This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published June 22-29. 

Biomedical Sciences

Coronary Atherosclerotic Plaque Activity and Future Coronary Events. Moss, Alastair, Marwa Daghem, Evangelos Tzolos, Mohammed N. Meah, Kang-Ling Wang, Anda Bularga, Philip D. Adamson, Jacek Kwiecinski, Alison Fletcher, Dana Dawson, Parthiban Arumugam, Nikant Sabharwal, John P. Greenwood, Jon N. Townend, Patrick A. Calvert, James H. F. Rudd, Dan Berman, Johan Verjans, Piotr Slomka, Damini Dey, Laura Forsyth, Lauren Murdoch, Robert J. Lee, Steff Lewis, Nicholas L. Mills, Edwin J. R. van Beek, Michelle C. Williams, Marc R. Dweck, David E. Newby, and PREFFIR Investigators. JAMA Cardiology, June.

Inter-Software and Inter-Scan Variability in Measurement of Epicardial Adipose Tissue: A Three-Way Comparison of a Research-Specific, a Freeware and a Coronary Application Software Platform. Chan, Jasmine, Udit Thakur, Sean Tan, Rahul G. Muthalaly, Harsh Thakkar, Vinay Goel, Yeong-Chee Cheen, Damini Dey, Adam J. Brown, Dennis T. L. Wong, and Nitesh Nerlekar. European Radiology, June.

Adenovirus-Derived Nano-Capsid Platforms for Targeted Delivery and Penetration of Macromolecules Into Resistant and Metastatic Tumors. Benhaghnazar, Rebecca Leah, and Lali Medina-Kauwe. Cancers 15 (12): 3240.

Updates on Radiotherapy-Immunotherapy Combinations: Proceedings of 6th Annual ImmunoRad Conference. Gregucci, Fabiana, Sheila Spada, Mary Helen Barcellos-Hoff, Nina Bhardwaj, Charleen Chan Wah Hak, Alba Fiorentino, Chandan Guha, Monica L. Guzman, Kevin Harrington, Fernanda G. Herrera, Jamie Honeychurch, Theodore Hong, Lorea Iturri, Elisabeth Jaffee, Sana D. Karam, Simon R. V. Knott, Constantinos Koumenis, David Lyden, Ariel E. Marciscano, Alan Melcher, Michele Mondini, Anna Mondino, Zachary S. Morris, Sean Pitroda, Sergio A. Quezada, Laura Santambrogio, Stephen Shiao, John Stagg, Irma Telarovic, Robert Timmerman, Marie-Catherine Vozenin, Ralph Weichselbaum, James Welsh, Anna Wilkins, Chris Xu, Roberta Zappasodi, Weiping Zou, Alexandre Bobard, Sandra Demaria, Lorenzo Galluzzi, Eric Deutsch, and Silvia C. Formenti. Oncoimmunology 12 (1): 2222560.

Using Digital Technology to Build COVID-19 Vaccine Confidence: A Qualitative Study Among Latinx Parents of Children Aged 5-11 in Under-Resourced Communities across Los Angeles County. Panameno, Michael, Luisa R. Blanco, Ann Marie Hernandez, Renato Escobar, Brittney Zendejas, Susana Rafaela, and Yelba M. Castellon-Lopez. Vaccines 11 (6): 1042.

Cardiac Surgery

Simultaneous Lung-Kidney Transplantation in the United States. Chen, Qiudong, Jad Malas, Amy Roach, Abirami Kumaresan, Jason Thomas, Michael E. Bowdish, Joanna Chikwe, Lorenzo Zaffiri, Reinaldo E. Rampolla, Pedro Catarino, and Dominick Megna. The Annals of Thoracic Surgery, June, S0003-4975(23)00614-8.

Cardiology

From Waveforms to Wisdom: Gleaning More From the ECG About Biological Aging. Ebinger, Joseph E., and Susan Cheng. Circulation. Cardiovascular Quality and Outcomes, June, e010176.

Characterization of Individuals With Apparent Resistant Hypertension Using Contemporary Guidelines: Insights From CV-QUIC. Ebinger, Joseph E., Ty J. Gluckman, Jose Magraner, Shih Ting Chiu, Deanna Rider, Chelsey Thomas, Sandeep R. Das, P. Michael Ho, Satya Shreenivas, and Steven Bradley. Hypertension (Dallas, Tex.: 1979), June.

Cardiovascular Autonomic Function and Incident COPD Hospitalizations in ARIC. MacDonald, David M., Yuekai Ji, Selcuk Adabag, Alvaro Alonso, Lin Yee Chen, Benjamin E. Henkle, Stephen Juraschek, Faye L. Norby, Pamela L. Lutsey, and Ken M. Kunisaki. Annals of the American Thoracic Society, June.

Implication of Right Atrial Pressure Estimated by Echocardiography in Patients With Severe Tricuspid Regurgitation. Omori, Taku, Ken Kuwajima, Florian Rader, Robert J. Siegel, and Takahiro Shiota. Journal of the American Society of Echocardiography, June, S0894-7317(23)00319-X.

Frailty and Uptake of Angiotensin Receptor Neprilysin Inhibitor for Heart Failure With Reduced Ejection Fraction. Lee, Yu-Chien, Joshua K. Lin, Darae Ko, Susan Cheng, Elisabetta Patorno, Robert J. Glynn, Theodore Tsacogianis, and Dae Hyun Kim. Journal of the American Geriatrics Society, June.

Biological Modification of Arrhythmogenic Substrates by Cell-Free Therapeutics. Lin, Yen-Nien, Rodrigo Miguel-Dos-Santos, and Eugenio Cingolani. Heart, Lung & Circulation, June, S1443-9506(23)00523-1.

Computational Biomedicine

Comparing Amyloid Imaging Normalization Strategies for Alzheimer’s Disease Classification Using an Automated Machine Learning Pipeline. Tong, Boning, Shannon L. Risacher, Jingxuan Bao, Yanbo Feng, Xinkai Wang, Marylyn D. Ritchie, Jason H. Moore, Ryan Urbanowicz, Andrew J. Saykin, and Li Shen. AMIA Joint Summits on Translational Science Proceedings. AMIA Joint Summits on Translational Science 2023: 525–33.

Exploring Automated Machine Learning for Cognitive Outcome Prediction From Multimodal Brain Imaging Using STREAMLINE. Wang, Xinkai, Yanbo Feng, Boning Tong, Jingxuan Bao, Marylyn D. Ritchie, Andrew J. Saykin, Jason H. Moore, Ryan Urbanowicz, and Li Shen. AMIA Joint Summits on Translational Science Proceedings. AMIA Joint Summits on Translational Science 2023: 544–53.

Imaging

Ultrasound Fusion: Applications in Musculoskeletal Imaging. Gross, Jordan Scott, Andrew Yaeger, Hisham Tchelepi, and George R. Matcuk. Life (Basel, Switzerland) 13 (6): 1278.

Medicine

Prognostic Models in Acute-on-Chronic Liver Failure. Goyes, Daniela, Hirsh D. Trivedi, and Michael P. Curry. Clinics in Liver Disease 27 (3): 681–90.

Response to Mion et al. Takakura, Will, and Ali Rezaie. The American Journal of Gastroenterology 118 (7): 1300–1301.

CSNK2A1-Mediated MAX Phosphorylation Upregulates HMGB1 and IL-6 Expression in Cholangiocarcinoma Progression. Yang, Bing, Jing Zhang, Jiaohong Wang, Wei Fan, Lucía Barbier-Torres, Xi Yang, Monica Anne R. Justo, Ting Liu, Yongheng Chen, Justin Steggerda, Komal Ramani, Shelly C. Lu, and Heping Yang. Hepatology Communications 7 (7): e00144.

Achieving Equity in Residency and Fellowship Applications With a Partial Blindfold: A Call for Measuring the Distance Traveled. Vijayan, Tara, Christopher J. Graber, Christina E. Harris, and Daniel Kozman. Annals of Internal Medicine, June.

Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci. Lai, John, Chi Kuen Wong, Daniel F. Schmidt, Miroslaw K. Kapuscinski, Karen Alpen, Robert J. Maclnnis, Daniel D. Buchanan, Aung K. Win, Jane C. Figueiredo, Andrew T. Chan, Tabitha A. Harrison, Michael Hoffmeister, Emily White, Loic Le Marchand, Rish K. Pai, Ulrike Peters, John L. Hopper, Mark A. Jenkins, and Enes Makalic. Cancer Epidemiology, Biomarkers & Prevention, June, EPI-22-1209.

Probing the Diabetes and Colorectal Cancer Relationship Using Gene - Environment Interaction Analyses. Dimou, Niki, Andre E. Kim, Orlagh Flanagan, Neil Murphy, Virginia Diez-Obrero, Anna Shcherbina, Elom K. Aglago, Emmanouil Bouras, Peter T. Campbell, Graham Casey, Steven Gallinger, Stephen B. Gruber, Ulrike Peters, et al. British Journal of Cancer, June.

Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns. Bhasin, Shalender, Douglas Seals, Marie Migaud, Nicolas Musi, and Joseph A. Baur. Endocrine Reviews, June, bnad019.

Ensuring Ethical and Responsible Integration of AI Tools in Healthcare. Samaan, Jamil S., Yee Hui Yeo, Nithya Rajeev, Wee Han Ng, Nitin Srinivasan, and Kamran Samakar. Obesity Surgery, June.

Real-World Evidence: New Opportunities for Osteoporosis Research. Recommendations From a Working Group From the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Moon, Rebecca J., Jean-Yves Reginster, Nasser M. Al-Daghri, Jotheeswaran A. Thiyagarajan, Charlotte Beaudart, Olivier Bruyère, Nansa Burlet, Manju Chandran, Mario Coelho da Silva, Philip G. Conaghan, Willard H. Dere, Adolfo Diez-Perez, Peyman Hadji, Philippe Halbout, Mickaël Hiligsmann, John A. Kanis, Eugene V. McCloskey, Sif Ormarsdottir, Daniel Prieto-Alhambra, Régis P. Radermecker, René Rizzoli, Yousef Al-Saleh, Stuart L. Silverman, Lee S. Simon, Friederike Thomasius, Tjeerd van Staa, Andrea Laslop, Cyrus Cooper, and Nicholas C. Harvey. Osteoporosis International, June.

Seven-Year Follow-Up of the Phase III KEYNOTE-006 Study: Pembrolizumab Versus Ipilimumab in Advanced Melanoma. Robert, Caroline, Matteo S. Carlino, Catriona McNeil, Antoni Ribas, Jean-Jacques Grob, Jacob Schachter, Marta Nyakas, Damien Kee, Teresa M. Petrella, Arnold Blaustein, Michal Lotem, Ana Arance, Adil I. Daud, Omid Hamid, James Larkin, James Anderson, Clemens Krepler, Dmitri Grebennik, and Georgina V. Long. Journal of Clinical Oncology, June, JCO2201599.

A Wireless Patch for the Monitoring of C-Reactive Protein in Sweat. Tu, Jiaobing, Jihong Min, Yu Song, Changhao Xu, Jiahong Li, Jeff Moore, Justin Hanson, Erin Hu, Tanyalak Parimon, Ting-Yu Wang, Elham Davoodi, Tsui-Fen Chou, Peter Chen, Jeffrey J. Hsu, Harry B. Rossiter, and Wei Gao. Nature Biomedical Engineering, June.

A Plain Language Summary of What Clinical Studies Can Tell Us About the Safety of Evobrutinib - a Potential Treatment for Multiple Sclerosis. Montalban, Xavier, Daniel Wallace, Mark C. Genovese, Davorka Tomic, Dana Parsons-Rich, Claire Le Bolay, Amy H. Kao, and Hans Guehring. Neurodegenerative Disease Management, June.

Intravenous Aviptadil and Remdesivir for Treatment of COVID-19-Associated Hypoxaemic Respiratory Failure in the USA (TESICO): A Randomised, Placebo-Controlled Trial. Brown, Samuel M., Christina E. Barkauskas, Birgit Grund, Shweta Sharma, Andrew N. Phillips, Lindsay Leither, Ithan D. Peltan, Michael Lanspa, Daniel L. Gilstrap, Ahmad Mourad, Kathleen Lane, Jeremy R. Beitler, ACTIV-3b/Therapeutics for Severely Ill Inpatients with COVID-19 (TESICO) Study Group, et al. The Lancet. Respiratory Medicine, June, S2213-2600(23)00147-9.

Prediagnostic CT or MRI Utilization and Outcomes in Hepatocellular Carcinoma: SEER-Medicare Database Analysis. Karim, Mohammad A., Amit G. Singal, Hye Chung Kum, Yi-Te Lee, Sulki Park, Nicole E. Rich, Mazen Noureddin, and Ju Dong Yang. Cancer Research Communications 3 (5): 874–83.

Researching COVID to Enhance Recovery (RECOVER) Adult Study Protocol: Rationale, Objectives, and Design. Horwitz, Leora I., Tanayott Thaweethai, Shari B. Brosnahan, Mine S. Cicek, Megan L. Fitzgerald, Jason D. Goldman, Rachel Hess, S. L. Hodder, Vanessa L. Jacoby, Michael R. Jordan, Jerry A. Krishnan, Adeyinka O. Laiyemo, Andrea S. Foulkes, et al. PloS One 18 (6): e0286297.

Neurology

Moderate Intrinsic Phenotypic Alterations in C9orf72 ALS/FTD IPSC-Microglia Despite the Presence of C9orf72 Pathological Features. Lorenzini, Ileana, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, and Rita Sattler. Frontiers in Cellular Neuroscience 17: 1179796.

OBGYN

Capacity-Building for Collecting Patient-Reported Outcomes and Experiences (PRO) Data Across Hospitals. Saeb, Samia, Lisa M. Korst, Moshe Fridman, Jeanette McCulloch, Naomi Greene, and Kimberly D. Gregory. Maternal and Child Health Journal, June.

Artificial Intelligence Steps Into Obstetrics. Melissa S. Wong, M. D., and M. D. Adam Lewkowitz, Vol 68 No 06, 68 (June).

Orthopaedics

Racial and Sex Disparities in Resident Attrition in Orthopaedic Surgery. Haruno, Lee S., Xi Chen, Melodie Metzger, Carol A. Lin, Milton T. M. Little, Linda E. A. Kanim, and Selina C. Poon. JB & JS Open Access 8 (2): e22.00148.

Pathology

Nonspecific Interstitial Pneumonia Pattern Is a Frequent Finding in Patients With Post-Acute COVID-19 Syndrome Treated With Bilateral Orthotopic Lung Transplantation: Current Best Evidence. Mortazavi, Samira, Alberto M. Marchevsky, and Mariza Venturina. Human Pathology, June, S0046-8177(23)00143-0.

Somatic Loss of ATM Is a Late Event in Pancreatic Tumorigenesis. Paranal, Raymond M., Zhengdong Jiang, Danielle Hutchings, Valentyna Kryklyva, Christian Gauthier, Kohei Fujikura, Neha Nanda, Bo Huang, Michael Skaro, Christopher L. Wolfgang, Jin He, David S. Klimstra, Randall E. Brand, Aatur D. Singhi, Angelo DeMarzo, Lei Zheng, Michael Goggins, Lodewijk Aa Brosens, Ralph H. Hruban, Alison P. Klein, Tamara Lotan, Laura D. Wood, and Nicholas J. Roberts. The Journal of Pathology, June.

Profiling Endogenous, Environmental, and Infectious Disease Mutational Signatures in Blastic Plasmacytoid Dendritic Cell Neoplasms. Small, Corinn, Soham Mukerjee, Diwash Jangam, Sumanth Gollapudi, Kunwar Singh, David L. Jaye, Phyu P. Aung, Christiane Querfeld, Keluo Yao, Karen M. Chisholm, Sheeja Pullarkat, Sa Wang, Alejandro Gru, Mohammad Hussaini, Tracy I. George, and Robert S. Ohgami. International Journal of Laboratory Hematology, June.

Pediatrics

Genomic Analyses in Cornelia de Lange Syndrome and Related Diagnoses: Novel Candidate Genes, Genotype-Phenotype Correlations and Common Mechanisms. Kaur, Maninder, Justin Blair, Batsal Devkota, Sierra Fortunato, Dinah Clark, Audrey Lawrence, Jiwoo Kim, Wonwook Do, Benjamin Semeo, Olivia Katz, Devanshi Mehta, Nobuko Yamamoto, Ian D. Krantz, et al. American Journal of Medical Genetics. Part A, June.

Radiation Oncology

Comparative Impact of Grade on Mortality Across Salivary Cancers: A Novel, Unifying Staging System. Ho, Allen S., Michael Luu, Bonnie L. Balzer, Katri Aro, Julie K. Jang, Alain C. Mita, Kevin S. Scher, Jon Mallen-St Clair, Missael Vasquez, Amanda J. Bastien, Joel B. Epstein, De-Chen Lin, Michelle M. Chen, and Zachary S. Zumsteg. Head & Neck, June.

Rehabilitation Medicine

Telehealth in PM&R: Past, Present and Future in Clinical Practice and Opportunities for Translational Research. Tenforde, Adam S., Joshua Alexander, Marcalee Alexander, Thiru Annaswamy, Conley Carr, Philip Chang, Monique Diaz, Mary A. Iaccarino, Stephen Lewis, Carolyn Millett, Sindhu Pandit, Claudia Ramirez, Robert Rinaldi, Megan Roop, Chloe Slocum, Gene Tekmyster, Deborah Venesy, Monica Verduzco-Gutierrez, Richard Zorowitz, and Todd Rowland. PM & R: The Journal of Injury, Function, and Rehabilitation, June.

Fatigue as an Understudied Barrier to Participation in Life Roles. Poole, Janet L., Susan L. Murphy, Erin R. Foster, Alix G. Sleight, Toni Van Denend, Arash Asher, Kristine Carandang, Marcia Finlayson, Donald Fogelberg, Heather S. L. Jim, Aileen Ledingham, Tanya Packer, Matthew Plow, Katherine Preissner, Stephen Wechsler, and Daniel Whibley. OTJR: Occupation, Participation and Health, June, 15394492231180832.

Surgery

Changes in Surgical Management of the Axilla Over 11 Years - Report on More Than 1500 Breast Cancer Patients Treated With Neoadjuvant Chemotherapy on the Prospective I-SPY2 Trial. Boughey, Judy C., Hongmei Yu, Catherine Lu Dugan, Mara A. Piltin, Lauren Postlewait, Jennifer D. Son, Kirsten K. Edmiston, Constantine V. Godellas, Marie C. Lee, Michael J. Carr, Jennifer E. Tonneson, Angelena Crown, Rachel B. Lancaster, Hannah E. Woriax, Cheryl A. Ewing, Harrison S. Chau, Anne K. Patterson, Jasmine M. Wong, Michael D. Alvarado, Rachel L. Yang, Theresa W. Chan, Jori B. Sheade, Gretchen M. Ahrendt, Kelsey E. Larson, Kayla Switalla, Todd M. Tuttle, Julia C. Tchou, Roshni Rao, Nina Tamirisa, Puneet Singh, Rebekah E. Gould, Alicia Terando, Candice Sauder, Kelly Hewitt, Akiko Chiba, Laura J. Esserman, and Rita A. Mukhtar. Annals of Surgical Oncology, June.

Surveillance Strategies Following Prophylactic Nipple-Sparing Mastectomy in BRCA Mutation Carriers. Weed, Christina, Ton Wang, Shelby Chun Fat, Alice Chung, Marissa K. Boyle, Armando Giuliano, and Farin Amersi. Annals of Surgical Oncology, June.

The Effect of 2019 Coronavirus Stay-at-Home Order on Geriatric Trauma Patients in Southern California. Manasa, Morgan, Eric O. Yeates, Areg Grigorian, Cristobal Barrios, Morgan Schellenberg, Natthida Owattanapanich, Galinos Barmparas, Daniel Margulies, Catherine Juillard, Kent Garber, Henry Cryer, Areti Tillou, Sigrid Burruss, Liz Penaloza-Villalobos, Ann Lin, Ryan Arthur Figueras, Raul Coimbra, Megan Brenner, Todd Costantini, Jarrett Santorelli, Terry Curry, Diane Wintz, Walter L. Biffl, Kathryn B. Schaffer, Thomas K. Duncan, Casey Barbaro, Graal Diaz, Arianne Johnson, Erika Tay-Lasso, Justine Chinn, Ariana Naaseh, Amanda Leung, Christina Grabar, and Jeffry Nahmias. The American Surgeon, June, 31348221124329.

Outcomes for Advanced Aged (35 and Older) Versus Younger Aged Pregnant Trauma Patients: A Multicenter Study. Aryan, Negaar, Areg Grigorian, Alexa N. Lucas, Erika Tay-Lasso, Danielle C. Zezoff, Nicole Fierro, Navpreet K. Dhillon, Eric J. Ley, Jennifer Smith, Alden Dahan, Arianne Johnson, William Ganske, Walter L. Biffl, Dunya Bayat, Matthew Castelo, Diane Wintz, Kathryn B. Schaffer, Dennis J. Zheng, Areti Tillou, Raul Coimbra, Jarrett E. Santorelli, Morgan Schellenberg, Kenji Inaba, Brent Emigh, Thomas K. Duncan, Graal Diaz, Sigrid Burruss, Rahul Tuli, and Jeffry Nahmias. American Journal of Surgery, June, S0002-9610(23)00255-6.

Opioid and Methadone Use for Infants With Surgically Treated Necrotizing Enterocolitis. Keane, Olivia A., Abigail K. Zamora, Shadassa Ourshalimian, Elaa M. Mahdi, Ashley Y. Song, Eugene Kim, Ashwini Lakshmanan, Eugene S. Kim, and Lorraine I. Kelley-Quon. JAMA Network Open 6 (6): e2318910.

A Multi-Modal Approach to Islet and Pancreas Transplantation With Calcineurin-Sparing Immunosuppression Maintains Long-Term Insulin Independence in Patients With Type I Diabetes. Wisel, Steven A., Andrew M. Posselt, Gregory L. Szot, Miguel Nunez, Keli Santos-Parker, James M. Gardner, Giulia Worner, Garrett R. Roll, Shareef Syed, Yvonne Kelly, Casey Ward, Medhi Tavakol, Kristina Johnson, Umesh Masharani, and Peter G. Stock. Transplant International 11367.

Urology

Exposure to Agent Orange and Risk of Bladder Cancer Among US Veterans. Williams, Stephen B., Jessica L. Janes, Lauren E. Howard, Ruixin Yang, Amanda M. De Hoedt, Jacques G. Baillargeon, Yong-Fang Kuo, Douglas S. Tyler, Martha K. Terris, and Stephen J. Freedland. JAMA Network Open 6 (6): e2320593.