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Faculty Publications Jan. 25-Feb. 1


A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Jan. 25-Feb. 1. 

Cardiac Surgery

Increasing Utilization of Extended Criteria Donor Hearts for Transplantation: The OCS Heart EXPAND Trial. Schroder, Jacob N., Chetan B. Patel, Adam D. DeVore, Sarah Casalinova, Kevin J. Koomalsingh, Ashish S. Shah, Anelechi C. Anyanwu, David A. D’Alessandro, Karol Mudy, Benjamin Sun, Martin Strueber, Asghar Khaghani, Yasuhiro Shudo, Fardad Esmailian, Kenneth Liao, Francis D. Pagani, Scott Silvestry, I.-Wen Wang, Christopher T. Salerno, Tarek S. Absi, Joren C. Madsen, Donna Mancini, Amy G. Fiedler, Carmelo A. Milano, and Jason W. Smith. JACC. Heart Failure, January, S2213-1779(23)00831-4.

Multi-Arterial Versus Single-Arterial Coronary Surgery: Ten Year Follow-up of One Million Patients. Sabik, Joseph F., J. Hunter Mehaffey, Vinay Badhwar, Marc Ruel, Patrick O. Myers, Sigrid Sandner, Faisal Bakaeen, John Puskas, David Taggart, Thomas Schwann, Joanna Chikwe, Thomas E. MacGillivray, Abel Kho, and Robert Habib. The Annals of Thoracic Surgery, January, S0003-4975(24)00063-8.


Clinical Predictors of Left Ventricular Thrombus After Myocardial Infarction as Detected by Magnetic Resonance Imaging. Fardman, Alexander, Eias Massalha, Sharon Shalom Natanzon, Yafim Brodov, Orly Goitein, Fernando Chernomordik, Romana Herscovici, Avishay Grupper, Rafael Kuperstein, Israel Mazin, Shlomi Matetzky, and Roy Beigel. Frontiers in Cardiovascular Medicine 10: 1275390.

Polarity-Dependent, Reduced or No-Output Shocks in Implantable Cardioverter-Defibrillators. Swerdlow, Charles D., and Michael Ringle. JACC. Clinical Electrophysiology, January, S2405-500X(23)00906-4.

Impact of Atherosclerosis Imaging-Quantitative Computed Tomography on Diagnostic Certainty, Downstream Testing, Coronary Revascularization and Medical Therapy: The CERTAIN Study. Nurmohamed, Nick S., Jason H. Cole, Matthew Budoff, Ronald P. Karlsberg, Himanshu Gupta, Lance E. Sullenberger, Carlos G. Quesada, Habib Rahban, Kevin M. Woods, Jeffrey R. Uzzilia, Scott L. Purga, Melissa Aquino, Udo Hoffmann, James K. Min, James P. Earls, and Andrew D. Choi. European Heart Journal. Cardiovascular Imaging, January, jeae029.

Influence of FTDP-17 Mutants on Circular Tau RNAs. Margvelani, Giorgi, Justin R. Welden, Andrea Arizaca Maquera, Jennifer E. Van Eyk, Christopher Murray, Sandra C. Miranda Sardon, and Stefan Stamm. Biochimica Et Biophysica Acta. Molecular Basis of Disease, January, 167036.

Heart Rhythm Society Quality Improvement Committee Update. Deering, Thomas F., John N. Catanzaro, Roopinder K. Sandhu, Matthew Singleton, Srikant Das, Marc W. Deyell, Siva K. Mulpuru, Christina L. Magnelli-Reyes, Bruce A. Koplan, Gaston R. Vergara, Christopher Austin, Fabrizio R. Assis, Kun Xiang, Michelle Moore, and Anne Marie Smith. Heart Rhythm 21 (2): 241–43.


A Holistic Approach to CT Protocol and Dose Management. Eastman, Emi, Barry D. Pressman, Lynne Roy, and Yifang Zhou. Journal of the American College of Radiology: JACR, January, S1546-1440(24)00113-3.


Case Report: An Exceptional Responder of Low-Dose Continuous 5-FU in a Patient With de-Novo Stage IV Triple-Negative Breast Cancer With Liver and Bone Marrow Failure. Chan, Bryan, Jin Sun Lee, and Yuan Yuan. Frontiers in Oncology 13: 1305584.

Distinct RBC Alloantibody Responses in Type 1 Interferon-Dependent and -Independent Lupus Mouse Models. Paul, Kausik, Rosario Hernández-Armengol, June Young Lee, Che-Yu Chang, Tomohiro Shibata, Michifumi Yamashita, Caroline Jefferies, and David R. Gibb. Frontiers in Immunology 14: 1304086.

Sister Haplotypes and Recombination Disequilibrium: A New Approach to Identify Associations of Haplotypes With Complex Diseases. Liao, Shun-Yao, and Yuan-De Tan. Frontiers in Genetics 14: 1295327.

Safety Profile of Pembrolizumab Monotherapy Based on an Aggregate Safety Evaluation of 8937 Patients. Brahmer, Julie R., Georgina V. Long, Omid Hamid, Edward B. Garon, Roy S. Herbst, Thierry Andre, Philippe Armand, Dean Bajorin, Joaquim Bellmunt, Barbara Burtness, Toni K. Choueiri, Ezra E. W. Cohen, Luis A. Diaz, Kohei Shitara, Girish Kulkarni, David McDermott, Manish Shah, Josep Tabernero, Arndt Vogel, Pier Luigi Zinzani, Niusha Jafari, Steven Bird, Ellen Snyder, Christine Gause, Oswaldo L. Bracco, M. Catherine Pietanza, Todd Gruber, and Antoni Ribas. European Journal of Cancer (Oxford, England: 1990) 199 (January): 113530.

OMERACT 2023 Systemic Lupus Erythematosus Special Interest Group: Winnowing and Binning Preliminary Candidate Domains for the Core Outcome Set. Nielsen, Wils, Vibeke Strand, Lee S. Simon, Ioannis Parodis, Alfred H. J. Kim, Maya Desai, Yvonne Enman, Daniel Wallace, Yashaar Chaichian, Sandra Navarra, Cynthia Aranow, Meggan MacKay, Kimberly Trotter, Oshrat E. Tayer-Shifman, Ali Duarte-Garcia, Lai Shan Tam, Manuel F. Ugarte-Gil, Guillermo J. PonsEstel, John A. Reynolds, Mandana Nikpour, Alberta Hoi, Juanita Romero-Diaz, Danaë Papachristos, Amita Aggarwal, Chi Chiu Mok, Keishi Fujio, Rosalind Ramsey-Goldman, Aaron Howe, Behdin Nowrouzi Kia, Dennisse Bonilla, Julian Thumboo, Marta Mosca, Martin Aringer, Sindhu R. Johnson, Aaron M. Drucker, Eric Morand, Ian Bruce, Zahi Touma, and OMERACT SLE Working Group. Seminars in Arthritis and Rheumatism 65 (January): 152380.

Allogeneic Bone Marrow Transplantation for Patients With Treatment-Refractory Crohn’s Disease. McDonald, George B., Ole J. B. Landsverk, Dermot P. B. McGovern, Anders Aasebø, Vemund Paulsen, Talin Haritunians, Henrik M. Reims, Bernadette M. McLaughlin, Timothy Zisman, Dalin Li, Elisabeth T. M. M. Elholm, Frode L. Jahnsen, George E. Georges, and Tobias Gedde-Dahl. Heliyon 10 (1): e24026.

Outcomes of Patients With Resected Stage III/IV Acral or Mucosal Melanoma, Treated With Adjuvant Anti-PD-1 Based Therapy. Jacques, Sarah K., Janet McKeown, Piyush Grover, Douglas B. Johnson, Anne Zaremba, Florentia Dimitriou, Roi Weiser, Mohamad Farid, Kenjiro Namikawa, Ryan J. Sullivan, Piotr Rutkowski, Celeste Lebbe, Omid Hamid, Jonathan S. Zager, Olivier Michielin, Bart Neyns, Yasuhiro Nakamura, Caroline Robert, Janice Mehnert, Paolo A. Ascierto, Prachi Bhave, Benjamin Park, Lisa Zimmer, Joanna Mangana, Megan Mooradian, Joanna Placzke, Clare Allayous, Isabella C. Glitza Oliva, Inderjit Mehmi, Danielle Depalo, Alexandre Wicky, Julia K. Schwarze, Severine Roy, Christina Boatwright, Vito Vanella, Georgina V. Long, Alexander M. Menzies, Serigne N. Lo, and Matteo S. Carlino. European Journal of Cancer (Oxford, England: 1990) 199 (January): 113563.

Different Minimal Alcohol Consumption in Male and Female Individuals With Metabolic Dysfunction-Associated Fatty Liver Disease. Zhu, Yixuan, Xiaoming Xu, Zhiwen Fan, Xiaoyan Ma, Fajuan Rui, Wenjing Ni, Xinyu Hu, Qi Gu, Junping Shi, Chao Wu, Yee Hui Yeo, and Jie Li. Liver International, January.

Consolidation Osimertinib Versus Durvalumab Versus Observation Following Concurrent Chemoradiation in Unresectable EGFR-Mutant Non-Small-Cell Lung Cancer: A Multicenter Retrospective Cohort Study. Nassar, Amin H., So Yeon Kim, Jacqueline V. Aredo, Jamie Feng, Frances Shepherd, Chao Xu, David Kaldas, Jhanelle E. Gray, Thomas J. Dilling, Joel W. Neal, Heather A. Wakelee, Yufei Liu, Sarah B. Goldberg, et al. Journal of Thoracic Oncology, January, S1556-0864(24)00032-7.

Survival Impact of Post-Operative Immunotherapy in Resected Stage III Cutaneous Melanomas in the Checkpoint Era. Hagopian, G., X. Jiang, C. Grant, D. Brazel, P. Kumar, M. Yamamoto, J. Jakowatz, W. Chow, T. Tran, W. Shen, and J. Moyers. ESMO Open 9 (2): 102193.

High-Throughput mRNA-Seq Atlas of Human Placenta Shows Vast Transcriptome Remodeling From First to Third Trimester. Gonzalez, Tania L., Sahar Wertheimer, Amy E. Flowers, Yizhou Wang, Chintda Santiskulvong, Ekaterina L. Clark, Caroline A. Jefferies, Kate Lawrenson, Jessica L. Chan, Nikhil V. Joshi, Yazhen Zhu, Hsian-Rong Tseng, S. Ananth Karumanchi, John Williams, and Margareta D. Pisarska. Biology of Reproduction, January, ioae007.

Disparities and Underutilization of Surgery for Early Stage Small Cell Lung Cancer. Fong, Abigail J., Heidi Reich, James Mirocha, Amelia Wong, and Taryne A. Imai. The Annals of Thoracic Surgery, January, S0003-4975(24)00067-5.

Feasibility of Combining Spatial Computing and AI for Mental Health Support in Anxiety and Depression. Spiegel, Brennan M. R., Omer Liran, Allistair Clark, Jamil S. Samaan, Carine Khalil, Robert Chernoff, Kavya Reddy, and Muskaan Mehra. NPJ Digital Medicine 7 (1): 22.

Global Incidence of Adverse Clinical Events in Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. Le, Michael H., David M. Le, Thomas C. Baez, Hansen Dang, Vy H. Nguyen, KeeSeok Lee, Christopher D. Stave, Takanori Ito, Yuankai Wu, Yee Hui Yeo, Fanpu Ji, Ramsey Cheung, and Mindie H. Nguyen. Clinical and Molecular Hepatology, January.

Systemic Neutrophil Gelatinase-Associated Lipocalin Alterations in Chronic Pancreatitis: A Multicenter, Cross-Sectional Study. Gumpper-Fedus, Kristyn, Kaylin Chasser, Valentina Pita-Grisanti, Molly Torok, Timothy Pfau, Thomas A. Mace, Rachel M. Cole, Martha A. Belury, Stacey Culp, Phil A. Hart, Somashekar G. Krishna, Luis F. Lara, Mitchell L. Ramsey, William Fisher, Evan L. Fogel, Chris E. Forsmark, Liang Li, Stephen Pandol, Walter G. Park, Jose Serrano, Stephen K. Van Den Eeden, Santhi Swaroop Vege, Dhiraj Yadav, Darwin L. Conwell, Zobeida Cruz-Monserrate, and Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). Clinical and Translational Gastroenterology, January.

Artificial Intelligence Model Predicts Sudden Cardiac Arrest Manifesting With Pulseless Electric Activity Versus Ventricular Fibrillation. Holmstrom, Lauri, Bryan Bednarski, Harpriya Chugh, Habiba Aziz, Hoang Nhat Pham, Arayik Sargsyan, Audrey Uy-Evanado, Damini Dey, Angelo Salvucci, Jonathan Jui, Kyndaron Reinier, Piotr J. Slomka, and Sumeet S. Chugh. Circulation. Arrhythmia and Electrophysiology, January, e012338.

Comparison of the Cost-Effectiveness of Sequential Treatment With Abaloparatide in US Men and Women at Very High Risk of Fractures. Hiligsmann, Mickael, Stuart L. Silverman, Andrea J. Singer, Leny Pearman, Yamei Wang, John Caminis, and Jean-Yves Reginster. Aging Clinical and Experimental Research 36 (1): 14.

An Unusual Presentation of Metastatic Prostate Cancer in a 44-Year-Old Man: A Case Report and Review of the Literature. Taheri, Homa, Pouya Ebrahimi, Pedram Nazari, Amirhosein Kefayat, and Abbas Mahdavian. Clinical Case Reports 12 (2): e8447.

Development of a Machine Learning-Based Model to Predict Hepatic Inflammation in Chronic Hepatitis B Patients With Concurrent Hepatic Steatosis: A Cohort Study. Rui, Fajuan, Yee Hui Yeo, Liang Xu, Qi Zheng, Xiaoming Xu, Wenjing Ni, Youwen Tan, Qing-Lei Zeng, Zebao He, Xiaorong Tian, Qi Xue, Yuanwang Qiu, Chuanwu Zhu, Weimao Ding, Jian Wang, Rui Huang, Yayun Xu, Yunliang Chen, Junqing Fan, Zhiwen Fan, Xiaolong Qi, Daniel Q. Huang, Qing Xie, Junping Shi, Chao Wu, and Jie Li. EClinicalMedicine 68 (February): 102419.

Rates, Patterns, and Predictors of Specialty Palliative Care Consultation Among Patients With Acute-on-Chronic Liver Failure. Patel, Arpan, Anne Walling, Fasiha Kanwal, Marina Serper, Ruben Hernaez, Vinay Sundaram, David Kaplan, Tamar Taddei, and Nadim Mahmud. JHEP Reports: Innovation in Hepatology 6 (2): 100976.

Targeting Prostate Tumor Low-Molecular Weight Tyrosine Phosphatase for Oxidation-Sensitizing Therapy. Stanford, Stephanie M., Tiffany P. Nguyen, Joseph Chang, Zixuan Zhao, G. Lavender Hackman, Eugenio Santelli, Colton M. Sanders, Madhusudhanarao Katiki, Eleonora Dondossola, Brooke L. Brauer, Michael A. Diaz, Yuan Zhan, Sterling H. Ramsey, Philip A. Watson, Banumathi Sankaran, Claudia Paindelli, Vanessa Parietti, Antonios G. Mikos, Alessia Lodi, Aditya Bagrodia, Andrew Elliott, Rana R. McKay, Ramachandran Murali, Stefano Tiziani, Arminja N. Kettenbach, and Nunzio Bottini. Science Advances 10 (5): eadg7887.

Paraneoplastic NMDA Encephalitis, a Case Report and an Extensive Review of Available Literature. Alzghoul, Hamza, Ferdous Kadri, Mohamed F. Ismail, Robeer Youssef, Mustafa Shamaileh, Ahmad R. Al-Assi, Liliya Adzhieva, and Bashar Alzghoul. Radiology Case Reports 19 (4): 1371–85.


Risk Factors for Reoperation Following Single-Level Cervical Disc Arthroplasty as Utilized in a Representative Sample of United States Clinical Practice: A Retrospective PearlDiver Study. Nilssen, Paal K., Nakul Narendran, Ida Chen, Linda E. Kanim, Corey T. Walker, Hyun W. Bae, David L. Skaggs, and Alexander Tuchman. Global Spine Journal, January, 21925682241230965.

Prosthesis Design and Likelihood of Achieving Physiological Range of Motion After Cervical Disc Arthroplasty: Analysis of ROM Data From 1,173 Patients From 7 IDE Clinical Trials. Patwardhan, Avinash G., Robert M. Havey, Frank M. Phillips, Jack E. Zigler, Domagoj Coric, Richard Guyer, Todd Lanman, and Muturi G. Muriuki. The Spine Journal, January, S1529-9430(24)00034-2.

Extreme-Aged Patients (??85 Years) Experience Similar Outcomes as Younger Geriatric Patients Following Chronic Subdural Hematoma Evacuation: A Matched Cohort Study. Nisson, Peyton L., John J. Francis, Michelot Michel, Keshav Goel, and Chirag G. Patil. GeroScience, January.

Spinal Cerebrospinal Fluid Leak Localization With Digital Subtraction Myelography: Tips, Tricks, and Pitfalls. Galvan, Javier, Marcel Maya, Ravi S. Prasad, Vikram S. Wadhwa, and Wouter Schievink. Radiologic Clinics of North America 62 (2): 321–32.


Experts Achieve Consensus on a Majority of Statements Regarding Platelet-Rich Plasma Treatments for Treatment of Musculoskeletal Pathology. Hurley, Eoghan T., Seth L. Sherman, Daniel J. Stokes, Scott A. Rodeo, Shane A. Shapiro, Kenneth Mautner, Don A. Buford, Jason L. Dragoo, Bert R. Mandelbaum, Kenneth R. Zaslav, Brian J. Cole, Rachel M. Frank, and Members of the Biologics Association. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 40 (2): 470-477.e1.

Skin Antisepsis Before Surgical Fixation of Extremity Fractures. PREP-IT Investigators, Sheila Sprague, Gerard Slobogean, Jeffrey L. Wells, Nathan N. O’Hara, Lehana Thabane, C. Daniel Mullins, Anthony D. Harris, Amber Wood, Darius Viskontas, Kelly L. Apostle, Robert V. O’Toole, The PREP-IT Investigators, et al. The New England Journal of Medicine 390 (5): 409–20.

Pathology and Laboratory Medicine

Overdiagnosis of Diffuse Mesothelioma: A Reminder That Pathologists Need to Think Outside the ‘Immunohistochemistry Diagnostic Box.’ Marchevsky, Alberto M. Annals of Diagnostic Pathology 68 (February): 152264.


Cutaneous Fistula Formation After Thyroid Nodule Rupture: A Rare Complication after Radiofrequency Ablation. Bastien, Amanda J., Luv Amin, Jeffrey Moses, Wendy Sacks, and Allen S. Ho. Head & Neck, January.

Placenta Accreta Spectrum Disorder at Single-Cell Resolution: A Loss of Boundary Limits in the Decidua and Endothelium. Afshar, Yalda, Ophelia Yin, Anhyo Jeong, Guadalupe Martinez, Jina Kim, Feiyang Ma, Christine Jang, Sarah Tabatabaei, Sungyong You, Hsian-Rong Tseng, Yazhen Zhu, and Deborah Krakow. American Journal of Obstetrics and Gynecology, January, S0002-9378(23)00729-9.

Trends in Surgical Critical Care Fellowship Match: An Analysis of National Resident Matching Program Data. Sohail, Amir H., Ivan B. Ye, Meher Oberoi, Kevin A. Martinez, Abu Baker Sheikh, Koral Cohen, Umar Bhatti, and D’andrea K. Joseph. Journal of Surgical Education, January, S1931-7204(23)00419-1.

Liposomal Bupivacaine Versus Conventional Anesthetic or Placebo for Hemorrhoidectomy: A Systematic Review and Meta-Analysis. Solis-Pazmino, P., L. Figueroa, K. La, O. Termeie, K. Oka, M. Schleicher, J. Cohen, M. Barnajian, and Y. Nasseri. Techniques in Coloproctology 28 (1): 29.

Outcomes of Pediatric Pilonidal Disease Treatment: Excision With off-Midline Flap Reconstruction Versus Endoscopic Pilonidal Sinus Treatment. Lee, William G., Celia Short, Allen Zhong, Vanya Vojvodic, Andrew Sundin, Ryan G. Spurrier, Kasper S. Wang, and Juan Carlos Pelayo. Pediatric Surgery International 40 (1): 46.


Competency in Robotic Surgery: Standard Setting for Robotic Suturing Using Objective Assessment and Expert Evaluation. Haque, Taseen F., J. Everett Knudsen, Jonathan You, Alvin Hui, Hooman Djaladat, Runzhuo Ma, Steven Cen, Mitchell Goldenberg, and Andrew J. Hung. Journal of Surgical Education, January, S1931-7204(23)00465-8.