This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published May 25-June1.

Anesthesiology

Comparison Analysis of Safety Outcomes and the Rate of Subsequent Spinal Procedures Between Interspinous Spacer Without Decompression Versus Minimally Invasive Lumbar Decompression. Rosner, Howard L., Oth Tran, Tina Vajdi, and Mary A. Vijjeswarapu. Regional Anesthesia and Pain Medicine, May, rapm-2022-104236.

Biomedical Sciences

The Fatty Liver, Cirrhosis, and Liver Cancer Study (TENDENCY): Protocol for a Multicenter Case-Control Study. Hussain, Yaqza, Ayman Bannaga, Neil Fisher, Ashwin Krishnamoorthy, Peter Kimani, Ahmad Malik, Maria Truslove, Shivam Joshi, Megan Hitchins, Abdullah Abbasi, Christopher Corbett, Matthew Brookes, Harpal Randeva, Nwe Ni Than, and Ramesh P. Arasaradnam. JMIR Research Protocols 12 (May): e44264.

Direct Synthesis of Multi-Contrast Brain MR Images From MR Multitasking Spatial Factors Using Deep Learning. Qiu, Shihan, Sen Ma, Lixia Wang, Yuhua Chen, Zhaoyang Fan, Franklin G. Moser, Marcel Maya, Pascal Sati, Nancy L. Sicotte, Anthony G. Christodoulou, Yibin Xie, and Debiao Li. Magnetic Resonance in Medicine, May.

Cardiology

A Vision for the Future of Quality in Echocardiographic Reporting: The American Society of Echocardiography ImageGuideEcho Registry, Current and Future States. Nagueh, Sherif F., Allan L. Klein, Marielle Scherrer-Crosbie, Nowell M. Fine, James N. Kirkpatrick, Daniel E. Forsha, Alina Nicoara, G. Burkhard Mackensen, Peter L. Tilkemeier, Rami Doukky, Baljash Cheema, Srinath Adusumalli, Jeffrey C. Hill, Varsha K. Tanguturi, David Ouyang, Sarah Beth Bdoyan, and Jordan B. Strom. Journal of the American Society of Echocardiography, May, S0894-7317(23)00250-X.

Impact of Statins Based on High-Risk Plaque Features on Coronary Plaque Progression in Mild Stenosis Lesions: Results From the PARADIGM Study. Park, Hyung-Bok, Reza Arsanjani, Ji Min Sung, Ran Heo, Byoung Kwon Lee, Fay Y. Lin, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro de Araújo Gonçalves, Jonathon A. Leipsic, Sang-Eun Lee, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Peter H. Stone, Daniel S. Berman, Jagat Narula, Leslee J. Shaw, Jeroen J. Bax, James K. Min, and Hyuk-Jae Chang. European Heart Journal. Cardiovascular Imaging, May, jead110.

Deep Learning-Based Electrocardiographic Screening for Chronic Kidney Disease. Holmstrom, Lauri, Matthew Christensen, Neal Yuan, J. Weston Hughes, John Theurer, Melvin Jujjavarapu, Pedram Fatehi, Alan Kwan, Roopinder K. Sandhu, Joseph Ebinger, Susan Cheng, James Zou, Sumeet S. Chugh, and David Ouyang. Communications Medicine 3 (1): 73.

Impact of Donor Hemodynamics on Recipient Survival in Heart Transplantation. Fu, Sheng, Chakradhari Inampudi, Bhavadharini Ramu, Mathew J. Gregoski, Jessica Atkins, Gregory R. Jackson, Amanda Celia, Jan M. Griffin, Daniel N. Silverman, Daniel P. Judge, Adrian B. Van Bakel, Lucas J. Witer, Arman Kilic, Brian A. Houston, Andrew J. Sauer, Michelle M. Kittleson, Kelly H. Schlendorf, Rebecca J. Cogswell, and Ryan J. Tedford. Journal of Cardiac Failure, May, S1071-9164(23)00186-0.

Computational Biomedicine

The Promise of AI and Technology to Improve Quality of Life and Care for Older Adults. Abadir, Peter M., Rama Chellappa, Niteesh Choudhry, George Demiris, Deepak Ganesan, Jason Karlawish, Rose M. Li, Jason H. Moore, Jeremy D. Walston, and Directors & Advisors of the AITCs. Nature Aging, May.

Is Low-Risk Status a Surrogate Outcome in Pulmonary Arterial Hypertension? An Analysis of Three Randomised Trials. Blette, Bryan S., Jude Moutchia, Nadine Al-Naamani, Corey E. Ventetuolo, Chao Cheng, Dina Appleby, Ryan J. Urbanowicz, Jason Fritz, Jeremy A. Mazurek, Fan Li, Steven M. Kawut, and Michael O. Harhay. The Lancet. Respiratory Medicine, May, S2213-2600(23)00155-8.

Imaging

When Does a Calcium Score Equates to Secondary Prevention?: Insights From the Multinational CONFIRM Registry. Budoff, Matthew J., April Kinninger, Heidi Gransar, Stephan Achenbach, Mouaz Al-Mallah, Jeroen J. Bax, Daniel S. Berman, Filippo Cademartiri, Tracy Q. Callister, Hyuk-Jae Chang, Benjamin J. W. Chow, Ricardo C. Cury, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Jonathon Leipsic, Fay Y. Lin, Yong-Jin Kim, Hugo Marques, Gianluca Pontone, Ronen Rubinshtein, Leslee J. Shaw, Todd C. Villines, James K. Min, and CONFIRM Investigators. JACC. Cardiovascular Imaging, April, S1936-878X(23)00151-1.

Medicine

Deceased Donor Kidney Nonuse: A Systematic Approach to Improvement. Bunnapradist, Suphamai, J. Thomas Rosenthal, Edmund Huang, Donald Dafoe, Tom Seto, Aaron Cohen, and Gabriel Danovitch. Transplantation Direct 9 (6): e1491.

The Application of GPT-4 in Patient Education and Healthcare Delivery. Yeo, Yee Hui, Jamil S. Samaan, and Wee Han Ng. Clinical and Molecular Hepatology, May.

Navigating Ethical Challenges in AI Application for Healthcare: Developers and Users in Focus.  Yeo, Yee Hui, Jamil S. Samaan, and Wee Han Ng. Clinical and Molecular Hepatology, May.

Efficacy and Safety of Tirzepatide for Treatment of Overweight or Obesity. A Systematic Review and Meta-Analysis. Tan, Bryan, Xin-Hui Pan, Han Shi Jocelyn Chew, Rachel Sze Jen Goh, Chaoxing Lin, Vickram Vijay Anand, Ethan Cheng Zhe Lee, Kai En Chan, Gwyneth Kong, Christen En Ya Ong, Hui Charlotte Chung, Dan Yock Young, Mark Y. Chan, Chin Meng Khoo, Anurag Mehta, Mark Dhinesh Muthiah, Mazen Noureddin, Cheng Han Ng, Nicholas W. S. Chew, and Yip Han Chin. International Journal of Obesity (2005), May.

Dementia and Electronic Health Record Phenotypes: A Scoping Review of Available Phenotypes and Opportunities for Future Research. Walling, Anne M., Joshua Pevnick, Antonia V. Bennett, V. G. Vinod Vydiswaran, and Christine S. Ritchie. Journal of the American Medical Informatics Association: JAMIA, May, ocad086.

A Genetic Locus Within the FMN1/GREM1 Gene Region Interacts With Body Mass Index in Colorectal Cancer Risk. Aglago, Elom K., Andre E. Kim, Yi Lin, Conghui Qu, Marina Evangelou, Yu Ren, John Morrison, Demetrius Albanes, Volker Arndt, Elizabeth L. Barry, James W. Baurley, Sonja I. Berndt, Peter T. Campbell, et al. Cancer Research, May, CAN-22-3713.

Protein Biomarkers of Disease Progression in Patients With Systemic Sclerosis Associated Interstitial Lung Disease. Cerro-Chiang, Giuliana, Matthew Ayres, Alejandro Rivas, Tahmineh Romero, Sarah J. Parker, Mitra Mastali, David Elashoff, Peter Chen, Jennifer E. Van Eyk, Paul J. Wolters, Francesco Boin, and Tanzira Zaman. Scientific Reports 13 (1): 8645.

Maladaptive TGF-? Signals to the Alveolar Epithelium Drive Fibrosis After COVID-19 Infection. Yao, Changfu, Tanyalak Parimon, Milena S. Espindola, Miriam S. Hohmann, Bindu Konda, Cory M. Hogaboam, Barry R. Stripp, and Peter Chen. American Journal of Respiratory and Critical Care Medicine, May.

Role of Mitochondria in the Myopathy of Juvenile Dermatomyositis and Implications for Skeletal Muscle Calcinosis. Duvvuri, Bhargavi, Lauren M. Pachman, Payton Hermanson, Ting Wang, Richard Moore, Dennis Ding-Hwa Wang, Aaron Long, Gabrielle A. Morgan, Stephen Doty, Rong Tian, Yasemin Sancak, and Christian Lood. Journal of Autoimmunity 138 (May): 103061.

POLE-Mutant Colon Cancer Treated With PD-1 Blockade Showing Clearance of Circulating Tumor DNA and Prolonged Disease-Free Interval. Bikhchandani, Mihir, Farin Amersi, Andrew Hendifar, Alexandra Gangi, Arsen Osipov, Karen Zaghiyan, Katelyn Atkins, May Cho, Francesca Aguirre, Dennis Hazelett, Rocio Alvarez, Lisa Zhou, Megan Hitchins, and Jun Gong. Genes 14 (5): 1054.

Combination L-Glutamine with Gemcitabine and Nab-Paclitaxel in Treatment-Naïve Advanced Pancreatic Cancer: The Phase I GlutaPanc Study Protocol. Gong, Jun, Arsen Osipov, Jeremy Lorber, Mourad Tighiouart, Albert K. Kwan, Hayato Muranaka, Rasaq Akinsola, Sandrine Billet, Abrahm Levi, Anser Abbas, John Davelaar, Neil Bhowmick, and Andrew E. Hendifar. Biomedicines 11 (5): 1392.

Experimental Workflow for Preclinical Studies of Human Antifibrotic Therapies. Reolizo, Lien, Michitaka Matsuda, and Ekihiro Seki. Methods in Molecular Biology (Clifton, N.J.) 2669: 285–306.

An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management. Khallouki, Farid, Lhoussain Hajji, Somayya Saber, Toufik Bouddine, Mouad Edderkaoui, Mohammed Bourhia, Nora Mir, Adrian Lim, Adil El Midaoui, John P. Giesy, Mourad A. M. Aboul-Soud, Sandrine Silvente-Poirot, and Marc Poirot. Journal of Personalized Medicine 13 (5): 754.

Neurology

Symptomatic Intracranial Hemorrhage With Tenecteplase vs Alteplase in Patients With Acute Ischemic Stroke: The Comparative Effectiveness of Routine Tenecteplase vs Alteplase in Acute Ischemic Stroke (CERTAIN) Collaboration. Warach, Steven J., Anna Ranta, Joosup Kim, Shlee S. Song, Adam Wallace, James Beharry, Daniel Gibson, Dominique A. Cadilhac, Christopher F. Bladin, Timothy J. Kleinig, Jackson Harvey, Logesh Palanikumar, Vinodh T. Doss, Ruth Marescalco, John N. Fink, Alicia Tyson, Konrad H. Schlick, Lydia Noh, Duncan Wilson, Sonia Figueroa, Marco A. Pech, Laurie B. Paletz, Maya K. Lewis, Marissa Castro, Daniel H. Sahlein, E. Frank Lafranchise, Justin Sandall, Kaiz S. Asif, Scott R. Geraghty, Paul A. Cullis, Tim Malisch, Terry A. Neill, Marian P. LaMonte, Bruce C. V. Campbell, and Teddy Y. Wu. JAMA Neurology, May, e231449.

Endoscopic Third Ventriculostomy in a 12-Year-Old with Recurrent Failure of Ventriculoperitoneal Shunts. Dhiman, Monica, Fahim Soukhak, and Jonathan Eskenazi. Cureus 15 (4): e38270.

Nursing

Recognizing and Reducing Delirium in the Intensive Care Unit. Dechant, Thomas, Lauren Smith, and Jose Chavez. Critical Care Nursing Quarterly 46 (3): 277–81.

OBGYN

E. Faecalis Sepsis and Asherman’s Syndrome as Complications of Sonata System Transcervical Fibroid Ablation. Hirsch, Anna M., Yaniv R. Raphael, and Matthew T. Siedhoff. Journal of Minimally Invasive Gynecology, May, S1553-4650(23)00202-9.

Remote Patient Monitoring for Postpartum Hypertensive Disorders of Pregnancy. Spiro, Leah, C. Noel Bairey Merz, Natalie Bello, Sarah Kilpatrick, Margo Minissian, and Janet Wei. Obstetrics & Gynecology 141 (5S): 68S.

Late-Onset Severe Fetal Growth Restriction and Isolated Severely Small Abdominal Circumference: Do Neonatal Outcomes Differ? Hirsch, Anna, Laura Ha, and Mariam Naqvi. Obstetrics & Gynecology 141 (5S): 32S.

Racial Differences in Activity Restriction Recommendations in Pregnancy. Ha, Laura, C. Noel Bairey Merz, Natalie Bello, Anna Hirsch, Sarah Kilpatrick, and Mariam Naqvi. Obstetrics & Gynecology 141 (5S): 76S.

Orthopaedics

Using Bookmarking Methods With Orthopedic Clinicians and Patients With Fractures Produces Score Interpretation Labels for Patient-Reported Outcome Measures. Rothrock, Nan E., Sandra A. Wilson, Marilyn Heng, Aleksandra Hodor, Alexander Joeris, Aaron J. Kaat, Karma McKelvey, Benjamin D. Schalet, and Mark Vrahas. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, May.

Microbial Colonization of Capsular Traction Sutures in Hip Arthroscopic Surgery. Patten, Ian S., Yuhang Sun, David R. Maldonado, Michael S. Lee, and Michael B. Banffy. Orthopaedic Journal of Sports Medicine 11 (5): 23259671231166704.

Pathology

Cross-Sectional Study Examining Household Factors Associated with SARS-CoV-2 Seropositivity in Low-Income Children in Los Angeles. Doctor, Jason N., Anders H. Berg, Tara K. Knight, Mika Kadono, Emily Stewart, Rajan Sonik, Michael Hochman, and Neeraj Sood. BMJ Open 13 (5): e070291.

Primary Cardiac Sarcoma: Demographics, Genomic Study Correlation, and Survival Benefits of Surgery With Adjuvant Therapy in U.S. Population. Khan, Rozi, Kathryn I. Sunthankar, Abdul Qahar Khan Yasinzai, Bisma Tareen, Muhammad Samsoor Zarak, Jaffar Khan, Hassan Nasir, Manando Nakasaki, Eiman Jahangir, Saleh Heneidi, and Asad Ullah. Clinical Research in Cardiology, May.

Current Clinical Practices and Challenges in Molecular Testing: A GOAL Consortium Hematopathology Working Group Report. Lee, Thomas D., Dara L. Aisner, Marjorie Parker David, Celeste C. Eno, Jeffrey Gagan, Christopher D. Gocke, Natalya V. Guseva, Lisa Haley, Audrey N. Jajosky, Daniel Jones, Mahesh M. Mansukhani, Pawel Mroz, Sarah S. Murray, Kimberly J. Newsom, Vera Ashley Paulson, Somak Roy, Chase Rushton, Jeremy P. Segal, T. Niroshini Senaratne, Alexa J. Siddon, Petr Starostik, Jessica A. G. Van Ziffle, David Wu, Rena R. Xian, Sophia Yohe, and Annette S. Kim. Blood Advances, May, bloodadvances.2023010149.

Gene Expression Profiling of Fibroepithelial Lesions of the Breast. Li, Xiaomo, Eric Vail, Horacio Maluf, Manita Chaum, Matthew Leong, Joseph Lownik, Mingtian Che, Armando Giuliano, Duoyao Cao, and Farnaz Dadmanesh. International Journal of Molecular Sciences 24 (10): 9041.

Surgery

CD24 Targeting With NK-CAR Immunotherapy in Testis, Prostate, Renal and (Luminal-Type) Bladder Cancer and Identification of Direct CD24 Interaction Partners. Söhngen, Christian, David J. Thomas, Margaretha A. Skowron, Felix Bremmer, Markus Eckstein, Anja Stefanski, Marc D. Driessen, Gamal A. Wakileh, Kai Stühler, Peter Altevogt, Dan Theodorescu, Rüdiger Klapdor, Axel Schambach, and Daniel Nettersheim. The FEBS Journal, May.

Association of Tumor Cell Metabolic Subtype and Immune Response With the Clinical Course of Hepatocellular Carcinoma. Wei, Xiaolin, Theodoros Michelakos, Qian He, Xianxing Wang, Yu Chen, Filippos Kontos, Huaizhi Wang, Xiangde Liu, Hui Liu, Wenjing Zheng, Soldano Ferrone, Yun Zhang, Cristina R. Ferrone, Xiaowu Li, and Lei Cai. The Oncologist, May, oyad113.