Comparative Efficacy of Drug Interventions on NAFLD Over 24 Weeks: A Traditional and Network Meta-Analysis of Randomized Controlled Trials. Wang, Yifan, He Yi, Weixia Sun, Hekai Yu, Wenxuan Tao, Xiaojin Yu, Dianrong Jia, Yingzhao Liu, Stephen J. Pandol, and Ling Li. Drugs, March.


Choroid Plexus Volume Differentiates MS From Its Mimics. Levit, Elle, Zheng Ren, Virgilio Gonzenbach, Christina J. Azevedo, Peter A. Calabresi, Bruce Ac Cree, Leorah Freeman, Erin E. Longbrake, Jiwon Oh, Matthew K. Schindler, Nancy L. Sicotte, Daniel S. Reich, Daniel Ontaneda, Pascal Sati, Quy Cao, Russell T. Shinohara, and Andrew J. Solomon. Multiple Sclerosis (Houndmills, Basingstoke, England), March, 13524585241238094.

Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: National Heart, Lung, and Blood Institute Workshop Report. Palakshappa, Jessica A., Jane A. E. Batt, Sue C. Bodine, Bronwen A. Connolly, Jason Doles, Jason R. Falvey, Lauren E. Ferrante, D. Clark Files, Michael O. Harhay, Kirsten Harrell, Joseph A. Hippensteel, Theodore J. Iwashyna, James C. Jackson, Meghan B. Lane-Fall, Michelle Monje, Marc Moss, Dale M. Needham, Matthew W. Semler, Shouri Lahiri, Lars Larsson, Carla M. Sevin, Tarek Sharshar, Benjamin Singer, Troy Stevens, Stephanie P. Taylor, Christian R. Gomez, Guofei Zhou, Timothy D. Girard, and Catherine L. Hough. American Journal of Respiratory and Critical Care Medicine, March.


Cost Sharing for Oral Lenvatinib Among Commercially Insured Patients. Liang, Margaret I., Ling Chen, Emeline M. Aviki, and Jason D. Wright. The American Journal of Managed Care 30 (3): 114–17.

Perinatal Outcomes According to Umbilical Artery Doppler Assessment Among Fetuses With Congenital Heart Disease. Pham, Amelie, Karampreet Kaur, Matthew R. Grace, Laura C. Ha, and Lisa C. Zuckerwise. Archives of Gynecology and Obstetrics, March.


Revision Surgery Risk After Open Reduction and Internal Fixation Versus Acute Total Hip Arthroplasty in Geriatric Acetabular Fractures: A Nationwide Study. Nilssen, Paal, Karma McKelvey, and Carol Lin. The Journal of the American Academy of Orthopaedic Surgeons, March.


2023 ASHG Lifetime Achievement Award: Neil Risch. Klein, Ophir. American Journal of Human Genetics 111 (3): 410–11.

Radiation Oncology

Motion Compensated Cone-Beam CT Reconstruction Using Ana Priorimotion Model From CT Simulation: A Pilot Study. Lauria, Michael Vincent, Claudia Miller, Kamal Singhrao, John Lewis, Weicheng Lin, Dylan O’Connell, Louise Naumann, Bradley Stiehl, Anand Santhanam, Peter Boyle, Ann C. Raldow, Jonathan Goldin, Igor Barjaktarevic, and Daniel A. Low. Physics in Medicine and Biology, March.

Perspective and Current Status of Radiotherapy Service in IRan (PERSIR)-1 Study: Assessment of Current External Beam Radiotherapy Facilities, Staff and Techniques Compared to the International Guidelines. Saeedian, Arefeh, Fatemeh-Sadat Tabatabaei, Amirali Azimi, Mohammad Babaei, Marzieh Lashkari, Ebrahim Esmati, Zeinab Abiar, Leila Moadabshoar, Saleh Sandoughdaran, Mitchell Kamrava, Arya Amini, and Reza Ghalehtaki. BMC Cancer 24 (1): 324.


Introduction to ‘Advances in Microsurgical Breast Reconstruction.’ Salibian, Ara A., and Ketan M. Patel. Gland Surgery 13 (2): 128–30.

Implications of Drug Intoxication on Donor Utilization and Outcomes in Liver Transplantation. Adjei, Michie, Steven A. Wisel, Ju Dong Yang, Nicholas N. Nissen, Irene K. Kim, and Justin A. Steggerda. Clinical Transplantation 38 (3): e15276.

Revision Rates in Cosmetic Plastic Surgery With and Without Resident Involvement. Newman, Ashley, Antonina R. Caudill, Eleanor Ball, and Steven P. Davison. Plastic and Reconstructive Surgery. Global Open 12 (3): e5678.

The Sac Evolution Imaging Follow-Up After EVAR: An International Expert Opinion-Based Delphi Consensus Study. Tinelli, Giovanni, Mario D’Oria, Simona Sica, Kevin Mani, Zoran Rancic, Timothy Andrew Resh, Flavia Beccia, Ali Azizzadeh, Marcelo Martins Da Volta Ferreira, Mauro Gargiulo, Sandro Lepidi, Yamume Tshomba, Gustavo S. Oderich, Stephan Haulon, and SLIM F-U EVAR Collaborative Study Group. Journal of Vascular Surgery, March, S0741-5214(24)00424-5.

Head-Down Topical Sinus Rinses: Cut Your Way to Success. Wu, Arthur William, Dennis Mansfield Tang, and Gene C. Liu. American Journal of Rhinology & Allergy, March, 19458924241238553.

Risk Factors for Microscopic Disease Positivity at Ileocolic Resection Margins for Crohn’s Disease. Truong, Adam, Jino Chough, Karen N. Zaghiyan, and Phillip R. Fleshner. Surgical Technology International 44 (March): sti44/1764.

Improving Classification Accuracy of Fine-Tuned CNN Models: Impact of Hyperparameter Optimization. Wojciuk, Mikolaj, Zaneta Swiderska-Chadaj, Krzysztof Siwek, and Arkadiusz Gertych. Heliyon 10 (5): e26586.


Do Hispanic Puerto Rican Men Have Worse Outcomes after Radical Prostatectomy? Results From SEARCH. Guerrios-Rivera, Lourdes, Jessica L. Janes, Amanda M. De Hoedt, Zachary Klaassen, Martha K. Terris, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane, William J. Aronson, Jay H. Fowke, and Stephen J. Freedland. Cancer Medicine 13 (4): e7012.

Variation in Defining Retention After Onabotulinum Toxin A for Overactive Bladder: A Systematic Review. Castaneda, Peris R., Andrew Chen, Paige Kuhlmann, Jennifer T. Anger, and Karyn S. Eilber. Urogynecology (Philadelphia, Pa.), March.

Drug-Drug Interaction Potential Among Patients With Nonmetastatic Castration-Resistant Prostate Cancer (nmCRPC) Treated With Novel Androgen Receptor Inhibitors. Appukkuttan, Sreevalsa, Gilbert Ko, Chunmay Fu, Breyanne Bannister, Sheldon X. Kong, Jay Jhaveri, and Stephen J. Freedland. Expert Review of Anticancer Therapy, March, 1–9.