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Faculty Publications March 28-April 4


A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published March 28-April 4. 


Domains Influencing Faculty Decisions on the Level of Supervision Required for Anesthesiology EPAs With Analysis of Feedback Comments. Tanaka, Pedro, Yoon Soo Park, Chien-Yu Chen, Roya Yumul, and Alex Macario. Journal of Surgical Education, March, S1931-7204(24)00099-0.

Biomedical Sciences

Differential Vulnerability and Response to Injury Among Brain Cell Types Comprising the Neurovascular Unit. Rajput, Padmesh, Allison Brookshier, Shweta Kothari, Lillie Eckstein, Heather Chang, Sophie Liska, Jessica Lamb, Samuel Sances, and Patrick Lyden. The Journal of Neuroscience, March, e1093222024.

Validation of a Fully Automated Deep Learning-Enabled Solution for CCTA Atherosclerotic Plaque and Stenosis Quantification in a Diverse Real-World Cohort. Lorenzatti, Daniel, Annalisa Filtz, Pamela Pina, Andrea Scotti, Aldo L. Schenone, Carlos A. Gongora, Alan C. Kwan, Victor Y. Cheng, Mario J. Garcia, Daniel S. Berman, Piotr J. Slomka, Damini Dey, and Leandro Slipczuk. Journal of Cardiovascular Computed Tomography, March, S1934-5925(24)00071-6.

Cardiac Surgery

Transcatheter Aortic Valve Implantation in Patients With High-Risk Symptomatic Native Aortic Regurgitation (ALIGN-AR): A Prospective, Multicentre, Single-Arm Study. Vahl, Torsten P., Vinod H. Thourani, Raj R. Makkar, Nadira Hamid, Omar K. Khalique, David Daniels, James M. McCabe, Lowell Satler, Mark Russo, Wen Cheng, Isaac George, Gabriel Aldea, Brett Sheridan, Dean Kereiakes, Harsh Golwala, Firas Zahr, Stanley Chetcuti, Pradeep Yadav, Susheel K. Kodali, Hendrik Treede, Stephan Baldus, Nicholas Amoroso, Lauren S. Ranard, Duane S. Pinto, and Martin B. Leon. Lancet (London, England), March, S0140-6736(23)02806-4.


TAVR-in-TAVR With a Balloon-Expandable Valve for Paravalvular Leak. Nagasaka, Takashi, Vivek Patel, Ofir Koren, Alon Shechter, Tarun Chakravarty, Wen Cheng, Hideki Ishii, Hasan Jilaihawi, Mamoo Nakamura, and Raj R. Makkar. Frontiers in Cardiovascular Medicine 11: 1374078.

Deep Learning-Derived Myocardial Strain. Kwan, Alan C., Ernest W. Chang, Ishan Jain, John Theurer, Xiu Tang, Nadia Francisco, Francois Haddad, David Liang, Alexandra Fábián, Andrea Ferencz, Neal Yuan, Béla Merkely, Robert Siegel, Susan Cheng, Attila Kovács, Márton Tokodi, and David Ouyang. JACC. Cardiovascular Imaging, March, S1936-878X(24)00063-9.

Dobutamine-Induced Myoclonus in a Patient With Advanced Heart Failure and Chronic Kidney Disease. Lee, Alexander Y., Shiva Barforoshi, Alvin Singh, Ritesh Shrestha, James Ha, and Michelle Kittleson. JACC. Case Reports 29 (6): 102255.

Comparison of Risk Profiles of Participants in the Women’s IschemiA TRial to Reduce Events in Non-ObstRuctive CAD (WARRIOR) Trial, Using Coronary Computed Tomography Angiography vs Invasive Coronary Angiography. Lakshmanan, Suvasini, Janet Wei, Galen Cook-Wiens, Carl J. Pepine, Eileen M. Handberg, Leslee J. Shaw, Matthew Budoff, and C. Noel Bairey Merz. Progress in Cardiovascular Diseases, March, S0033-0620(24)00053-7.

Biological Pacemakers: Present and Future. Mesquita, Thassio, Rodrigo Miguel-Dos-Santos, and Eugenio Cingolani. Circulation Research 134 (7): 837–41.

Interlaboratory Comparison of Antibody-Free LC-MS/MS Measurements of C-Peptide and Insulin. Moradian, Annie, Elisha Goonatilleke, Tai-Tu Lin, Maya Hatten-Beck, Michelle Emrick, Athena A. Schepmoes, Thomas L. Fillmore, Michael J. MacCoss, Salvatore Sechi, Kimia Sobhani, Randie Little, Kuanysh Kabytaev, Jennifer E. van Eyk, Wei-Jun Qian, and Andrew N. Hoofnagle. Clinical Chemistry, March, hvae034.

Patient-Physician Sex Concordance and Outcomes in Cardiovascular Disease: A Systematic Review. Harik, Lamia, Ko Yamamoto, Takeshi Kimura, Lisa Q. Rong, Birgit Vogel, Roxana Mehran, C. Noel Bairey-Merz, and Mario Gaudino. European Heart Journal, March, ehae121.

A Woman With Eptifibatide (Integrilin)-Induced Thrombocytopenia Following Treatment of a Clot in Her Coronary Artery: A Case Report and Literature Review. Safi, Morteza, Roozbeh Nazari, Nahid Senobari, Homa Taheri, and Pouya Ebrahimi. Clinical Case Reports 12 (4): e8694.

Interatrial Shunt Therapy in Advanced Heart Failure: Outcomes From the Open-Label Cohort of the RELIEVE-HF Trial. Rodés-Cabau, Josep, JoAnn Lindenfeld, William T. Abraham, Michael R. Zile, Saibal Kar, Antoni Bayés-Genís, Neal Eigler, Richard Holcomb, Julio Núñez, Elizabeth Lee, Michal Laufer Perl, Gil Moravsky, Michael Pfeiffer, John Boehmer, John Gorcsan, Jeroen J. Bax, Stefan Anker, and Gregg W. Stone. European Journal of Heart Failure, April.

?-Adrenergic Signaling Drives Structural and Functional Maturation of Mouse Cardiomyocytes. Eliezeck, Marcos, Itamar Couto Guedes Jesus, Sergio A. Scalzo, Bruno de Lima Sanches, Kaoma S. C. Silva, Mateus Costa, Thassio Mesquita, Cibele Rocha-Resende, Raphael E. Szawka, and Silvia Guatimosim. American Journal of Physiology. Cell Physiology, April.

Prevention of Sudden Cardiac Death: Beyond Automated External Defibrillators and Implantable Cardioverter Defibrillators. Chugh, Sumeet S. Circulation 149 (14): 1059–61.

Association Between Proactive Esophageal Cooling and Increased Lab Throughput. Zagrodzky, William, Julie Cooper, Christopher Joseph, Matthew Sackett, Jose Silva, Richard Kuk, Julia McHugh, Babette Brumback, Shirley Park, Robert Hayward, Taresh Taneja, Andrew Vu, Taylor Liu, Erik Kulstad, Andrew Kaplan, Archana Ramireddy, and Samuel Omotoye. Journal of Cardiovascular Electrophysiology, April.

Pregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks Gestation. Woolcock, Helen, Natalia Natalia Parra, Yijia Zhang, Uma Reddy, Natalie A. Bello, Eliza Miller, and Whitney Alexandra Booker. American Journal of Perinatology, April.

Atherosclerotic Coronary Plaque Regression From Lipid-Lowering Therapies: A Meta-Analysis and Meta-Regression. Rivera, Frederick Berro, Sung Whoy Cha, Michelle Capahi Varona, Elaiza Marie Fernandez Co, John Vincent Magalong, John Paul Aparece, Diana De Oliveira-Gomes, Gurleen Kaur, and Martha Gulati. American Journal of Preventive Cardiology 18 (June): 100645. 


Efficacy and Safety of the MDM2-P53 Antagonist Brigimadlin (BI 907828) in Patients With Advanced Biliary Tract Cancer: A Case Series. Yamamoto, Noboru, Anthony Tolcher, Navid Hafez, Iwona Lugowska, Rodryg Ramlau, Teresa Macarulla, Junxian Geng, Jian Li, Michael Teufel, Angela Märten, and Patricia LoRusso. OncoTargets and Therapy 17: 267–80.

Increased Risk of Aspiration Pneumonia Associated With Endoscopic Procedures Among Patients With Glucagon-like Peptide-1 Receptor Agonist Use. Yeo, Yee Hui, Srinivas Gaddam, Wee Han Ng, Pin-Chia Huang, Gastrointestinal Motility and Metabolic Pharmacoepidemiology Group, Kevin Sheng-Kai Ma, and Ali Rezaie. Gastroenterology, March, S0016-5085(24)00298-1.

Artificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging. Feher, Attila, Bryan Bednarski, Robert J. Miller, Aakash Shanbhag, Mark Lemley, Leonidas Miras, Albert J. Sinusas, Edward J. Miller, and Piotr J. Slomka. Journal of Nuclear Medicine, March, jnumed.123.266761.

Inter- and Intraobserver Variability on Endoscopic Scoring Systems in Crohn’s Disease and Ulcerative Colitis: A Systematic Review and Meta-Analysis. Hashash, Jana G., Faye Yu Ci Ng, Francis A. Farraye, Yeli Wang, Daniel R. Colucci, Shrujal Baxi, Sadaf Muneer, Mitchell Reddan, Pratik Shingru, and Gil Y. Melmed. Inflammatory Bowel Diseases, March, izae051.

Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease in Premenopausal Women: Global Trends and Projections to 2040. Danpanichkul, Pojsakorn, Cheng Han Ng, Mark D. Muthiah, Kwanjit Duangsonk, Siwanart Kongarin, Karan Srisurapanont, Phakkamon Pingwang, Nonlawan Songmueang, Chalida Nonthasoot, Worapaka Manosroi, Surakit Nathisuwan, Fang Li, Ju Dong Yang, Vincent L. Chen, Donghee Kim, Mazen Noureddin, Daniel Q. Huang, and Karn Wijarnpreecha. Mayo Clinic Proceedings, March, S0025-6196(24)00035-1.

Racial Differences in Treatment Intensity at the End of Life Among Older Adults With Heart Failure: Evidence From the Health and Retirement Study. McCleskey, Sara G., Arturo Vargas Bustamante, Sangeeta C. Ahluwalia, Teryl K. Nuckols, Gerald F. Kominski, and Emmeline Chuang. Journal of Palliative Medicine, March.

Description of a Novel Splice Site Variant in UBA1 Gene Causing VEXAS Syndrome. Ospina Cardona, Daniela, Ignasi Rodriguez-Pinto, Sonia Iosim, Nuria Bonet, Anna Mensa-Vilaro, Mei-Kay Wong, Gary Ho, Marc Tormo, Jordi Yagüe, Wonwoo Shon, Daniel Wallace, Ferran Casals, David B. Beck, Rachel Abuav, and Juan I. Arostegui. Rheumatology (Oxford, England), March, keae201.

Predicting Mortality From AI Cardiac Volumes Mass and Coronary Calcium on Chest Computed Tomography. Miller, Robert J. H., Aditya Killekar, Aakash Shanbhag, Bryan Bednarski, Anna M. Michalowska, Terrence D. Ruddy, Andrew J. Einstein, David E. Newby, Mark Lemley, Konrad Pieszko, Serge D. Van Kriekinge, Paul B. Kavanagh, Joanna X. Liang, Cathleen Huang, Damini Dey, Daniel S. Berman, and Piotr J. Slomka. Nature Communications 15 (1): 2747.

Laser Capture Microscopy (LCM)-RNAseq for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis. Van Espen, Benjamin, E. Barton Prideaux, Andrew R. Wilson, Camilla R. L. Machado, Sho Sendo, James Parker, Grégory Seumois, Cristiano Sacchetti, Anna C. Belongia, Narayanan B. Perumal, Pandurangan Vijayanand, Matthew D. Linnik, Robert J. Benschop, Wei Wang, Nunzio Bottini, Gary S. Firestein, and Stephanie M. Stanford. Arthritis & Rheumatology (Hoboken, N.J.), March.

Genetic Risk Impacts the Association of Menopausal Hormone Therapy With Colorectal Cancer Risk. Tian, Yu, Yi Lin, Conghui Qu, Volker Arndt, James W. Baurley, Sonja I. Berndt, Stephanie A. Bien, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Arif Budiarto, Peter T. Campbell, Jenny Chang-Claude, et al. British Journal of Cancer, April.

Health Care Delivery Innovations-Implementation Matters in Understanding What Works. Nuckols, Teryl K. JAMA Network Open 7 (4): e243675.

ChatGPT as a Source of Information for Bariatric Surgery Patients: A Comparative Analysis of Accuracy and Comprehensiveness Between GPT-4 and GPT-3.5. Samaan, Jamil S., Nithya Rajeev, Wee Han Ng, Nitin Srinivasan, Jonathan A. Busam, Yee Hui Yeo, and Kamran Samakar. Obesity Surgery, April.

Feasibility and Performance of Continuous Glucose Monitoring to Guide Computerized Insulin Infusion Therapy in Cardiovascular Intensive Care Unit. Ang, Lynn, Yu Kuei Lin, Lee F. Schroeder, Yiyuan Huang, Christina A. DeGeorge, Patrick Arnold, Folake Akanbi, Sharon Knotts, Elizabeth DuBois, Nicole Desbrough, Yunyan Qu, Regi Freeman, Nazanene H. Esfandiari, Rodica Pop-Busui, and Roma Gianchandani. Journal of Diabetes Science and Technology, April, 19322968241241005.

Our Extended Microbiome: The Human-Relevant Metabolites and Biology of Fermented Foods. Caffrey, Elisa B., Justin L. Sonnenburg, and Suzanne Devkota. Cell Metabolism 36 (4): 684–701.

Implementation of an Intervention Aimed at Deprescribing Benzodiazepines in a Large US Healthcare System Using Patient Education Materials: A Pre/Post-Observational Study With a Control Group. Le, Tammy M., Scott Campbell, Alexa Andraos, Pedro Ahlmark, Ha Hoang, Sean Isserman, Caroline L. Goldzweig, Allison M. Mays, Kristin Bradley, and Michelle S. Keller. BMJ Open 14 (4): e080109.

Drp1 Controls Complex II Assembly and Skeletal Muscle Metabolism by Sdhaf2 Action on Mitochondria. Zhou, Zhenqi, Alice Ma, Timothy M. Moore, Dane M. Wolf, Nicole Yang, Peter Tran, Mayuko Segawa, Alexander R. Strumwasser, Wenjuan Ren, Kai Fu, Jonathan Wanagat, Alexander M. van der Bliek, Rachelle Crosbie-Watson, Marc Liesa, Linsey Stiles, Rebecca Acin-Perez, Sushil Mahata, Orian Shirihai, Mark O. Goodarzi, Michal Handzlik, Christian M. Metallo, David W. Walker, and Andrea L. Hevener. Science Advances 10 (14): eadl0389.


 Neurostimulation for Advanced Parkinson Disease and Quality of Life at 5 Years: A Nonrandomized Controlled Trial. Jost, Stefanie T., Salima Aloui, Julian Evans, Keyoumars Ashkan, Anna Sauerbier, Alexandra Rizos, Jan Niklas Petry-Schmelzer, Alexandra Gronostay, Gereon R. Fink, Veerle Visser-Vandewalle, Angelo Antonini, Monty Silverdale, Lars Timmermann, Pablo Martinez-Martin, K. Ray Chaudhuri, Haidar S. Dafsari, and International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group and EUROPAR. JAMA Network Open 7 (1): e2352177.

Safety and Efficacy of Continuous Subcutaneous Levodopa-Carbidopa Infusion (ND0612) for Parkinson’s Disease With Motor Fluctuations (BouNDless): A Phase 3, Randomised, Double-Blind, Double-Dummy, Multicentre Trial. Espay, Alberto J., Fabrizio Stocchi, Rajesh Pahwa, Alberto Albanese, Aaron Ellenbogen, Joaquim J. Ferreira, Nir Giladi, Tanya Gurevich, Sharon Hassin-Baer, Jorge Hernandez-Vara, Stuart H. Isaacson, Karl Kieburtz, Peter A. LeWitt, Lydia Lopez-Manzanares, C. Warren Olanow, Werner Poewe, Harini Sarva, Tami Yardeni, Liat Adar, Laurence Salin, Nelson Lopes, Nissim Sasson, Ryan Case, Olivier Rascol, and BouNDless Study Group. The Lancet. Neurology, March, S1474-4422(24)00052-8.


Urgent Spinal Surgery in a Lateral Decubitus on a Patient With a Left Ventricular Assist Device on Full Anticoagulation: A Case Report. Do, Angelique S., Monis A. Khan, Lindsey Ross, Robert Ravinsky, Adam J. Milam, Seung J. Lee, Omar Durra, and J. Patrick Johnson. Cureus 16 (2): e55266.


Analysis of Three-Dimensional Spine Growth for Vertebral Body Tethering Patients at 2 and 5 Years Post Operatively. Boulet, Mathieu, Jennifer Hurry, David Skaggs, Michelle Cameron Welborn, Lindsay Andras, Craig Louer, A. Noelle Larson, Firoz Miyanji, Stefan Parent, PSSG, and Ron El-Hawary. Spine Deformity, April.

Pathology and Laboratory Medicine

Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer. Matusiak, Magdalena, John W. Hickey, David G. P. van IJzendoorn, Guolan Lu, Lukasz Kidzinski, Shirley Zhu, Deana R. C. Colburg, Bogdan Luca, Darci J. Phillips, Sky W. Brubaker, Gregory W. Charville, Jeanne Shen, Kyle M. Loh, Derick K. Okwan-Duodu, Garry P. Nolan, Aaron M. Newman, Robert B. West, and Matt van de Rijn. Cancer Discovery, March.


Severe Late Cardiovascular Sequelae of Kawasaki Disease in a Young Adult. Marek-Iannucci, Stefanie, Joey Junarta, Alec Vishnevsky, Indranee N. Rajapreyar, James Jeffrey Fradin, Moshe Arditi, Andrew Peters, Yair Lev, and Yevgeniy Brailovsky. Journal of Paediatrics and Child Health, March.

Proliferation-Driven Mechanical Compression Induces Signalling Centre Formation During Mammalian Organ Development. Shroff, Neha Pincha, Pengfei Xu, Sangwoo Kim, Elijah R. Shelton, Ben J. Gross, Yucen Liu, Carlos O. Gomez, Qianlin Ye, Tingsheng Yu Drennon, Jimmy K. Hu, Jeremy B. A. Green, Otger Campàs, and Ophir D. Klein. Nature Cell Biology, April.

Effect of Pre-Emptive Rituximab on EBV DNA Levels and Prevention of Post-Transplant Lymphoproliferative Disorder in Pediatric Kidney Transplant Recipients: A Case Series From the Pediatric Nephrology Research Consortium. Ashoor, Isa F., Samhar Al-Akash, Sarah Kizilbash, Asha Moudgil, Dechu Puliyanda, Saritha Ranabothu, Yi Shi, and Vikas Dharnidharka. Pediatric Transplantation 28 (3): e14743.

Radiation Oncology

Development of a Multivariable Model to Predict the Need for Bone Marrow Sampling in Persons With Monoclonal Gammopathy of Undetermined Significance: A Cohort Study Nested in a Clinical Trial. Eythorsson, Elias, Saemundur Rognvaldsson, Sigrun Thorsteinsdottir, Thorir Einarsson Long, Elin Ruth Reed, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni A. Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Fridbjorn Sigurdsson, Asdis Rosa Thordardottir, Runolfur Palsson, Olafur Skuli Indridason, Asbjorn Jonsson, Gauti Kjartan Gislason, Andri Olafsson, Jon Sigurdsson, Hlif Steingrimsdottir, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Ola Landgren, Thor Aspelund, Thorvardur Jon Love, and Sigurdur Yngvi Kristinsson. Annals of Internal Medicine, April.

Patterns of Failure in Patients With Borderline Resectable/Locally Advanced Pancreatic Cancer After Preoperative Chemotherapy and Stereotactic Body Radiation Therapy. Chung, Eric M., Diana J. Lu, Anthony T. Nguyen, Andrew E. Hendifar, Nicholas N. Nissen, Jun Gong, Arsen Osipov, Alexandra Gangi, Marc A. Attiyeh, Katelyn M. Atkins, and Mitchell Kamrava. Advances in Radiation Oncology 9 (5): 101471.


High-Grade Liver Injuries With Contrast Extravasation Managed Initially With Interventional Radiology Versus Observation: A Secondary Analysis of a WTA Multicenter Study. Aryan, Negaar, Areg Grigorian, Erika Tay-Lasso, Michael Cripps, Heather Carmichael, Robert McIntyre, Shane Urban, Catherine Velopulos, Clay Cothren Burlew, Shana Ballow, Rachel C. Dirks, Aimee LaRiccia, Michael S. Farrell, Deborah M. Stein, Michael S. Truitt, Heather M. Grossman Verner, Caleb J. Mentzer, T. J. Mack, Chad G. Ball, Kaushik Mukherjee, Georgi Mladenov, Daniel J. Haase, Hossam Abdou, Thomas J. Schroeppel, Jennifer Rodriquez, Miklosh Bala, Natasha Keric, Morgan Crigger, Navpreet K. Dhillon, Eric J. Ley, Tanya Egodage, John Williamson, Tatiana Cp Cardenas, Vadine Eugene, Kumash Patel, Kristen Costello, Stephanie Bonne, Fatima S. Elgammal, Warren Dorlac, Claire Pederson, Nicole L. Werner, James M. Haan, Kelly Lightwine, Gregory Semon, Kristen Spoor, Laura A. Harmon, Jason M. Samuels, M. C. Spalding, and Jeffry Nahmias. American Journal of Surgery, March, S0002-9610(24)00179-X.

Using Machine Learning to Predict Outcomes of Patients With Blunt Traumatic Aortic Injuries. Lu, Eileen, Joseph Dubose, Mythreye Venkatesan, Zhiping Paul Wang, Benjamin W. Starnes, Naveed U. Saqib, Charles C. Miller, Ali Azizzadeh, and Elizabeth L. Chou. The Journal of Trauma and Acute Care Surgery, March.

Outcomes of Severely Injured Pregnant Trauma Patients: A Multicenter Analysis. Awad, Kyrillos G., Jeffry Nahmias, Negaar Aryan, Alexa N. Lucas, Nicole Fierro, Navpreet K. Dhillon, Eric J. Ley, Jennifer Smith, Sigrid Burruss, Alden Dahan, Arianne Johnson, William Ganske, Walter L. Biffl, Dunya Bayat, Matthew Castelo, Diane Wintz, Kathryn B. Schaffer, Dennis J. Zheng, Areti Tillou, Raul Coimbra, Rahul Tuli, Jarrett E. Santorelli, Brent Emigh, Morgan Schellenberg, Kenji Inaba, Thomas K. Duncan, Graal Diaz, Erika Tay-Lasso, Danielle C. Zezoff, and Areg Grigorian. Updates in Surgery, March.


Commentary to Can Paediatric Surgical Registrars Safely Perform Supervised Hypospadias Surgery? Freedman, Andrew L. Journal of Pediatric Urology, March, S1477-5131(24)00172-4.

Emerging Racial Disparities among Medicare Beneficiaries and Veterans With Metastatic Castration-Sensitive Prostate Cancer. George, Daniel J., Neeraj Agarwal, Krishnan Ramaswamy, Zachary Klaassen, Rhonda L. Bitting, David Russell, Rickard Sandin, Birol Emir, Hongbo Yang, Wei Song, Yilu Lin, Agnes Hong, Wei Gao, and Stephen J. Freedland. Prostate Cancer and Prostatic Diseases, April.

Assessing the Causal Relationship Between Waterpipe Smoking and Bladder Cancer. Rosser, Charles J. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 33 (4): 461–62.