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Faculty Publications: Dec. 29 - Jan.5


A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Dec. 29-Jan. 5.


ASRA Pain Medicine Consensus Guidelines on the Management of the Perioperative Patient on Cannabis and Cannabinoids. Shah, Shalini, Eric S. Schwenk, Rakesh V. Sondekoppam, Hance Clarke, Mark Zakowski, Rachel S. Rzasa-Lynn, Brent Yeung, Kate Nicholson, Gary Schwartz, W. Michael Hooten, Mark Wallace, Eugene R. Viscusi, and Samer Narouze. Regional Anesthesia and Pain Medicine, January, rapm-2022-104013.


Magnetic Resonance Imaging for Characterization of Hepatocellular Carcinoma Metabolism. Wang, Lixia, Ju Dong Yang, Charles C. Yoo, Keane K. Y. Lai, Jonathan Braun, Dermot P. B. McGovern, Yibin Xie, Stephen J. Pandol, Shelly C. Lu, and Debiao Li. Frontiers in Physiology 13: 1056511.

Novel DZ-SIM Conjugate Targets Cancer Mitochondria and Prolongs Survival in Pancreatic Ductal Adenocarcinoma. Ou, Yan, Ruoxiang Wang, Gina Chia-Yi Chu, Omer Hany Miligy Elmadbouh, Adrian Lim, Leland Wei-Kuo Chung, Mouad Edderkaoui, Yi Zhang, and Stephen Jacob Pandol. Advanced Therapeutics 5 (10): 2200021.

Efficacy and Safety of Lifileucel, a One-Time Autologous Tumor-Infiltrating Lymphocyte (TIL) Cell Therapy, in Patients With Advanced Melanoma After Progression on Immune Checkpoint Inhibitors and Targeted Therapies: Pooled Analysis of Consecutive Cohorts of the C-144-01 Study. Chesney, Jason, Karl D. Lewis, Harriet Kluger, Omid Hamid, Eric Whitman, Sajeve Thomas, Martin Wermke, Mike Cusnir, Evidio Domingo-Musibay, Giao Q. Phan, John M. Kirkwood, Jessica C. Hassel, Marlana Orloff, James Larkin, Jeffrey Weber, Andrew J. S. Furness, Nikhil I. Khushalani, Theresa Medina, Michael E. Egger, Friedrich Graf Finckenstein, Madan Jagasia, Parameswaran Hari, Giri Sulur, Wen Shi, Xiao Wu, and Amod Sarnaik. Journal for Immunotherapy of Cancer 10 (12): e005755.

The Shadows Hang Over Immunotherapy-Neutrophil Extracellular Traps in Cancer. Pu, Dan, Liyuan Yin, Xiaoqian Zhai, Ruoxiang Wang, Lin Huang, Qiang Wu, Lingling Zhu, Yuwen Zhou, Qinghua Zhou, and Lu Li. Science China. Life Sciences, December.

Circulating Vitamin D and Breast Cancer Risk: An International Pooling Project of 17 Cohorts. Visvanathan, Kala, Alison M. Mondul, Anne Zeleniuch-Jacquotte, Molin Wang, Mitchell H. Gail, Shiaw-Shyuan Yaun, Stephanie J. Weinstein, Marjorie L. McCullough, A. Heather Eliassen, Nancy R. Cook, Claudia Agnoli, Martin Almquist, Regina G. Ziegler, et al. European Journal of Epidemiology, January.

Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results From the ColoCare Study. Lindley, Clara L., Biljana Gigic, Anita R. Peoples, Claire J. Han, Tengda Lin, Caroline Himbert, Christy A. Warby, Juergen Boehm, Sheetal Hardikar, Anjelica Ashworth, Martin Schneider, Alexis Ulrich, Petra Schrotz-King, Jane C. Figueiredo, Christopher I. Li, David Shibata, Erin M. Siegel, Adetunji T. Toriola, Cornelia M. Ulrich, Karen L. Syrjala, and Jennifer Ose. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, January, EPI-22-0882.

Concurrent Prognostic Utility of Lymph Node Count and Lymph Node Density for Men With Pathological Node-Positive Prostate Cancer. Masterson, John M., Michael Luu, Aurash Naser-Tavakolian, Stephen J. Freedland, Howard Sandler, Zachary S. Zumsteg, and Timothy J. Daskivich. Prostate Cancer and Prostatic Diseases, January.

Separating the Effects of Early and Later Life Adiposity on Colorectal Cancer Risk: A Mendelian Randomization Study. Papadimitriou, Nikos, Caroline J. Bull, Mazda Jenab, David J. Hughes, Joshua A. Bell, Eleanor Sanderson, Nicholas J. Timpson, George Davey Smith, Demetrius Albanes, Peter T. Campbell, Sébastien Küry, Loic Le Marchand, Cornelia M. Ulrich, Kala Visvanathan, Jane C. Figueiredo, Polly A. Newcomb, Rish K. Pai, Ulrike Peters, Kostas K. Tsilidis, Jolanda M. A. Boer, Emma E. Vincent, Daniela Mariosa, Marc J. Gunter, Tom G. Richardson, and Neil Murphy. BMC Medicine 21 (1): 5.

Statins and Cancer Prevention-Association Does Not Mean Causation. Das, Sanjay, and Stephen J. Freedland. Cancer Prevention Research (Philadelphia, Pa.) 16 (1): 1–3.

Randomized Clinical Trial of Tissue Equivalent Bolus Prescription in Postmastectomy Radiotherapy Stratified by Skin Involvement Status. Sapienza, Lucas Gomes, Maria Aparecida Conte Maia, Maria José Leite Gomes, André Mattar, Glauco Baiocchi, and Vinicius Fernando Calsavara. Clinical and Translational Radiation Oncology 39 (March): 100570.


Apparent Risks of Postural Orthostatic Tachycardia Syndrome Diagnoses After COVID-19 Vaccination and SARS-Cov-2 Infection. Kwan, Alan C., Joseph E. Ebinger, Janet Wei, Catherine N. Le, Jillian R. Oft, Rachel Zabner, Debbie Teodorescu, Patrick G. Botting, Jesse Navarrette, David Ouyang, Matthew Driver, Brian Claggett, Brittany N. Weber, Peng-Sheng Chen, and Susan Cheng. Nature Cardiovascular Research 1 (12): 1187–94.

Time Course of Oversensing and Impedance Changes in Developing Implantable Cardioverter-Defibrillator Lead Fracture. Himes, Adam, Scott Hoium, and Charles D. Swerdlow. Heart Rhythm O2 3 (6Part A): 688–98.

Trajectory of Decongestion and Mortality in Young Adults With Acute Heart Failure. Jain, Vardhmaan, Muhammad Haisum Maqsood, Tariq Jamal Siddiqi, Ahmed Kamal Siddiqi, Zulfiqar Qutrio Baloch, Michelle M. Kittleson, Marat Fudim, G. Michael Felker, Stephen J. Greene, Javed Butler, and Muhammad Shahzeb Khan. Current Problems in Cardiology, December, 101579.

How to Identify Cardiac Amyloidosis Patients Who Might Benefit From Cardiac Transplantation. Ambardekar, Amrut V., Marianna Fontana, Mathew S. Maurer, Barry Trachtenberg, and Michelle Kittleson. JACC. Heart Failure 11 (1): 115–20.

Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy. Maron, Martin S., Ahmad Masri, Lubna Choudhury, Iacopo Olivotto, Sara Saberi, Andrew Wang, Pablo Garcia-Pavia, Neal K. Lakdawala, Sherif F. Nagueh, Florian Rader, Albree Tower-Rader, Aslan T. Turer, Caroline Coats, Michael A. Fifer, Anjali Owens, Scott D. Solomon, Hugh Watkins, Roberto Barriales-Villa, Christopher M. Kramer, Timothy C. Wong, Sharon L. Paige, Stephen B. Heitner, Stuart Kupfer, Fady I. Malik, Lisa Meng, Amy Wohltman, Theodore Abraham, and REDWOOD-HCM Steering Committee and Investigators. Journal of the American College of Cardiology 81 (1): 34–45.

Risk of Bias in Randomized Clinical Trials Comparing Transcatheter and Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis. Barili, Fabio, James M. Brophy, Daniele Ronco, Patrick O. Myers, Miguel Sousa Uva, Rui M. S. Almeida, Mateo Marin-Cuartas, Amedeo Anselmi, Jacques Tomasi, Jean-Philippe Verhoye, Francesco Musumeci, John Mandrola, Sanjay Kaul, Stefania Papatheodorou, Alessandro Parolari, and International Evidence Grading Research Initiative Targeting Transparency and Quality (INTEGRITTY). JAMA Network Open 6 (1): e2249321.

Epidemiology and Modifiable Risk Factors for Atrial Fibrillation. Elliott, Adrian D., Melissa E. Middeldorp, Isabelle C. Van Gelder, Christine M. Albert, and Prashanthan Sanders. Nature Reviews. Cardiology, January.

Computational Biomedicine

Neighbor-Specific Gene Expression Revealed From Physically Interacting Cells During Mouse Embryonic Development. Kim, Junil, Michaela Mrugala Rothová, Esha Madan, Siyeon Rhee, Guangzheng Weng, António M. Palma, Linbu Liao, Eyal David, Ido Amit, Morteza Chalabi Hajkarim, Vignesh Vudatha, Andrés Gutiérrez-García, Eduardo Moreno, Robert Winn, Jose Trevino, Paul B. Fisher, Joshua M. Brickman, Rajan Gogna, and Kyoung Jae Won. Proceedings of the National Academy of Sciences of the United States of America 120 (2): e2205371120.


Correction to: Integration of Coronary Artery Calcium Scoring From CT Attenuation Scans by Machine Learning Improves Prediction of Adverse Cardiovascular Events in Patients Undergoing SPECT/CT Myocardial Perfusion Imaging. Feher, Attila, Konrad Pieszko, Robert Miller, Mark Lemley, Aakash Shanbhag, Cathleen Huang, Leonidas Miras, Yi-Hwa Liu, Albert J. Sinusas, Edward J. Miller, and Piotr J. Slomka. Journal of Nuclear Cardiology, January.


Design and Execution of Sham-Controlled Endoscopic Trials in Acute Pancreatitis: Lessons Learned From the SHARP Trial. Cote, Gregory A., Valerie Durkalski-Mauldin, April Williams, Haley Nitchie, Jose Serrano, Dhiraj Yadav, and SHARP Consortium. Pancreatology [et Al.], December, S1424-3903(22)00833-X.

Impact of COVID-19 Infection and Vaccination in Pancreatobiliary IgG4-Related Disease Patients: An International Multicenter Study. Tang, Raymond S. Y., Onuma Sattayalertyanyong, Yu-Ting Kuo, Kenneth H. Park, Constantinos Anastassiades, Dario Ligresti, Nobuhiko Hayashi, Aws Hasan, Tae-Hyeon Kim, Nonthalee Pausawasdi, Hsiu-Po Wang, Simon K. Lo, Khek-Yu Ho, Luca Barresi, Mario Traina, Ichiro Yasuda, Thomas J. Savides, Chieh-Sian Koo, Ting Ting Chan, Thomas Y. T. Lam, and Joseph J. Y. Sung. Journal of Gastroenterology and Hepatology, December.


Transcriptomic Analysis of Human ALS Skeletal Muscle Reveals a Disease-Specific Pattern of Dysregulated CircRNAs. Tsitsipatis, Dimitrios, Krystyna Mazan-Mamczarz, Ying Si, Allison B. Herman, Jen-Hao Yang, Abhishek Guha, Yulan Piao, Jinshui Fan, Jennifer L. Martindale, Rachel Munk, Xiaoling Yang, Supriyo De, Brijesh K. Singh, Ritchie Ho, Myriam Gorospe, and Peter H. King. Aging 14 (December).

Education in Neuropalliative Care. Kramer, Neha M., Jessica Besbris, and Christine Hudoba. Handbook of Clinical Neurology 191: 259–72.


The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors. Tay, Angelique Sao-Mai S., Keith L. Black, and John S. Yu. Advances in Experimental Medicine and Biology 1394: 51–72.


Patient Perceptions of Virtual Reality for Pain Relief in Labor: A Qualitative Study. Wong, Melissa S., Kimberly D. Gregory, Brennan M. R. Spiegel, and Carine Khalil. Frontiers in Pain Research (Lausanne, Switzerland) 3: 1063751.


Clean or Dirty? A Systematic Review of Splash Basin Use and Its Infectious Potential in Orthopaedic Surgery. Rezzadeh, Kevin, Harin Parikh, Isabella Guanche, Eytan Debbi, Sean Rajaee, Ran Schwarzkopf, and Guy Paiement. The Iowa Orthopaedic Journal 42 (2): 82–89.

A Conceptual Model for Spine Surgery Recovery: A Qualitative Study of Patients’ Expectations, Experiences, and Satisfaction. Brintz, Carrie E., Rogelio A. Coronado, David G. Schlundt, Christine Haug Jenkins, Mackenzie L. Bird, Jordan A. Bley, Jacquelyn S. Pennings, Stephen T. Wegener, and Kristin R. Archer. Spine, November.

Does the Global Alignment and Proportion Score Predict Mechanical Complications in Circumferential Minimally Invasive Surgery for Adult Spinal Deformity? Gendelberg, David, Arya Rao, Andrew Chung, Jose H. Jimenez-Almonte, Anita Anand, Jerry Robinson, Bardia Khandehroo, Babak Khandehroo, Sheila Kahwaty, and Neel Anand. Neurosurgical Focus 54 (1): E11.

Exercise-Based Knee and Anterior Cruciate Ligament Injury Prevention. Arundale, Amelia J. H., Mario Bizzini, Celeste Dix, Airelle Giordano, Ryan Kelly, David S. Logerstedt, Bert Mandelbaum, David A. Scalzitti, Holly Silvers-Granelli, and Lynn Snyder-Mackler. The Journal of Orthopaedic and Sports Physical Therapy 53 (1): CPG1–34.

A Retrospective Cohort Study on Chronic Opioid Use After Geriatric Hip Fracture Surgery-Risk Factors, Trends, and Outcomes. Stone, Julia M., Amit Pujari, John Garlich, and Carol Lin. The Journal of the American Academy of Orthopaedic Surgeons, January.


25: A Multicenter Cohort Analysis of Rapid Genome Sequencing in the PICU. Rodriguez, Katherine, Erica Sanford Kobayashi, Heather VanDongen-Trimmer, Lisa Salz, Jennifer Foley, Drewann Whalen, Okonkwo Oluchukwu, Kuang Chuen Liu, Jennifer Burton, Prachi Syngal, Stephen Kingsmore, and Nicole Coufal. Critical Care Medicine 51 (1): 13.

1053: Improving PICU Patient Safety by Implementing a Robust Supply Chain Management Process. Rice, Amy, Carol Noseworthy, Kaiser Ashraf, Edward Seferian, and Pooja Nawathe. Critical Care Medicine 51 (1): 521.

1067: Reducing Length of Stay in Spinal Fusion Patients With Rapid Recovery Protocol in the PICU. VanDongen-Trimmer, Heather, Elaine Butterworth, David Skaggs, Stephen Robert, and Pooja Nawathe. Critical Care Medicine 51 (1): 528.

Notch1 Signaling Impairs Regulatory T Cells During Multisystem Inflammatory Syndrome in Children. Noval Rivas, Magali, and Moshe Arditi. The Journal of Clinical Investigation 133 (1): e166016.

Circulating Spike Protein Detected in Post-COVID-19 MRNA Vaccine Myocarditis. Yonker, Lael M., Zoe Swank, Yannic C. Bartsch, Madeleine D. Burns, Abigail Kane, Brittany P. Boribong, Jameson P. Davis, Maggie Loiselle, Tanya Novak, Yasmeen Senussi, Chi-An Cheng, Eleanor Burgess, Andrea G. Edlow, Janet Chou, Audrey Dionne, Duraisamy Balaguru, Manuella Lahoud-Rahme, Moshe Arditi, Boris Julg, Adrienne G. Randolph, Galit Alter, Alessio Fasano, and David R. Walt. Circulation, January.


Collaborative Mental Health Care: A Narrative Review. Reist, Christopher, Incia Petiwala, Jennifer Latimer, Sarah Borish Raffaelli, Maurice Chiang, Daniel Eisenberg, and Scott Campbell. Medicine 101 (52): e32554.

Radiation Oncology

Five-Year Patient Reported Outcomes in NRG Oncology RTOG 0938, Evaluating Two Ultrahypofractionated Regimens for Prostate Cancer. Lukka, Himanshu R., Snehal Deshmukh, Deborah W. Bruner, Jean-Paul Bahary, Colleen A. F. Lawton, Jason A. Efstathiou, Rajat J. Kudchadker, Lee E. Ponsky, Samantha A. Seaward, Ian S. Dayes, Darindra D. Gopaul, Jeff M. Michalski, Guila Delouya, Irving D. Kaplan, Eric M. Horwitz, Mack Roach, Felix Y. Feng, Stephanie L. Pugh, Howard M. Sandler, and Lisa A. Kachnic. International Journal of Radiation Oncology, Biology, Physics, December, S0360-3016(22)03671-9.

Analysis of a Biopsy-Based Genomic Classifier in High-Risk Prostate Cancer: Meta-Analysis of the NRG Oncology/RTOG 9202, 9413, and 9902 Phase III Randomized Trials. Nguyen, Paul L., Huei-Chung Rebecca Huang, Daniel E. Spratt, Elai Davicioni, Howard M. Sandler, William U. Shipley, Jason A. Efstathiou, Jeffry P. Simko, Alan Pollack, Adam P. Dicker, Mack Roach, Seth A. Rosenthal, Kenneth L. Zeitzer, Lucas C. Mendez, Alan C. Hartford, William A. Hall, Anand B. Desai, Rachel A. Rabinovitch, Christopher A. Peters, Joseph P. Rodgers, Phuoc Tran, and Felix Y. Feng. International Journal of Radiation Oncology, Biology, Physics, December, S0360-3016(22)03688-4.