This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Sept. 21-28. 

Biomedical Sciences 

Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons. Otero, Maria G., Shaughn Bell, Alexander H. Laperle, George Lawless, Zachary Myers, Marian A. Castro, Jaquelyn M. Villalba, and Clive N. Svendsen. International Journal of Molecular Sciences 24 (18): 14227.

GMP-Grade Human Neural Progenitors Delivered Subretinally Protect Vision in Rat Model of Retinal Degeneration and Survive in Minipigs. Lu, Bin, Pablo Avalos, Soshana Svendsen, Changqing Zhang, Laura Nocito, Melissa K. Jones, Cosmo Pieplow, Joshua Saylor, Sean Ghiam, Amanda Block, Michael Fernandez, Alexander V. Ljubimov, Kent Small, David Liao, Clive N. Svendsen, and Shaomei Wang. Journal of Translational Medicine 21 (1): 650.

Cardiac Surgery 

Racial Disparities in Failure to Rescue After Pediatric Heart Surgeries in the United States. Alabbadi, Sundos, Georgina Rowe, George Gill, Joanna Chikwe, and Natalia Egorova. The Journal of Pediatrics, September, 113734.

Cardiology 

Outcome of Patients With Both Moderate Aortic Stenosis and Moderate Mitral Stenosis. Yamane, Takafumi, Ken Kuwajima, Shunsuke Kagawa, Hiroko Hasegawa, Florian Rader, Robert J. Siegel, and Takahiro Shiota. Structural Heart: The Journal of the Heart Team 7 (5): 100183.

The Stroke Enigma: Decoding the Sex Risk Factor in Atrial Fibrillation. Middeldorp, Melissa E., and Roopinder K. Sandhu. European Heart Journal, September, ehad531.

Symptom Presentation Among Women With Suspected Ischemia and No Obstructive Coronary Artery Disease (INOCA). Taha, Yasmeen K., Jennifer R. Dungan, Michael T. Weaver, Ke Xu, Eileen M. Handberg, Carl J. Pepine, and C. Noel Bairey Merz. Journal of Clinical Medicine 12 (18): 5836.

Atrioesophageal Fistula Rates Before and After Adoption of Active Esophageal Cooling During Atrial Fibrillation Ablation. Sanchez, Javier, Christopher Woods, Jason Zagrodzky, Jose Nazari, Matthew J. Singleton, Amir Schricker, Annie Ruppert, Babette Brumback, Benjamin Jenny, Charles Athill, Christopher Joseph, Dipak Shah, Mark Metzl, et al. JACC. Clinical Electrophysiology, September, S2405-500X(23)00673-4.

5-Year Prospective Evaluation of Mitral Valve-in-Valve, Valve-in-Ring, and Valve-in-MAC Outcomes: MITRAL Trial Final Results. Guerrero, Mayra E., Mackram F. Eleid, Dee Dee Wang, Amit Pursnani, Susheel K. Kodali, Isaac George, Igor Palacios, Hyde Russell, Raj R. Makkar, Saibal Kar, Lowell F. Satler, Vivek Rajagopal, George Dangas, Gilbert H. L. Tang, James M. McCabe, Brian K. Whisenant, Kenith Fang, Prakash Balan, Richard Smalling, Tatiana Kaptzan, Bradley Lewis, Pamela S. Douglas, Rebecca T. Hahn, Jeremy Thaden, Jae K. Oh, Martin Leon, William O’Neill, and Charanjit Rihal. JACC. Cardiovascular Interventions 16 (18): 2211–27.

Medical Therapy Before, During, and After Hospitalization in Medicare Beneficiaries With Heart Failure and Diabetes: The Get With The Guidelines - Heart Failure Registry. Bhatt, Ankeet S., Gregg C. Fonarow, Stephen J. Greene, DaJuanicia N. Holmes, Brooke Alhanti, Adam D. DeVore, Javed Butler, Paul A. Heidenreich, Joanna C. Huang, Michelle M. Kittleson, Karthik Linganathan, Karen E. Joynt Maddox, James J. McDermott, Anjali Tiku Owens, Pamela N. Peterson, Scott D. Solomon, Orly Vardeny, Clyde W. Yancy, and Muthiah Vaduganathan. Journal of Cardiac Failure, September, S1071-9164(23)00344-5.

Utilization of P2Y12 Inhibitors in Older Adults With ST-Elevation Myocardial Infarction and Frailty. Ko, Darae, Ashvin Pande, Kueiyu Joshua Lin, Alexander Cervone, Lily G. Bessette, Su Been Lee, Susan Cheng, Robert J. Glynn, and Dae Hyun Kim. The American Journal of Cardiology 207 (September): 245–52.

Computational Biomedicine 

Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial. Calsavara, Vinicius F., Norah L. Henry, Ron D. Hays, Sungjin Kim, Michael Luu, Márcio A. Diniz, Gillian Gresham, Reena S. Cecchini, Greg Yothers, Patricia A. Ganz, André Rogatko, and Mourad Tighiouart. Cancer Prevention Research (Philadelphia, Pa.), September.

Imaging

A New Architecture Combining Convolutional and Transformer-Based Networks for Automatic 3D Multi-Organ Segmentation on CT Images. Li, Chengyin, Hassan Bagher-Ebadian, Rafi Ibn Sultan, Mohamed Elshaikh, Benjamin Movsas, Dongxiao Zhu, and Indrin J. Chetty. Medical Physics, September.

Progression of Non-Obstructive Coronary Plaque: A Practical CCTA-Based Risk Score From the PARADIGM Registry. Pontone, Gianluca, Alexia Rossi, Andrea Baggiano, Daniele Andreini, Edoardo Conte, Laura Fusini, Chaterine Gebhard, Mark G. Rabbat, Andrea Guaricci, Marco Guglielmo, Giuseppe Muscogiuri, Saima Mushtaq, Mouaz H. Al-Mallah, Daniel S. Berman, Matthew J. Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Eun Ju Chun, Pedro de Araújo Gonçalves, Ilan Gottlieb, Martin Hadamitzky, Yong Jin Kim, Byoung Kwon Lee, Sang-Eun Lee, Erica Maffei, Hugo Marques, Habib Samady, Sanghoon Shin, Ji Min Sung, Alexander van Rosendael, Renu Virmani, Jeroen J. Bax, Jonathon A. Leipsic, Fay Y. Lin, James K. Min, Jagat Narula, Leslee J. Shaw, and Hyuk-Jae Chang. European Radiology, September.

Medicine

Genetic Variation in Environmental Enteropathy and Stunting in Zambian Children: A Pilot Genome Wide Association Study Using the H3Africa Chip. Mweetwa, Monica N., Talin Haritunians, Shishir Dube, Kanta Chandwe, Beatrice Amadi, Kanekwa Zyambo, Ta-Chiang Liu, Dermot McGovern, and Paul Kelly. PloS One 18 (9): e0291311.

SC1_2. Validation of a Machine-Learning Based Algorithm to Detect Preeclampsia-Related Adverse Outcomes on a Dataset With Different Demographic Properties Than the Training Dataset. Hackeloeer, M., A. Hoyler, S. Rana, O. Rieger, M. Neznansky, A. Karumanchi, W. Henrich, and S. Verlohren. Pregnancy Hypertension, ISSHP 2022 Abstracts, 33 (September): e75–76.

Clinical and Psychosocial Impact of Communication About Oral Potentially Malignant Disorders: A Scoping Review. Arboleda, Lady P. A., Thaís C. E. Pereira, Joel B. Epstein, Cesar A. Migliorati, Saman Warnakulasuriya, Márcio Diniz-Freitas, Marcio A. Lopes, and Alan R. Santos-Silva. Dentistry Journal 11 (9): 209.

Antibody-Drug Conjugates in Breast Cancer: Current Status and Future Directions. Mark, Cynthia, Jin Sun Lee, Xiaojiang Cui, and Yuan Yuan. International Journal of Molecular Sciences 24 (18): 13726.

Blood ACE2 Protein Level Correlates With COVID-19 Severity. Shevchuk, Oksana, Anastasia Pak, Svitlana Palii, Yana Ivankiv, Kateryna Kozak, Mykhaylo Korda, and Sandor G. Vari. International Journal of Molecular Sciences 24 (18): 13957.

A Paratope-Enhanced Method to Determine Breadth and Depth TCR Clonal Metrics of the Private Human T-Cell Vaccine Response After SARS-CoV-2 Vaccination. Li, Dalin, Ana Jimena Pavlovitch-Bedzyk, Joseph E. Ebinger, Abdul Khan, Mohamed Hamideh, Akil Merchant, Jane C. Figueiredo, Susan Cheng, Mark M. Davis, Dermot P. B. McGovern, Gil Y. Melmed, Alexander M. Xu, and Jonathan Braun. International Journal of Molecular Sciences 24 (18): 14223.

Top 10 Tips Palliative Care Clinicians Should Know About Messaging for the Public. Back, Anthony L., Joe D. Rotella, Asadeh Dashti, Kate DeBartolo, William E. Rosa, Tessie W. October, and Marian S. Grant. Journal of Palliative Medicine, September.

Characterizing the Risk of HLA-Incompatible Living Donor Kidney Transplantation in Older Recipients. Long, Jane J., Jennifer D. Motter, Kyle R. Jackson, Jennifer Chen, Babak J. Orandi, Robert A. Montgomery, Mark D. Stegall, Stanley C. Jordan, Enrico Benedetti, Ty B. Dunn, Lloyd E. Ratner, Sandip Kapur, Ronald P. Pelletier, John P. Roberts, Marc L. Melcher, Pooja Singh, Debra L. Sudan, Marc P. Posner, Jose M. El-Amm, Ron Shapiro, Matthew Cooper, Jennifer E. Verbesey, George S. Lipkowitz, Michael A. Rees, Christopher L. Marsh, Bashir R. Sankari, David A. Gerber, Jason R. Wellen, Adel Bozorgzadeh, A. Osama Gaber, Eliot C. Heher, Francis L. Weng, Arjang Djamali, J. Harold Helderman, Beatrice P. Concepcion, Kenneth L. Brayman, Jose Oberholzer, Tomasz Kozlowski, Karina Covarrubias, Allan B. Massie, Mara A. McAdams-DeMarco, Dorry L. Segev, and Jacqueline M. Garonzik-Wang. American Journal of Transplantation, September, S1600-6135(23)00698-6.

Providers’ Knowledge and Perceptions of Bariatric Surgery: A Systematic Review. Rajeev, Nithya D., Jamil S. Samaan, Agnes Premkumar, Erin Yu, Nitin Srinivasan, and Kamran Samakar. Obesity Surgery, September.

Sex Differences in Biological Aging and the Association With Clinical Measures in Older Adults. Phyo, Aung Zaw Zaw, Peter D. Fransquet, Jo Wrigglesworth, Robyn L. Woods, Sara E. Espinoza, and Joanne Ryan. GeroScience, September.

Low Dosage Combination Treatment With Metformin and Simvastatin Inhibits Obesity-Promoted Pancreatic Cancer Development in Male KrasG12D Mice. Teper, Yaroslav, Linda Ye, Richard T. Waldron, Aurelia Lugea, Xiaoying Sun, James Sinnett-Smith, Oscar J. Hines, Stephen J. Pandol, Enrique Rozengurt, and Guido Eibl. Scientific Reports 13 (1): 16144.

Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk. Tobias, Deirdre K., Alisa K. Manning, Jennifer Wessel, Sridharan Raghavan, Kenneth E. Westerman, Alexander G. Bick, Daniel Dicorpo, Eric A. Whitsel, Jason Collins, Adolfo Correa, L. Adrienne Cupples, Josée Dupuis, Mark O. Goodarzi, Xiuqing Guo, Barbara Howard, Leslie A. Lange, Simin Liu, Laura M. Raffield, Alex P. Reiner, Stephen S. Rich, Kent D. Taylor, Lesley Tinker, James G. Wilson, Peitao Wu, April P. Carson, Ramachandran S. Vasan, Myriam Fornage, Bruce M. Psaty, Charles Kooperberg, Jerome I. Rotter, James Meigs, JoAnn E. Manson, and TOPMed Diabetes Working Group; National Heart, Lung, and Blood Institute TOPMed Consortium. Diabetes Care, September, dc230805.

Circulating Tumor DNA and Bone Marrow Minimal Residual Disease Negativity Confers Superior Outcome for Multiple Myeloma Patients. Mithraprabhu, Sridurga, John Reynolds, Hang Quach, Noemi Horvath, Ian Kerridge, Tiffany Khong, Brian Gm Durie, and Andrew Spencer. Haematologica, September.

Neurosurgery

Exposure to Environmental Airborne Particulate Matter Caused Wide-Ranged Transcriptional Changes and Accelerated Alzheimer’s-Related Pathology: A Mouse Study. Israel, Liron L., Oliver Braubach, Ekaterina S. Shatalova, Oksana Chepurna, Sachin Sharma, Dmytro Klymyshyn, Anna Galstyan, Antonella Chiechi, Alysia Cox, David Herman, Bishop Bliss, Irene Hasen, Amanda Ting, Rebecca Arechavala, Michael T. Kleinman, Rameshwar Patil, Eggehard Holler, Julia Y. Ljubimova, Maya Koronyo-Hamaoui, Tao Sun, and Keith L. Black. Neurobiology of Disease 187 (September): 106307.

Neurology 

Delayed Diagnosis in Cerebral Venous Thrombosis: Associated Factors and Clinical Outcomes. Bakradze, Ekaterina, Liqi Shu, Nils Henninger, Shyam Prabhakaran, James E. Siegler, Gian Marco De Marchis, James A. Giles, Tolga Dittrich, Mirjam R. Heldner, Kateryna Antonenko, Wayneho Kam, David S. Liebeskind, Alexis N. Simpkins, Thanh N. Nguyen, Shadi Yaghi, and Ava L. Liberman. Journal of the American Heart Association, September, e030421D.

Orthopaedics 

Retention of Human iPSC-Derived or Primary Cells Following Xenotransplantation Into Rat Immune-Privileged Sites. Später, Thomas, Giselle Kaneda, Melissa Chavez, Julia Sheyn, Jacob Wechsler, Victoria Yu, Patricia Del Rio, Dave Huang, Melodie Metzger, Wafa Tawackoli, and Dmitriy Sheyn. Bioengineering (Basel, Switzerland) 10 (9): 1049.

Surgery

Targeting Key Players of Neuroendocrine Differentiation in Prostate Cancer. Zamora, Irene, Michael R. Freeman, Ignacio J. Encío, and Mirja Rotinen. International Journal of Molecular Sciences 24 (18): 13673.

ASO Visual Abstract: De-Implementation of Low-Value Care in Women ? 70 Years With Low-Risk Breast Cancer During the COVID-19 Pandemic. Wang, Ton, Christina Weed, Joshua Tseng, Alice Chung, Marissa K. Boyle, Farin Amersi, Jaswinder Jutla, Amin Mirhadi, and Armando E. Giuliano. Annals of Surgical Oncology, September.

Adult Blunt Hepatic Injury: A Western Trauma Association Critical Decisions Algorithm. Keric, Natasha, David V. Shatz, Morgan Schellenberg, Marc de Moya, Laura J. Moore, Carlos V. R. Brown, Jennifer L. Hartwell, Kenji Inaba, Eric J. Ley, Kimberly A. Peck, Charles J. Fox, Nelson G. Rosen, Jordan A. Weinberg, Raul S. Coimbra, Rosemary Kozar, and Matthew J. Martin. The Journal of Trauma and Acute Care Surgery, September.

Malpractice Trends Involving Active Surveillance Across Cancers. Chang, Samuel, Timothy J. Daskivich, Missael Vasquez, Wendy L. Sacks, Zachary S. Zumsteg, and Allen S. Ho. Annals of Surgery, September.