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Faculty Publications: Feb. 23 - March 2


A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23 - March 2. 


Optimizing One-Lung Ventilation in Thoracic Surgery - Does Mode of Ventilation Matter? Nurok, Michael, and Daniel S. Talmor. The Annals of Thoracic Surgery, February, S0003-4975(23)00162-5.

Biomedical Sciences

A Novel Approach to Determining Tumor Progression Using a Three-Site Pilot Clinical Trial of Spectroscopic MRI-Guided Radiation Dose Escalation in Glioblastoma. Ramesh, Karthik K., Vicki Huang, Jeffrey Rosenthal, Eric A. Mellon, Mohammed Goryawala, Peter B. Barker, Saumya S. Gurbani, Anuradha G. Trivedi, Alexander S. Giuffrida, Eduard Schreibmann, Hui Han, Macarena de le Fuente, Erin M. Dunbar, Matthias Holdhoff, Lawrence R. Kleinberg, Hui-Kuo G. Shu, Hyunsuk Shim, and Brent D. Weinberg. Tomography (Ann Arbor, Mich.) 9 (1): 362–74.

Pericoronary Adipose Tissue as a Marker of Cardiovascular Risk: JACC Review Topic of the Week. Tan, Neville, Damini Dey, Thomas H. Marwick, and Nitesh Nerlekar. Journal of the American College of Cardiology81 (9): 913–23.


Survival and Economic Impact of Rapid Prostate-Specific Antigen Doubling Time in Patients With Nonmetastatic Castration-Resistant Prostate Cancer. Freedland, Stephen J., Krishnan Ramaswamy, Ahong Huang, Rickard Sandin, Jack Mardekian, Neil M. Schultz, Nora Janjan, and Daniel J. George. Clinical Genitourinary Cancer, January, S1558-7673(23)00022-8.

Safety and Efficacy Outcomes From a Single-Center Study of Image-Guided Percutaneous Microwave Ablation for Primary and Metastatic Lung Malignancy. Chan, Stephen M., Peter J. Julien, Peter Kaganjo, Robert J. McKenna, Charles Forscher, Ronald Natale, Robert N. Wolfe, Kristi Butenschoen, Rene J. Siegel, and James Mirocha. JTO Clinical and Research Reports 4 (2): 100454.

Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility. Hurwitz, Lauren M., Penelope M. Webb, Susan J. Jordan, Jennifer A. Doherty, Holly R. Harris, Marc T. Goodman, Yurii B. Shvetsov, Francesmary Modugno, Kirsten B. Moysich, Joellen M. Schildkraut, Andrew Berchuck, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Susan J. Ramus, Anna H. Wu, Celeste Leigh Pearce, Nicolas Wentzensen, Shelley S. Tworoger, Paul D. P. Pharoah, and Britton Trabert. JAMA Network Open 6 (2): e230666.

Chimeric Antigen Receptor T-Cell Therapy and Hematopoiesis. Reinhardt, Bryanna, Patrick Lee, and Joshua P. Sasine. Cells 12 (4): 531.

Doubling Down on the Future of Gynecologic Oncology: The SGO Future of the Profession Summit Report. Blank, Stephanie V., Warner K. Huh, Maria Bell, Sarah Dilley, Melissa Hardesty, Ebony R. Hoskins, Jason Lachance, Fernanda Musa, Emily Prendergast, B. J. Rimel, Mark Shahin, and Fidel Valea. Gynecologic Oncology 171 (February): 76–82.

Intraoperative Radiotherapy for Brain Metastases: First-Stage Results of a Single-Arm, Open-Label, Phase 2 Trial. Castro, Douglas Guedes de, Paulo Issamu Sanematsu, Antônio Cassio Assis Pellizzon, Sérgio Hideki Suzuki, Ricardo Cesar Fogaroli, José Eduardo Souza Dias, Guilherme Rocha Melo Gondim, Daniel Alvarez Estrada, Maria Letícia Gobo Silva, Marcio Saquy Rassi, Michael Jenwei Chen, Richard Giacomelli, Henderson Ramos, Elson Santos Neto, Carolina Humeres Abrahão, Tharcisio Machado Coelho, Liao Shin Yu, Cassio de Queiroz Tannous, Vinicius Fernando Calsavara, Frank Anton Giordano, and Jean Gonçalves de Oliveira. Journal of Neuro-Oncology, February.

Targeting STAT3-VISTA Axis to Suppress Tumor Aggression and Burden in Acute Myeloid Leukemia. Mo, Jianshan, Lin Deng, Keren Peng, Shumin Ouyang, Wen Ding, Linlin Lou, Ziyou Lin, Jianzheng Zhu, Jingwei Li, Qiyi Zhang, Pengyan Wang, Yuanzhen Wen, Xiaobing Chen, Peibin Yue, Jin-Jian Lu, Kai Zhu, Yongjiang Zheng, Yuanxiang Wang, and Xiaolei Zhang. Journal of Hematology & Oncology 16 (1): 15.

‘My Body, My Rhythm, My Voice’: A Community Dance Pilot Intervention Engaging Breast Cancer Survivors in Physical Activity in a Middle-Income Country. Rubio, María Alejandra, Carlos M. Mejía-Arbeláez, Maria A. Wilches-Mogollon, Sergio Moreno, Carolyn Finck, Lisa G. Rosas, Sol A. Romero, Paula Guevara, Santiago Cabas, Oscar Rubiano, Alberto Flórez-Pregonero, José G. León, Luis Fernando Alarcón, Robert Haile, Olga L. Sarmiento, and Abby C. King. Pilot and Feasibility Studies 9 (1): 30.

PP.42 Phase 1 Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced NSCLC. Cho, Byoung Chul, Grace K. Dy, Tae Min Kim, Debashis Sarker, Omid Hamid, Stephen K. Williamson, Sang-We Kim, Hatim Husain, Shuquan Chen, Jayakumar Mani, Vladimir Jankovic, Anne Paccaly, Sheila Masinde, Israel Lowy, Laura Brennan, and Giuseppe Gullo. Journal of Thoracic Oncology, Abstracts from IASLC Latin American Conference on Lung Cancer, 18 (3, Supplement 2): S25.


Association of Blood Pressure Variability During Acute Care Hospitalization and Incident Dementia. Ebinger, Joseph E., Matthew P. Driver, Patrick Botting, Minhao Wang, Susan Cheng, and Zaldy S. Tan. Frontiers in Neurology 14: 1085885.

Regulation of Human Endogenous Metabolites by Drug Transporters and Drug Metabolizing Enzymes: An Analysis of Targeted SNP-Metabolite Associations. Granados, Jeffry C., Jeramie D. Watrous, Tao Long, Sara Brin Rosenthal, Susan Cheng, Mohit Jain, and Sanjay K. Nigam. Metabolites 13 (2): 171.

The Prognostic Value of Pulmonary Venous Flow Reversal in Patients With Significant Degenerative Mitral Regurgitation. Shechter, Alon, Steele C. Butcher, Robert J. Siegel, Jenan Awesat, Merry Abitbol, Mordehay Vaturi, Alex Sagie, Ran Kornowski, Yaron Shapira, and Idit Yedidya. Journal of Cardiovascular Development and Disease 10 (2): 49.

Case Report: A Transcatheter Aortic Valve Replacement Failure Secondary to COVID-19 Infection. Tacon, P. Ryan, Louie Cao, Kade Birkeland, and Ilan Kedan. European Heart Journal. Case Reports 7 (2): ytad054

Catheter Ablation of Typical and Atypical Atrial Flutters in a Patient With Transcatheter Tricuspid Valve Replacement. Braunstein, Eric D., Sumeet S. Chugh, Raj R. Makkar, Ashkan Ehdaie, Michael Shehata, and Xunzhang Wang. HeartRhythm Case Reports 9 (2): 105–8.

Systemic Delivery of Extracellular Vesicles Attenuates Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction. Zhang, Rui, Thassio Mesquita, Jae Hyung Cho, Chang Li, Lizbeth Sanchez, Kevin Holm, Akbarshakh Akhmerov, Weixin Liu, Yigang Li, Ahmed G. Ibrahim, and Eugenio Cingolani. JACC. Clinical Electrophysiology 9 (2): 147–58.

Blood Type A1 Mismatch Does Not Affect Heart Transplant Outcomes at One Year. Cao, Louie, Seongkyu Kim, Ellen Klapper, Jon A. Kobashigawa, and Michelle M. Kittleson. Journal of Clinical Medicine 12 (4): 1337.

Temporary Mechanical Circulatory Support in Patients With Cardiogenic Shock: Clinical Characteristics and Outcomes. Abiragi, Michael, Tahli Singer-Englar, Robert M. Cole, Dominic Emerson, Fardad Esmailian, Dominick Megna, Jaime Moriguchi, Jon A. Kobashigawa, and Michelle M. Kittleson. Journal of Clinical Medicine 12 (4): 1622.

Endovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial. Azizi, Michel, Manish Saxena, Yale Wang, J. Stephen Jenkins, Chandan Devireddy, Florian Rader, Naomi D. L. Fisher, Roland E. Schmieder, Felix Mahfoud, Jason Lindsey, Kintur Sanghvi, Thomas M. Todoran, John Pacella, John Flack, Joost Daemen, Andrew S. P. Sharp, Philipp Lurz, Michael J. Bloch, Michael A. Weber, Melvin D. Lobo, Jan Basile, Lisa Claude, Helen Reeve-Stoffer, Candace K. McClure, Ajay J. Kirtane, and RADIANCE II Investigators and Collaborators. JAMA 329 (8): 651–61.

Patient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials. Kirtane, Ajay J., Andrew S. P. Sharp, Felix Mahfoud, Naomi D. L. Fisher, Roland E. Schmieder, Joost Daemen, Melvin D. Lobo, Philipp Lurz, Jan Basile, Michael J. Bloch, Michael A. Weber, Manish Saxena, Yale Wang, Kintur Sanghvi, J. Stephen Jenkins, Chandan Devireddy, Florian Rader, Philippe Gosse, Marc Sapoval, Neil C. Barman, Lisa Claude, Dimitri Augustin, Lisa Thackeray, Christopher M. Mullin, Michel Azizi, and RADIANCE Investigators and Collaborators. JAMA Cardiology, February.

Randomized Trial of Targeted Transendocardial Mesenchymal Precursor Cell Therapy in Patients With Heart Failure. Perin, Emerson C., Kenneth M. Borow, Timothy D. Henry, Farrell O. Mendelsohn, Leslie W. Miller, Elizabeth Swiggum, Eric D. Adler, David H. Chang, R. David Fish, Alain Bouchard, Margaret Jenkins, Alex Yaroshinsky, Jack Hayes, Olga Rutman, Christopher W. James, Eric Rose, Silviu Itescu, and Barry Greenberg. Journal of the American College of Cardiology 81 (9): 849–63.

Computational Biomedicine 

Preference Matrix Guided Sparse Canonical Correlation Analysis for Genetic Study of Quantitative Traits in Alzheimer’s Disease. Sha, Jiahang, Jingxuan Bao, Kefei Liu, Shu Yang, Zixuan Wen, Yuhan Cui, Junhao Wen, Christos Davatzikos, Jason H. Moore, Andrew J. Saykin, Qi Long, Li Shen, and ADNI. Proceedings. IEEE International Conference on Bioinformatics and Biomedicine 2022 (December): 541–48.

Ketohexokinase-C Regulates Global Protein Acetylation to Decrease Carnitine Palmitoyltransferase 1a-Mediated Fatty Acid Oxidation. Helsley, Robert N., Se-Hyung Park, Hemendra J. Vekaria, Patrick G. Sullivan, Lindsey R. Conroy, Ramon C. Sun, María Del Mar Romero, Laura Herrero, Joanna Bons, Christina D. King, Jacob Rose, Jesse G. Meyer, Birgit Schilling, C. Ronald Kahn, and Samir Softic. Journal of Hepatology, February, S0168-8278(23)00098-3.


Assessment of Lifestyle ‘Vital Signs’ in Healthcare Settings. Rozanski, Alan, Sakul Sakul, Jagat Narula, and Daniel Berman. Progress in Cardiovascular Diseases, February, S0033-0620(23)00008-7.

Usefulness of Phase Analysis on ECG Gated Single Photon Emission Computed Tomography Myocardial Perfusion Imaging. Kuronuma, Keiichiro, Naoya Matsumoto, Serge D. Van Kriekinge, Piotr J. Slomka, and Daniel S. Berman. Journal of Cardiology, February, S0914-5087(23)00047-3.

The Global Reading Room: Localizing a Breast Lesion. Bitencourt, Almir G. V., Eun Young Ko, Benoît Mesurolle, and Mariam Thomas. AJR. American Journal of Roentgenology, March.


Advances in the Assessment of Coronary Artery Disease Activity With PET/CT and CTA. Kwiecinski, Jacek, Rafal Wolny, Alicja Chwala, and Piotr Slomka. Tomography (Ann Arbor, Mich.) 9 (1): 328–41.

Editorial: Leukocyte Biology and Muscle Pathology: Leukocytes as Potential Targets to Control Muscle Inflammation, Mass, and Pain. Hohmann, Miriam S. N., Waldiceu A. Verri, Flavia A. Guarnier, Barbara St Pierre Schneider, and Sergio M. Borghi. Frontiers in Pharmacology 14: 1154559.

Probiotics in Functional Dyspepsia. Tziatzios, Georgios, Paraskevas Gkolfakis, Gabriela Leite, Ruchi Mathur, Georgia Damoraki, Evangelos J. Giamarellos-Bourboulis, and Konstantinos Triantafyllou. Microorganisms 11 (2): 351.

Linear IgA Bullous Dermatosis and Elevated Bullous Interleukin-6 Levels: Responsive to Treatment With Anti-IL-6 Receptor Monoclonals. Jordan, Stanley C., Bonnie Balzer, Cynthia Nast, Janet Atienza, Katherine Lim, Sanjeev Kumar, Nicholas Nissen, and Bongha Shin. Clinical Case Reports 11 (2): e6998.

Baricitinib for Systemic Lupus Erythematosus: A Double-Blind, Randomised, Placebo-Controlled, Phase 3 Trial (SLE-BRAVE-I). Morand, Eric F., Edward M. Vital, Michelle Petri, Ronald van Vollenhoven, Daniel J. Wallace, Marta Mosca, Richard A. Furie, Maria E. Silk, Christina L. Dickson, Gabriella Meszaros, Bochao Jia, Brenda Crowe, Inmaculada de la Torre, and Thomas Dörner. Lancet (London, England), February, S0140-6736(22)02607-1.

Immunity to Fungi in the Lung. Heung, Lena J., Darin L. Wiesner, Keyi Wang, Amariliz Rivera, and Tobias M. Hohl. Seminars in Immunology 66 (February): 101728.

Power Doppler Ultrasound Signal Predicts Abnormal HDL Function in Patients With Rheumatoid Arthritis. Charles-Schoeman, Christina, Jennifer Wang, Ani Shahbazian, Holly Wilhalme, Jenny Brook, Gurjit S. Kaeley, Buzand Oganesian, Ami Ben-Artzi, David A. Elashoff, and Veena K. Ranganath. Rheumatology International, February.

Effect of the Population Health Inpatient Medicare Advantage Pharmacist Intervention on Hospital Readmissions: A Quasi-Experimental Controlled Study. Nguyen, An T., Jesse Wisniewski, Donna W. Leang, Michelle S. Keller, Sonja Rosen, Rita Shane, and Joshua M. Pevnick. Journal of Managed Care & Specialty Pharmacy 29 (3): 266–75.

Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults. Oh, Janice, Lizhou Huang, Will Takakura, Kevin Khuu, Jiajing Wang, Edward Kowalewski, Shao-Chi Huang, Bianca Chang, Mark Pimentel, and Ali Rezaie. Clinical and Translational Gastroenterology, March.


Myofibrillar Myopathy Presenting With an Inclusion Body Myositis-Like Phenotype. Diaz, Frank, Payam Soltanzadeh, Shaweta Khosa, Negar Khanlou, Robert Freundlich, and Shri K. Mishra. Muscle & Nerve, February.


A Novel Untethering and Duraplasty Technique for Postsurgical Tethered Spinal Cord. Cohen, Justin D., Robert A. Ravinsky, Monis A. Khan, Jake Sossamon, Terrence Kim, Kamal Woods, Robert Naruse, Ulrich Batzdorf, and J. Patrick Johnson. Cureus 15 (1): e34137.

Postoperative Spinal Cerebrospinal Fluid-Venous Fistulas Associated With Dural Tears in Patients With Intracranial Hypotension or Superficial Siderosis-A Digital Subtraction Myelography Study. Schievink, Wouter I., Marcel M. Maya, Ray M. Chu, Tiffany G. Perry, Franklin G. Moser, Rachelle B. Taché, Vikram S. Wadhwa, and Ravi S. Prasad. Neurosurgery, March.


Medical-Surgical Nursing. Trias, Ryan, and Roque Anthony Velasco. The American Journal of Nursing 123 (3): 19.


Temporary Internal Distraction for Severe Scoliosis. Badin, Daniel, David L. Skaggs, and Paul D. Sponseller. JBJS Essential Surgical Techniques 12 (3): e22.00006.

Comparison of Total Elbow Arthroplasty Complications Between Various Surgical Indications at 90-Day and One-Year Follow-Ups in 1600 Elbows. Romero, Brandon, Weston Smith, Ryan D. Lopez, Alexandra Stavrakis, Christos Photopoulos, and John G. Horneff. Journal of Shoulder and Elbow Surgery, February, S1058-2746(23)00115-5.

Spinal Deformity Complexity Checklist (SDCC) for Minimally Invasive Surgery: Expert Consensus From the Minimally Invasive International Spine Study Group. Anand, Neel, Praveen V. Mummaneni, Juan S. Uribe, Jay Turner, Khoi D. Than, Dean Chou, Pierce D. Nunley, Michael Y. Wang, Richard G. Fessler, Vivian Le, Jerry Robinson, Corey Walker, Sheila Kahwaty, Babak Khanderhoo, Robert K. Eastlack, David O. Okonkwo, Adam S. Kanter, Kai-Ming G. Fu, Gregory M. Mundis, Peter Passias, Paul Park, and International Spine Study Group*. World Neurosurgery, February, S1878-8750(23)00235-8.

Perioperative Management of Nonorthopaedic Devices in the Pediatric Neuromuscular Patient Population. Tetreault, Tyler A., Kenneth D. Illingworth, Matthew Oetgen, and David L. Skaggs. The Journal of the American Academy of Orthopaedic Surgeons, February.

Influence of Personal and Injury-Related Factors Predicting Deficits in Quality of Life Domains Among Pediatric Athletes: Findings From the Sport Concussion Outcomes in Pediatrics Study. Valovich McLeod, Tamara C., Traci Snedden, Mark Halstead, Julie Wilson, Christina Master, Matthew Grady, Matthew Fazekas, Jonathan Santana, Tracy Zaslow, Shane Miller, Rachel Coel, David R. Howell, and PRiSM Concussion Research Interest Group. Clinical Journal of Sport Medicine, March.


Autoimmunity in Infection-Related Glomerulonephritis. Choung, Hae Yoon Grace, and Rickinder Grewal. Glomerular Diseases 3 (1): 32–41.

Membranous Nephropathy in Syphilis Is Associated With Neuron-Derived Neurotrophic Factor. Sethi, Sanjeev, Benjamin Madden, Marta Casal Moura, Raman Deep Singh, Samih H. Nasr, Jean Hou, Alok Sharma, Karl A. Nath, Ulrich Specks, Fernando C. Fervenza, and Mark Haas. Journal of the American Society of Nephrology: JASN 34 (3): 374–84.


IL-17A Expression by Both T Cells and Non-T Cells Contribute to HSV-IL-2-Induced CNS Demyelination. Hirose, Satoshi, Shaohui Wang, Ujjaldeep Jaggi, Harry H. Matundan, Mihoko Kato, Xue-Ying Song, Sara J. Molesworth-Kenyon, Robert N. Lausch, and Homayon Ghiasi. Frontiers in Immunology 14: 1102486.

Long-Term Outcomes and Factors Predicting Outcome of Ileal Pouch-Anal Anastomosis When Used Intentionally for Well-Defined Crohn’s Disease. Aviran, Eyal, Dan Assaf, Karen Zaghiyan, and Phillip Fleshner. Diseases of the Colon and Rectum, March.