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Faculty Publications: Dec.15 - Dec. 22


A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Dec.15 - Dec. 22.


Same Smile as She…. Johnson, Calvin. Anesthesia and Analgesia 136 (1): 190. 

Biomedical Sciences

Spatially Resolved Transcriptomics Reveals Genes Associated With the Vulnerability of Middle Temporal Gyrus in Alzheimer’s Disease. Chen, Shuo, Yuzhou Chang, Liangping Li, Diana Acosta, Yang Li, Qi Guo, Cankun Wang, Emir Turkes, Cody Morrison, Dominic Julian, Mark E. Hester, Douglas W. Scharre, Chintda Santiskulvong, Sarah XueYing Song, Jasmine T. Plummer, Geidy E. Serrano, Thomas G. Beach, Karen E. Duff, Qin Ma, and Hongjun Fu. Acta Neuropathologica Communications 10 (1): 188.

Paging the Clinical Informatics Community: Respond STAT to Dobbs v Jackson’s Women’s Health Organization. Arvisais-Anhalt, Simone, Akshay Ravi, Benjamin Weia, Jos Aarts, Hasan B. Ahmad, Ellen Araj, Julie A. Bauml, Marge Benham-Hutchins, Andrew D. Boyd, Aimee Brecht-Doscher, Kerryn Butler-Henderson, Atul Butte, Shobha Sadasivaiah, et al. Applied Clinical Informatics, December.


Approach to Systemic Therapy in Advanced Hepatocellular Carcinoma. Sankar, Kamya, Jun Gong, Kambiz Kosari, Nicholas N. Nissen, and Ju Dong Yang. Hepatobiliary Surgery and Nutrition 11 (6): 931–34.

Diabetes and Risk of Hepatocellular Carcinoma in Cirrhosis Patients With Nonalcoholic Fatty Liver Disease. Teng, Pai-Chi, Daniel Q. Huang, Ting-Yi Lin, Mazen Noureddin, and Ju Dong Yang. Gut and Liver, December.

Deciphering Colorectal Cancer Genetics Through Multi-Omic Analysis of 100,204 Cases and 154,587 Controls of European and East Asian Ancestries. Fernandez-Rozadilla, Ceres, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Díez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Ulrike Peters, et al. Nature Genetics, December.

Cardiac Surgery

Evaluating Age-Based Eligibility Thresholds for Heart Re-Transplantation - an Analysis of the United Network for Organ Sharing Database. Chen, Qiudong, Jad Malas, Joshua Chan, Gabriel Esmailian, Dominic Emerson, Dominick Megna, Pedro Catarino, Michael E. Bowdish, Michelle Kittleson, Jignesh Patel, Joanna Chikwe, Jon Kobashigawa, and Fardad Esmailian. The Journal of Heart and Lung Transplantation, December, S1053-2498(22)02246-X.

Experience With SynCardia Total Artificial Heart as a Bridge to Transplantation in 100 Patients. Malas, Jad, Qiudong Chen, Akbarshakh Akhmerov, Louis Philippe Tremblay, Natalia Egorova, Aasha Krishnan, Jaime Moriguchi, Jon Kobashigawa, Lawrence Czer, Robert Cole, Dominic Emerson, Joanna Chikwe, Francisco Arabia, and Fardad Esmailian. The Annals of Thoracic Surgery, December, S0003-4975(22)01539-9.

Soluble Urokinase Plasminogen Activator Receptor: From Biomarker to Active Participant in Atherosclerosis and Cardiovascular Disease. Goodchild, Traci T., Zhen Li, and David J. Lefer. The Journal of Clinical Investigation 132 (24): e165868.


MicroRNA-Dependent Suppression of Biological Pacemaker Activity Induced by TBX18. Sanchez, Lizbeth, Thassio Mesquita, Rui Zhang, Ke Liao, Russell Rogers, Yen-Nien Lin, Rodrigo Miguel-Dos-Santos, Akbarshakh Akhmerov, Liang Li, Asma Nawaz, Kevin Holm, Eduardo Marbán, and Eugenio Cingolani. Cell Reports. Medicine 3 (12): 100871.

Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women. Makarem, Nour, Kristi Chau, Eliza C. Miller, Cynthia Gyamfi-Bannerman, Isabella Tous, Whitney Booker, Janet M. Catov, David M. Haas, William A. Grobman, Lisa D. Levine, Rebecca McNeil, C. Noel Bairey Merz, Uma Reddy, Ronald J. Wapner, Melissa S. Wong, and Natalie A. Bello. JAMA Network Open 5 (12): e2248165.

Immune Checkpoint Inhibitors: Acute and Chronic Cardiovascular Complications. Josan, Kiranbir, and Tomas G. Neilan. Nature Reviews. Cardiology, December.

Reproductive Health After Thoracic Transplantation: An ISHLT Expert Consensus Statement. Kittleson, Michelle M., Ersilia M. DeFilippis, Catriona J. Bhagra, Jillian P. Casale, Matthew Cauldwell, Lisa A. Coscia, Rohan D’Souza, Nicole Gaffney, Vicky Gerovasili, Patricia Ging, Kristin Horsley, Francesca Macera, Joan M. Mastrobattista, Miranda A. Paraskeva, Lynn R. Punnoose, Kismet D. Rasmusson, Quitterie Reynaud, Heather J. Ross, Mitesh V. Thakrar, and Mary Norine Walsh. The Journal of Heart and Lung Transplantation, October, S1053-2498(22)02177-5.

Serial 7-Day Electrocardiogram Patch Screening for AF in High-Risk Older Women by the CHARGE-AF Score. Lin, Jeffrey Y., Joseph Larson, Jenny Schoenberg, Alejandra Sepulveda, Lesley Tinker, Matthew Wheeler, Christine Albert, JoAnn E. Manson, Gretchen Wells, Lisa W. Martin, Victor Froelicher, Mike LaMonte, Charles Kooperberg, Mark A. Hlatky, Philip Greenland, Marcia L. Stefanick, and Marco V. Perez. JACC. Clinical Electrophysiology 8 (12): 1523–34.

Pursuit of Myocardial Ischemia for Therapeutic Decision-Making in Patients With Diabetes and Stable Ischemic Heart Disease: Reconciling Randomized Controlled Trials and Observational Studies. Kaul, Sanjay. Diabetes Care 45 (12): 2823–27.

A Panel of Blood Biomarkers Unique to Sudden Cardiac Arrest. Norby, Faye L., Kotoka Nakamura, Qin Fu, Vidya Venkatraman, Niveda Sundararaman, Mitra Mastali, Kyndaron Reinier, Angelo Salvucci, Jonathan Jui, Jennifer E. Van Eyk, and Sumeet S. Chugh. Heart Rhythm, December, S1547-5271(22)02720-5.

Post-Discharge Noninvasive Telemonitoring and Nurse Telephone Coaching Improve Outcomes in Heart Failure Patients With High Burden of Comorbidity. Kimchi, Asher, Harriet U. Aronow, Yu-Ming Ni, Michael K. Ong, James Mirocha, Jeanne T. Black, Andrew D. Auerbach, Theodore G. Ganiats, Sheldon Greenfield, Patrick S. Romano, Ilan Kedan, and BEAT-HF Research Group. Journal of Cardiac Failure, December, S1071-9164(22)01221-0.

Continuous Mechanical Aspiration Thrombectomy Performs Equally Well in Main Versus Branch Pulmonary Emboli: A Subgroup Analysis of the EXTRACT-PE Trial. Leong, Derek W., Bahram Ayadi, David J. Dexter, Michael Rosenberg, James M. Horowitz, Michael L. Chuang, and Suhail Dohad. Catheterization and Cardiovascular Interventions, December.

Reversal of Right Ventricular Pressure Loading Improves Function Independent of Fibrosis. Jones, Xaviar Michael, Rachel Fox, Jacob Motawakel, and Rishi K. Trivedi. The Journal of Physiology, December.

Comprehensive Collection of COVID-19 Related Prosthetic Valve Failure: A Systematic Review. Trieu, Theresa K., Kade Birkeland, Asher Kimchi, and Ilan Kedan. Journal of Thrombosis and Thrombolysis, December, 1–16.

Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke : A Prospective Cohort Study. Maheshwari, Ankit, Faye L. Norby, Riccardo M. Inciardi, Wendy Wang, Michael J. Zhang, Elsayed Z. Soliman, Alvaro Alonso, Michelle C. Johansen, Rebecca F. Gottesman, Scott D. Solomon, Amil M. Shah, and Lin Yee Chen. Annals of Internal Medicine, December.

Valve-in-Valve Transcatheter Aortic Valve Replacement Versus Redo Surgical Aortic Valve Replacement for Failed Surgical Aortic Bioprostheses: A Systematic Review and Meta-Analysis. Raschpichler, Matthias, Suzanne de Waha, David Holzhey, Guido Schwarzer, Nir Flint, Danon Kaewkes, Paul T. Bräuchle, Danny Dvir, Raj Makkar, Gorav Ailawadi, Mohamed Abdel-Wahab, Holger Thiele, and Michael A. Borger. Journal of the American Heart Association 11 (24): e7965. 

Late Fabric and Peridevice Leak of Watchman Left Atrial Appendage Occluder During Long-Term Follow-Up. Chakravarty, Tarun, John Friedman, Florian Rader, and Raj R. Makkar. JACC. Cardiovascular Interventions 15 (24): 2571–72.

Computational Biomedicine

Label-Free Quantification From Direct Infusion Shotgun Proteome Analysis (DISPA-LFQ) With CsoDIAq Software. Jiang, Yuming, Alexandre Hutton, Caleb W. Cranney, and Jesse G. Meyer. Analytical Chemistry, December.

Risk Prediction: Methods, Challenges, and Opportunities. Li, Ruowang, Rui Duan, Lifang He, and Jason H. Moore. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 28: 546–48.


Noninvasive In Vivo Coronary Artery Thrombus Imaging. Tzolos, Evangelos, Rong Bing, Jack Andrews, Mark G. MacAskill, Adriana A. S. Tavares, Gillian Macnaught, Tim Clark, Nicholas L. Mills, Takeshi Fujisawa, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Marcus-Andre Deutsch, Edwin J. R. van Beek, Michelle C. Williams, Sven Hermann, Verena Hugenberg, Marc R. Dweck, and David E. Newby. JACC. Cardiovascular Imaging, December, S1936-878X(22)00606-4.


Molecular Targets in Acromegaly. Labadzhyan, Artak, and Shlomo Melmed. Frontiers in Endocrinology 13: 1068061.

Prevention of Posttransplant Diabetes: A Complex Problem Without a Simple Solution. Oveyssi, Justin, and Edmund Huang. Transplantation, October.

Early Time-Restricted Eating Affects Weight, Metabolic Health, Mood, and Sleep in Adherent Completers: A Secondary Analysis. Steger, Felicia L., Humaira Jamshed, David R. Bryan, Joshua S. Richman, Amy H. Warriner, Cody J. Hanick, Corby K. Martin, Sarah-Jeanne Salvy, and Courtney M. Peterson. Obesity (Silver Spring, Md.), December.

Efficacy and Safety of the Bruton’s Tyrosine Kinase Inhibitor Evobrutinib in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Trial. Wallace, Daniel J., Thomas Dörner, David S. Pisetsky, Jorge Sanchez-Guerrero, Anand C. Patel, Dana Parsons-Rich, Claire Le Bolay, Elise E. Drouin, Amy H. Kao, Hans Guehring, and Maria Dall’Era. ACR Open Rheumatology, December.

Fructose Might Be a Clue to the Origin of Preeclampsia Insights From Nature and Evolution. Nakagawa, Takahiko, null Ana Andres-Hernando, Tomoki Kosugi, Laura G. Sanchez-Lozada, Peter Stenvinkel, Karolina Kublickiene, S. Ananth Karumanchi, Duk-Hee Kang, Hideto Kojima, Bernardo Rodriguez-Iturbe, Dean R. Tolan, Miguel A. Lanaspa, and Richard J. Johnson. Hypertension Research, December.


The Reversible Impairment of Behavioral Variant Frontotemporal Brain Sagging Syndrome: Challenges and Opportunities. Schievink, Wouter I., Marcel Maya, Zachary Barnard, Rachelle B. Taché, Ravi S. Prasad, Vikram S. Wadhwa, Franklin G. Moser, and Miriam Nuño. Alzheimer’s & Dementia (New York, N. Y.) 8 (1): e12367.

Determinants of Approved Acetylcholinesterase Inhibitor Response Outcomes in Alzheimer’s Disease: Relevance for Precision Medicine in Neurodegenerative Diseases. Lista, Simone, Andrea Vergallo, Stefan J. Teipel, Pablo Lemercier, Filippo Sean Giorgi, Audrey Gabelle, Francesco Garaci, Nicola B. Mercuri, Claudio Babiloni, Bhakta Prasad Gaire, Yosef Koronyo, Maya Koronyo-Hamaoui, Harald Hampel, Robert Nisticò, and Neurodegeneration Precision Medicine Initiative (NPMI). Ageing Research Reviews, December, 101819.


Biomechanical Analysis of Three Different Reconstruction Techniques for Scapholunate Instability: A Cadaveric Study. Chae, Seungbum, Junho Nam, Il-Jung Park, Steve S. Shin, Michelle H. McGarry, and Thay Q. Lee. Clinics in Orthopedic Surgery 14 (4): 613–21.


Clinicopathologic Significance of Predominant Lambda Light Chain Deposition in IgA Nephropathy. Ravipati, Prasanth, Rebecca L. Freese, Virginie Royal, Lihong Bu, Pietro Canetta, Debbie Gipson, Mahmood Kallash, Krzysztof Kiryluk, Cynthia Nast, Heather N. Reich, Michelle N. Rheault, Manish Saha, Patrick H. Nachman, and CureGN Consortium. Kidney International Reports 7 (11): 2462–73.


Utilization of SARS-CoV-2-Positive Donors in Pediatric Renal Transplantation. Pizzo, Helen, Priya R. Soni, Santhosh Nadipuram, Jonathan Garrison, Stanley C. Jordan, and Dechu Puliyanda. Pediatric Transplantation, December, e14451.

Radiation Oncology

Consensus Quality Measures and Dose Constraints for Prostate Cancer From the Veterans Affairs Radiation Oncology Quality Surveillance Program and American Society for Radiation Oncology Expert Panel. Solanki, Abhishek A., Lindsay L. Puckett, Ksenija Kujundzic, Evangelia Katsoulakis, John Park, Rishabh Kapoor, Michael Hagan, Maria Kelly, Jatinder Palta, Leslie K. Ballas, John DeMarco, Karen E. Hoffman, Colleen A. F. Lawton, Jeff Michalski, Louis Potters, Michael Zelefsky, Randi Kudner, Samantha Dawes, Emily Wilson, and Howard Sandler. Practical Radiation Oncology, December, S1879-8500(22)00274-0.

Increasing Diversity of Patients in Radiation Oncology Clinical Trials. Roy, Emily, Fumiko Chino, Benjamin King, Chika Madu, Malcolm Mattes, Rosalyn Morrell, Dr Julianne Pollard-Larkin, Malika Siker, Christiane Takita, and Michelle Ludwig. International Journal of Radiation Oncology, Biology, Physics, December, S0360-3016(22)03619-7.