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Faculty Publications Feb 2. - Feb. 9


A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 2 - Feb. 9.

Biomedical Sciences

Thrombus Signal on T1-Weighted Black-Blood MR Predicts Outcomes of Catheter-Directed Thrombolysis in Acute Deep Vein Thrombosis. Huang, Chen, Xueping He, Yueyuan Xie, Hanwei Chen, Yufeng Ye, Yi Sun, Rohan Dharmakumar, Robert K. Ryu, Debiao Li, Guoxi Xie, and Zhaoyang Fan. Thrombosis and Haemostasis, February.

Association Between Spontaneous Internal Carotid Artery Dissection and Perivascular Adipose Tissue Attenuation on Computed Tomography Angiography. Cheng, Kevin, Andrew Lin, Ximena Stecher, Tomas Bernstein, Paulo Zuñiga, Enrico Mazzon, Alejandro Brunser, Violeta Diaz, Gonzalo Martinez, William Cameron, Stephen Nicholls, Sanjay Patel, Damini Dey, Dennis T. L. Wong, and Paula Munoz Venturelli. International Journal of Stroke, February, 17474930231158538.

Murine-Derived Glioma Organoids and Cell Line Culture Systems. Ayala-Sarmiento, Alberto E., David Rincon Fernandez Pacheco, and Joshua J. Breunig. Current Protocols 3 (2): e665.


LITESPARK-011: Belzutifan Plus Lenvatinib vs Cabozantinib in Advanced Renal Cell Carcinoma After Anti-PD-1/PD-L1 Therapy. Motzer, Robert J., Manuela Schmidinger, Masatoshi Eto, Cristina Suarez, Robert Figlin, Yanfang Liu, Rodolfo Perini, Yayan Zhang, and Daniel Yc Heng. Future Oncology (London, England), February.

Prevalence of Smoldering Multiple Myeloma Based on Nationwide Screening. Thorsteinsdóttir, Sigrún, Gauti K. Gíslason, Thor Aspelund, Sæmundur Rögnvaldsson, Jón Þórir Óskarsson, Guðrún Á Sigurðardóttir, Ásdís R. Þórðardóttir, Brynjar Viðarsson, Páll T. Önundarson, Bjarni A. Agnarsson, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, Ísleifur Ólafsson, Elías Eyþórsson, Ásbjörn Jónsson, Oscar Berlanga, Malin Hulcrantz, Brian G. M. Durie, Thorvardur J. Löve, Stephen Harding, Ola Landgren, and Sigurður Y. Kristinsson. Nature Medicine, February.

Re: Repeat Transurethral Resection of Muscle-Invasive Bladder Cancer Prior to Radical Cystectomyis Prognostic but Not Therapeutic. Castaneda, Peris R., Michael Ahdoot, and Charles J. Rosser. The Journal of Urology, February, 101097JU0000000000003362.

Mitophagy Is a Novel Protective Mechanism for Drug-Tolerant Persister (DTP) Cancer Cells. Li, Yun, Hengxing Chen, Daning Lu, H. Phillip Koeffler, Yin Zhang, and Dong Yin. Autophagy, February.

Working Hard or Hardly Working? A Brief Commentary of Latest Research on Exercise and Prostate Cancer. Galván, Gloria Cecilia, Sanjay Das, James P. Daniels, Nadine A. Friedrich, and Stephen J. Freedland. Prostate Cancer and Prostatic Diseases, February.

A Healthy Diet, a Healthy Prostate? A Brief Commentary on the Latest Research on Diet and Prostate Cancer. Galván, Gloria Cecilia, James P. Daniels, Nadine A. Friedrich, Sanjay Das, and Stephen J. Freedland.Prostate Cancer and Prostatic Diseases, February.

The Impact of Life Expectancy on Cost-Effectiveness of Treatment Options for Clinically Localized Prostate Cancer. Naser-Tavakolian, Aurash, Abhishek Venkataramana, Brennan Spiegel, Christopher Almario, Paul Kokorowski, Stephen J. Freedland, Jennifer T. Anger, John T. Leppert, and Timothy J. Daskivich. Urologic Oncology, February, S1078-1439(23)00005-4.

Development of Artificial Intelligence–Derived Histological Biomarkers for First-Line Treatment Selection in Metastatic Pancreatic Ductal Adenocarcinoma (MPDAC). Krishna, Viswesh, Ekin Tiu, Vrishab Krishna, Damir Vrabac, Kunal Shah, Waleed Abuzeid, Katelyn Smith, John Davelaar, Christopher Nuesca, Brent K Larson, Christos Fountzilas, Pranav Rajpurkar, Andrew Eugene Hendifar, Eric Andrew Collisson, Anirudh Joshi, and Aatur D. Singhi. Journal of Clinical Oncology 41 (4_suppl): 743–743.

Patient’s Perceptions of Oral and Oropharyngeal Cancer Diagnosis Disclosure: Communication Aspects Based on SPIKES Protocol. Alves, Carolina G. B., Ana Carolina Prado Ribeiro, Thaís Bianca Brandão, Juliana O. Tonaki, Caique Mariano Pedroso, César Rivera, Joel B. Epstein, Cesar Augusto Migliorati, Luiz Paulo Kowalski, Milena Perez Mak, Gilberto Castro, Marcio Ajudarte Lopes, and Alan Roger Santos-Silva. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, December, S2212-4403(22)01303-7.

Cardiac Surgery 

Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a ‘2-Hit’ Murine Model. LaPenna, Kyle B., Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, and David J. Lefer. Journal of the American Heart Association, February, e028480.

Venoarterial or Venovenous Extracorporeal Membrane Oxygenation for Severe Primary Graft Dysfunction After Lung Transplant? Chen, Qiudong, and Pedro Catarino. The Annals of Thoracic Surgery, February, S0003-4975(23)00102-9.


Mavacamten: A First-in-Class Oral Modulator of Cardiac Myosin for the Treatment of Symptomatic Hypertrophic Obstructive Cardiomyopathy. Reyes, Klevin Roger L., Gizem Bilgili, and Florian Rader. Heart International 16 (2): 91–98.

Mechanically Ventilated Patients With Coronavirus Disease 2019 Had a Higher Chance of In-Hospital Death If Treated With High-Flow Nasal Cannula Oxygen Before Intubation. Nurok, Michael, Oren Friedman, Matthew Driver, Nancy Sun, Abirami Kumaresan, Peter Chen, Susan Cheng, Daniel S. Talmor, and Joseph Ebinger. Anesthesia and Analgesia, November.

Sudden Cardiac Arrest During Sports Activity in Older Adults. Holmstrom, Lauri, Harpriya S. Chugh, Audrey Uy-Evanado, Arayik Sargsyan, Chad Sorenson, Shiva Salmasi, Faye L. Norby, Sean Hurst, Christopher Young, Angelo Salvucci, Jonathan Jui, Kyndaron Reinier, and Sumeet S. Chugh. JACC. Clinical Electrophysiology, November, S2405-500X(22)00950-1.

Prognostic Value of Mitral Valve Haemodynamic Parameters Obtained by Intraprocedural Echocardiography in Transcatheter Edge-to-Edge Repair. Shechter, Alon, Sharon Shalom Natanzon, Keita Koseki, Danon Kaewkes, Mirae Lee, Ofir Koren, Vivek Patel, Sabah Skaf, Tarun Chakravarty, Moody Makar, Raj R. Makkar, and Robert J. Siegel. European Heart Journal. Cardiovascular Imaging, February, jead011.

Adverse Pregnancy Outcomes-Risk Enhancers Whose Time Has Finally Arrived. Bello, Natalie A. JAMA329 (5): 373–75.

Video-Based Deep Learning for Automated Assessment of Left Ventricular Ejection Fraction in Pediatric Patients. Reddy, Charitha D., Leo Lopez, David Ouyang, James Y. Zou, and Bryan He. Journal of the American Society of Echocardiography, February, S0894-7317(23)00068-8.

Towards Artificial Intelligence-Based Learning Health System for Population-Level Mortality Prediction Using Electrocardiograms. Sun, Weijie, Sunil Vasu Kalmady, Nariman Sepehrvand, Amir Salimi, Yousef Nademi, Kevin Bainey, Justin A. Ezekowitz, Russell Greiner, Abram Hindle, Finlay A. McAlister, Roopinder K. Sandhu, and Padma Kaul. NPJ Digital Medicine 6 (1): 21.

Society of Thoracic Surgeons Risk Score and Left Atrial Pressure for Predicting Clinical Outcomes Among Transcatheter Mitral Edge-to-Edge Repair Patients. Natanzon, Sharon Shalom, Keita Koseki, Danon Kaewkes, Ofir Koren, Vivek Patel, Alon Shechter, Alexander Fardman, Mamoo Nakamura, Tarun Chakravarty, and Raj Makkar. Catheterization and Cardiovascular Interventions, February.

Vericiguat in HFrEF: Insights From the GWTG-HF Registry. Kittleson, Michelle M. JACC. Heart Failure 11 (2): 224–26.

Computational Biomedicine 

Automatic Extraction of Medication Mentions From Tweets-Overview of the BioCreative VII Shared Task 3 Competition. Weissenbacher, Davy, Karen O’Connor, Siddharth Rawal, Yu Zhang, Richard Tzong-Han Tsai, Timothy Miller, Dongfang Xu, Carol Anderson, Bo Liu, Qing Han, Jinfeng Zhang, Igor Kulev, Berkay Köprü, Raul Rodriguez-Esteban, Elif Ozkirimli, Ammer Ayach, Roland Roller, Stephen Piccolo, Peijin Han, V. G. Vinod Vydiswaran, Ramya Tekumalla, Juan M. Banda, Parsa Bagherzadeh, Sabine Bergler, João F. Silva, Tiago Almeida, Paloma Martinez, Renzo Rivera-Zavala, Chen-Kai Wang, Hong-Jie Dai, Luis Alberto Robles Hernandez, and Graciela Gonzalez-Hernandez. Database: The Journal of Biological Databases and Curation2023 (February): baac108.

LoFTK: A Framework for Fully Automated Calculation of Predicted Loss-of-Function Variants and Genes. Alasiri, Abdulrahman, Konrad J. Karczewski, Brian Cole, Bao-Li Loza, Jason H. Moore, Sander W. van der Laan, Folkert W. Asselbergs, Brendan J. Keating, and Jessica van Setten. BioData Mining 16 (1): 3.


Role of Four-Dimensional Computer Tomography (4D-CT) in Non-Localising and Discordant First-Line Imaging in Primary Hyperparathyroidism. Sayed, S., A. Das, B. Turner, V. S. Wadhwa, and K. A. Pathak. Annals of the Royal College of Surgeons of England, February.

Comparing the Pooled Cohort Equations and Coronary Artery Calcium Scores in a Symptomatic Mixed Asian Cohort. Baskaran, Lohendran, Jing Kai Lee, Michelle Shi Min Ko, Subhi J. Al’Aref, Yu Pei Neo, Jien Sze Ho, Weiting Huang, Yeonyee Elizabeth Yoon, Donghee Han, Rine Nakanishi, Swee Yaw Tan, Mouaz Al-Mallah, Matthew J. Budoff, and Leslee J. Shaw. Frontiers in Cardiovascular Medicine 10: 1059839.


Virtual Reality: A New Treatment Paradigm for Disorders of Gut-Brain Interaction? Lacy, Brian E., David J. Cangemi, and Brennan R. Spiegel. Gastroenterology & Hepatology 19 (2): 86–94.

Hyperphosphorylation of Hepatic Proteome Characterizes Nonalcoholic Fatty Liver Disease in S-Adenosylmethionine Deficiency. Robinson, Aaron E., Aleksandra Binek, Komal Ramani, Niveda Sundararaman, Lucía Barbier-Torres, Ben Murray, Vidya Venkatraman, Simion Kreimer, Angela Mc Ardle, Mazen Noureddin, David Fernández-Ramos, Fernando Lopitz-Otsoa, Virginia Gutiérrez de Juan, Oscar Millet, José M. Mato, Shelly C. Lu, and Jennifer E. Van Eyk. IScience 26 (2): 105987.

Response to Chasing ?-Fection in Thyroidology. Tessler, Franklin N., Mark E. Zafereo, Gonzalo J. Acosta, and Wendy Sacks. Thyroid, February.

Potential Determinants of Low Circulating Glucagon-like Peptide 2 Concentrations in Zambian Children With Non-Responsive Stunting. Besa, Ellen, Mizinga Jacqueline Tembo, Chola Mulenga, Monica Mweetwa, Naheed Choudhry, Kanta Chandwe, Chad Storer, Richard Head, Beatrice Amadi, Talin Haritunians, Dermot McGovern, Geoffrey Kwenda, Madusha Peiris, and Paul Kelly. Experimental Physiology, February.

Cost Effectiveness Analyses of Interventions for Osteoporosis in Men: A Systematic Literature Review. Li, Nannan, Charlotte Beaudart, Jane A. Cauley, Steven W. Ing, Nancy E. Lane, Jean-Yves Reginster, Stuart Silverman, Andrea J. Singer, and Mickaël Hiligsmann. PharmacoEconomics, February.

Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells. Kostyunina, Daria S., Simon C. Rowan, Nikolai V. Pakhomov, Eugene Dillon, Keith D. Rochfort, Philip M. Cummins, Malachy J. O’Rourke, and Paul McLoughlin. American Journal of Respiratory Cell and Molecular Biology, February.

Cleaving It All Behind: ADAMTS7 Degrades Factor H. Heeger, Peter S., and Paolo Cravedi. Journal of the American Society of Nephrology: JASN 34 (2): 182–83.

Pneumococcal Vaccination Recommendation and Completion Rates Among Patients With Inflammatory Bowel Disease and Barriers to Vaccination. Dasharathy, Sonya S., Folasade P. May, Anthony Myint, Liu Yang, Harman K. Rahal, Vivy Cusumano, Philip A. Kozan, Sarina C. Lowe, Peter Y. Beah, Berkeley N. Limketkai, and Jenny S. Sauk. Journal of Clinical Gastroenterology, January.

Racial and Ethnic Disparities in Years of Potential Life Loss Among Patients With Cirrhosis During the COVID-19 Pandemic in the United States. Zhao, Yunyu, Yee Hui Yeo, Jamil Samaan, Fan Lv, Xinyuan He, Jinli Liu, Mei Li, Ning Gao, Justin Park, Ju Dong Yang, Walid S. Ayoub, Lei Zhang, Michelle C. Odden, Fanpu Ji, and Mindie H. Nguyen. The American Journal of Gastroenterology, January.


Emergent Low-Frequency Activity in Cortico-Cerebellar Networks With Motor Skill Learning. Fleischer, Pierson J., Aamir Abbasi, Andrew W. Fealy, Nathan P. Danielsen, Ramneet Sandhu, Philip R. Raj, and Tanuj Gulati. ENeuro, February, ENEURO.0011-23.2023.

Patient Relevance of the Modified Rankin Scale in Subarachnoid Hemorrhage Research: An International Cross-Sectional Survey. Niznick, Naomi, Victoria Saigle, Maria Luisa Marti, Josephine Laframboise, Xiaohui Zha, Chris Andersen, Justin Presseau, Michaël Chassé, Lauralyn McIntyre, Dean Fergusson, Alexis F. Turgeon, François Lauzier, Stephan A. Mayer, Shouri Lahiri, Tim Ramsay, and Shane English. Neurology, February, 10.1212/WNL.0000000000206879.

The Evolving Evidence for Real-Time Neurophysiological Monitoring in Mitigating the Risk of Stroke With Cardiac Surgery. Lahiri, Shouri, and Michael Nurok. The Annals of Thoracic Surgery, February, S0003-4975(23)00098-X.


A Call to Action for Ergonomic Surgical Devices Designed for Diverse Surgeon End Users. Wong, Jacqueline M. K., Erin T. Carey, Cara King, Kelly N. Wright, Louise P. King, and Rosanne M. Kho. Obstetrics and Gynecology, February.


Racial and Sex Disparities in Resident Attrition Among Surgical Subspecialties. Haruno, Lee S., Xi Chen, Melodie Metzger, Carol A. Lin, Milton T. M. Little, Linda E. A. Kanim, and Selina C. Poon. JAMA Surgery, February.

Characterizing Single-Star Negative Online Reviews of Orthopaedic Trauma Association Members. Richman, Evan H., Nicolas P. Kuttner, Lukas O. Foster, Christopher J. Bruske, Jordan R. Pollock, Joseph C. Brinkman, and Milton T. M. Little. The Journal of the American Academy of Orthopaedic Surgeons, January.

Racial, Ethnic and Socioeconomic Healthcare Disparities in Orthopaedics: What about Orthopaedic Trauma? Cannada, Lisa K., Gil Ortega, Toni M. McLaurin, Nirmal C. Tejwani, Milton Tm Little, Emily Benson, Gerald Lang, Sarah N. Pierrie, and Jacque Krumrey. Journal of Orthopaedic Trauma, January.

Free Vascularized Fibula Graft for Staged Reconstruction of Infected Humerus Nonunions. Lefebvre, Rachel, Sofia Bougioukli, Geoffrey Marecek, Mark Howard, Landon Cohen, and Milan Stevanovic. Journal of Orthopaedic Trauma, December.


Molecular Characterization of Visible Low Grade Dysplastic Lesions in Patients With Inflammatory Bowel Disease. Dhall, Deepti, Elias Makhoul, Roberto Taguibao, Kevin Waters, Wenjuan Zhang, Eric Vail, Goo Lee, Sameer Al Diffalha, Chirag Patel, Upender Manne, Michael Behring, Shefali Chopra, and Shuko Harada. Human Pathology, February, S0046-8177(23)00028-X.


Privacy, Bias and the Clinical Use of Facial Recognition Technology: A Survey of Genetics Professionals. Aboujaoude, Elias, Janice Light, Julia E. H. Brown, W. John Boscardin, Benedikt Hallgrímsson, and Ophir D. Klein. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, February.

Radiation Oncology

Neighborhood Deprivation and Rurality Associated With Patient-Reported Outcomes and Survival in Men With Prostate Cancer in NRG RTOG 0415. Bai, Jinbing, Stephanie L. Pugh, Ronald Eldridge, Katherine A. Yeager, Qi Zhang, W. Robert Lee, Amit B. Shah, Ian S. Dayes, David P. D’Souza, Jeff M. Michalski, Jason A. Efstathiou, John M. Longo, Thomas M. Pisansky, Jordan M. Maier, Sergio L. Faria, Anand B. Desai, Samantha A. Seaward, Howard M. Sandler, Mary E. Cooley, and Deborah W. Bruner. International Journal of Radiation Oncology, Biology, Physics, February, S0360-3016(23)00082-2.

Click Chemistry-Generated Auristatin F-Linker-Benzylguanine for a SNAP-Tag-Based Recombinant Antibody-Drug Conjugate Demonstrating Selective Cytotoxicity Toward EGFR-Overexpressing Tumor Cells. Huysamen, Allan M., Olaolu E. Fadeyi, Grace Mayuni, Dennis M. Dogbey, Neelakshi Mungra, Fleury A. N. Biteghe, Natasha Hardcastle, Dharanidharan Ramamurthy, Olusiji A. Akinrinmade, Krupa Naran, Susan Cooper, Dirk Lang, Wolfgang Richter, Roger Hunter, and Stefan Barth. ACS Omega 8 (4): 4026–37.


Blunt Splenic Injury, ED to Discharge: A Western Trauma Association Critical Decisions Algorithm. Shatz, David V., Marc de Moya, Karen J. Brasel, Carlos V. R. Brown, Jennifer L. Hartwell, Kenji Inaba, Eric J. Ley, Ernest E. Moore, Kimberly A. Peck, Anne G. Rizzo, Nelson G. Rosen, Jason L. Sperry, Jordan A. Weinberg, Alexis M. Moren, Raul Coimbra, and Matthew J. Martin. The Journal of Trauma and Acute Care Surgery, November.

Cover With Caution: Management of the Left Subclavian Artery in TEVAR for Trauma. Romagnoli, Anna Noel, Jeanette Paterson, Anahita Dua, David Kauvar, Naveed Saqib, Charles Miller, Benjamin Starnes, Ali Azizzadeh, and Joseph DuBose. The Journal of Trauma and Acute Care Surgery, November.

Approaches for Optimizing Venous Thromboembolism (VTE) Prevention in Injured Patients: Findings From the Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma. Teichman, Amanda L., Bryan A. Cotton, James Byrne, Navpreet K. Dhillon, Allison E. Berndtson, Michelle A. Price, Tracy A. Johns, Eric J. Ley, Todd Costantini, and Elliott R. Haut. The Journal of Trauma and Acute Care Surgery, December.

Novel Therapeutic Medications for Venous Thromboembolism Prevention in Trauma Patients: Findings From the Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma. Dhillon, Navpreet K., Elliott R. Haut, Michelle A. Price, Todd W. Costantini, Amanda L. Teichman, Bryan A. Cotton, and Eric J. Ley. The Journal of Trauma and Acute Care Surgery, December.

SAGES Video Acquisition Framework-Analysis of Available OR Recording Technologies by the SAGES AI Task Force. Filicori, Filippo, Daniel P. Bitner, Hans F. Fuchs, Mehran Anvari, Ganesh Sankaranaraynan, Matthew B. Bloom, Daniel A. Hashimoto, Amin Madani, Pietro Mascagni, Christopher M. Schlachta, Mark Talamini, and Ozanan R. Meireles. Surgical Endoscopy, February.

Three-Dimensional Video Microscopy: Potential for Improved Ergonomics Without Increased Operative Time? Samaha, Yasmina, and Edward Ray. Archives of Plastic Surgery 50 (1): 125–29.


An Analysis of Stated Insurance Coverage and Estimated Patient-Incurred Costs of Treatments for Lower Urinary Tract Symptoms. Khalfay, Nuha, Eric Lo, Tamara Grisales, and A. Lenore Ackerman. Urogynecology (Hagerstown, Md.) 29 (2): 287–94.