This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published June 6-13.

Biomedical Sciences

Advanced Material Technologies for Space and Terrestrial Medicine. Chua, Corrine Ying Xuan, Miguel Jimenez, Maedeh Mozneb, Giovanni Traverso, Ray Lugo, Arun Sharma, Clive N. Svendsen, William R. Wagner, Robert Langer, and Alessandro Grattoni. Nature Reviews Materials, June, 1–14.

Standards for Quantitative Assessments by Coronary Computed Tomography Angiography (CCTA): An Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT). Nieman, Koen, Hector M. García-García, Alexandre Hideo-Kajita, Carlos Collet, Damini Dey, Francesca Pugliese, Gaby Weissman, Jan G. P. Tijssen, Jonathon Leipsic, Maksymilian P. Opolski, Maros Ferencik, Michael T. Lu, Michelle C. Williams, Nico Bruining, Pablo Javier Blanco, Pal Maurovich-Horvat, and Stephan Achenbach. Journal of Cardiovascular Computed Tomography, June, S1934-5925(24)00341-1.

A Shifting Role of Thalamocortical Connectivity in the Emergence of Cortical Functional Organization. Park, Shinwon, Koen V. Haak, Stuart Oldham, Hanbyul Cho, Kyoungseob Byeon, Bo-Yong Park, Phoebe Thomson, Haitao Chen, Wei Gao, Ting Xu, Sofie Valk, Michael P. Milham, Boris Bernhardt, Adriana Di Martino, and Seok-Jun Hong. Nature Neuroscience, June.

Nutrient-Delivery and Metabolism Reactivation Therapy for Melanoma. Chen, Yang, Chaochao Wang, Yelin Wu, Ya Wang, Yun Meng, Fan Wu, Huilin Zhang, Yuen Yee Cheng, Xingwu Jiang, Jieyun Shi, Huiyan Li, Peiran Zhao, Jinfeng Wu, Bin Zheng, Dayong Jin, and Wenbo Bu. Nature Nanotechnology, June. 

Cardiology

C. Thomas Peter, MD (1943-2024). Chen, Peng-Sheng, Kalyanam Shivkumar, and Melvin Scheinman. JACC. Clinical Electrophysiology, May, S2405-500X(24)00288-3.

Canadian Cardiovascular Society/Canadian Women’s Heart Health Alliance Clinical Practice Update on Myocardial Infarction With No Obstructive Coronary Artery Disease (MINOCA). Pacheco, Christine, Thais Coutinho, Alexandra Bastiany, Rob Beanlands, Kevin E. Boczar, Martha Gulati, Shuangbo Liu, Judy Luu, Sharon L. Mulvagh, Amelie Paquin, Jacqueline Saw, and Tara Sedlak. The Canadian Journal of Cardiology 40 (6): 953–68.

Persistence and Adherence to PCSK9 Inhibitor Monoclonal Antibodies Versus Ezetimibe in Real-World Settings. Muntner, Paul, Lama Ghazi, Jenna Jones, Nafeesa Dhalwani, Bharat Poudel, Ying Wen, Ligong Chen, Zhixin Wang, Vera Bittner, Bethany Kalich, Michael E. Farkouh, Mark Woodward, Lisandro D. Colantonio, and Robert S. Rosenson. Advances in Therapy 41 (6): 2399–2413.

C. Thomas Peter, MD (1943-2024). Chen, Peng-Sheng, Kalyanam Shivkumar, and Melvin Scheinman. Heart Rhythm, June, S1547-5271(24)02523-2.

Two-Year Clinical Outcomes of Staged Transcatheter Mitral Edge-to-Edge Repair After Transcatheter Aortic Valve Replacement. Nagasaka, Takashi, Alon Shechter, Vivek Patel, Ofir Koren, Tarun Chakravarty, Wen Cheng, Hideki Ishii, Hasan Jilaihawi, Mamoo Nakamura, and Raj R. Makkar. The American Journal of Cardiology, June, S0002-9149(24)00413-2.

Cardiovascular Risk in Prostate Cancer-A Call to Action? Atkins, Katelyn M., and Andriana P. Nikolova. JAMA Oncology, June.

Sex and Racial Disparities in Proportionate Mortality of Premature Myocardial Infarction in the United States: 1999 to 2020. Gonuguntla, Karthik, Irisha Badu, Sanchit Duhan, Harigopal Sandhyavenu, Muchi Ditah Chobufo, Amro Taha, Harshith Thyagaturu, Yasar Sattar, Bijeta Keisham, Shafaqat Ali, Muhammad Zia Khan, Sharaad Latchana, Minahil Naeem, Ayesha Shaik, Sudarshan Balla, and Martha Gulati. Journal of the American Heart Association, June, e033515.

Sex Differences in Left Ventricular Function and Cardiac Mechanics. Lau, Emily S., Yunong Zhao, Emelia J. Benjamin, Vasan S. Ramachandran, Vanessa Xanthakis, Susan Cheng, and Jennifer E. Ho. Journal of the American Heart Association, June, e035781.

Intersection of Immunology and Metabolism in Myocardial Disease. Thorp, Edward B., and Anja Karlstaedt. Circulation Research 134 (12): 1824–40.

Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy. Nollet, Edgar E., Maike Schuldt, Vasco Sequeira, Aleksandra Binek, Thang V. Pham, Stephan A. C. Schoonvelde, Mark Jansen, Bauke V. Schomakers, Michel van Weeghel, Fred M. Vaz, Riekelt H. Houtkooper, Jennifer E. Van Eyk, Connie R. Jimenez, Michelle Michels, Kenneth C. Bedi, Kenneth B. Margulies, Cristobal G. Dos Remedios, Diederik W. D. Kuster, and Jolanda van der Velden. Circulation. Genomic and Precision Medicine, June, e004369.

Predictors and 5-Year Clinical Outcomes of Pacemaker After TAVR: Analysis From the PARTNER 2 SAPIEN 3 Registries. Chen, Shmuel, Jose M. Dizon, Rebecca T. Hahn, Philippe Pibarot, Isaac George, Yanglu Zhao, Philipp Blanke, Samir Kapadia, Vasilis Babaliaros, Wilson Y. Szeto, Raj Makkar, Vinod H. Thourani, John G. Webb, Michael J. Mack, Martin B. Leon, Susheel Kodali, and Tamim M. Nazif. JACC. Cardiovascular Interventions 17 (11): 1325–36.

Non-Coding RNA yREX3 From Human Extracellular Vesicles Exerts Macrophage-Mediated Cardioprotection via a Novel Gene-Methylating Mechanism. Ciullo, Alessandra, Liang Li, Chang Li, Kara Tsi, Colin Farrell, Matteo Pellegrini, Eduardo Marbán, and Ahmed G. E. Ibrahim. European Heart Journal, June, ehae357.

Medicine

Excess Non-COVID-19-Related Mortality Among Inflammatory Bowel Disease Decedents During the COVID-19 Pandemic. Rotondo-Trivette, Sarah, Xin-Yuan He, Jamil S. Samaan, Fan Lv, Emily Truong, Michaela Juels, Anthony Nguyen, Xu Gao, Jian Zu, Yee Hui Yeo, Fan-Pu Ji, and Gil Y. Melmed. World Journal of Gastroenterology 30 (20): 2677–88.

Talazoparib in Patients With Solid Tumors With BRCA1/2 Mutation: Results From the Targeted Agent and Profiling Utilization Registry Study. Srkalovic, Gordan, Michael Rothe, Pam K. Mangat, Elizabeth Garrett-Mayer, Eugene R. Ahn, Gregory Brouse, John Chan, Inderjit Mehmi, Maya Khalil, Herbert L. Duvivier, Anu Gaba, Harshraj Leuva, Ramya Thota, Kathleen J. Yost, Gina N. Grantham, Abigail Gregory, Dominique C. Hinshaw, Susan Halabi, and Richard L. Schilsky. JCO Precision Oncology 8 (June): e2400026.

Hypothalamic MRI-Derived Microstructure Is Associated With Neurocognitive Aging in Humans. Aleksic, Sandra, Roman Fleysher, Erica F. Weiss, Noa Tal, Timothy Darby, Helena M. Blumen, Juan Vazquez, Kenny Q. Ye, Tina Gao, Shira M. Siegel, Nir Barzilai, Michael L. Lipton, and Sofiya Milman. Neurobiology of Aging 141 (June): 102–12.

Long-Term Survival Follow-up for Tebentafusp in Previously Treated Metastatic Uveal Melanoma. Sacco, Joseph J., Richard D. Carvajal, Marcus O. Butler, Alexander N. Shoushtari, Jessica C. Hassel, Alexandra Ikeguchi, Leonel Hernandez-Aya, Paul Nathan, Omid Hamid, Josep M. Piulats, Matthew Rioth, Douglas B. Johnson, Jason J. Luke, Enrique Espinosa, Serge Leyvraz, Laura Collins, Chris Holland, and Takami Sato. Journal for Immunotherapy of Cancer 12 (6): e009028.

Mpox Surveillance Based on Rash Characteristics - 13 Emergency Departments, United States, June-December 2023. Berdahl, Carl T., Anusha Krishnadasan, Kavitha Pathmarajah, Gregory J. Moran, Jesus R. Torres, Matthew Waxman, William Mower, Omai B. Garner, Lorenzo P. Duvergne, Anne W. Rimoin, Pamina M. Gorbach, David A. Talan, and EMERGEncy ID NET Study Group. MMWR. Morbidity and Mortality Weekly Report 73 (22): 507–13.

Oral Octreotide Capsules for Acromegaly Treatment: Application of Clinical Trial Insights to Real-World Use. Fleseriu, Maria, Lisa B. Nachtigall, Susan L. Samson, and Shlomo Melmed. Expert Review of Endocrinology & Metabolism, June, 1–9.

Management of Androgenic Alopecia: A Systematic Review of the Literature. Rosenthal, Amanda, Geena Conde, Joseph F. Greco, and Nima M. Gharavi. Journal of Cosmetic and Laser Therapy, June, 1–16.

Quality of Life With Neoadjuvant Ipilimumab (IPI) and Nivolumab (NIVO) Versus Adjuvant Nivolumab in Resectable Stage III Melanoma: 36-Week Data From the Phase 3 NADINA Trial. Lucas, Minke W., Reetta Arokoski, Alexander M. Menzies, Saskia Pulleman, Robyn P.M. Saw, Winan J. van Houdt, Mark B Faries, Caroline Robert, Paolo Antonio Ascierto, Celeste Lebbe, Matteo S. Carlino, Ellen Kapiteijn, Karijn Suijkerbuijk, Piotr Rutkowski, Shahneen Sandhu, Astrid Aplonia Maria Van Der Veldt, Georgina V. Long, Christian U. Blank, Lonneke van de Poll-Franse, and Judith Lijnsvelt. Journal of Clinical Oncology 42 (17_suppl): LBA9584–LBA9584.

Results From a Randomised, Open-Label Trial of a Multimodal Intervention (Exercise, Nutrition and Anti-Inflammatory Medication) Plus Standard Care Versus Standard Care Alone to Attenuate Cachexia in Patients With Advanced Cancer Undergoing Chemotherapy. Solheim, Tora S., Barry J A Laird, Trude R. Balstad, Guro Birgitte Stene, Vickie Baracos, Asta Bye, Olav Dajani, Andrew Eugene Hendifar, Florian Strasser, Martin Robert Chasen, Matthew Maddocks, Melanie R. Simpson, Eva Skovlund, Gareth Owen Griffiths, Jonathan Hicks, Janet Shirley Graham, Fiona Kyle, Joanna Bowden, Marie T. Fallon, and Stein Kaasa. Journal of Clinical Oncology 42 (17_suppl): LBA12007–LBA12007.

The RELAX Randomized Controlled Trial: Stretching Versus Meditation for Nocturnal Muscle Cramps. Tapper, Elliot B., Hirsh Trivedi, Douglas A. Simonetto, Vilas Patwardhan, Erin Ospina, Beanna Martinez, Xi Chen, Susan Walker, and Samantha Nikirk. Liver International, June.

Refining Quality Measures for Electrodiagnostic Testing in Suspected Carpal Tunnel Syndrome to Account for Acceptable Variations in Practice: Expert Review Process. Shetty, Kanaka D., Aashna R. Basu, Teryl K. Nuckols, and Multi?Society Working Group for Electrodiagnosis Quality Measures in CTS. Muscle & Nerve, June.

Age and Urban-Rural Disparities in Cutaneous Melanoma Mortality Rates in the United States During the COVID-19 Pandemic. Hu, Ting, Zhimiao Ma, Yuxin Guo, Sikai Qiu, Fan Lv, Ying Liu, Wee Han Ng, Jian Zu, Yee Hui Yeo, Fanpu Ji, Ernest Y. Lee, and Zhengxiao Li. Pigment Cell & Melanoma Research, June.

Neurology

Tips and Advice on Choosing a Stroke Fellowship Program in the United States of America. Harris, Jennifer, and Stephanie Lyden. Stroke, June. 

Tenecteplase Is a Better Alternative to Alteplase for Patients With Large Vessel Occlusion Stroke Receiving Bridging Therapy. Song, Shlee S., and Steven Warach. Neurology 103 (1): e209581.

Neurosurgery

Tau Modulation Through AAV9 Therapy Augments Akt/Erk Survival Signalling in Glaucoma Mitigating the Retinal Degenerative Phenotype. Thananthirige, Kanishka Pushpitha Maha, Nitin Chitranshi, Devaraj Basavarajappa, Rashi Rajput, Mojdeh Abbasi, Viswanthram Palanivel, Veer Bala Gupta, Joao A. Paulo, Maya Koronyo-Hamaoui, Mehdi Mirzaei, Stuart L. Graham, and Vivek Gupta. Acta Neuropathologica Communications 12 (1): 89.

Pediatric Post-Dural Puncture Headache and Paraplegia. Schievink, Wouter I., Marcel M. Maya, Rachelle B. Taché, and Corey T. Walker. Headache, June.

Skeletal Overgrowth in a Pre-Pubescent Child Treated With Pan-FGFR Inhibitor. Majlessipour, Fataneh, Gaohui Zhu, Nicole Baca, Meenasri Kumbaji, Vivian Hwa, and Moise Danielpour. Heliyon 10 (11): e30887.

Nursing

A Qualitative Study to Explore the Nurses’ Experience of Writing Caring Notes in Diaries for Extracorporeal Oxygenation Membrane (ECMO) Patients: Explore the Nurse’s Experience. Norton, Tamara, Laura Chechel, Courtney Sanchez, and Garni Terterian. Critical Care Nursing Quarterly 47 (3): 184–92.

OBGYN

Gynecologic Perivascular Epithelioid Cell Tumors (PEComas): A Review of Recent Evidence. Levin, Gabriel, Mariana Pilon Capella, Raanan Meyer, Yoav Brezinov, and Walter H. Gotlieb. Archives of Gynecology and Obstetrics 309 (6): 2381–86.

Utilization and Surgical Outcomes of Sentinel Lymph Node Biopsy for Endometrial Intraepithelial Neoplasia. Levin, Gabriel, Jason D. Wright, Yechiel Z. Burke, Kacey M. Hamilton, and Raanan Meyer. Obstetrics and Gynecology, June.

Orthopaedics

Robotic-Assisted Total Knee Arthroplasty Reduces Soft-Tissue Releases Which Improves Functional Outcomes: A Retrospective Study. Spitzer, Andrew, Robert Gorab, William Barrett, Nader Nassif, Michael Hunter, Ian Leslie, James Lesko, and David Dalury. The Knee 49 (June): 52–61.

Risk Stratification for Early Postoperative Infection in Pediatric Spinal Deformity Correction: Development and Validation of the Pediatric Scoliosis Infection Risk Score (PSIR Score). Chan, Vivien, Geoffrey Shumilak, Matiar Jafari, Michael G. Fehlings, Michael M. H. Yang, and David L. Skaggs. European Spine Journal, June.

Lumbar Total Disc Replacement Leads to Increased Subsequent Facet Injections Compared to Anterolateral Lumbar Interbody Fusions. Narendran, Nakul, Christopher M. Mikhail, Paal K. Nilssen, Alexander Tuchman, and David L. Skaggs. Global Spine Journal, June, 21925682241260733.

The Fate of The Broken Tether: How Do Curves Treated With Vertebral Body Tethering Behave After Tether Breakage? Tetreault, Tyler A., Tiffany N. Phan, Tishya A. L. Wren, Michael J. Heffernan, Michelle C. Welborn, John T. Smith, Ron El-Hawary, Kenneth Cheung, Kenneth D. Illingworth, David L. Skaggs, Lindsay M. Andras, and Pediatric Spine Study Group. Spine, June.

Pediatrics

Myosin II Mediates Shh Signals to Shape Dental Epithelia via Control of Cell Adhesion and Movement. Du, Wei, Adya Verma, Qianlin Ye, Wen Du, Sandy Lin, Atsushi Yamanaka, Ophir D. Klein, and Jimmy K. Hu. PLoS Genetics 20 (6): e1011326.

Physical Medicine & Rehabilitation

Telemedicine Impact on Patient Disparities and Physician Practice Patterns in Cancer Rehabilitation: A Multicenter Retrospective Study. Leong, David, Amy Ng, Philip Chang, Jasmine Zheng, Richard Wilson, Matthew Edwin Chen, and Mary Vargo. PM & R: The Journal of Injury, Function, and Rehabilitation, June.

Surgery

Individualized Neoantigen Therapy mRNA-4157 (V940) Plus Pembrolizumab in Resected Melanoma: 3-Year Update From the mRNA-4157-P201 (KEYNOTE-942) Trial. Weber, Jeffrey S., Muhammad Adnan Khattak, Matteo S. Carlino, Tarek Meniawy, Matthew H. Taylor, George Ansstas, Kevin B. Kim, Meredith McKean, Ryan J. Sullivan, Mark B Faries, Thuy Tran, Charles Lance Cowey, Theresa Medina, Jennifer Margaret Segar, Victoria Atkinson, Geoffrey Thomas Gibney, Jason J. Luke, Elizabeth Iannotti Buchbinder, Georgina V. Long, Robert S. Meehan, and INT Research and Development Author Group. Journal of Clinical Oncology 42 (17_suppl): LBA9512–LBA9512.

The Anti-Apoptotic Function of HSV-1 LAT in Neuronal Cell Cultures But Not Its Function During Reactivation Correlates With Expression of Two Small Non-Coding RNAs, sncRNA1&2. Oh, Jay J., Ujjaldeep Jaggi, Kati Tormanen, Shaohui Wang, Satoshi Hirose, and Homayon Ghiasi. PLoS Pathogens 20 (6): e1012307.

Urology

Surgical Gestures to Evaluate Apical Dissection of Robot-Assisted Radical Prostatectomy. Otiato, Maxwell X., Runzhuo Ma, Timothy N. Chu, Elyssa Y. Wong, Christian Wagner, and Andrew J. Hung. Journal of Robotic Surgery 18 (1): 245.

Capturing Relationships Between Suturing Sub-Skills to Improve Automatic Suturing Assessment. Cui, Zijun, Runzhuo Ma, Cherine H. Yang, Anand Malpani, Timothy N. Chu, Ahmed Ghazi, John W. Davis, Brian J. Miles, Clayton Lau, Yan Liu, and Andrew J. Hung. NPJ Digital Medicine 7 (1): 152.