This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Nov. 17-23.

Anesthesiology

Remimazolam - Can It Become a Cost-Effective Alternative to Propofol for Intravenous Anesthesia and Sedation? White, Paul F. Journal of Clinical Anesthesia 84 (November): 110977.

Electrographic Lead I and V5 Monitoring Could Have Detected a Missed Left-Side Pneumothorax Intraoperatively. Lee, Chihjen, Roya Yumul, Colby Vongchaichinsri, Kevin Tsai, and Lena Wang. Annals of Noninvasive Electrocardiology, Inc, November, e13017.

Biomedical Sciences

Lymphocyte Antigen 6 Complex Locus G6D Downregulation Is a Novel Parameter for Functional Impairment of Neutrophils in Aged Mice. Saito, Suguru, Alato Okuno, Toshio Maekawa, Ryoki Kobayashi, Osamu Yamashita, Noriyuki Tsujimura, Morihiko Inaba, Yasushi Kageyama, and Noriko M. Tsuji. Frontiers in Immunology 13: 1001179.

Mycobiota and Diet-Derived Fungal Xenosiderophores Promote Salmonella Gastrointestinal Colonization. Santus, William, Amisha P. Rana, Jason R. Devlin, Kaitlyn A. Kiernan, Carol C. Jacob, Joshua Tjokrosurjo, David M. Underhill, and Judith Behnsen. Nature Microbiology, November.

Physiological Concentrations of Glucocorticoids Induce Pathological DNA Double-Strand Breaks. Akter, Salma, Akihiro Shimba, Koichi Ikuta, Rasel Al Mahmud, Shintaro Yamada, Hiroyuki Sasanuma, Masataka Tsuda, Masakatsu Sone, Yukio Ago, Kenichi Murai, Hisashi Tanaka, and Shunichi Takeda. Genes to Cells: Devoted to Molecular & Cellular Mechanisms, November.

Cancer

Breast Cancer Liver Metastasis: Pathogenesis and Clinical Implications. Liu, Cuiwei, Srivarshini C. Mohan, Jielin Wei, Ekihiro Seki, Manran Liu, Reva Basho, Armando E. Giuliano, Yanxia Zhao, and Xiaojiang Cui. Frontiers in Oncology 12: 1043771.

DNA Methylation Topology Differentiates Between Normal and Malignant in Cell Models, Resected Human Tissues, and Exfoliated Sputum Cells of Lung Epithelium. Tajbakhsh, Jian, Fariborz Mortazavi, and Nirdesh K. Gupta. Frontiers in Oncology 12: 991120.

Trends in Segmentectomy for the Treatment of Stage 1A Non-Small Cell Lung Cancers: Does the Robot Have an Impact? Leung, Alexander, Akbarshakh Akhmerov, Monica Justo, Abigail Fong, Amirhossein Mahfoozi, Harmik J. Soukiasian, and Taryne A. Imai. American Journal of Surgery, October, S0002-9610(22)00646-8.

ASO Visual Abstract: Surgical Management of the Axilla in Breast Cancer-Evolving but Still Necessary. Schwartz, Theresa, Ashley D. Marumoto, and Armando E. Giuliano. Annals of Surgical Oncology, November.

Updates in Cancer Rehabilitation Telehealth. Chang, Philip, and Jasmine Zheng. Current Physical Medicine and Rehabilitation Reports, November, 1–7.

Filipinos’ Attitudes, Barriers, and Enablers on Colorectal Cancer Screening: Insights From a Qualitative Research Study. Khalil, Carine, Antwon Chaplin, Shenazar Esmundo, Austin Crochetiere, and Christopher V. Almario. Cancer Treatment and Research Communications 33 (November): 100657.

Lifestyle and Personal Factors Associated With Having Macroscopic Residual Disease after Ovarian Cancer Primary Cytoreductive Surgery. Phung, Minh Tung, Penelope M. Webb, Anna DeFazio, Sian Fereday, Alice W. Lee, David D. L. Bowtell, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Beth Y. Karlan, Jenny Lester, Keitaro Matsuo, Francesmary Modugno, James D. Brenton, Toon Van Gorp, Paul D. P. Pharoah, Joellen M. Schildkraut, Karen McLean, Rafael Meza, Bhramar Mukherjee, Jean Richardson, Bronwyn Grout, Anne Chase, Cindy McKinnon Deurloo, Kathryn L. Terry, Gillian E. Hanley, Malcolm C. Pike, Andrew Berchuck, Susan J. Ramus, Celeste Leigh Pearce, and Ovarian Cancer Association Consortium. Gynecologic Oncology 168 (November): 68–75.

N-Glycosylation Regulates Intrinsic IFN-? Resistance in Colorectal Cancer: Implications for Immunotherapy. Krug, Julia, Gabriele Rodrian, Katja Petter, Hai Yang, Svetlana Khoziainova, Wei Guo, Alan Bénard, Susanne Merkel, Susan Gellert, Simone Maschauer, Monika Spermann, Maximilian Waldner, Peter Bailey, Christian Pilarsky, Andrea Liebl, Philipp Tripal, Jan Christoph, Elisabeth Naschberger, Roland Croner, Vera S. Schellerer, Christoph Becker, Arndt Hartmann, Thomas Tüting, Olaf Prante, Robert Grützmann, Sergei I. Grivennikov, Michael Stürzl, and Nathalie Britzen-Laurent. Gastroenterology, November, S0016-5085(22)01294-X.

Early Application of Next-Generation Sequencing Identifies Pancreatic Mass as Metastasis From an EGFR-Mutated Lung Adenocarcinoma. Chen, Luxi, John Davelaar, Srinivas Gaddam, Kambiz Kosari, Nicholas Nissen, George Chaux, Christopher Lee, Eric Vail, Andrew Hendifar, Jun Gong, Karen Reckamp, and Arsen Osipov. Journal of the National Comprehensive Cancer Network: JNCCN, November, 1–6.

In Response to Predicting Pathologic Lymph Node Positivity in CN0 Pharynx and Larynx Cancers. Anderson, Eric, Michael Luu, Allen S. Ho, and Zachary S. Zumsteg. The Laryngoscope, November.

Toxicity Index, Patient-Reported Outcomes, and Persistence of Breast Cancer Chemotherapy-Associated Side Effects in NRG Oncology/NSABP B-30. Henry, N. Lynn, Sungjin Kim, Ron D. Hays, Marcio A. Diniz, Mourad Tighiouart, Gillian Gresham, Michael Luu, Reena S. Cecchini, Greg Yothers, André Rogatko, and Patricia A. Ganz. NPJ Breast Cancer 8 (1): 123.

Identity-Related Experiences of Asian American Trainees in Gynecologic Oncology. Dholakia, Jhalak, Yeon Woo Lee, Karen H. Lu, Warner K. Huh, S. Diane Yamada, Katherine C. Fuh, Amanika S. Kumar, Margaret I. Liang, Navya Nair, and Kenneth H. Kim. Gynecologic Oncology Reports 44 (December): 101097.

The Evolving Landscape of Neuroendocrine Tumors. Russo, Ashley, and Alexandra Gangi. Surgical Oncology Clinics of North America 32 (1): 185–98.

Cardiology

ECGs in Critical Care Cardiology: Do Not Miss That Myocardial Infarction. Chyu, Kuang-Yuh, and Prediman K. Shah. JACC. Case Reports 4 (19): 1297–1305.

Trends in Use of Oral Anticoagulants in Older Adults With Newly Diagnosed Atrial Fibrillation, 2010-2020. Ko, Darae, Kueiyu Joshua Lin, Lily G. Bessette, Su Been Lee, Allan J. Walkey, Susan Cheng, Erin Kim, Robert J. Glynn, and Dae Hyun Kim. JAMA Network Open 5 (11): e2242964.

Electrocardiograms in Critical Care Cardiology: Is It Acute Coronary Syndrome? Chyu, Kuang-Yuh, and Prediman K. Shah. JACC. Case Reports 4 (21): 1394–98.

Considerations for Treatment of Lipid Disorders During Pregnancy and Breastfeeding. Kaur, Gurleen, and Martha Gulati. Progress in Cardiovascular Diseases, November, S0033-0620(22)00113-X.

BA lloon Expandable vs. SElf Expanding Transcatheter VaLve for Degenerated BioprosthesIs: Design and Rationale of the BASELINE Trial. Nuis, Rutger-Jan, Eric van Belle, Rui Teles, Daniel Blackman, Verena Veulemans, Ignacio Amat Santos, Thomas Pilgrim, Giuseppe Tarantini, Francesco Saia, Ioannis Iakovou, Julia Mascherbauer, Flavien Vincent, Marcel Geleijnse, Janarthanan Sathananthan, David Wood, Raj Makkar, Nicolas M. Van Mieghem, and BASELINE Investigators. American Heart Journal, November, S0002-8703(22)00295-2.

Protein Arginine Deiminase 2 (PAD2) Modulates the Polarization of THP-1 Macrophages to the Anti-Inflammatory M2 Phenotype. Stachowicz, Aneta, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman, Jennifer E. Van Eyk, and Justyna Fert-Bober. Journal of Inflammation (London, England) 19 (1): 20.

Atomoxetine for Suppression of Vasovagal Syncope. Sheldon, Robert S., Colette Seifer, Ratika Parkash, Roopinder K. Sandhu, Rasha Hamzeh, and Satish R. Raj. Clinical Autonomic Research, November.

Medicine

Diagnostic and Therapeutic Potential of RNASET2 in Crohn’s Disease: Disease-Risk Polymorphism Modulates Allelic-Imbalance in Expression and Circulating Protein Levels and Recombinant-RNASET2 Attenuates pro-Inflammatory Cytokine Secretion. Biener-Ramanujan, Eva, Florian Rosier, Simon G. Coetzee, Dermot D. P. McGovern, Dennis Hazelett, Stephan R. Targan, and Rivkah Gonsky. Frontiers in Immunology 13.

Novel Approaches in the Treatment of Hansen’s Disease (Leprosy): A Case Series of Multidrug Therapy of Monthly Rifampin, Moxifloxacin, and Minocycline (RMM) in the United States. Franco-Paredes, Carlos, Elizabeth Garcia-Creighton, Andrés Henao-Martínez, Diane L. Kallgren, Rashmi Banjade, Jon A. Dyer, Taylor Nelson, Araya Zaesim, Michael J. Peluso, Vivek Jain, Dong Heun Lee, Lucio R. Minces, Mary Wirshup, Miguel Sierra Hoffman, Jenn Katsolis, Karen Brust, Jose Giron, Lauren Smiarowski, Pauline A. Hoosepian-Mer, and Barbara Stryjewska. Therapeutic Advances in Infectious Disease 9: 20499361221135884.

Personalized Medicine Approaches in Cystic Fibrosis Related Pancreatitis. Mun, Kyu Shik, Jaimie D. Nathan, Anil G. Jegga, Kathryn A. Wikenheiser-Brokamp, Maisam Abu-El-Haija, and Anjaparavanda P. Naren. American Journal of Translational Research 14 (10): 7612–20.

Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease. Yang, Bing, Xi Yang, Xumei Tan, Liqing Lu, Wei Fan, Lucía Barbier-Torres, Justin Steggerda, Ting Liu, and Heping Yang. Canadian Journal of Gastroenterology & Hepatology 2022: 6799414.

Clinical Trials in Pancreatitis: Opportunities and Challenges in the Design and Conduct of Patient-Focused Clinical Trials in Recurrent Acute and Chronic Pancreatitis: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Hart, Phil A., Dana K. Andersen, Erica Lyons, Gregory A. Cote, Zobeida Cruz-Monserrate, Robert H. Dworkin, B. Joseph Elmunzer, Evan L. Fogel, Christopher E. Forsmark, Ian Gilron, Megan Golden, Aysegul Gozu, Lindsay McNair, Stephen J. Pandol, Emily R. Perito, Anna Evans Phillips, Jennifer A. Rabbitts, David C. Whitcomb, John A. Windsor, Dhiraj Yadav, and Tonya M. Palermo. Pancreas 51 (7): 715–22.

Salivary Biomarker Evaluation of Chronic Pancreatitis Patients Reveals Alterations in Human Proteins, Cytokines, Prostaglandin E2 Levels, and Bacterial Diversity. Waldron, Richard T., Elaina K. Jones, Vincent I. Anani, Jolaine M. Hines, Jing Zhao, Aurelia Lugea, Marcio A. Diniz, Sungjin Kim, Aida Habtezion, Kristi L. Hoffman, Joseph F. Petrosino, William E. Fisher, Liang Li, Ryan J. Lennon, Ravinder Jit Singh, Santhi Swaroop Vege, Stephen J. Pandol, and Mark D. Topazian. Pancreas 51 (7): 723–32.

Acute Pancreatitis Precedes Chronic Pancreatitis in the Majority of Patients: Results From the NAPS2 Consortium. Singh, Vikesh K., David C. Whitcomb, Peter A. Banks, Samer AlKaade, Michelle A. Anderson, Stephen T. Amann, Randall E. Brand, Darwin L. Conwell, Gregory A. Cote, Timothy B. Gardner, Andres Gelrud, Nalini Guda, Christopher E. Forsmark, Michele Lewis, Stuart Sherman, Thiruvengadam Muniraj, Joseph Romagnuolo, Xiaoqing Tan, Gong Tang, Bimaljit S. Sandhu, Adam Slivka, C. Mel Wilcox, Dhiraj Yadav, and NAPS Consortium. Pancreatology (IAP), October, S1424-3903(22)00754-2.

Inferior Mesenteric Vein Thrombosis Resulting in Pylephlebitis in a Patient With Inflammatory Bowel Disease. Becker, Erica C., Dheera Grover, Sanket Patel, Purabi Dhakras, and Lisa Rossi. ACG Case Reports Journal 9 (11): e00903.

Quality Improvement Project on the Development of a Management Algorithm for Iatrogenic Perforations and the Long-Term Impact on Physician Knowledge. Lew, Daniel, Yazan Abboud, Suellen M. Picha, Ellis C. Lai, Kenneth H. Park, Stephen J. Pandol, Christopher V. Almario, Simon K. Lo, and Srinivas Gaddam. Endoscopy International Open 10 (11): E1481–90.

Retinal Toxicity in a Multinational Inception Cohort of Patients With Systemic Lupus on Hydroxychloroquine. Almeida-Brasil, Celline C., John G. Hanly, Murray Urowitz, Ann Elaine Clarke, Guillermo Ruiz-Irastorza, Caroline Gordon, Rosalind Ramsey-Goldman, Michelle A. Petri, Ellen M. Ginzler, Daniel J. Wallace, Sang-Cheol Bae, Juanita Romero-Diaz, Mary-Anne Dooley, Christine Peschken, David Isenberg, Anisur Rahman, Susan Manzi, Søren Jacobsen, S. Sam Lim, Ronald van Vollenhoven, Ola Nived, Andreas Jönsen, Diane L. Kamen, Cynthia Aranow, Jorge Sánchez-Guerrero, Dafna D. Gladman, Paul R. Fortin, Graciela S. Alarcon, Joan T. Merrill, Kenneth Kalunian, Manuel Ramos-Casals, Kristjan Steinsson, A. Zoma, Anca D. Askanase, Munther Khamashta, Ian N. Bruce, Murat Inanc, Luck Lukusa, and Sasha Bernatsky. Lupus Science & Medicine 9 (1): e000789.

Marketing Malaria Control: Nets, Neoliberalism, and a New Approach to Fighting Malaria. Moore-Sheeley, Kirsten. Social History of Medicine, November, hkac056.

Abdominal Bloating in the US: Results of a Survey of 88,795 Americans Examining Prevalence and Healthcare Seeking. Oh, Janice E., William D. Chey, and Brennan Spiegel. Clinical Gastroenterology and Hepatology, November, S1542-3565(22)01020-5.

Digital Tools Designed to Obtain the History of Present Illness From Patients: Scoping Review. Berdahl, Carl T., Andrew J. Henreid, Joshua M. Pevnick, Kai Zheng, and Teryl K. Nuckols. Journal of Medical Internet Research 24 (11): e36074.

The Effects of FTO Gene Rs9939609 Polymorphism on the Association Between Breast Cancer and Dietary Intake. Doaei, Saeid, Sepideh Abdollahi, Golsa Khalatbari Mohseni, Maryam Gholamalizadeh, Mohammad Esmail Akbari, Seyed Mohammad Poorhosseini, Seyedeh Elaheh Bagheri, Soudeh Ghafouri-Fard, Ghasem Azizi Tabesh, Alireza Moslem, Naeemeh Hasanpour Ardekanizadeh, Saeed Omidi, Azita Hekmatdoost, Mahdi Alam Rajabi, Seyed Alireza Mosavi Jarrahi, and Mark O. Goodarzi. Journal of Cellular and Molecular Medicine, November.

A Reduced Pancreatic Polypeptide Response Is Associated With New Onset Pancreatogenic Diabetes versus Type 2 Diabetes. Hart, Phil A., Yogish C. Kudva, Dhiraj Yadav, Dana K. Andersen, Yisheng Li, Frederico G. S. Toledo, Fuchenchu Wang, Melena D. Bellin, David Bradley, Randall E. Brand, Kenneth Cusi, William Fisher, Kieren Mather, Walter G. Park, Zeb Saeed, Robert V. Considine, Sarah C. Graham, Jo Ann Rinaudo, Jose Serrano, and Mark O. Goodarzi. The Journal of Clinical Endocrinology and Metabolism, November, dgac670.

Neurology

Prone Positioning Reduces Frontal and Hippocampal Neuronal Dysfunction in a Murine Model of Ventilator-Induced Lung Injury. Sparrow, Nicklaus A., Gena Guidry, Faizan Anwar, Sonja Darwish, Scott A. Kelly, S. Ananth Karumanchi, and Shouri Lahiri. Frontiers in Medicine 9: 987202.

Orthopaedics

Reduced Costs, Complications, and Length of Stay After Arthroscopic Versus Open Irrigation and Débridement for Knee Septic Arthritis. Upfill-Brown, Alexander, Brendan Shi, Matthew Carter, Carlos Maturana, Dane Brodke, Akash A. Shah, Peter Hsiue, Christos Photopoulos, Christopher Lee, and Alexandra Stavrakis. The Journal of the American Academy of Orthopaedic Surgeons 30 (23): e1515–25.

Pathology

Bortezomib May Be an Effective Treatment for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. Akgun, Yamac. Medical Hypotheses 168 (November): 110972.

Current Understanding of ‘Mixed Corticomedullary Adrenal Tumor’ and an Insight into Genomic Profiling. Ullah, Asad, Farah Ayman Elsaid Mohamed, Jaffar Khan, Katharine Tracy, Muhabat Khan, Samiha Mohsen, Abdul Qahar Khan Yasinzai, Kaleemullah Badini, Philip T. Sobash, Saleh Heneidi, and Nagla Abdel Karim. Clinics and Practice 12 (6): 918–25.

The Impact of Carbamylation and Anemia on HbA1c’s Association With Renal Outcomes in Patients With Diabetes and Chronic Kidney Disease. Tang, Mengyao, Anders Berg, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, and Sahir Kalim. Diabetes Care, November, dc221399.

MYC-Nonamplified Secondary Lymphatic-Type Angiosarcoma With Prominent Lymphocytic Infiltrate Following Radiation Therapy for Myxoid Liposarcoma. Krajisnik, Andrea, Bonnie L. Balzer, Eric Vail, Earl Brien, and Wonwoo Shon. The American Journal of Dermatopathology 44 (12): 955–57.

Radiation Oncology

CD8+ T-Cell Immune Escape by SARS-CoV-2 Variants of Concern. Kombe Kombe, Arnaud John, Fleury Augustin Nsole Biteghe, Zélia Nelly Ndoutoume, and Tengchuan Jin. Frontiers in Immunology 13: 962079.

Surgery

Role of ROR2 in Promoting Gastric Cancer Metastasis by Enhancing C-JUN-Mediated MMP3 Transcription. Ge, Xiaoxiao, Fengjuan Lin, Zheng Wu, Ying Lin, Wenbo Tang, Michael J. McKay, Arvind Sahu, Leonardo S. Lino-Silva, Joshua Tseng, and Jin Li. Annals of Translational Medicine 10 (20): 1117.

Impact of Postoperative Telemedicine Visit Versus In-Person Visit on Patient Satisfaction: A Randomized Clinical Trial. Yao, Lucille Y., Phillip R. Fleshner, and Karen N. Zaghiyan. Surgery, November, S0039-6060(22)00848-0.

Blunt Pancreatic Trauma: A Western Trauma Association Critical Decisions Algorithm. Moren, Alexis M., Walter L. Biffl, Chad G. Ball, Marc de Moya, Karen J. Brasel, Carlos V. R. Brown, Jennifer L. Hartwell, Kenji Inaba, Eric J. Ley, Ernest E. Moore, Kimberly A. Peck, Anne G. Rizzo, Nelson G. Rosen, Jason L. Sperry, Jordan A. Weinberg, Raul S. Coimbra, David V. Shatz, and Matthew J. Martin. The Journal of Trauma and Acute Care Surgery, November.

Streptomyces Spiramenti Sp. Nov., Isolated From a Deep-Sea Microbial Mat. Loughran, Rachel M., Caitlin M. Diefendorf, Jassmine R. Reill-VanSise, Edward A. Mitchell, Oliver B. Vining, David A. Gallegos, Gregory Miller, Marc J. Koyack, David K. Oline, Orion S. Rivers, Blake Ushijima, Jimmy H. Saw, Michael O. Gaylor, Kerry L. McPhail, and Patrick Videau. Archives of Microbiology 204 (12): 717.

The Surgical Management of Ileal Pouch Strictures. Aviran, Eyal, Karen Zaghiyan, and Phillip Fleshner. Diseases of the Colon and Rectum 65 (S1): S105–12.