This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published April 25-May 2.

Biomedical Sciences

Coronary Plaque Phenotype Associated With Positive Remodeling. Kinoshita, Daisuke, Keishi Suzuki, Haruhito Yuki, Takayuki Niida, Daichi Fujimoto, Yoshiyasu Minami, Damini Dey, Hang Lee, Iris McNulty, Junya Ako, Maros Ferencik, Tsunekazu Kakuta, Jong Chul Ye, and Ik-Kyung Jang. Journal of Cardiovascular Computed Tomography, April, S1934-5925(24)00100-X.

Fine-Mapping Analysis Including Over 254,000 East Asian and European Descendants Identifies 136 Putative Colorectal Cancer Susceptibility Genes. Chen, Zhishan, Xingyi Guo, Ran Tao, Jeroen R. Huyghe, Philip J. Law, Ceres Fernandez-Rozadilla, Jie Ping, Guochong Jia, Jirong Long, Chao Li, Quanhu Shen, Yuhan Xie, Wei Zheng, et al. Nature Communications 15 (1): 3557.

Evolving Role of Aortic Valve Calcification Scoring - Time For Opportunistic Screening? Slipczuk, Leandro, Philippe Pibarot, Piotr J. Slomka, Marc R. Dweck, and Damini Dey. Journal of Cardiovascular Computed Tomography, April, S1934-5925(24)00105-9.

Second Primary Cancer Risks According to Race and Ethnicity Among U.S. Breast Cancer Survivors. Brandt, Carolyn, Jacqueline B. Vo, Gretchen L. Gierach, Iona Cheng, Vanessa N. Torres, Wayne R. Lawrence, Lauren E. McCullough, Lene H. S. Veiga, Amy Berrington de González, and Cody Ramin. International Journal of Cancer, April.

Cardiac Surgery

2024 ACC/AHA Clinical PerFormance and Quality Measures For Adults With Valvular and Structural Heart Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on PerFormance Measures. Jneid, Hani, Joanna Chikwe, Suzanne V. Arnold, Robert O. Bonow, Steven M. Bradley, Edward P. Chen, Rebecca L. Diekemper, Setri Fugar, Douglas R. Johnston, Dharam J. Kumbhani, Roxana Mehran, Arunima Misra, Manesh R. Patel, Ranya N. Sweis, and Molly Szerlip. Circulation: Cardiovascular Quality and Outcomes 17 (4): e000129.

Treatment Of Concomitant Atrial Fibrillation and Aortic Valve Disease: A Missed Opportunity. Hasan, Irsa, and Armin Kiankhooy. The Annals of Thoracic Surgery, April, S0003-4975(24)00295-9.

Cardiology

Point of Care Ultrasound For Diagnosis and Management in Heart Failure: A Targeted Literature Review. Yampolsky, Sabina, Alan Kwan, Susan Cheng, and Ilan Kedan. POCUS Journal 9 (1): 117–30.

Vision-Language Foundation Model For Echocardiogram Interpretation. Christensen, Matthew, Milos Vukadinovic, Neal Yuan, and David Ouyang. Nature Medicine, April.

Left and Right Ventricular Longitudinal Systolic Function Following Aortic Valve Replacement in the PARTNER 2 Trial and Registry. Silva, Iria, Julien Ternacle, Rebecca T. Hahn, Mohamed Salah-Annabi, Abdellaziz Dahou, Laura Krapf, Erwan Salaun, Ezequiel Guzzetti, Ke Xu, Marie-Annick Clavel, Mathieu Bernier, Jonathan Beaudoin, Paul C. Cremer, Wael Jaber, Leonardo Rodriguez, Federico M. Asch, Neil J. Weismann, Jeroen Bax, Nina Ajmone, Maria C. Alu, Faouzi Kallel, Michael J. Mack, John G. Webb, Samir Kapadia, Raj Makkar, Susheel Kodali, Howard C. Herrmann, Vinod Thourani, Martin B. Leon, and Philippe Pibarot. European Heart Journal. Cardiovascular Imaging, May, jeae114.

Statin Utilization and Cardiovascular Outcomes in a Real-World Primary Prevention Cohort of Older Adults. Walker, Aaron J., Jianhui Zhu, Floyd Thoma, Oscar Marroquin, Amber Makani, Martha Gulati, Eugenia Gianos, Salim S. Virani, Fatima Rodriguez, Steven E. Reis, Christie Ballantyne, Suresh Mulukutla, and Anum Saeed. American Journal of Preventive Cardiology 18 (June): 100664.

Medicine

Hepatocellular Carcinoma Screening in a Contemporary Cohort of At-Risk Patients. Daher, Darine, Karim Seif El Dahan, Nicole E. Rich, Nabihah Tayob, Vincent Merrill, Daniel Q. Huang, Ju Dong Yang, Anand V. Kulkarni, Fasiha Kanwal, Jorge Marrero, Neehar Parikh, and Amit G. Singal. JAMA Network Open 7 (4): e248755.

Upregulated Matrisomal Proteins and Extracellular Matrix Mechanosignaling Underlie Obesity-Associated Promotion of Pancreatic Ductal Adenocarcinoma. Waldron, Richard T., Aurelia Lugea, Hui-Hua Chang, Hsin-Yuan Su, Crystal Quiros, Michael S. Lewis, Mingtian Che, V. Krishnan Ramanujan, Enrique Rozengurt, Guido Eibl, and Stephen J. Pandol. Cancers 16 (8): 1593.

Extracellular and Intracellular Antiviral Effects of Ultraviolet A Against Severe Acute Respiratory Syndrome Coronavirus-2 Are Variant-Independent. Leite, Gabriela, Sepideh Mehravar, Mark Pimentel, Ruchi Mathur, Gil Y. Melmed, Volha Teagle, Gillian M. Barlow, and Ali Rezaie. Photodiagnosis and Photodynamic Therapy, April, 104097.

Interleukin 33 Supports Squamous Cell Carcinoma Growth via a Dual Effect on Tumour Proliferation, Migration and Invasion, and T Cell Activation. Perri, Graziela, Vanessa Garcia Vilas Boas, Maria Renata Sales Nogueira, Edgard José Franco Mello Júnior, Ana Lucia Coelho, Edwin M. Posadas, Cory Hogaboam, Karen A. Cavassani, and Ana Paula Campanelli. Cancer Immunology, Immunotherapy: CII 73 (6): 110.

Sequencing of Anti-CD19 Therapies in the Management of Diffuse Large B-Cell Lymphoma. Lownik, Joseph, Jonathan Boiarsky, Ruemu Birhiray, Akil Merchant, and Monica Mead. Clinical Cancer Research, April.

Higher Adalimumab Concentration Is Associated With Complete Fistula Healing in Patients With Perianal Fistulizing Crohn’s Disease. Papamichael, Konstantinos, Andrea Centritto, Lucas Guillo, Jessica Hier, Zachary Sherman, International Consortium of Therapeutic drug Monitoring (spECTRUM), and Adam S. Cheifetz. Clinical Gastroenterology and Hepatology, April, S1542-3565(24)00397-5.

Direct Oral Anticoagulants Increase Bleeding Risk Following Mohs Micrographic Surgery: A Prospective Study. Juhasz, Margit, Tuyet A. Nguyen, and Nima M. Gharavi. Dermatologic Surgery, April.

Long-Term Effectiveness of Eliglustat Treatment: A Real-World Analysis From the International Collaborative Gaucher Group Gaucher Registry. Mistry, Pramod K., Manisha Balwani, Joel Charrow, Jeremy Lorber, Claus Niederau, Jenny L. Carwile, Antonio Oliveira-Dos-Santos, Maria Gabriela Perichon, Sefika Uslu Cil, and Priya S. Kishnani. American Journal of Hematology, April.

Updates in Characteristics and Survival Rates of Cirrhosis in a Nationwide Cohort of Real-World U.S. Patients, 2003-2021. Tran, Sally, Biyao Zou, KeeSeok Lee, Leslie Kam, YeeHui Yeo, Linda Henry, Ramsey Cheung, and Mindie H. Nguyen. Alimentary Pharmacology & Therapeutics, May.

Social Support via Internet Communication Technology For Diabetes Self-Management: A Scoping Review. Hazime, Danielle, and Elizabeth Burner. mHealth 10: 18. https://doi.org/10.21037/mhealth-23-34.

Neurosurgery

Progressive Superficial Siderosis Despite Complete Remission of Intracranial Hypotension Symptoms Following Epidural Patching: Case Report. Carroll, Ian, and Wouter Schievink. Headache: The Journal of Head and Face Pain 64 (4): 460–63.

Friedman’s Gradient-Boosting Algorithm Predicts Lactate-Pyruvate Ratio Predicts Trends in Cases of Intracerebral Hemorrhages. Kang, Jaeyoung, Ishan Shah, Shane Shahrestani, Christopher Nguyen, Patrick M. Chen, Alexander M. Lopez, and Jefferson W. Chen. World Neurosurgery, April, S1878-8750(24)00709-5.

Integration of Chronological Age Does Not Improve the PerFormance of a Mixed-Effect Model Using Comorbidity Burden and Frailty to Predict 90-Day Readmission After Surgery For Degenerative Scoliosis. Shahrestani, Shane, Lawrance K. Chung, Nolan J. Brown, Sofia Reese, Ryan C. Liu, R. Apurva A. Prasad, R. Kiran Alluri, Raymond Hah, John C. Liu, and Michael M. Safaee. World Neurosurgery, April, S1878-8750(24)00702-2.

Outcomes With General Anesthesia Compared to Conscious Sedation For Endovascular Treatment of Medium Vessel Occlusions: Results of an International Multicentric Study. Radu, R?zvan Alexandru, Vincent Costalat, Michele Romoli, Basel Musmar, James E. Siegler, Sherief Ghozy, Jane Khalife, Hamza Salim, Hamza Shaikh, Nimer Adeeb, Hugo H. Cuellar-Saenz, Ajith J. Thomas, MAD-MT Consortium, et al. Clinical Neuroradiology, April.

NMDAR-Mediated Activation of Pannexin1 Channels Contributes to the Detonator Properties of Hippocampal Mossy Fiber Synapses. Rangel-Sandoval, Cinthia, Marisol Soula, Wei-Ping Li, Pablo E. Castillo, and David L. Hunt. iScience 27 (5): 109681.

OBGYN

Complex Benign Gynecology: Shaping the Future Beyond a Name Change Through Training and Leadership. Truong, Mireille, and Arnold Advincula. Journal of Minimally Invasive Gynecology, April, S1553-4650(24)00180-8.

Pathology and Laboratory Medicine

A Machine Learning Algorithm Improves the Diagnostic Accuracy of the Histologic Component of Antibody Mediated Rejection (AMR-H) in Cardiac Transplant Endomyocardial Biopsies. Glass, Matthew, Zhicheng Ji, Richard Davis, Elizabeth Pavlisko, Louis DiBernardo, John Carney, Gregory Fishbein, Daniel Luthringer, Dylan Miller, Richard Mitchell, Brandon Larsen, Yasmeen Butt, Melanie Bois, Joseph Maleszewski, Marc Halushka, Michael Seidman, Chieh-Yu Lin, Maximilian Buja, James Stone, David Dov, Lawrence Carin, and Carolyn Glass. Cardiovascular Pathology, April, 107646.

Pediatrics

Rapid Whole-Genome Sequencing and Clinical Management in the PICU: A Multicenter Cohort, 2016-2023. Rodriguez, Katherine M., Jordan Vaught, Lisa Salz, Jennifer Foley, Zaineb Boulil, Heather M. Van Dongen-Trimmer, Drewann Whalen, Okonkwo Oluchukwu, Kuang Chuen Liu, Jennifer Burton, Prachi Syngal, Ofelia Vargas-Shiraishi, Stephen F. Kingsmore, Erica SanFord Kobayashi, and Nicole G. Coufal. Pediatric Critical Care Medicine: A Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, April.

Physical Medicine & Rehabilitation

Emerging From the Haze^TM: Pilot Feasibility Study Comparing Two Virtual Formats of a Cognitive Rehabilitation Intervention. Myers, Jamie S., Jeffrey C. Wertheimer, Jaromme Geebum Kim, Jianghua He, Celina H. Shirazipour, Dedrick Hooper, Mary Penne Mays, Jennifer R. Klemp, Carli Zegers, and Arash Asher. Oncology Nursing Forum 51 (3): 223–42.

Psychiatry & Behavioral Neurosciences

Contextual Barriers and Enablers to Establishing an Addiction-Focused Consultation Team For Hospitalized Adults With Opioid Use Disorder. Evans, Sandra K., Allison J. Ober, Ariella R. Korn, Alex Peltz, Peter D. Friedmann, Kimberly Page, Cristina Murray-Krezan, Sergio Huerta, Stephen J. Ryzewicz, Lina Tarhuni, Teryl K. Nuckols, Katherine E Watkins, and Itai Danovitch. Addiction Science & Clinical Practice 19 (1): 31.

Surgery

Why Can’t We Improve Turnover Time? A Systematic Review. Cohen, Tara N., Falisha F. Kanji, Jennifer Zamudio, Daniel Shouhed, Bruce L. Gewertz, and Harry C. Sax. World Journal of Surgery 48 (1): 72–85.

Gender-Specific Differences in Preoperative Concerns in Patients Undergoing Endoscopic Sinus Surgery For Chronic Rhinosinusitis. Tam, Benjamin, Jessica Le, Dennis M. Tang, Arthur W. Wu, Martin L. Hopp, Michela Borrelli, Dale H. Rice, Bozena B. Wrobel, and Kevin Hur. Annals of Otology, Rhinology & Laryngology 133 (4): 454–57.

Surgical Treatment of Breast Lymphedema: A Distinct Pathology With Unique Challenges. Szymanski, Kathryn, Shelby Chun Fat, and Philip S. Brazio. Annals of Plastic Surgery 92 (5S Suppl 3): S315–19.

We Are Not Speaking the Same Language: Current Procedural Terminology Coding and Provision of Care in Lymphatic Reconstruction. Attalla, Philopatir, Miriam Becker, Robert Craig Clark, Chris M. Reid, and Philip S. Brazio. Annals of Plastic Surgery 92 (5S Suppl 3): S310–14.

Urology

The Role of Vibrators in Women’s Pelvic Health: An Alluring Tool to Improve Physical, Sexual, and Mental Health. Dubinskaya, Alexandra, Priya Kohli, Poone Shoureshi, Catherine Breese, Victoria Scott, Jennifer T. Anger, and Karyn S. Eilber. International Urogynecology Journal, April.

Racial Disparities in Stage at Bladder Cancer Diagnosis in the US Veterans Affairs Healthcare System. Bree, Kelly K., Jessica L. Janes, Patrick J. Hensley, Aditya Srinivasan, Amanda M. De Hoedt, Sanjay Das, Stephen J. Freedland, and Stephen B. Williams. BJU International, April.