A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators
This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Oct. 5-12.
Anesthesiology
Development and Pilot Testing of a Programmatic System for Competency Assessment in US Anesthesiology Residency Training. Woodworth, Glenn E., Zachary T. Goldstein, Aditee P. Ambardekar, Mary E. Arthur, Caryl F. Bailey, Gregory J. Booth, Patricia A. Carney, Fei Chen, Michael J. Duncan, Ilana R. Fromer, Matthew R. Hallman, Thomas Hoang, Robert Isaak, Lisa L. Klesius, Beth L. Ladlie, Sally Ann Mitchell, Amy K. Miller Juve, John D. Mitchell, Brian J. McGrath, John A. Shepler, Charles R. Sims, Christina M. Spofford, Pedro P. Tanaka, and Robert B. Maniker. Anesthesia and Analgesia, October.
Biomedical Sciences
How Early Can Atherosclerosis Be Detected by Coronary CT Angiography? Insights From Quantitative CT Analysis of Serial Scans in the PARADIGM Trial. Cardoso, Rhanderson, Andrew D. Choi, Arthur Shiyovich, Stephanie A. Besser, James K. Min, James Earls, PARADIGM Investigators, and Ron Blankstein. Journal of Cardiovascular Computed Tomography, October, S1934-5925(23)00426-4.
Coronary Artery Disease Reporting and Data System (CAD-RADS), Vascular Inflammation and Plaque Vulnerability. Kinoshita, Daisuke, Keishi Suzuki, Haruhito Yuki, Takayuki Niida, Daichi Fujimoto, Yoshiyasu Minami, Damini Dey, Hang Lee, Iris McNulty, Junya Ako, Brian Ghoshhajra, Maros Ferencik, Tsunekazu Kakuta, and Ik-Kyung Jang. Journal of Cardiovascular Computed Tomography, October, S1934-5925(23)00436-7.
Cardiology
Effect of Right Ventricular Free Wall Longitudinal Strain on All-Cause Death in Patients With Isolated Severe Tricuspid Regurgitation and Atrial Fibrillation. Ogawa, Mana, Ken Kuwajima, Takafumi Yamane, Hiroko Hasegawa, Nobuichiro Yagi, and Takahiro Shiota. Frontiers in Cardiovascular Medicine 10: 1188005.
1- or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After PCI. Valgimigli, Marco, Alessandro Spirito, Samantha Sartori, Dominick J. Angiolillo, Pascal Vranckx, Jose M. de la Torre Hernandez, Mitchell W. Krucoff, Sripal Bangalore, Deepak L. Bhatt, Gianluca Campo, Davide Cao, Bassem M. Chehab, James W. Choi, Yihan Feng, Junbo Ge, James Hermiller, Vijay Kunadian, Sydney Lupo, Raj R. Makkar, Aziz Maksoud, Franz-Josef Neumann, Hector Picon, Shigeru Saito, Gennaro Sardella, Holger Thiele, Ralph Toelg, Olivier Varenne, Birgit Vogel, Yujie Zhou, Stephan Windecker, and Roxana Mehran. JACC. Cardiovascular Interventions, September, S1936-8798(23)01158-5.
The HFSA Advanced Heart Failure and Transplant Cardiology Fellowship Consensus Conference. Drazner, Mark H., Amrut V. Ambardekar, Kathryn Berlacher, Vanessa Blumer, Safia Chatur, Richard Cheng, Richard K. Cheng, E. Wilson Grandin, Eiran Z. Gorodeski, Rachna Kataria, Jason N. Katz, Michelle M. Kittleson, Arun Krishnamoorthy, Anuradha Lala, Andrew J. Lenneman, Nicole L. Lohr, Kenneth B. Margulies, Robert J. Mentz, Nosheen Reza, Jane Wilcox, Quentin R. Youmans, Shelley Zieroth, and John R. Teerlink. Journal of Cardiac Failure, September, S1071-9164(23)00346-9.
HLA Sensitization Is Associated With an Increased Risk of Primary Graft Dysfunction After Heart Transplantation. Han, Jiho, Josh Rushakoff, Yasbanoo Moayedi, Erik Henricksen, Roy Lee, R. N. Helen Luikart, Omar Shalakhti, Loren Gragert, Lillian Benck, Darren Malinoski, Jon Kobashigawa, Jeffrey Teuteberg, Kiran K. Khush, Jignesh Patel, and Evan Kransdorf. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation, October, S1053-2498(23)02030-2.
Optimizing Heart Transplantation: The Importance of Experience. Kittleson, Michelle M. The Annals of Thoracic Surgery, October, S0003-4975(23)01032-9.
Another Piece in the Diabetes and Multivessel Coronary Disease Puzzle. Farkouh, Michael E., and Verghese Mathew. JACC. Cardiovascular Interventions 16 (19): 2423–25.
Body Mass Index, Adverse Pregnancy Outcomes, and Cardiovascular Disease Risk. Khan, Sadiya S., Lucia C. Petito, Xiaoning Huang, Katharine Harrington, Rebecca B. McNeil, Natalie A. Bello, C. N. Bairey Merz, Eliza C. Miller, Rupa Ravi, Christina Scifres, Janet Catov, Victoria Pemberton, Jasmina Varagic, Phyllis C. Zee, Lynn M. Yee, Mitali Ray, Jin Kyung Kim, Abbi Lane-Cordova, Jennifer Lewey, Lauren H. Theilen, George R. Saade, Philip Greenland, William A. Grobman, and NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks. Circulation Research, October.
Risk Factors for Sudden Cardiac Arrest Among Hispanic or Latino Adults in Southern California: Ventura PRESTO and HCHS/SOL. Reinier, Kyndaron, Jee-Young Moon, Harpriya S. Chugh, Arayik Sargsyan, Kotoka Nakamura, Faye L. Norby, Audrey Uy-Evanado, Gregory A. Talavera, Linda C. Gallo, Martha L. Daviglus, Katy Hadduck, Daniel Shepherd, Angelo Salvucci, Robert C. Kaplan, and Sumeet S. Chugh. Journal of the American Heart Association, October, e030062.
Computational Biomedicine
Aliro: An Automated Machine Learning Tool Leveraging Large Language Models. Choi, Hyunjun, Jay Moran, Nicholas Matsumoto, Miguel E. Hernandez, and Jason H. Moore. Bioinformatics (Oxford, England), October, btad606.
CellNeighborEX: Deciphering Neighbor-Dependent Gene Expression From Spatial Transcriptomics Data. Kim, Hyobin, Amit Kumar, Cecilia Lövkvist, António M. Palma, Patrick Martin, Junil Kim, Praveen Bhoopathi, Jose Trevino, Paul Fisher, Esha Madan, Rajan Gogna, and Kyoung Jae Won. Molecular Systems Biology, October, e11670.
Imaging
Computed Tomography Dose Index Determination in Dose Modulation Prospectively Involving the Third-Generation Iterative Reconstruction and Noise Index. Scott, Alexander W., Alok Shankar Pookotte Alancherry, Christina Lee, Emi Eastman, and Yifang Zhou. Journal of Applied Clinical Medical Physics, October, e14167.
Flurpiridaz F-18 PET Myocardial Perfusion Imaging in Patients With Suspected Coronary Artery Disease. Maddahi, Jamshid, Denis Agostini, Timothy M. Bateman, Jeroen J. Bax, Rob S. B. Beanlands, Daniel S. Berman, Sharmila Dorbala, Ernest V. Garcia, James Feldman, Gary V. Heller, Juhani M. Knuuti, Pedro Martinez-Clark, Matthieu Pelletier-Galarneau, Benjamin Shepple, Nagara Tamaki, Francois Tranquart, and James E. Udelson. Journal of the American College of Cardiology 82 (16): 1598–1610.
Medicine
Associations Between Avocado Intake and Measures of Glucose and Insulin Homeostasis in Hispanic Individuals With and Without Type 2 Diabetes: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Senn, MacKenzie K., Mark O. Goodarzi, Gautam Ramesh, Matthew A. Allison, Mariaelisa Graff, Kristin L. Young, Gregory A. Talavera, Amanda C. McClain, Tanya P. Garcia, Jerome I. Rotter, and Alexis C. Wood. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, August, S0939-4753(23)00325-3.
A Survey of United States Obstetric Anesthesiologists’ Perceived Value of Obstetric Anesthesiology Fellowship. Thomas, C., K. E. Neumann, C. Smith, J. E. Dominguez, A. Traynor, M. K. Farber, M. Zakowski, R. J. McCarthy, and F. M. Peralta. International Journal of Obstetric Anesthesia 56 (September): 103930.
Precision Subclassification of Type 2 Diabetes: A Systematic Review. Misra, Shivani, Robert Wagner, Bige Ozkan, Martin Schön, Magdalena Sevilla-Gonzalez, Katsiaryna Prystupa, Caroline C. Wang, Raymond J. Kreienkamp, Sara J. Cromer, Mary R. Rooney, Daisy Duan, Anne Cathrine Baun Thuesen, Amelia S. Wallace, Aaron Leong, Aaron J. Deutsch, Mette K. Andersen, Liana K. Billings, Robert H. Eckel, Wayne Huey-Herng Sheu, Torben Hansen, Norbert Stefan, Mark O. Goodarzi, Debashree Ray, Elizabeth Selvin, Jose C. Florez, ADA/EASD PMDI, James B. Meigs, and Miriam S. Udler. Communications Medicine 3 (1): 138.
Real-World Use of Avatrombopag in Patients With Chronic Liver Disease and Thrombocytopenia Undergoing a Procedure. Satapathy, Sanjaya K., Vinay Sundaram, Mitchell L. Shiffman, and Brian D. Jamieson. Medicine 102 (40): e35208.
?-Ketoglutarate-Dependent KDM6 Histone Demethylases Regulate Interferon Stimulated Gene Expression in Lupus. Montano, Erica N., Moumita Bose, Lihong Huo, Gantsetseg Tumurkhuu, Gabriela De Los Santos, Brianna Simental, Aleksandr B. Stotland, Janet Wei, C. Noel Bairey Merz, Jo Suda, Gislaine Martins, Sarfaraz Lalani, Kate Lawrenson, Yizhou Wang, Sarah Parker, Swamy Venuturupalli, Mariko Ishimori, Daniel J. Wallace, and Caroline A. Jefferies. Arthritis & Rheumatology (Hoboken, N.J.), October.
Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase 1b Trial. Nawrocki, Steffan T., Julian Olea, Claudia Villa Celi, Homa Dadrastoussi, Kaijin Wu, Denice Tsao-Wei, Anthony Colombo, Matthew Coffey, Eduardo Fernandez Hernandez, Xuelian Chen, Gerard J. Nuovo, Jennifer S. Carew, Ann F. Mohrbacher, Paul Fields, Peter Kuhn, Imran Siddiqi, Akil Merchant, and Kevin R. Kelly. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, October.
Risk of Major Adverse Cardiovascular Events in Immune-Mediated Inflammatory Disorders on Biologics and Small Molecules: Network Meta-Analysis. Mattay, Shivani Shah, Mohammad Zamani, Dany Saturno, Edward V. Loftus, Matthew A. Ciorba, Andres Yarur, Siddharth Singh, and Parakkal Deepak. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, October, S1542-3565(23)00767-X.
A Personalized Medicine Approach to Optimize Care for a Pediatric Cystic Fibrosis Patient With Atypical Clinical Symptoms. Lee, Jesun, Ammar Husami, Kavisha Arora, Weiqiang Zhang, Ferdous Kadri, Sunitha Yarlagadda, Changsuk Moon, Kyu Shik Mun, Kejian Zhang, Yunjie Huang, Pramodha Liyanage, John Brewington, John P. Clancy, Ala Shaikhkhalil, Grace Paul, and Anjaparavanda P. Naren. Pediatric Pulmonology, October.
Emerging Concepts in Immune Dysregulation. Weisman, Michael H. Rheumatic Diseases Clinics of North America 49 (4): xiii–xiv.
Neurology
The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography. Wicklein, Rebecca, Charmaine Yam, Christina Noll, Lilian Aly, Nicolas Banze, Eva Feodora Romahn, Elisabeth Wolf, Bernhard Hemmer, Frederike C. Oertel, Hanna Zimmermann, Philipp Albrecht, Marius Ringelstein, Carmen Baumann, Nikolaus Feucht, Josef Penkava, Joachim Havla, Jonathan A. Gernert, Christian Mardin, Eleni S. Vasileiou, Anneke Van Der Walt, Omar Al-Louzi, Sergio Cabello, Angela Vidal-Jordana, Julia Krämer, Heinz Wiendl, Jana Lizrova Preiningerova, Olga Ciccarelli, Elena Garcia-Martin, Veronika Kana, Peter A. Calabresi, Friedemann Paul, Shiv Saidha, Axel Petzold, Ahmed T. Toosy, Benjamin Knier, and IMSVISUAL Consortium. Neurology(R) Neuroimmunology & Neuroinflammation 10 (6): e200169.
European Academy of Neurology/Peripheral Nerve Society Guideline on Diagnosis and Treatment of Guillain-Barré Syndrome. Doorn, Pieter A. van, Peter Y. K. Van den Bergh, Robert D. M. Hadden, Bert Avau, Patrik Vankrunkelsven, Shahram Attarian, Patricia H. Blomkwist-Markens, David R. Cornblath, H. Stephan Goedee, Thomas Harbo, Bart C. Jacobs, Susumu Kusunoki, Helmar C. Lehmann, Richard A. Lewis, Michael P. Lunn, Eduardo Nobile-Orazio, Luis Querol, Yusuf A. Rajabally, Thirugnanam Umapathi, Haluk A. Topaloglu, and Hugh J. Willison. Journal of the Peripheral Nervous System: JPNS, October.**
European Academy of Neurology/Peripheral Nerve Society Guideline on Diagnosis and Treatment of Guillain-Barré Syndrome. Doorn, Pieter A. van, Peter Y. K. Van den Bergh, Robert D. M. Hadden, Bert Avau, Patrik Vankrunkelsven, Shahram Attarian, Patricia H. Blomkwist-Markens, David R. Cornblath, H. Stephan Goedee, Thomas Harbo, Bart C. Jacobs, Susumu Kusunoki, Helmar C. Lehmann, Richard A. Lewis, Michael P. Lunn, Eduardo Nobile-Orazio, Luis Querol, Yusuf A. Rajabally, Thirugnanam Umapathi, Haluk A. Topaloglu, and Hugh J. Willison. European Journal of Neurology, October.**
**This article represents a guidelines publication that has been simultaneously published with approval in the European Academy of Neurology and the Journal of the Peripheral Nervous System.
Orthopaedics
In Reply to the Letter to the Editor Regarding ‘Comparative Outcome of Lidocaine Versus Bupivacaine for Cervical Medial Branch Block in Chronic Cervical Facet Arthropathy: A Randomized Double-Blind Study.’ Pasuhirunnikorn, Porntipa, Teerachat Tanasansomboon, Weerasak Singhatanadgige, Wicharn Yingsakmongkol, and Pornpan Chalermkitpanit. World Neurosurgery 178 (October): 295.
Metallosis in Total Hip Arthroplasty. Lee, Anderson, Guy D. Paiement, Brad L. Penenberg, and Sean S. Rajaee. JBJS Reviews 11 (10).
Subject Matter Predicts Where Top Pediatric Spine Articles Are Shared: Citations vs. Social Media. Farivar, Daniel, Kenneth D. Illingworth, Adrian J. Lin, Evan D. Nigh, Ryan Finkel, and David L. Skaggs. Journal of Pediatric Orthopedics. Part B, October.
Patient-Reported Outcome Measurement in Orthopaedic Trauma. Jayakumar, Prakash, Marilyn Heng, Bandele Okelana, Mark Vrahas, Antia Rodriguez-Villalon, and Alexander Joeris. The Journal of the American Academy of Orthopaedic Surgeons 31 (20): e906–19.
Pathology
Recommendations for Cell-Free DNA Assay Validations: A Joint Consensus Recommendation of the Association for Molecular Pathology and College of American Pathologists. Lockwood, Christina M., Laetitia Borsu, Milena Cankovic, Jonathan S. L. Earle, Christopher D. Gocke, Meera Hameed, Danielle Jordan, Jean R. Lopategui, Mrudula Pullambhatla, Jacquelyn Reuther, Kandelaria M. Rumilla, Laura J. Tafe, Robyn L. Temple-Smolkin, Panieh Terraf, and Apostolia M. Tsimberidou. The Journal of Molecular Diagnostics: JMD, October, S1525-1578(23)00219-2.
Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification. Sethi, Sanjeev, Laurence H. Beck, Richard J. Glassock, Mark Haas, An S. De Vriese, Tiffany N. Caza, Elion Hoxha, Gérard Lambeau, Nicola M. Tomas, Benjamin Madden, Hanna Debiec, Vivette D. D’Agati, Mariam P. Alexander, Hatem Amer, Gerald B. Appel, Sean J. Barbour, Fernando Caravaca-Fontan, Daniel C. Cattran, Marta Casal Moura, Domingos O. D’Avila, Renato G. Eick, Vesna D. Garovic, Eddie L. Greene, Loren P. Herrera Hernandez, J. Charles Jennette, John C. Lieske, Glen S. Markowitz, Karl A. Nath, Samih H. Nasr, Cynthia C. Nast, Antonello Pani, Manuel Praga, Giuseppe Remuzzi, Helmut G. Rennke, Piero Ruggenenti, Dario Roccatello, Maria Jose Soler, Ulrich Specks, Rolf A. K. Stahl, Raman Deep Singh, Jason D. Theis, Jorge A. Velosa, Jack F. M. Wetzels, Christopher G. Winearls, Federico Yandian, Ladan Zand, Pierre Ronco, and Fernando C. Fervenza. Mayo Clinic Proceedings, September, S0025-6196(23)00372-5.**
**This article is being co-published with approval by the International Society of Nephrology (ISN) in Kidney International and May Clinic Proceedings.
Pediatrics
A Human Factors Approach for Event Analysis in A Pediatric Intensive Care Unit. Kanji F, Nawathe P and CohenT. Journal of Pediatrics & Child Care. September 2023 Volume:9, Issue:1
Progression of Pediatric Crohn’s Disease Is Associated With Anti-TNF Timing and BMI Z-Score Normalization. Geem, Duke, David Hercules, Ranjit S. Pelia, Suresh Venkateswaran, Anne Griffiths, Joshua D. Noe, Jennifer L. Dotson, Scott Snapper, Shervin Rabizadeh, Joel R. Rosh, Robert N. Baldassano, James F. Markowitz, Thomas D. Walters, Ashwin Ananthakrishnan, Garima Sharma, Lee A. Denson, Jeffrey S. Hyams, and Subra Kugathasan. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, October, S1542-3565(23)00757-7.
Surgery
Outcomes of Extracorporeal Life Support Utilization for Pediatric Patients With COVID-19 Infections. Jacobson, Jillian C., Mark L. Ryan, Adam M. Vogel, Steven C. Mehl, Shannon N. Acker, Connor Prendergast, Benjamin E. Padilla, Justin Lee, Stephanie D. Chao, Nolan R. Martin, Katie W. Russell, Kezlyn Larsen, Matthew T. Harting, Allison F. Linden, Romeo C. Ignacio, Bethany J. Slater, David Juang, Aaron R. Jensen, Caroline G. Melhado, Juan Carlos Pelayo, Allen Zhong, Brianna L. Spencer, Samir K. Gadepalli, Mia Maamari, Maria Jimenez Valencia, Faisal G. Qureshi, and Samir R. Pandya. ASAIO Journal (American Society for Artificial Internal Organs: 1992), October.
Novel Antibiotic Irrigation Device Versus Standard O-Ring Wound Retractor in the Prevention of Surgical Site Infection Following Colorectal Resection. Nasseri, Yosef, Eli Kasheri, Ruoyan Zhu, Abbas Smiley, Jason Cohen, Joshua Ellenhorn, Moshe Barnajian, and Kimberly Oka. International Journal of Colorectal Disease 38 (1): 252.
Robotic Bilateral Nephrectomy for Large Polycystic Kidney Disease. Masterson, John M., Hanson Zhao, Lior Taich, Aurash Naser-Tavakolian, Hayley Johnson, Reiad Najjar, Irene K. Kim, and Amit Gupta. BJUI Compass 4 (6): 701–8.
Urology
Management of Neovaginal Secretions After Salvage Gender Affirming Right-Colon Vaginoplasty Using Glycopyrrolate. Bang, Alexander Sydat, Maurice Marcel Garcia, Kieron Seymour Leslie, and Erin Huiras Amerson. Transgender Health 8 (5): 477–80.