This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Dec. 8 - Dec. 15.

Cancer

Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study. Shah, Manish A., Takayuki Yoshino, Niall C. Tebbutt, Axel Grothey, Josep Tabernero, Rui-Hua Xu, Andres Cervantes, Sang Cheul Oh, Kensei Yamaguchi, Marwan Fakih, Alfredo Falcone, Christina Wu, Vi K. Chiu, Jiri Tomasek, Johanna Bendell, Marilyn Fontaine, Matthew Hitron, Bo Xu, Julien Taieb, and Eric Van Cutsem. Clinical Colorectal Cancer, November, S1533-0028(22)00125-6.

Epidemiologic Risk Factors for Patients Admitted With Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma in the United States. Lew, Daniel, Fatima Kamal, Khiem Phan, Karamvir Randhawa, Sam Cornwell, Ayrton I. Bangolo, Simcha Weissman, and Stephen J. Pandol. World Journal of Clinical Oncology 13 (11): 907–17.

Dynamic Changes in the Extracellular Matrix in Primary, Metastatic, and Recurrent Ovarian Cancers. Gertych, Arkadiusz, Ann E. Walts, Keyi Cheng, Manyun Liu, Joshi John, Jenny Lester, Beth Y. Karlan, and Sandra Orsulic. Cells 11 (23): 3769.

PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells. Li, Yun, Hengxing Chen, Xuan Xie, Bing Yang, Xiaojuan Wang, Jingyuan Zhang, Tian Qiao, Jiao Guan, Yuntan Qiu, Yong-Xin Huang, Duanqing Tian, Xinyi Yao, Daning Lu, H. Phillip Koeffler, Yin Zhang, and Dong Yin. Cancer Research, December, CAN-22-2370.

PAK4 Inhibition Improves PD1 Blockade Immunotherapy in Prostate Cancer by Increasing Immune Infiltration. Su, Shengchen, Sungyong You, Yanping Wang, Patrick Tamukong, Michael J. Quist, Catherine S. Grasso, and Hyung L. Kim. Cancer Letters, December, 216034.

Ruxolitinib and Methylprednisolone for Treatment of Patients With Relapsed/Refractory Multiple Myeloma. Berenson, James R., Daisy Martinez, Tahmineh Safaie, Ralph Boccia, Honghao Yang, Mehdi Moezi, Stephen Lim, Gary Schwartz, Shahrooz Eshaghian, Regina Swift, Benjamin M. Eades, Sean Bujarski, Bernard Regidor, Clara Kim, Susanna Kim, and Robert Vescio. British Journal of Haematology, December.

Tumor-Infiltrating Lymphocyte Therapy in Melanoma: Facts to the Future. Betof Warner, Allison, Pippa G. Corrie, and Omid Hamid. Clinical Cancer Research, December, CCR-22-1922.

Cardiac Sursery

Commentary: Minimally Invasive Lobectomy for Lung Cancer: Safely Finishing What You Started. Brownlee, Andrew R., and Harmik J. Soukiasian. The Journal of Thoracic and Cardiovascular Surgery, November, S0022-5223(22)01237-5.

Surgical Outcomes after Reconstruction of the Aortomitral Curtain. Bojko, Markian, Korri S. Hershenhouse, Ramsey S. Elsayed, Brittany Abt, Robbin G. Cohen, Raymond Lee, Michael E. Bowdish, and Vaughn A. Starnes. Seminars in Thoracic and Cardiovascular Surgery, December, S1043-0679(22)00275-1.

Cardiology

Morphine-Mediated Release of Astrocyte-Derived Extracellular Vesicle MiR-23a Induces Loss of Pericyte Coverage at the Blood-Brain Barrier: Implications for Neuroinflammation. Liao, Ke, Fang Niu, Guoku Hu, and Shilpa Buch. Frontiers in Cell and Developmental Biology 10: 984375.

Electrocardiograms in Critical Care Cardiology. Chyu, Kuang-Yuh, and Prediman K. Shah. JACC. Case Reports 4 (23): 101632.

Transforming Atrial Fibrillation Research to Integrate Social Determinants of Health: A National Heart, Lung, and Blood Institute Workshop Report. Benjamin, Emelia J., Kevin L. Thomas, Alan S. Go, Patrice Desvigne-Nickens, Christine M. Albert, Alvaro Alonso, Alanna M. Chamberlain, Utibe R. Essien, Inmaculada Hernandez, Mellanie True Hills, Kiarri N. Kershaw, Phillip D. Levy, Jared W. Magnani, Daniel D. Matlock, Emily C. O’Brien, Carlos J. Rodriguez, Andrea M. Russo, Elsayed Z. Soliman, Lawton S. Cooper, and Sana M. Al-Khatib. JAMA Cardiology, December.

The Association of Protein Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction. Takvorian, Katherine S., Dongyu Wang, Paul Courchesne, Ramachandran S. Vasan, Emelia J. Benjamin, Susan Cheng, Martin G. Larson, Daniel Levy, and Jennifer E. Ho. Circulation. Heart Failure, December, e009446.

A Myocardial Infarct Border-Zone-on-a-Chip Demonstrates Distinct Regulation of Cardiac Tissue Function by an Oxygen Gradient. Rexius-Hall, Megan L., Natalie N. Khalil, Sean S. Escopete, Xin Li, Jiayi Hu, Hongyan Yuan, Sarah J. Parker, and Megan L. McCain. Science Advances 8 (49): eabn7097.

Imaging

Computed Tomography-Derived Characterization of Pericoronary, Epicardial, and Paracardial Adipose Tissue and Its Association With Myocardial Ischemia as Assessed by Computed Fractional Flow Reserve. Duncker, Hendrik, Stephan Achenbach, Maximilian Moshage, Damini Dey, Daniel O. Bittner, Fabian Ammon, Mohamed Marwan, and Markus Goeller. Journal of Thoracic Imaging 38 (1): 46–53.

Medicine

Editorial: The Methane Moment - Cross-Boundary Significance of Methanogens: Preface. Lyu, Zhe, Amelia-Elena Rotaru, Mark Pimentel, Cui-Jing Zhang, and Simon K.-M. R. Rittmann. Frontiers in Microbiology13: 1055494.

Supplementing a Widely Available Weight Loss Program With Gamified Inhibitory Control Training: A Randomized Pilot Study. Cáceres, Nenette A., Qihan Yu, Marie Lauzon, Marcio A. Diniz, Rebecca Tuckerman, Audrey Carrillo, Mark Philipp, Gary D. Foster, Aaron R. Seitz, and Sarah-Jeanne Salvy. Obesity Science & Practice 8 (6): 775–83.

Characteristics and Treatment Rate of Patients With Hepatitis C Virus Infection in the Direct-Acting Antiviral Era and During the COVID-19 Pandemic in the United States. Nguyen, Vy H., Leslie Kam, Yee Hui Yeo, Daniel Q. Huang, Linda Henry, Ramsey Cheung, and Mindie H. Nguyen. JAMA Network Open 5 (12): e2245424.

Remodeling of Imbalanced Extracellular Matrix Homeostasis for Reversal of Pancreatic Fibrosis. Qi, Liang, Han Han, Meng-Meng Han, Ying Sun, Lei Xing, Hu-Lin Jiang, Stephen J. Pandol, and Ling Li. Biomaterials 292 (December): 121945.

Genetic Diversity Fuels Gene Discovery for Tobacco and Alcohol Use. Saunders, Gretchen R. B., Xingyan Wang, Fang Chen, Seon-Kyeong Jang, Mengzhen Liu, Chen Wang, Shuang Gao, Yu Jiang, Chachrit Khunsriraksakul, Jacqueline M. Otto, Clifton Addison, Masato Akiyama, Scott Vrieze, et al. Nature, December.

Management of Individuals With Diabetes at High Risk for Hypoglycemia: An Endocrine Society Clinical Practice Guideline. McCall, Anthony L., David C. Lieb, Roma Gianchandani, Heidemarie MacMaster, Gregory A. Maynard, M. Hassan Murad, Elizabeth Seaquist, Joseph I. Wolfsdorf, Robin Fein Wright, and Wojtek Wiercioch. The Journal of Clinical Endocrinology and Metabolism, December, dgac596.

An Addiction-Based Digital Weight Loss Intervention: A Multi-Centre Randomized Controlled Trial. Vidmar, Alaina P., Sarah J. Salvy, Choo Phei Wee, Robert Pretlow, D. Steven Fox, Jennifer K. Yee, Cambria Garell, Suzette Glasner, and Steven D. Mittelman. Pediatric Obesity, December, e12990.

An Experience- and Preference-Based EQ-5D-3L Value Set Derived Using 18 Months of Longitudinal Data in Patients Who Sustained a Fracture: Results From the ICUROS. Svedbom, Axel, Fredrik Borgstöm, Emma Hernlund, Vidmantas Alekna, Maria Luisa Bianchi, Patricia Clark, Manuel Diaz-Curiel, Hans Peter Dimai, Mikk Jürisson, Olga Lesnyak, Eugene McCloskey, Kerrie M. Sanders, Stuart Silverman, Marija Tamulaitiene, Thierry Thomas, Anna N. A. Tosteson, Bengt Jönsson, and John A. Kanis. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, December.

Association of Direct-Acting Antiviral Therapy With Liver and Nonliver Complications and Long-Term Mortality in Patients With Chronic Hepatitis C. Ogawa, Eiichi, Nicholas Chien, Leslie Kam, Yee Hui Yeo, Fanpu Ji, Daniel Q. Huang, Ramsey Cheung, and Mindie H. Nguyen. JAMA Internal Medicine, December.

Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn’s Disease Location. Shih, Terri, Susy Yusung, Rivkah Gonsky, Rhiannon Dutra-Clarke, David Ziring, Shervin Rabizadeh, Subra Kugathasan, Lee A. Denson, Dalin Li, and Jonathan Braun. Inflammatory Bowel Diseases, December, izac251.

Life Satisfaction Among Persons Living With Dementia and Those Without Dementia. Gotanda, Hiroshi, Yusuke Tsugawa, Haiyong Xu, and David B. Reuben. Journal of the American Geriatrics Society, December.

Diagnostic Potential of Minimally Invasive Biomarkers: A Biopsy-Centered Viewpoint From the Banff Minimally Invasive Diagnostics Working Group. Huang, Edmund, Michael Mengel, Marian C. Clahsen-van Groningen, and Annette M. Jackson. Transplantation 107 (1): 45–52.

Neurology

Postmortem Quantitative MRI Disentangles Histological Lesion Types in Multiple Sclerosis. Galbusera, Riccardo, Erik Bahn, Matthias Weigel, Sabine Schaedelin, Jonas Franz, Po-Jui Lu, Muhamed Barakovic, Lester Melie-Garcia, Peter Dechent, Antoine Lutti, Pascal Sati, Daniel S. Reich, Govind Nair, Wolfgang Brück, Ludwig Kappos, Christine Stadelmann, and Cristina Granziera. Brain Pathology (Zurich, Switzerland), December, e13136.

Nursing

What the Joint Commission Medication Management Titration Standards Mean to Quality Care for Complex Patients. Chechel, Laura, Barbara McLean, Theresa Slazinski, and Teresa Rincon. Clinical Nurse Specialist CNS 37 (1): 36–41.

Pathology

Modified Taq DNA Polymerase for Allele-Specific Ultra-Sensitive Detection of Genetic Variants. Lim, Youngshin, Il-Hyun Park, Huy-Ho Lee, Kyuwon Baek, Byung-Chul Lee, and Ginam Cho. The Journal of Molecular Diagnostics: JMD 24 (11): 1128–42.

Injury Patterns and Potential Diagnostic Pitfalls Associated With Radiation and Radio-Chemotherapy in the Stomach and Gastroesophageal Junction. Birkness-Gartman, Jacqueline E., Danielle A. Hutchings, Elizabeth A. Montgomery, and Lysandra Voltaggio. Human Pathology, December, S0046-8177(22)00280-5.

The Clinical Relevance of Human Papillomavirus Negative Status in Unsatisfactory Cervical Cytology. Barakzai, Syem K., Ailene Nguyen, Sanchala Sehgal, Koji Matsuo, Wenjing Shi, Sonia Veran-Taguibao, Melissa L. Wilson, and Brian J. Gordon. Archives of Gynecology and Obstetrics, December.

Practice Patterns for Reporting Digestive System Neuroendocrine Neoplasms: Results From a Large, Comprehensive International Survey. Karamchandani, Dipti M., Brian Cox, Stefano La Rosa, Andrew M. Bellizzi, Chanjuan Shi, and Raul S. Gonzalez. Histopathology, December.

High-Fidelity Detection, Subtyping, and Localization of Five Skin Neoplasms Using Supervised and Semi-Supervised Learning. Requa, James, Tuatini Godard, Rajni Mandal, Bonnie Balzer, Darren Whittemore, Eva George, Frenalyn Barcelona, Chalette Lambert, Jonathan Lee, Allison Lambert, April Larson, and Gregory Osmond. Journal of Pathology Informatics 14: 100159.

Pediatrics

Programming Multicellular Assembly With Synthetic Cell Adhesion Molecules. Stevens, Adam J., Andrew R. Harris, Josiah Gerdts, Ki H. Kim, Coralie Trentesaux, Jonathan T. Ramirez, Wesley L. McKeithan, Faranak Fattahi, Ophir D. Klein, Daniel A. Fletcher, and Wendell A. Lim. Nature, December.

Radiation Oncology

Single-Fraction High-Dose-Rate Brachytherapy: A Scoping Review on Outcomes and Toxicities for All Disease Sites. Kazemi, Mehdi, Sarah Nadarajan, and Mitchell Kamrava. Journal of Contemporary Brachytherapy 14 (5): 481–94.

Surgery

Arterial Spin Labeling Magnetic Resonance Imaging Quantifies Tissue Perfusion Around Foot Ulcers. Pantoja, Joe Luis, Fadil Ali, Donald T. Baril, Steven M. Farley, Scott Boynton, J. Paul Finn, Peng Hu, and Peter F. Lawrence. Journal of Vascular Surgery Cases and Innovative Techniques 8 (4): 817–24.