A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators
This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Sept. 28-Oct. 5.
Biomedical Sciences
Motion-Compensated T1 Mapping in Cardiovascular Magnetic Resonance Imaging: A Technical Review. Sheagren, Calder D., Tianle Cao, Jaykumar H. Patel, Zihao Chen, Hsu-Lei Lee, Nan Wang, Anthony G. Christodoulou, and Graham A. Wright. Frontiers in Cardiovascular Medicine 10: 1160183.
Combining Asian and European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Racial and Ethnic Populations. Thomas, Minta, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C. Sakoda, Stephanie L. Schmit, Maria N. Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J. Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Li Hsu, et al. Nature Communications 14 (1): 6147.
Human Neural Progenitors Expressing GDNF Enhance Retinal Protection in a Rodent Model of Retinal Degeneration. Shahin, Saba, Patrick Tan, Jason Chetsawang, Bin Lu, Soshana Svendsen, Stephany Ramirez, Trevor Conniff, Jorge S. Alfaro, Michael Fernandez, Aaron Fulton, Alexander H. Laperle, Clive N. Svendsen, and Shaomei Wang. Stem Cells Translational Medicine, October, szad054.
Cardiac Surgery
Robotic-Assisted Lung Transplantation: First in Man. Emerson, Dominic, Pedro Catarino, Reinaldo Rampolla, Joanna Chikwe, and Dominick Megna. The Journal of Heart and Lung Transplantation, September, S1053-2498(23)02054-5.
Impact of Donor-Recipient Age-Difference in Adolescent Heart Transplantation. Gill, George, Georgina Rowe, M. Mujeeb Zubair, Qiudong Chen, Jason Thomas, Peter Chiu, Asishana Osho, Vikram Sood, Kurt R. Schumacher, Dominic Emerson, Michael E. Bowdish, Joanna Chikwe, and Francis Fynn-Thompson. Clinical Transplantation, September, e15146.
Cardiology
Progression of Non-Significant Mitral and Tricuspid Regurgitation After Surgical Aortic Valve Replacement for Aortic Regurgitation. Kazum, Shirit, Mordehay Vaturi, Idit Yedidya, Shmuel Schwartzenberg, Olga Morelli, Keren Skalsky, Hadas Ofek, Ram Sharony, Ran Kornowski, Yaron Shapira, and Alon Shechter. Journal of Clinical Medicine 12 (19): 6280.
The Fallen Athlete: Fellow Athletes Are Not Performing Cardiopulmonary Resuscitation When a Teammate Suffers Sudden Cardiac Arrest. Chukumerije, Merije, Thomas S. Truglio, Gregory A. Dadekian, and Lorrel E. B. Toft. The American Journal of Emergency Medicine, September, S0735-6757(23)00492-8.
Understanding T2MI: Thank Goodness for the Women. Bairey Merz, C. Noel, Martha Gulati, and Janet Wei. Journal of the American College of Cardiology, September, S0735-1097(23)06470-7.
Basic Science of Cardiac Contractility Modulation Therapy: Molecular and Electrophysiological Mechanisms. Masarone, Daniele, Michelle M. Kittleson, Antonio D’Onofrio, Luigi Falco, Isabella Fumarolo, Massimo Massetti, Filippo Crea, Nadia Aspromonte, and Giuseppe Pacileo. Heart Rhythm, September, S1547-5271(23)02767-4.
Two-Year Outcomes of Valve-in-Valve Using New-Generation Transcatheter Devices Compared With Redo-SAVR. Nagasaka, Takashi, Ofir Koren, Vivek Patel, Robert Naami, Edmund Naami, Alon Shechter, Siamak Kohan, Zev Allison, Addee Lerner, Daniel Eugene Cheng, Tarun Chakravarty, Wen Cheng, Hasan Jilaihawi, Hideki Ishii, Mamoo Nakamura, and Raj R. Makkar. The American Journal of Cardiology 207 (September): 380–89.
IgM Marks Persistent IgG Anti-Human Leukocyte Antigen Antibodies in Highly Sensitized Heart Transplant Patients. Li, Fang, Loren Gragert, D. Giovanni Biagini, Jignesh K. Patel, Jon A. Kobashigawa, Johannes Trück, Oscar Rodriguez, Corey T. Watson, David Gibb, Xiaohai Zhang, and Evan P. Kransdorf. The Journal of Heart and Lung Transplantation, October, S1053-2498(23)02055-7.
Proprotein Convertase Subtisilin/Kexin 9 (PCSK9) Levels Decline With HCV Therapy in People With HIV/HCV and Correlate With Inflammation. Gandhi, Malini M., Kim-Lien Nguyen, Jordan E. Lake, Diana Liao, Aleen Khodabakhshian, Mario Guerrero, Chrisandra L. Shufelt, C. Noel Bairey Merz, Wilbert C. Jordan, Eric S. Daar, Debika Bhattacharya, and Kara W. Chew. AIDS (London, England), October.
Cancer
Community Outreach and Engagement at U.S. Cancer Centers: Notes From the 3rd Cancer Center Community Impact Forum. Leader, Amy E., Heather M. Brandt, Katherine J. Briant, Gina Curry, Kiara Ellis, Evelyn T. Gonzalez, Carmen E. Guerra, Garrett Harding, Pamela C. Hull, Aimee Israel, Rebecca Melillo, Rachel J. Mesia, Jenna E. Schiffelbein, Yawei Song, Zul Surani, Jasmin A. Tiro, Susan T. Vadaparampil, Robin C. Vanderpool, and Electra D. Paskett. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, October.
Imaging
Effects of Renin-Angiotensin-Aldosterone-System Inhibitors on Coronary Atherosclerotic Plaques: The PARADIGM Registry. Williams, Curtis, Donghee Han, Hidenobu Takagi, Christopher B. Fordyce, Stephanie Sellers, Philipp Blanke, Fay Y. Lin, Leslee J. Shaw, Sang-Eun Lee, Daniele Andreini, Mouaz H. Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araújo Gonçalves, Ilan Gottlieb, Martin Hadamitzky, Erica Maffei, Gianluca Pontone, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Renu Virmani, Habib Samady, Peter H. Stone, Daniel S. Berman, Jagat Narula, Jeroen J. Bax, Jonathon A. Leipsic, and Hyuk-Jae Chang. Atherosclerosis 383 (September): 117301.
Medicine
Fat and Inflammation: Adipocyte-Myeloid Cell Crosstalk in Atherosclerosis. Mazitova, Aleksandra M., Ana Cristina Márquez-Sánchez, and Ekaterina K. Koltsova. Frontiers in Immunology 14: 1238664.
Peptide-Based Immunotherapy in Lupus: Where Are We Now? P Singh, Ram, David S Bischoff, Satendra S Singh, and Bevra H Hahn. Rheumatology and Immunology Research 4 (3): 139–49.
The Effectiveness of Shared Decision Making for Diabetes Prevention: 24- and 36-Month Results From the Prediabetes Informed Decision and Education (PRIDE) Trial. Duru, O. Kenrik, Carol M. Mangione, Norman Turk, Janet Chon, Jeffery Fu, Grace Cheng, Felicia Cheng, Amanda Moss, Dominick Frosch, Kia Skrine Jeffers, Yelba Castellon-Lopez, Chi-Hong Tseng, Richard Maranon, Keith C. Norris, and Tannaz Moin. Diabetes Care, September, dc230829.
TRKing Sarcomas for Precision Medicine: Seek, and Ye Shall Find! Moyers, Justin T., and Vivek Subbiah. Cancer, September.
Postvaccination Symptoms After a Fourth Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease. Lee, Yoo Jin, Dalin Li, Angela Mujukian, Philip Debbas, Melissa Hampton, Emebet Mengesha, Susan Cheng, Joseph E. Ebinger, Michael Chiorean, Donald Lum, Oriana M. Damas, Jonathan Braun, Dermot P. B. McGovern, Gil Y. Melmed, and CORALE-IBD Study Group. Inflammatory Bowel Diseases, September, izad198.
Pneumonitis After Chemoradiation and Adjuvant Durvalumab in Stage III Non-Small-Cell Lung Cancer. Edwards, Donna M., Kamya Sankar, Aaren Alseri, Ralph Jiang, Matthew Schipper, Sean Miller, Kathryn Dess, Garth W. Strohbehn, David A. Elliott, Drew Moghanaki, Nithya Ramnath, Michael D. Green, and Alex K. Bryant. International Journal of Radiation Oncology, Biology, Physics, October, S0360-3016(23)07971-3.
Sex Differences Impact Ergonomic Endoscopic Training for Gastroenterology Fellows. Suhail, Fathima K., Yuying Luo, Kevin Williams, Rashmi Advani, Kirsti Campbell, Katie Dunleavy, Anam Rizvi, Alana Persaud, Renee L. Williams, and Loren G. Rabinowitz. Gastrointestinal Endoscopy, October, S0016-5107(23)02934-6.
Precision Medicine in Monogenic Inflammatory Bowel Disease: Proposed mIBD REPORT Standards. Uhlig, Holm H., Claire Booth, Judy Cho, Marla Dubinsky, Anne M. Griffiths, Bodo Grimbacher, Sophie Hambleton, Ying Huang, Kelsey Jones, Jochen Kammermeier, Hirokazu Kanegane, Sibylle Koletzko, Daniel Kotlarz, Christoph Klein, Michael J. Lenardo, Bernice Lo, Dermot P. B. McGovern, Ahmet Özen, Lissy de Ridder, Frank Ruemmele, Dror S. Shouval, Scott B. Snapper, Simon P. Travis, Dan Turner, David C. Wilson, and Aleixo M. Muise. Nature Reviews. Gastroenterology & Hepatology, October.
Response of Locally Advanced Pancreatic Cancer to Intratumoral Injection of Large Surface Area Microparticle Paclitaxel: Initial Report of Safety and Clinical Outcome. Sharma, Neil R., Simon K. Lo, Andrew Hendifar, Mohamed O. Othman, Kalpesh Patel, Antonio Mendoza-Ladd, Shelagh Verco, Holly A. Maulhardt, James Verco, Alison Wendt, Alyson Marin, Christian Max Schmidt, and Gere diZerega. Pancreas, October.
Second International Consensus Report on Gaps and Opportunities for the Clinical Translation of Precision Diabetes Medicine. Tobias, Deirdre K., Jordi Merino, Abrar Ahmad, Catherine Aiken, Jamie L. Benham, Dhanasekaran Bodhini, Amy L. Clark, Kevin Colclough, Rosa Corcoy, Sara J. Cromer, Daisy Duan, Jamie L. Felton, Paul W. Franks, et al. Nature Medicine, October.
Neurology
Intervention to Improve Acute Care Nurses Confidence and Knowledge in Hospital Dementia Care. Rhinehart, Deana M., Dyane L. Gatmaitan, Erica Spivack, Phong Chip Chung, Harriet U. Aronow, and Zaldy S. Tan. Geriatric Nursing (New York, N.Y.) 54 (September): 144–47.
Internet-Delivered Cognitive Behavioural Therapy Programme to Reduce Depressive Symptoms in Patients With Multiple Sclerosis: A Multicentre, Randomised, Controlled, Phase 3 Trial. Gold, Stefan M., Tim Friede, Björn Meyer, Rona Moss-Morris, Joanna Hudson, Susanna Asseyer, Judith Bellmann-Strobl, Andreas Leisdon, Leonie Ißels, Kristin Ritter, David Schymainski, Hayley Pomeroy, Sharon G. Lynch, Julia S. Cozart, Joan Thelen, Cristina A. F. Román, Margaret Cadden, Erin Guty, Stephanie Lau, Jana Pöttgen, Caren Ramien, Susan Seddiq-Zai, Anna-Maria Kloidt, Johannes Wieditz, Iris-Katharina Penner, Friedemann Paul, Nancy L. Sicotte, Jared M. Bruce, Peter A. Arnett, and Christoph Heesen. The Lancet. Digital Health 5 (10): e668–78.
Orthopaedics
High Compliance With the 11+ Injury Prevention Program Results in Better Win-Loss Records. Silvers-Granelli, Holly, Mario Bizzini, Bert Mandelbaum, Amelia Arundale, Ryan Pohlig, and Lynn Snyder-Mackler. International Journal of Sports Physical Therapy 18 (5): 1065–75.
Evaluating ChatGPT Responses in the Context of a 53-Year-Old Male With a Femoral Neck Fracture: A Qualitative Analysis. Zhou, Yushy, Charles Moon, Jan Szatkowski, Derek Moore, and Jarrad Stevens. European Journal of Orthopaedic Surgery & Traumatology: Orthopedie Traumatologie, September.
Geographic Access to Pediatric Neurosurgeons in the USA: An Analysis of Sociodemographic Factors. Farivar, Daniel, Nicholas J. Peterman, Nakul Narendran, Kenneth D. Illingworth, Teryl K. Nuckols, David Bonda, and David L. Skaggs. Child’s Nervous System: ChNS, October.
Utility of a Clinical Prediction Tool for Persisting Postconcussive Symptoms in a Multicenter Sample of Youth Athletes With Concussion: The Sport Concussion Outcomes in Pediatrics (SCOPE) Study. Miller, Shane M., Tamara C. Valovich McLeod, Tracy L. Zaslow, Julie C. Wilson, Christina L. Master, Traci R. Snedden, Mark E. Halstead, Matthew F. Grady, Matthew L. Fazekas, Jonathan A. Santana, Rachel A. Coel, and David R. Howell. The American Journal of Sports Medicine, October, 3635465231201610.
Pathology
Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification. Sethi, Sanjeev, Laurence H. Beck, Richard J. Glassock, Mark Haas, An S. De Vriese, Tiffany N. Caza, Elion Hoxha, Gérard Lambeau, Nicola M. Tomas, Benjamin Madden, Hanna Debiec, Vivette D. D’Agati, Mariam P. Alexander, Hatem Amer, Gerald B. Appel, Sean J. Barbour, Fernando Caravaca-Fontan, Daniel C. Cattran, Marta Casal Moura, Domingos O. D’Avila, Renato G. Eick, Vesna D. Garovic, Eddie L. Greene, Loren P. Herrera Hernandez, J. Charles Jennette, John C. Lieske, Glen S. Markowitz, Karl A. Nath, Samih H. Nasr, Cynthia C. Nast, Antonello Pani, Manuel Praga, Giuseppe Remuzzi, Helmut G. Rennke, Piero Ruggenenti, Dario Roccatello, Maria Jose Soler, Ulrich Specks, Rolf A. K. Stahl, Raman Deep Singh, Jason D. Theis, Jorge A. Velosa, Jack F. M. Wetzels, Christopher G. Winearls, Federico Yandian, Ladan Zand, Pierre Ronco, and Fernando C. Fervenza. Kidney International, September, S0085-2538(23)00490-8.
Pediatrics
Factors Associated With Post-Extubation Stridor in Infants Intubated in the Pediatric ICU. Lewis, Deirdre, Dev Darshan Khalsa, Alexandra Cummings, James Schneider, and Sareen Shah. Journal of Intensive Care Medicine, October, 8850666231204208.
Bacillus Calmette-Guérin Vaccination as Defense Against SARS-CoV-2 (BADAS): A Randomized Controlled Trial to Protect Healthcare Workers in the USA by Enhanced Trained Immune Responses. DiNardo, Andrew R., Moshe Arditi, Ashish M. Kamat, Kent J. Koster, Santiago Carrero, Tomoki Nishiguchi, Maxim Lebedev, Aaron B. Benjamin, Pablo Avalos, Marisa Lozano, Madeleine G. Moule, Brittany McCune, Baysia Herron, Malik Ladki, Daanish Sheikh, Matthew Spears, Ivan A. Herrejon, Courtney Dodge, Sathish Kumar, Robert W. Hutchison, Theresa U. Ofili, Lynne A. Opperman, Jessica A. Bernard, Seth P. Lerner, George Udeani, Gabriel Neal, Mihai G. Netea, and Jeffrey D. Cirillo. Trials 24 (1): 636.
Radiation Oncology
Radiotherapy Plus Cisplatin With or Without Lapatinib for Non-Human Papillomavirus Head and Neck Carcinoma: A Phase 2 Randomized Clinical Trial. Wong, Stuart J., Pedro A. Torres-Saavedra, Nabil F. Saba, George Shenouda, Jeffrey M. Bumpous, Robert E. Wallace, Christine H. Chung, Adel K. El-Naggar, Clement K. Gwede, Barbara Burtness, Paul A. Tennant, Neal E. Dunlap, Rebecca Redman, William A. Stokes, Soumon Rudra, Loren K. Mell, Assuntina G. Sacco, Sharon A. Spencer, Lisle Nabell, Min Yao, Fabio L. Cury, Darrion L. Mitchell, Christopher U. Jones, Selim Firat, Joseph N. Contessa, Thomas Galloway, Adam Currey, Jonathan Harris, Walter J. Curran, and Quynh-Thu Le. JAMA Oncology, September, e233809.
Surgery
Systemic Therapy for Tumor Control in Metastatic Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline. Del Rivero, Jaydira, Kimberly Perez, Erin B. Kennedy, Erik S. Mittra, Namrata Vijayvergia, Juniad Arshad, Sandip Basu, Aman Chauhan, Arvind N. Dasari, Andrew M. Bellizzi, Alexandra Gangi, Erin Grady, James R. Howe, Jana Ivanidze, Mark Lewis, Josh Mailman, Nitya Raj, Heloisa P. Soares, Michael C. Soulen, Sarah B. White, Jennifer A. Chan, Pamela L. Kunz, Simron Singh, Thorvardur R. Halfdanarson, Jonathan R. Strosberg, and Emily K. Bergsland. Journal of Clinical Oncology, September, JCO2301529.
Urology
Real-World Treatment Patterns and Overall Survival Among Men With Metastatic Castration-Resistant Prostate Cancer (mCRPC) in the US Medicare Population. Freedland, Stephen J., Matthew Davis, Andrew J. Epstein, Bhakti Arondekar, and Jasmina I. Ivanova. Prostate Cancer and Prostatic Diseases, October.
Cancer Screening for Transgender Individuals: Guidelines, Best Practices, and a Proposed Care Model. Sterling, Joshua, Jeffrey Carbonella, Tashzna Jones, Stephanie Hanchuk, Paris Kelly, and Maurice M. Garcia. The Urologic Clinics of North America 50 (4): 563–76.