This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published July 6-13.

Biomedical Sciences

Noninvasive In Vivo Thrombus Imaging in Patients with Ischemic Stroke or Transient Ischemic Attack. Whittington, Beth, Evangelos Tzolos, Rong Bing, Jack Andrews, Christophe Lucatelli, Mark G. MacAskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Edwin J. R. van Beek, Colin Smith, Marc R. Dweck, Michelle C. Williams, William Whiteley, Joanna M. Wardlaw, and David E. Newby. Arteriosclerosis, Thrombosis, and Vascular Biology, July.

Constitutional MLH1 Methylation Is a Major Contributor to Mismatch Repair-Deficient, MLH1-Methylated Colorectal Cancer in Patients Aged 55 Years and Younger. Hitchins, Megan P., Estela Dámaso, Rocio Alvarez, Lisa Zhou, Yajing Hu, Marcio A. Diniz, Marta Pineda, Gabriel Capella, Rachel Pearlman, and Heather Hampel. Journal of the National Comprehensive Cancer Network: JNCCN 21 (7): 743-752.e11.

Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures. Grausam, Katie B., and Joshua J. Breunig. Journal of Visualized Experiments: JoVE, no. 196 (June).

Cancer

CSPG4 as a Target for the Specific Killing of Triple-Negative Breast Cancer Cells by a Recombinant SNAP-Tag-Based Antibody-Auristatin F Drug Conjugate. Mungra, Neelakshi, Fleury A. N. Biteghe, Zaria Malindi, Allan M. Huysamen, Maryam Karaan, Natasha S. Hardcastle, Rubina Bunjun, Shivan Chetty, Krupa Naran, Dirk Lang, Wolfgang Richter, Roger Hunter, and Stefan Barth. Journal of Cancer Research and Clinical Oncology, July.

Management of Multiple Myeloma-Related Renal Impairment: Recommendations From the International Myeloma Working Group. Dimopoulos, Meletios A., Giampaolo Merlini, Frank Bridoux, Nelson Leung, Joseph Mikhael, Simon J. Harrison, Efstathios Kastritis, Laurent Garderet, Alessandro Gozzetti, Niels W. C. J. van de Donk, Katja C. Weisel, Ashraf Z. Badros, Meral Beksac, Jens Hillengass, Mohamad Mohty, P. Joy Ho, Ioannis Ntanasis-Stathopoulos, Maria-Victoria Mateos, Paul Richardson, Joan Blade, Philippe Moreau, Jesus San-Miguel, Nikhil Munshi, S. Vincent Rajkumar, Brian G. M. Durie, Heinz Ludwig, Evangelos Terpos, and International Myeloma Working Group. The Lancet. Oncology 24 (7): e293–311.

Cardiology

Women in Cardiovascular Imaging: A Call for Action to Address Ongoing Challenges. Joshi, Shruti S., Sabeeda Kadavath, Giulia Elena Mandoli, Alessia Gimelli, Martha Gulati, Ritu Thamman, Gina Lundberg, Roxana Mehran, Sharon L. Mulvagh, Leyla Elif Sade, Bharati Shivalkar, Leslee J. Shaw, Krasimira Hristova, Marc R. Dweck, Ana G. Almeida, and Grapsa Julia. European Heart Journal. Cardiovascular Imaging, July, jead158.

The Impacts of Exercise Interventions on Inflammaging Markers in Overweight/Obesity Patients with Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Malandish, Abbas, and Martha Gulati. International Journal of Cardiology. Heart & Vasculature 47 (August): 101234.

SGLT2 Inhibitors Are Associated With Reduced Cardiovascular Disease in Patients With Type 2 Diabetes: An Analysis of Real-World Data. Wang, Wendy, Lin Yee Chen, Rob F. Walker, Lisa S. Chow, Faye L. Norby, Alvaro Alonso, James S. Pankow, and Pamela L. Lutsey. Mayo Clinic Proceedings 98 (7): 985–96.

Computational Biomedicine

Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility. Gregga, Isabelle, Paul Dp Pharoah, Simon A. Gayther, Ani Manichaikul, Hae Kyung Im, Siddhartha P. Kar, Joellen M. Schildkraut, and Heather E. Wheeler. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, July, EPI-23-0309.

Imaging

Decline in Typical Angina Among Patients Referred for Cardiac Stress Testing. Rozanski, Alan, Donghee Han, Robert J. H. Miller, Heidi Gransar, Piotr J. Slomka, Sean W. Hayes, John D. Friedman, Louise E. J. Thomson, and Daniel S. Berman. Journal of Nuclear Cardiology, July

Eye-Lens Dose Reduction Using Region of Interest (ROI) Attenuators in Neuroimaging. Orji, Martina P., Chao Guo, Zhenyu Xiong, S. V. Setlur Nagesh, Stephen Rudin, and Daniel R. Bednarek. Proceedings of SPIE--the International Society for Optical Engineering 12463 (February): 124632V.

Medicine

Type 2 Diabetes, Hepatic Decompensation, and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: An Individual Participant-Level Data Meta-Analysis. Huang, Daniel Q., Nabil Noureddin, Veeral Ajmera, Maral Amangurbanova, Ricki Bettencourt, Emily Truong, Tolga Gidener, Harris Siddiqi, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Masato Yoneda, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Alina M. Allen, Mazen Noureddin, and Rohit Loomba. The Lancet. Gastroenterology & Hepatology, July, S2468-1253(23)00157-7.

Diabetes of the Exocrine Pancreas: Implications for Pharmacological Management. Goodarzi, Mark O., and Maxim S. Petrov. Drugs, July.

Incremental Prognostic Value of Stress Phase Entropy Over Standard PET Myocardial Perfusion Imaging Variables. Kuronuma, Keiichiro, Robert J. H. Miller, Serge D. Van Kriekinge, Donghee Han, Ananya Singh, Heidi Gransar, Damini Dey, Daniel S. Berman, and Piotr J. Slomka. European Journal of Nuclear Medicine and Molecular Imaging, July.

A Framework for Assessing Interactions for Risk Stratification Models: The Example of Ovarian Cancer. Phung, Minh Tung, Alice W. Lee, Karen McLean, Hoda Anton-Culver, Elisa V. Bandera, Michael E. Carney, Jenny Chang-Claude, Daniel W. Cramer, Jennifer Anne Doherty, Renee T. Fortner, Marc T. Goodman, Holly R. Harris, Allan Jensen, Francesmary Modugno, Kirsten B. Moysich, Paul D. P. Pharoah, Bo Qin, Kathryn L. Terry, Linda J. Titus, Penelope M. Webb, Australian Ovarian Cancer Study Group, Anna H. Wu, Nur Zeinomar, Argyrios Ziogas, Andrew Berchuck, Kathleen R. Cho, Gillian E. Hanley, Rafael Meza, Bhramar Mukherjee, Malcolm C. Pike, Celeste Leigh Pearce, Britton Trabert, and Ovarian Cancer Association Consortium. Journal of the National Cancer Institute, July, djad137.

Aging Delays Lung Repair: Insights From Omics Analysis in Mice With Pulmonary Fibrosis. Liang, Jiurong, and Giovanni Ligresti. American Journal of Respiratory Cell and Molecular Biology, July.

Diagnosis of Chronic Pancreatitis Using Semi-Quantitative MRI Features of the Pancreatic Parenchyma: Results From the Multi-Institutional MINIMAP Study. Tirkes, Temel, Dhiraj Yadav, Darwin L. Conwell, Paul R. Territo, Xuandong Zhao, Scott A. Persohn, Anil K. Dasyam, Zarine K. Shah, Sudhakar K. Venkatesh, Naoki Takahashi, Ashley Wachsman, Liang Li, Yan Li, Stephen J. Pandol, Walter G. Park, Santhi Swaroop Vege, Phil A. Hart, Mark Topazian, Dana K. Andersen, Evan L. Fogel, and Consortium for the Study of Chronic Pancreatitis, Diabetes, Pancreatic Cancer (CPDPC). Abdominal Radiology (New York), July.

Prescription Opioid Utilization Patterns, and Associated Outcomes, Among Privately-Insured Patients Prescribed Opioids to Manage Pain Associated With Osteoarthritis. Schepman, Patricia, Bradford J. Rice, Craig G. Beck, Alan White, Rebecca L. Robinson, Sheena Thakkar, Catherine Fernan, Birol Emir, and Stuart Silverman. Current Medical Research and Opinion, July, 1–18.

A Narrative Review of High-Level Isolation Unit Operational and Infrastructure Features. Lukowski, Joseph, Angela Vasa, Christa Arguinchona, Wael ElRayes, Maria G. Frank, Alison L. Galdys, Mary C. Garcia, Jennifer A. Garland, Susan Kline, Caroline Persson, Darrell Ruby, Lauren M. Sauer, Sami Vasistha, Sharon Carrasco, and Jocelyn J. Herstein. BMJ Global Health 8 (7): e012037.

Editorial: Racial Health Disparity in Cancer: Assessments of Need. Williams, Jennie L., Jennifer A. Freedman, Camille Ragin, Folakemi T. Odedina, and Patricia Thompson. Frontiers in Oncology 13: 1226697.

Neurology

Long-Term Survival After Salvage Pemetrexed for Refractory Primary T-Cell Lymphoma of the CNS. Liu, Andy, Huda Alalami, Xuemo Fan, Chirag Patil, Jaya M. Gill, Santosh Kesari, and Jethro Hu. CNS Oncology, July, CNS100.

Neurosurgery

The Effects of Enhancing Angiotensin Converting Enzyme in Myelomonocytes on Ameliorating Alzheimer’s-Related Disease and Preserving Cognition. Danziger, Ron, Dieu-Trang Fuchs, Yosef Koronyo, Altan Rentsendorj, Julia Sheyn, Eric Y. Hayden, David B. Teplow, Keith L. Black, Sebastien Fuchs, Kenneth E. Bernstein, and Maya Koronyo-Hamaoui. Frontiers in Physiology 14: 1179315.

OBGYN

Robotic Surgery in Obstetrics and Gynecology: A Bibliometric Study. Levin, Gabriel, Matthew Siedhoff, Kelly N. Wright, Mireille D. Truong, Kacey Hamilton, Yoav Brezinov, Walter Gotlieb, and Raanan Meyer. Journal of Robotic Surgery, July.

Orthopaedics

Return to Sports Following Sports-Related Concussion in Collision Sports: An Expert Consensus Statement Using the Modified Delphi Technique. Hohmann, Erik, Paul Bloomfield, Jiri Dvorak, Ruben Echemendia, Rachel M. Frank, Janesh Ganda, Leigh Gordon, Louis Holtzhausen, Alan Kourie, Jerome Mampane, Michael Makdissi, Jon Patricios, Elizabeth Pieroth, Margot Putukian, Dina C. Janse van Rensburg, Pierre Viviers, Vernon Williams, and Jean de Wilde. Arthroscopy: The Journal of Arthroscopic & Related Surgery, July, S0749-8063(23)00488-7.

Breast Cancer Incidence, Mortality, and Cost in Adolescent Idiopathic Scoliosis Patients and the Role of Low Dose Biplanar Radiography. Farivar, Daniel, David L. Skaggs, Keith Gabriel, and Kenneth D. Illingworth. The Journal of the American Academy of Orthopaedic Surgeons, July.

Comparison of the Outcomes of Microendoscopic Cervical Foraminotomy versus Full-Endoscopic Cervical Foraminotomy for the Treatment of Cervical Radiculopathy. Gideon, Blumstein, Kento Takebayashi, Takahiro Inui, Yasushi Oshima, Hiroki Iwai, Hirohiko Inanami, and Hisashi Koga. Neurologia Medico-Chirurgica, July.

Medical Sports Injuries in American Football Players. Matusak, Mark E., Catherine C. Yau, and Kenton H. Fibel. HSS Journal: The Musculoskeletal Journal of Hospital for Special Surgery 19 (3): 277–84.

The National Football League Concussion Protocol: A Review. Jacobi, Jaclyn, Erin B. Wasserman, Christina D Mack, Morgan Heinzelmann, Javier Cárdenas, Robb Rehberg, Gary Solomon, Allen Sills, and Bert Vargas. HSS Journal: The Musculoskeletal Journal of Hospital for Special Surgery 19 (3): 269–76.

An Atypical Presentation of Early Periprosthetic Infection After Cervical Disc Arthroplasty: A Case Report. Nigh, Evan D., Ryan A. Finkel, Arash J. Sayari, Todd H. Lanman, Eli M. Baron, and Jason M. Cuellar. JBJS Case Connector 13 (3).

Biomechanical Characteristics of a New Looping Stitch Versus the Classic Krackow Stitch for Distal Biceps Fixation. Long, Charles, Andrew Nakla, Min-Shik Chung, Daniel Kwak, Michelle H. McGarry, Oliver Hauck, Orr Limpisvasti, Gregory J. Adamson, and Thay Q. Lee. JSES International 7 (4): 685–91.

Pathology

Machine Learning for Cryosection Pathology Predicts the 2021 WHO Classification of Glioma. Nasrallah, MacLean P., Junhan Zhao, Cheng Che Tsai, David Meredith, Eliana Marostica, Keith L. Ligon, Jeffrey A. Golden, and Kun-Hsing Yu. Med (New York, N.Y.), June, S2666-6340(23)00189-7.

Seronegative Atypical Anti-Glomerular Basement Membrane Glomerulonephritis Associated With Thrombotic Microangiopathy: Case Report and Literature Analysis. Roy, Sasmit, Jean Hou, Prabal Chourasia, Anish Yalamanchili, Debargha Basuli, Praveen Kumar Errabelli, Samanvitha Sai Yarram, Raul Ayala, and Sreedhar Adapa. Journal of Investigative Medicine High Impact Case Reports 11: 23247096231184760.

Pediatrics

Angiotensin II Type 1 Receptor Antibodies and Native Kidney Function in Pediatric Liver and Intestinal Transplant Recipients. Stern, Rachel, Lucia Chen, Alvin P. Chan, Laura J. Wozniak, and Meghan Pearl. Pediatric Nephrology (Berlin, Germany), July.

Radiation Oncology

Re-Examining Predictors of Pathologic Lymph Node Positivity in Clinically Node Negative Oral Cavity Cancer. Anderson, Eric M., Michael Luu, Eric M. Chung, Christopher Gay, Jon Mallen-St Clair, Allen S. Ho, and Zachary S. Zumsteg. Oral Oncology 144 (July): 106490.

Surgery

Debating Sentinel Lymph Node Biopsy for Melanoma in the Modern Adjuvant Era. Zhang, Xiaoran, Laura Ferris, Mark B. Faries, and Jason J. Luke. Journal of Clinical Oncology, July, JCO2300255.

Urology

Investigating Trends in Interest for Benign Prostatic Hyperplasia Surgery Options Using Google Trends. Daniels, James P., Devin N. Patel, Gloria Cecilia Galvan, Nadine A. Friedrich, Sanjay Das, Arash Akhavein, Timothy Daskivich, David Josephson, Premal Desai, Cosimo De Nunzio, and Stephen J. Freedland. Prostate Cancer and Prostatic Diseases, July.

Long-Term Outcomes from a Phase 2 Study of Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer (SWOG S1314; NCT02177695). Flaig, Thomas W., Catherine M. Tangen, Siamak Daneshmand, Ajjai Shivaram Alva, M. Scott Lucia, David James McConkey, Dan Theodorescu, Amir Goldkorn, Matthew I. Milowsky, Rick Bangs, Gary R. MacVicar, Bruno R. Bastos, Jared S. Fowles, Daniel L. Gustafson, Melissa Plets, Ian M. Thompson, and Seth P. Lerner. European Urology, July, S0302-2838(23)02945-7.

Diagnostic Performance and Safety of Positron Emission Tomography With 18F-RhPSMA-7.3 in Patients With Newly Diagnosed Unfavourable Intermediate- to Very-High-Risk Prostate Cancer: Results From a Phase 3, Prospective, Multicentre Study (LIGHTHOUSE). Surasi, Devaki Shilpa, Matthias Eiber, Tobias Maurer, Mark A. Preston, Brian T. Helfand, David Josephson, Ashutosh K. Tewari, Diederik M. Somford, Soroush Rais-Bahrami, Bridget F. Koontz, Peter J. Bostrom, Albert Chau, Phillip Davis, David M. Schuster, Brian F. Chapin, and LIGHTHOUSE Study Group. European Urology, July, S0302-2838(23)02949-4.

Impact of Asian Race on Prognosis in De Novo Metastatic Prostate Cancer. Ni, Xudong, Luu Michael, Weiwei Ma, Tingwei Zhang, Yu Wei, Stephen J. Freedland, Dingwei Ye, Timothy J. Daskivich, and Yao Zhu. Journal of the National Comprehensive Cancer Network: JNCCN 21 (7): 733-741.e3.

Disparities in COVID-19 Disease Incidence by Income and Vaccination Coverage - 81 Communities, Los Angeles, California, July 2020-September 2021. Masterson, John M., Michael Luu, Kai B. Dallas, Lauren P. Daskivich, Brennan Spiegel, and Timothy J. Daskivich. MMWR. Morbidity and Mortality Weekly Report 72 (26): 728–31.