This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Jan. 11-18.

Biomedical Sciences

Coronary Inflammation on Chest Computed Tomography and COVID-19 Mortality. Tuttolomondo, Domenico, Andrea Ticinesi, Damini Dey, Chiara Martini, Antonio Nouvenne, Maria Nicastro, Massimo De Filippo, Nicola Sverzellati, Francesco Nicolini, Tiziana Meschi, and Nicola Gaibazzi. European Radiology, January.

Overcoming Resistance in Prostate Cancer Therapy Using a DZ-Simvastatin Conjugate. Ou, Yan, Gina Chia-Yi Chu, Ji Lyu, Liyuan Yin, Adrian Lim, Ning Zhai, Xiaojiang Cui, Michael S. Lewis, Mouad Edderkaoui, Stephen J. Pandol, Ruoxiang Wang, and Yi Zhang. Molecular Pharmaceutics, January.

The Characteristics of Pre-Existing Humoral Imprint Determine Efficacy of S. Aureus Vaccines and Support Alternative Vaccine Approaches. Caldera, J. R., Chih-Ming Tsai, Desmond Trieu, Cesia Gonzalez, Irshad A. Hajam, Xin Du, Brian Lin, and George Y. Liu. Cell Reports. Medicine 5 (1): 101360.

Cardiac Surgery

Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death. Samovich, Svetlana N., Karolina Mikulska-Ruminska, Haider H. Dar, Yulia Y. Tyurina, Vladimir A. Tyurin, Austin B. Souryavong, Alexander A. Kapralov, Andrew A. Amoscato, Ofer Beharier, S. Ananth Karumanchi, Claudette M. St Croix, Xin Yang, Theodore R. Holman, Andrew P. VanDemark, Yoel Sadovsky, Rama K. Mallampalli, Sally E. Wenzel, Wei Gu, Yuri L. Bunimovich, Ivet Bahar, Valerian E. Kagan, and Hülya Bayir. Angewandte Chemie (International Ed. in English), January, e202314710.

Cardiology

Clinical Aspects of Ischemia With No Obstructive Coronary Artery Disease (INOCA). Polyak, Alexander, Janet Wei, Martha Gulati, and Noel Bairey Merz. American Heart Journal Plus: Cardiology Research and Practice 37 (January): 100352.

Lack of Leisure Time Physical Activity and Variations in Cardiovascular Mortality Across US Communities: A Comprehensive County-Level Analysis (2011-2019). Abohashem, Shady, Khurram Nasir, Malak Munir, Ahmed Sayed, Wesam Aldosoky, Taimur Abbasi, Erin D. Michos, Martha Gulati, and Jamal S. Rana. British Journal of Sports Medicine, January, bjsports-2023-107220.

Skin Sympathetic Nerve Activity During Unprovoked Syncope in an Ambulatory Patient With Postural Orthostatic Tachycardia Syndrome. Liu, Xiao, Jewel N. Reaso, Anxhela Kote, K. Taiga Andersson, and Peng-Sheng Chen. Heart Rhythm, January, S1547-5271(24)00025-0.

Usage of Older Donors Is Associated With Higher Mortality After Heart Transplantation: A UNOS Observational Study. Jaiswal, Abhishek, Michelle Kittleson, Ashwin Pillai, David Baran, and William L. Baker. The Journal of Heart and Lung Transplantation, January, S1053-2498(24)00009-3.

Evolutions in Combined Heart-Kidney Transplant. Jain, Rashmi, and Michelle M. Kittleson. Current Heart Failure Reports, January.

Interaction Between Anemia and Renal Dysfunction in Relation to Long-Term Survival Following Acute Myocardial Infarction. Shechter, Alon, Arthur Shiyovich, Keren Skalsky, Harel Gilutz, and Ygal Plakht. Clinical Research in Cardiology, January.

The 2023 Report on the Proteome From the HUPO Human Proteome Project. Omenn, Gilbert S., Lydie Lane, Christopher M. Overall, Cecilia Lindskog, Charles Pineau, Nicolle H. Packer, Ileana M. Cristea, Susan T. Weintraub, Sandra Orchard, Michael H. A. Roehrl, Edouard Nice, Tiannan Guo, Jennifer E. Van Eyk, Siqi Liu, Nuno Bandeira, Ruedi Aebersold, Robert L. Moritz, and Eric W. Deutsch. Journal of Proteome Research, January.

Implications of Mitral Annular Calcification on Outcomes Following Mitral Transcatheter Edge-to-Edge Repair. Shechter, Alon, Mirae Lee, Danon Kaewkes, Vivek Patel, Ofir Koren, Tarun Chakravarty, Keita Koseki, Takashi Nagasaka, Sabah Skaf, Moody Makar, Raj R. Makkar, and Robert J. Siegel. Circulation. Cardiovascular Interventions, January, e013424.

Computational Biomedicine

Overview of the 8th Social Media Mining for Health Applications (#SMM4H) Shared Tasks at the AMIA 2023 Annual Symposium. Klein, Ari Z., Juan M. Banda, Yuting Guo, Ana Lucia Schmidt, Dongfang Xu, Ivan Flores Amaro, Raul Rodriguez-Esteban, Abeed Sarker, and Graciela Gonzalez-Hernandez. Journal of the American Medical Informatics Association: JAMIA, January, ocae010.

An Updated PREDICT Breast Cancer Prognostic Model Including the Benefits and Harms of Radiotherapy. Grootes, Isabelle, Gordon C. Wishart, and Paul David Peter Pharoah. NPJ Breast Cancer 10 (1): 6.

Editorial Viewpoints of Scientific Publishing for Early-Career Research Scientists. Peng, Pei-Chen, and Fadie T. Coleman. BMC Proceedings 18 (Suppl 1): 4.

Medicine

Interstitial Macrophages Mediate Efferocytosis of Alveolar Epithelium During Influenza Infection. Zuttion, Marilia Sanchez Santos Rizzo, Tanyalak Parimon, Changfu Yao, Barry R. Stripp, Ying Wang, Christopher M. Soto, Zackary Ortega, Xiao Li, William J. Janssen, and Peter Chen. American Journal of Respiratory Cell and Molecular Biology, January.

Promoting Equity in Inflammatory Bowel Disease: A Global Approach to Care. Sebastian, Shaji, Britta Siegmund, Fasika Teferra, Dermot P. B. McGovern, Natalia Sousa Freitas Queiroz, C. Janneke van der Woude, and Vishal Sharma. The Lancet. Gastroenterology & Hepatology, January, S2468-1253(23)00368-0.

Advancing Mouse Models for Transplantation Research. Cravedi, Paolo, Leonardo V. Riella, Mandy Ford, Anna Valujskikh, Madhav C. Menon, Allan D. Kirk, Maria-Luisa Alegre, Sandy Feng, Patricia Kehn, Nader Najafian, Wayne Hancock, Peter S. Heeger, Jonathan Maltzman, Roslyn B. Mannon, Satish Nadig, Jonah Odim, Heth Turnquist, Julia Shaw, Lori West, Xunrong Luo, Anita Chong, Jonathan Bromberg, and AST COTS MOuse MOdels in Transplantation (MOMOT) work group. American Journal of Transplantation, January, S1600-6135(24)00071-6.

Developing a Framework to Infer Opioid Use Disorder Severity From Clinical Notes to Inform Natural Language Processing Methods: Characterization Study. Poulsen, Melissa N., Philip J. Freda, Vanessa Troiani, and Danielle L. Mowery. JMIR Mental Health 11 (January): e53366.

Racial and Ethnic Variation in Healthcare Utilization Before and During the COVID-19 Pandemic: Differential Effects for Overall Versus Telehealth Care. Haderlein, Taona P., Alison B. Hamilton, Robin M. Masheb, Rashmi Mullur, Christine A. Lam, and Donna L. Washington. Journal of General Internal Medicine, January.

Inhibition of Ephrin B2 Reverse Signaling Suppresses Multiple Myeloma Pathogenesis. Sasine, Joshua P., Natalia Y. Kozlova, Lisa Valicente, Jennifer Dukov, Dana H. Tran, Heather A. Himburg, Sanjeev Kumar, Sarah Khorsandi, Aldi Chan, Samantha Grohe, Michelle Li, Jenny Kan, Mary E. Sehl, Gary J. Schiller, Bryanna Reinhardt, Brijesh Kumar Singh, Ritchie Ho, Peibin Yue, Elena B. Pasquale, and John P. Chute. Cancer Research, January.

Neurology

Imaging Chronic Active Lesions in Multiple Sclerosis: A Consensus Statement. Bagnato, Francesca, Pascal Sati, Christopher C. Hemond, Colm Elliott, Susan A. Gauthier, Daniel M. Harrison, Caterina Mainero, Jiwon Oh, David Pitt, Russell T. Shinohara, Seth A. Smith, Bruce Trapp, Christina J. Azevedo, Peter A. Calabresi, Roland G. Henry, Cornelia Laule, Daniel Ontaneda, William D. Rooney, Nancy L. Sicotte, Daniel S. Reich, and Martina Absinta. Brain: A Journal of Neurology, January, awae013.

OBGYN

It Takes One to Know One-Machine Learning for Identifying OBGYN Abstracts Written by ChatGPT. Levin, Gabriel, Raanan Meyer, Paul-Adrien Guigue, and Yoav Brezinov. International Journal of Gynaecology and Obstetrics, January.

Orthopaedics

Internal Brace Augmentation Improves the Biomechanical Properties of Trapeziometacarpal Joint Dorsoradial Ligament Repair. Shin, Seung-Han, Steven S. Shin, Michelle H. McGarry, and Thay Q. Lee. Hand Surgery & Rehabilitation, January, 101643.

Psychiatry & Behavioral Neuroscience

Comparative Effectiveness of Psychotherapy vs Antidepressants for Depression in Heart Failure: A Randomized Clinical Trial. IsHak, Waguih William, Michele A. Hamilton, Samuel Korouri, Marcio A. Diniz, James Mirocha, Rebecca Hedrick, Robert Chernoff, Jeanne T. Black, Harriet Aronow, Brigitte Vanle, Jonathan Dang, Gabriel Edwards, Tarneem Darwish, Gabrielle Messineo, Stacy Collier, Mia Pasini, Kaleab K. Tessema, John G. Harold, Michael K. Ong, Brennan Spiegel, Kenneth Wells, and Itai Danovitch. JAMA Network Open 7 (1): e2352094.

Radiation Oncology

Carfilzomib, Thalidomide, and Dexamethasone Is Safe and Effective in Relapsed and/or Refractory Multiple Myeloma: Final Report of the Single Arm, Multicenter Phase II ALLG MM018/AMN002 Study. Ninkovic, Slavisa, Simon J. Harrison, Je-Jung Lee, Nick Murphy, Jae Hoon Lee, Jane Estell, Vivien M. Chen, Noemi Horvath, Kihuyn Kim, Richard Eek, Bradley Augustson, Soo-Mee Bang, Shang-Yi Huang, Rajeev Rajagopal, Ferenc Szabo, Daniel Engeler, Belinda E. Butcher, Peter Mollee, Brian Durie, Wee Joo Chng, and Hang Quach. Haematologica, January.

Surgery

Traumatic Brain Injury Endotypes in Polytrauma TBI: Gathering Steam. Melo, Nicolas. American Journal of Surgery, December, S0002-9610(23)00660-8.

CORR Insights®: High Rates of Treatment Failure and Amputation in Modular Endoprosthesis Prosthetic Joint Infections Caused by Fungal Infections With Candida. Allison, Daniel C. Clinical Orthopaedics and Related Research, January.