This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published June 20-27.

Biomedical Sciences

Cardiovascular Imaging, Climate Change, and Environmental Sustainability. Gunasekaran, Suvai, Andrew Szava-Kovats, Thomas Battey, Jonathan Gross, Eugenio Picano, Subha V. Raman, Emil Lee, Malenka M. Bissell, Mirvat Alasnag, Adrienne E. Campbell-Washburn, and Kate Hanneman. Radiology. Cardiothoracic Imaging 6 (3): e240135.

Cardiac Surgery

Enhanced Monitoring for Postoperative Hospital Wards - Evidence to Implementation. Upadhyay, Prateek, Megan Henley Hicks, and Ashish K. Khanna. Indian Journal of Anaesthesia 68 (6): 511–13.

Donation After Circulatory Death Heart Transplantation - Where Do We Go From Here? Chen, Qiudong, and Pedro Catarino. The Annals of Thoracic Surgery, June, S0003-4975(24)00518-6.

Cardiology

Sex, Racial, Ethnic, and Geographical Disparities in Major Adverse Cardiovascular Outcome of Glucagon-like Peptide-1 Receptor Agonists Among Patients With and Without Diabetes Mellitus: A Meta-Analysis of Placebo-Controlled Randomized Controlled Trials. Rivera, Frederick Berro, Nathan Ross B. Bantayan, John Paul Aparece, Linnaeus Louisse A. Cruz, John Vincent Magallong, Polyn Luz Pine, Anne Mira Nicca Idian-Javier, Grace Nooriza O. Lumbang, Edgar V. Lerma, Kyla M. Lara-Breitinger, Martha Gulati, and Krishnaswami Vijayaraghavan. Journal of Clinical Lipidology, April, S1933-2874(24)00047-3.

Autophagic Signaling Promotes Systems-Wide Remodeling in Skeletal Muscle upon Oncometabolic Stress by D2-HG. Gao, Yaqi, Kyoungmin Kim, Heidi Vitrac, Rebecca L. Salazar, Benjamin D. Gould, Daniel Soedkamp, Weston Spivia, Koen Raedschelders, An Q. Dinh, Anna G. Guzman, Lin Tan, Stavros Azinas, David J. R. Taylor, Walter Schiffer, Daniel McNavish, Helen B. Burks, Roberta A. Gottlieb, Philip L. Lorenzi, Blake M. Hanson, Jennifer E. Van Eyk, Heinrich Taegtmeyer, and Anja Karlstaedt. Molecular Metabolism, June, 101969.

Incident Stroke in Individuals With Peripartum Cardiomyopathy. Ibeh, Chinwe, Erin R. Kulick, Amelia K. Boehme, Alexander M. Friedman, Eliza C. Miller, and Natalie A. Bello. American Heart Journal, June, S0002-8703(24)00160-1.

Computational Biomedicine

Unveiling Contact-Mediated Cellular Crosstalk. Kim, Hyobin, Kwang-Eun Kim, Esha Madan, Patrick Martin, Rajan Gogna, Hyun-Woo Rhee, and Kyoung-Jae Won. Trends in Genetics: TIG, June, S0168-9525(24)00132-X.

Imaging

The Ethnic and Racial Diversity of Patients Undergoing Coronary Artery Calcium Scanning. Rozanski, Alan, Heidi Gransar, Rebekah Park, Robert J. H. Miller, Donghee Han, Sean W. Hayes, John D. Friedman, Louise E. J. Thomson, and Daniel S. Berman. Progress in Cardiovascular Diseases, June, S0033-0620(24)00093-8.

Age Is a Predictor of Elbow Stiffness After Type III or IV Supracondylar Humerus Fractures. Gupta, Kavish, Mary Kate Erdman, Ali Siddiqui, Mathew Schur, Erin Meisel, and Rachel Y. Goldstein. European Journal of Orthopaedic Surgery & Traumatology: Orthopedie Traumatologie, June.

Medicine

CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression Via PLK1-FBW7 Pathway. Hu, Kaishun, Limin Xie, Wenjing Wu, Jingyuan Zhang, Yu Li, Jiehua He, Yin Zhang, Daning Lu, H. Phillip Koeffler, Lehang Lin, and Dong Yin. International Journal of Biological Sciences 20 (8): 3140–55.

Diversity and Compositional Differences in the Oral Microbiome of Oral Squamous Cell Carcinoma Patients and Healthy Controls: A Scoping Review. Dijk, M. C. van, J. F. Petersen, J. E. Raber-Durlacher, J. B. Epstein, and A. M. G. A. Laheij. Frontiers in Oral Health 5: 1366153.

Radiomics-Based Analysis of Intestinal Ultrasound Images for Inflammatory Bowel Disease: A Feasibility Study. Gu, Phillip, Jui-Hsuan Chang, Dan Carter, Dermot P. B. McGovern, Jason Moore, Paul Wang, and Xiuzhen Huang. Crohn’s & Colitis 360 6 (2): otae034.

Esophageal Self-Expandable Metal Stents Can Fracture in the Distal Third When Used for Post-Bariatric Surgery Complications: A Single Center Experience and Review of the Literature With Video. Abboud, Yazan, Mohamad Othman El Helou, Joseph Meza, Jamil S. Samaan, Liliana Bancila, Navkiran Randhawa, Kenneth H. Park, Shahab Mehdizadeh, Srinivas Gaddam, and Simon K. Lo. Journal of Clinical Medicine 13 (12): 3419.

Revisiting Meta-Analyses of Placebo Response in Drug Trials for Irritable Bowel Syndrome: A Call to Disclose Excipients. Busam, Jonathan A., Ali Rezaie, and Mark Pimentel. Clinical Gastroenterology and Hepatology, June, S1542-3565(24)00551-2.

Machine Learning-Based Models for Advanced Fibrosis and Cirrhosis Diagnosis in Chronic Hepatitis B Patients With Hepatic Steatosis. Rui, Fajuan, Liang Xu, Yee Hui Yeo, Yayun Xu, Wenjing Ni, Youwen Tan, Qi Zheng, Xiaorong Tian, Qing-Lei Zeng, Zebao He, Yuanwang Qiu, Chuanwu Zhu, Weimao Ding, Jian Wang, Rui Huang, Qi Xue, Xueqi Wang, Yunliang Chen, Junqing Fan, Zhiwen Fan, Eiichi Ogawa, Min-Sun Kwak, Xiaolong Qi, Junping Shi, Vincent Wai-Sun Wong, Chao Wu, and Jie Li. Clinical Gastroenterology and Hepatology, June, S1542-3565(24)00553-6.

An iPSC-Derived Small Intestine-on-Chip With Self-Organizing Epithelial, Mesenchymal, and Neural Cells. Moerkens, Renée, Joram Mooiweer, Aarón D. Ramírez-Sánchez, Roy Oelen, Lude Franke, Cisca Wijmenga, Robert J. Barrett, Iris H. Jonkers, and Sebo Withoff. Cell Reports 43 (7): 114247.

Phase I Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced Melanoma. Hamid, Omid, Karl D. Lewis, Amy Weise, Meredith McKean, Kyriakos P. Papadopoulos, John Crown, Tae Min Kim, Dae Ho Lee, Sajeve S. Thomas, Janice Mehnert, John Kaczmar, Nehal J. Lakhani, Kevin B. Kim, Mark R. Middleton, Guilherme Rabinowits, Alexander I. Spira, Melinda Yushak, Inderjit Mehmi, Fang Fang, Shuquan Chen, Jayakumar Mani, Vladimir Jankovic, Fang Wang, Nathalie Fiaschi, Laura Brennan, Anne Paccaly, Sheila Masinde, Mark Salvati, Matthew G. Fury, Glenn Kroog, Israel Lowy, and Giuseppe Gullo. Journal of Clinical Oncology, June, JCO2302172.

Reducing the Risk of Cancer With Bariatric Surgery: The Need for Evidence to Guide Practice. Saeed, Usman, Sheraz Yaqub, Savio G. Barreto, Stephen Pandol, and Tom Mala. Scandinavian Journal of Surgery: SJS, June, 14574969241264064.

How Much Does Intravenous Fluid Cause Hematocrit to Drop? Improving Interpretation of Hematocrit Toward Better Post-Hemorrhage Care. Qureshi, Nabeel, Matthew Bloom, and Joshua Pevnick. Military Medicine, June, usae325.

SMAD4 Depletion Contributes to Endocrine Resistance by Integrating ER and ERBB Signaling in HR?+?HER2- Breast Cancer. Li, Kang, Dan Shu, Han Li, Ailin Lan, Wenjie Zhang, Zhaofu Tan, Man Huang, Maria Lauda Tomasi, Aishun Jin, Haochen Yu, Meiying Shen, and Shengchun Liu. Cell Death & Disease 15 (6): 444.

The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum. Byndloss, Mariana, Suzanne Devkota, Frank Duca, Jan Hendrik Niess, Max Nieuwdorp, Marju Orho-Melander, Yolanda Sanz, Valentina Tremaroli, and Liping Zhao. Diabetologia, June.

The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications-2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum. Byndloss, Mariana, Suzanne Devkota, Frank Duca, Jan Hendrik Niess, Max Nieuwdorp, Marju Orho-Melander, Yolanda Sanz, Valentina Tremaroli, and Liping Zhao. Diabetes, June, dbi240028.

A Druggable Cascade Links Methionine Metabolism to Epigenomic Reprogramming in Squamous Cell Carcinoma. Nam, Chehyun, Li-Yan Li, Qian Yang, Benjamin Ziman, Hua Zhao, Boyan Hu, Casey Collet, Pei Jing, Qifang Lei, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, Uttam K. Sinha, and De-Chen Lin. Proceedings of the National Academy of Sciences of the United States of America 121 (26): e2320835121.

Sex Differences in Coronary Atherosclerotic Plaque Activity Using 18F-Sodium Fluoride Positron Emission Tomography. Kwiecinski, Jacek, Kang-Ling Wang, Evangelos Tzolos, Alastair Moss, Marwa Daghem, Philip D. Adamson, Damini Dey, Patrycja Molek-Dziadosz, Dana Dawson, Parthiban Arumugam, Nikant Sabharwal, John P. Greenwood, John N. Townend, Patrick A. Calvert, James Hf Rudd, Daniel Berman, Johan W. Verjans, Michelle C. Williams, Piotr Slomka, Marc R. Dweck, and David E. Newby. European Journal of Nuclear Medicine and Molecular Imaging, June.

Guidance on Mucositis Assessment From the MASCC Mucositis Study Group and ISOO: An International Delphi Study. Abdalla-Aslan, Ragda, Pierluigi Bonomo, Dorothy Keefe, Nicole Blijlevens, Katrina Cao, Yin Ting Cheung, Eduardo Rodrigues Fregnani, Robert Miller, Judith Raber-Durlacher, Joel Epstein, Ysabella Van Sebille, Elisa Kauark-Fontes, Abhishek Kandwal, Emma McCurdy-Franks, Joel Finkelstein, Victoria McCarvell, Yehuda Zadik, Giulia Ottaviani, Rui Amaral Mendes, Caroline Margina Speksnijder, Hannah Rose Wardill, Paolo Bossi, and MASCC Mucositis Study Group. EClinicalMedicine 73 (July): 102675.

Nonhealing Surgical Wounds in a Patient With Plasminogen Deficiency Type 1 Successfully Treated With Intravenous Plasminogen: A Case Report. Decker, Robert Wayne, Joseph Mickler Parker, Jeremy Lorber, Roberto Crea, and Karen Thibaudeau. Advances in Skin & Wound Care 37 (7): 387–91.

Identifying Solutions to Minimize Meal Tray Waste: A Mixed-Method Approach. Fuleihan, Kimberly, Kaytlena Stillman, Joshua Hakimian, Korak Sarkar, Jan Michael Ballesteros, Christopher V. Almario, and Celina H. Shirazipour. Clinical Nutrition ESPEN 62 (August): 43–56.

Neurology

Response to ‘Assessment of Risk of ALS Conferred by the GGGGCC Hexanucleotide Expansion in C9orf72 Among First-Degree Relatives of Patients With ALS Carrying the Repeat Expansion.’ Dratch, Laynie, Daniel D. Kinnamon, Elizabeth A. Harrington, Jill Goldman, Jamie C. Fong, Tara Jones, Wendy R. Uhlmann, and Jennifer Roggenbuck. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, June, 1–3.

Communication in Neuropalliative Care. Besbris, Jessica, Jessica Baker, and Neha M. Kramer. Seminars in Neurology, June.

TRPV4 Neuromuscular Disease Registry Highlights Bulbar, Skeletal and Proximal Limb Manifestations. Kosmanopoulos, Gage, Jack K. Donohue, Maya Hoke, Simone Thomas, Margo A. Peyton, Linh Vo, Thomas O. Crawford, Reza Sadjadi, David N. Herrmann, Sabrina W. Yum, Mary M. Reilly, Steven S. Scherer, Richard S. Finkel, Richard A. Lewis, Davide Pareyson, Chiara Pisciotta, David Walk, Michael E. Shy, Charlotte J. Sumner, Inherited Neuropathy Consortium, and Brett A. McCray. Brain: A Journal of Neurology, June, awae201.

Orthopaedics

The Effects of Longer Use of Teriparatide on Clinical and Radiographic Outcomes After Spinal Fusion in Geriatric Patients. Kim, Young-Hoon, Kee-Yong Ha, Hyun W. Bae, Hyung-Youl Park, Young-Il Ko, Myung-Sup Ko, and Sang-Il Kim. Medicina (Kaunas, Lithuania) 60 (6): 946.

What Is the Role of Plastic Surgery for Incisional Closures in Pediatric Spine Surgery? Results From a Pediatric Spine Study Group Survey. Zusman, Natalie L., Jacquelyn N. Valenzuela-Moss, Tishya A. L. Wren, Tyler A. Tetreault, Kenneth D. Illingworth, Jaysson T. Brooks, David L. Skaggs, Lindsay M. Andras, Michael J. Heffernan, and Pediatric Spine Study Group. Journal of Pediatric Orthopedics. Part B, June.

Pathology and Laboratory Medicine

Molecular Characterization of a Rare Case of High-Grade B-Cell Lymphoma With MYC, BCL2, BCL6, and CCND1 Rearrangements. Monika, Fnu, Ahmed Sabri, David Cantu, Eric Vail, and Andrew Siref. Journal of Hematopathology, June.

Pediatrics

A Narrative Review of the Dorsal Root Ganglia and Spinal Cord Mechanisms of Action of Neuromodulation Therapies in Neuropathic Pain. Silva, Matheus Deroco Veloso da, Geovana Martelossi-Cebinelli, Kelly Megumi Yaekashi, Thacyana T. Carvalho, Sergio M. Borghi, Rubia Casagrande, and Waldiceu A. Verri. Brain Sciences 14 (6): 589.

Surgery

Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? Gikandi, Ajami, Zhi Ven Fong, Motaz Qadan, Raja R. Narayan, Thinzar Lwin, Carlos Fernández-Del Castillo, Keith D. Lillemoe, and Cristina R. Ferrone. Annals of Surgery Open: Perspectives of Surgical History, Education, and Clinical Approaches 5 (2): e400.

Outcomes of Prosthetic Upper Arm Arteriovenous Graft vs Brachiobasilic Fistula for Hemodialysis Access. Lu, Eileen, Donald T. Baril, Cassra N. Arbabi, Elizabeth L. Chou, Ali Azizzadeh, and Navyash Gupta. Journal of Vascular Surgery, June, S0741-5214(24)01225-4.

Patient Perceptions Underlying ctDNA Molecular Surveillance for HPV(+) Oropharyngeal Squamous Cell Carcinoma. Bastien, Amanda J., Jewel Ng, Iris Cong, Jonathan Garcia, Evan S. Walgama, Michael Luu, Julie K. Jang, Alain C. Mita, Kevin S. Scher, Justin T. Moyers, Jon Mallen-St Clair, Ellie Maghami, Michelle M. Chen, Zachary S. Zumsteg, and Allen S. Ho. Oral Oncology 156 (June): 106894.

ONECUT2 Acts as a Lineage Plasticity Driver in Adenocarcinoma as Well as Neuroendocrine Variants of Prostate Cancer. Qian, Chen, Qian Yang, Mirja Rotinen, Rongrong Huang, Hyoyoung Kim, Brad Gallent, Yiwu Yan, Radu M. Cadaneanu, Baohui Zhang, Salma Kaochar, Stephen J. Freedland, Edwin M. Posadas, Leigh Ellis, Dolores Di Vizio, Colm Morrissey, Peter S. Nelson, Lauren Brady, Ramachandran Murali, Moray J. Campbell, Wei Yang, Beatrice S. Knudsen, Elahe A. Mostaghel, Huihui Ye, Isla P. Garraway, Sungyong You, and Michael R. Freeman. Nucleic Acids Research, June, gkae547.

Urology

Prostate-Specific Antigen Values in Transgender Women Receiving Estrogen. Nik-Ahd, Farnoosh, Amanda M. De Hoedt, Christi Butler, Jennifer T. Anger, Peter R. Carroll, Matthew R. Cooperberg, and Stephen J. Freedland. JAMA, June.