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Faculty Publications Feb. 22-29


A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 22-29. 

Biomedical Sciences

SOX9 Switch Links Regeneration to Fibrosis at the Single-Cell Level in Mammalian Kidneys. Aggarwal, Shikhar, Zhanxiang Wang, David Rincon Fernandez Pacheco, Anna Rinaldi, Alex Rajewski, Jasper Callemeyn, Elisabet Van Loon, Baptiste Lamarthée, Ambart Ester Covarrubias, Jean Hou, Michifumi Yamashita, Haruhiko Akiyama, S. Ananth Karumanchi, Clive N. Svendsen, Paul W. Noble, Stanley C. Jordan, Joshua J. Breunig, Maarten Naesens, Pietro E. Cippà, and Sanjeev Kumar. Science (New York, N.Y.) 383 (6685): eadd6371.


Editorial: Arrhythmias in Women. Barajas-Martinez, Hector, Michael Shehata, and Yang Liu. Frontiers in Cardiovascular Medicine 11: 1348878.

Severe Diastolic Dysfunction as a Clue to the Cause of Stroke: A Case Report. Maalouf, Maya, William J. Mandel, and Charles Pollick. European Heart Journal. Case Reports 8 (2): ytae034.

European Association of Cardio-Thoracic Surgery (EACTS) Expert Consensus Statement on Perioperative Myocardial Infarction After Cardiac Surgery. Gaudino, Mario, Marcus Flather, Davide Capodanno, Milan Milojevic, Deepak L. Bhatt, Giuseppe Biondi Zoccai, William E. Boden, P. J. Devereaux, Torsten Doenst, Michael Farkouh, Nicholas Freemantle, Stephen Fremes, John Puskas, Giovanni Landoni, Jennifer Lawton, Patrick O. Myers, Björn Redfors, and Sigrid Sandner. European Journal of Cardio-Thoracic Surgery, 65 (2): ezad415.

Comparative Evaluation of Alcohol Septal Ablation: Left Anterior Descending Versus Nonleft Anterior Descending Artery Approaches. Harano, Yoshihiro, Yuki Sahashi, Yoshiaki Kawase, and Hitoshi Matsuo. The American Journal of Cardiology, February, S0002-9149(24)00106-1.

What Electrophysiologists Should Know About Cardiac Implantable Electronic Device Recalls. Hauser, Robert G., and Charles D. Swerdlow. Heart Rhythm, February, S1547-5271(24)00211-X.

CAM3.0: Determining Cell Type Composition and Expression From Bulk Tissues With Fully Unsupervised Deconvolution. Wu, Chiung-Ting, Dongping Du, Lulu Chen, Rujia Dai, Chunyu Liu, Guoqiang Yu, Saurabh Bhardwaj, Sarah J. Parker, Zhen Zhang, Robert Clarke, David M. Herrington, and Yue Wang. Bioinformatics (Oxford, England), February, btae107.

An ECG-Based Artificial Intelligence Model for Assessment of Sudden Cardiac Death Risk. Holmstrom, Lauri, Harpriya Chugh, Kotoka Nakamura, Ziana Bhanji, Madison Seifer, Audrey Uy-Evanado, Kyndaron Reinier, David Ouyang, and Sumeet S. Chugh. Communications Medicine 4 (1): 17.

Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial. Reynolds, Harmony R., Derek D. Cyr, C. Noel Bairey Merz, Leslee J. Shaw, Bernard R. Chaitman, William E. Boden, Karen P. Alexander, Yves D. Rosenberg, Sripal Bangalore, Gregg W. Stone, Claes Held, John Spertus, Kaatje Goetschalckx, Olga Bockeria, Jonathan D. Newman, Jeffrey S. Berger, Ahmed Elghamaz, Renato D. Lopes, James K. Min, Daniel S. Berman, Michael H. Picard, Raymond Y. Kwong, Robert A. Harrington, Boban Thomas, Sean M. O’Brien, David J. Maron, Judith S. Hochman, and ISCHEMIA Research Group *. Journal of the American Heart Association, February, e029850.

Intraoperative Anemia Mediates Sex Disparity in Operative Mortality After Coronary Artery Bypass Grafting. Harik, Lamia, Robert H. Habib, Arnaldo Dimagli, Mohamed Rahouma, Roberto Perezgrovas-Olaria, Giovanni Jr Soletti, Talal Alzghari, Kevin R. An, Lisa Q. Rong, Sigrid Sandner, C. Noel Bairey-Merz, Bjorn Redfors, Leonard Girardi, and Mario Gaudino. Journal of the American College of Cardiology 83 (9): 918–28.

Computational Biomedicine

Artificial Intelligence and Technology Collaboratories: Empowering Innovation in AI + AgeTech. Li, Rose M., Peter M. Abadir, Alexis Battle, Rama Chellappa, Niteesh K. Choudhry, George Demiris, Deepak Ganesan, Jason Karlawish, Jason H. Moore, and Jeremy D. Walston. Journal of the American Geriatrics Society, February.

Interaction Models Matter: An Efficient, Flexible Computational Framework for Model-Specific Investigation of Epistasis. Batista, Sandra, Vered Senderovich Madar, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Apurva S. Chitre, Abraham A. Palmer, and Jason H. Moore. BioData Mining 17 (1): 7.


Left Main Coronary Artery Calcium and Diabetes Confer Very-High-Risk Equivalence in Coronary Artery Calcium >1,000. Razavi, Alexander C., Leslee J. Shaw, Daniel S. Berman, Matthew J. Budoff, Nathan D. Wong, Viola Vaccarino, Marly van Assen, Carlo N. De Cecco, Arshed A. Quyyumi, Anurag Mehta, Paul Muntner, Michael D. Miedema, Alan Rozanski, John A. Rumberger, Khurram Nasir, Roger S. Blumenthal, Laurence S. Sperling, Martin Bødtker Mortensen, Seamus P. Whelton, Michael J. Blaha, and Omar Dzaye. JACC. Cardiovascular Imaging, February, S1936-878X(24)00026-3.


New Developments and the Role of Gravity in the Pathogenesis of Irritable Bowel Syndrome. Spiegel, Brennan. Gastroenterology & Hepatology 19 (11): 670–73.

Vitamin D Supplementation and Prior Oral Poliovirus Vaccination Decrease Odds of COVID-19 Outcomes Among Adults Recently Inoculated With Inactivated Poliovirus Vaccine. Comunale, Brittany A., Yea-Jen Hsu, Robin J. Larson, Aditi Singh, Erin Jackson-Ward, and Lilly D. Engineer. Vaccines 12 (2): 121.

Metabolic Basis of Cardiac Dysfunction in Cancer Patients. Figueiredo, Jane C., Neil Adri Bhowmick, and Anja Karlstaedt. Current Opinion in Cardiology, February.

Patient-Reported Symptom Monitoring: Using (Big) Data to Improve Supportive Care at the Macro-, Meso-, and Micro-Levels. Wang, Yan, Matthew J. Allsop, Joel B. Epstein, Doris Howell, Bernardo L. Rapoport, Penelope Schofield, Ysabella Van Sebille, Melissa S. Y. Thong, Iris Walraven, Julie Ryan Wolf, and Corina J. G. van den Hurk. Supportive Care in Cancer, 32 (3): 182.

Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council. Slart, Riemer H. J. A., Frank M. Bengel, Cigdem Akincioglu, Jamieson M. Bourque, Wengen Chen, Marc R. Dweck, Marcus Hacker, Saurabh Malhotra, Edward J. Miller, Matthieu Pelletier-Galarneau, René R. S. Packard, Thomas H. Schindler, Richard L. Weinberg, Antti Saraste, and Piotr J. Slomka. Journal of Nuclear Medicine, February, jnumed.123.266858.

Body Mass Index Stratified Meta-Analysis of Genome-Wide Association Studies of Polycystic Ovary Syndrome in Women of European Ancestry. Burns, Kharis, Benjamin H. Mullin, Loes M. E. Moolhuijsen, Triin Laisk, Jaakko S. Tyrmi, Jinrui Cui, Ky’Era V. Actkins, Yvonne V. Louwers, Estonian Biobank Research Team, Lea K. Davis, Frank Dudbridge, Ricardo Azziz, Mark O. Goodarzi, Hannele Laivuori, Reedik Mägi, Jenny A. Visser, Joop S. E. Laven, Scott G. Wilson, FinnGen, International PCOS Consortium, Felix R. Day, and Bronwyn G. A. Stuckey. BMC Genomics 25 (1): 208.

Management of Chronic Pancreatitis. Hines, O. Joe, and Stephen J. Pandol. BMJ (Clinical Research Ed.) 384 (February): e070920.

89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors. Chan, Ann M., Tove Olafsen, Jessica Tsui, Felix B. Salazar, Brian Aguirre, Kirstin A. Zettlitz, Michael Condro, Anna M. Wu, Jonathan Braun, Lynn K. Gordon, Negin Ashki, Julian Whitelegge, Shili Xu, Oluwatayo Ikotun, Jason Thanh Lee, and Madhuri Wadehra. Molecular Cancer Therapeutics, February.

Risk Factors and Health Behaviors Associated With Loneliness Among Cancer Survivors During the COVID-19 Pandemic. Aßmann, Elena S., Jennifer Ose, Cassandra A. Hathaway, Laura B. Oswald, Sheetal Hardikar, Caroline Himbert, Vimalkumar Chellam, Tengda Lin, Bailee Daniels, Anne C. Kirchhoff, Biljana Gigic, Douglas Grossman, Jonathan Tward, Thomas K. Varghese, David Shibata, Jane C. Figueiredo, Adetunji T. Toriola, Anna Beck, Courtney Scaife, Christopher A. Barnes, Cindy Matsen, Debra S. Ma, Howard Colman, Jason P. Hunt, Kevin B. Jones, Catherine J. Lee, Mikaela Larson, Tracy Onega, Wallace L. Akerley, Christopher I. Li, William M. Grady, Martin Schneider, Andreas Dinkel, Jessica Y. Islam, Brian D. Gonzalez, Amy K. Otto, Frank J. Penedo, Erin M. Siegel, Shelley S. Tworoger, Cornelia M. Ulrich, and Anita R. Peoples. Journal of Behavioral Medicine, February.

Insurance Companies’ Poor Adherence to Guidelines for Moderate to Severe Ulcerative Colitis/Crohn’s Disease Management. Anderson, Kelsey L., Rajsavi Anand, and Joseph D. Feuerstein. The American Journal of Gastroenterology, February.

Management of the Sensitized Pediatric Renal Transplant Candidate. Puliyanda, Dechu P., and Stanley C. Jordan. Pediatric Transplantation 28 (2): e14694.

Nonclassic Congenital Adrenal Hyperplasia Metabolic Resolution Post Roux-En-Y Gastric Bypass and Associated Weight Loss. Romo, Karina G., Sharon W. Shu, Qasim Z. Iqbal, and Gabriel I. Uwaifo. JCEM Case Reports 2 (3): luae018.


Incidence and Clinical Outcomes of Perforations During Mechanical Thrombectomy for Medium Vessel Occlusion in Acute Ischemic Stroke: A Retrospective, Multicenter, and Multinational Study. Dmytriw, Adam A., Basel Musmar, Hamza Salim, Sherief Ghozy, James E. Siegler, Hassan Kobeissi, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Jeremy J. Heit, MAD-MT Consortium, et al. European Stroke Journal, February, 23969873231219412.


Functional Impact of Multi-Omic Interactions in Lung Cancer. Díaz-Campos, Miguel Ángel, Jorge Vasquez-Arriaga, Soledad Ochoa, and Enrique Hernández-Lemus. Frontiers in Genetics 15: 1282241.

Open Access Transition in Obstetrics and Gynecology Journals-The International Impact. Levin, Gabriel, Yoav Brezinov, Yossi Tzur, and Raanan Meyer. International Journal of Gynaecology and Obstetrics, February.

A Treatment Algorithm for High-Tone Pelvic Floor Dysfunction. Torosis, Michele, Erin Carey, Kristin Christensen, Melissa R. Kaufman, Kimberly Kenton, Rhonda Kotarinos, H. Henry Lai, Una Lee, Jerry L. Lowder, Melanie Meister, Theresa Spitznagle, Kelly Wright, and A. Lenore Ackerman. Obstetrics and Gynecology, February.

Pathology and Laboratory Medicine

Quantification of SARS-CoV-2 Viral Load in Patients Using Time-to-Results in Antigen Lateral Flow Tests. Braunstein, Elsa W., Eric Vail, David D. Ho, Lihong Liu, Hiroshi Mohri, Matthew Gayhart, and Glenn D. Braunstein. Clinical and Translational Science 17 (2): e13719.

IgA Vasculitis Nephritis: Insights From Kidney Biopsies. Haas, Mark. Current Opinion in Nephrology and Hypertension, February.

Siderophores Promote Cooperative Interspecies and Intraspecies Cross-Protection Against Antibiotics in Vitro. Galdino, Anna Clara M., Mylene Vaillancourt, Diana Celedonio, Kara Huse, Yohei Doi, Janet S. Lee, and Peter Jorth. Nature Microbiology, February.


International Society for Extracellular Vesicles Workshop. QuantitatEVs: Multiscale Analyses, From Bulk to Single Extracellular Vesicle. Basso, Manuela, Alessandro Gori, Caterina Nardella, Mari Palviainen, Marija Holcar, Ioannis Sotiropoulos, Sylwia Bobis-Wozowicz, Vito G. D’Agostino, Elena Casarotto, Yari Ciani, Shiro Suetsugu, Alice Gualerzi, Lorena Martin-Jaular, Daniela Boselli, Anna Kashkanova, Pietro Parisse, Lien Lippens, Martina Pagliuca, Martin Blessing, Roberto Frigerio, Thibaut Fourniols, Ana Meliciano, Anna Fietta, Paolo Vincenzo Fioretti, Karolina Soroczy?ska, Silvia Picciolini, Amanda Salviano-Silva, Paolo Bergese, Davide Zocco, Marcella Chiari, Guido Jenster, Levi Waldron, Aleksandar Milosavljevic, John Nolan, Marco P. Monopoli, Kenneth W. Witwer, Benedetta Bussolati, Dolores Di Vizio, Juan Falcon Perez, Metka Lenassi, Marina Cretich, and Francesca Demichelis. Journal of Extracellular Biology 3 (1): e137.

Seek and Ye Shall Find: The Utility of Perioperative VTE Screening in High-Risk Oncologic Patients Undergoing Abdominopelvic Surgery. Pletcher, Eric R., Allison Nguyen-Thai, Tiffany Lim, and Allan W. Silberman. Journal of Surgical Oncology, February.

Precision Oncology in Pediatric Cancer Surgery. Lee, William G., and Eugene S. Kim. Surgical Oncology Clinics of North America 33 (2): 409–46.


The New Urology Match: How Recent Innovations Including Virtual Interviews and Preference Signaling Have Changed Match Outcomes. Heard, John, Rushil Y. Rawal, Bradley Amazan, Karl-Ray Jeune, and Andrew Freedman. Cureus 16 (1): e53167.

Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia From Prostate Cancer in Caucasian and African American Men. Mahaveer Chand, Nischal, Poornima K. Tekumalla, Matt T. Rosenberg, Albert Dobi, Amina Ali, Gregory M. Miller, Juan J. Aristizabal-Henao, Elder Granger, Stephen J. Freedland, Mark D. Kellogg, Shiv Srivastava, David G. McLeod, Niven R. Narain, and Michael A. Kiebish. Cancers 16 (4): 712.

Use of Himplant® for Correction of Residual Deformity Following Prior Treatment of Peyronie’s Disease: A Case Series. Levine, Laurence A., Elsayed Desouky, James J. Elist, Daniel Moon, and Steven K. Wilson. International Journal of Impotence Research, February.

Variation in Communication of Side Effects in Prostate Cancer Treatment Consultations. Daskivich, Timothy J., Aurash Naser-Tavakolian, Rebecca Gale, Michael Luu, Nadine Friedrich, Abhi Venkataramana, Dmitry Khodyakov, Edwin Posadas, Howard Sandler, Brennan Spiegel, and Stephen J. Freedland. Prostate Cancer and Prostatic Diseases, February.

A Framework for Evaluating Clinical Artificial Intelligence Systems Without Ground-Truth Annotations. Kiyasseh, Dani, Aaron Cohen, Chengsheng Jiang, and Nicholas Altieri. Nature Communications 15 (1): 1808.