This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published May 18-25.

Biomedical Sciences

Sorry, But the Ethicist Said Your Life Isn’t Actually Worth Living: Misunderstanding Ethics and the Role of the Ethics Consultant. Kondrat, Andy. The American Journal of Bioethics: AJOB 23 (6): 24–27.

Macrophage Angiotensin-Converting Enzyme (ACE) Reduces Atherosclerosis by Increasing PPAR? and Fundamentally Changing Lipid Metabolism. Cao, DuoYao, Zakir Khan, Xiaomo Li, Suguru Saito, Ellen A. Bernstein, Aaron R. Victor, Faizan Ahmed, Aoi O. Hoshi, Luciana C. Veiras, Tomohiro Shibata, Mingtian Che, Lei Cai, Ryan E. Temel, Jorge F. Giani, Daniel J. Luthringer, Ajit S. Divakaruni, Derick Okwan-Duodu, and Kenneth E. Bernstein. Cardiovascular Research, May, cvad082.

Mitofusin 1 Overexpression Rescues the Abnormal Mitochondrial Dynamics Caused by the Mitofusin 2 K357T Mutation in Vitro. Stavropoulos, Filippos, Elena Georgiou, Natasa Schiza, Shaughn Bell, Robert H. Baloh, Kleopas A. Kleopa, and Irene Sargiannidou. Journal of the Peripheral Nervous System: JPNS, May.

Dapagliflozin Prevents Abdominal Visceral and Subcutaneous Adipose Tissue Dysfunction in the Insulin-Resistant Canine Model. Kabir, Morvarid, Richard N. Bergman, Jay Porter, Darko Stefanovski, Rebecca L. Paszkiewicz, Francesca Piccinini, Orison O. Woolcott, HsiuChiung Yang, V. Sashi Gopaul, Linsey Stiles, and Cathryn M. Kolka. Obesity (Silver Spring, Md.), May.

Selenomonas Sputigena Acts as a Pathobiont Mediating Spatial Structure and Biofilm Virulence in Early Childhood Caries. Cho, Hunyong, Zhi Ren, Kimon Divaris, Jeffrey Roach, Bridget M. Lin, Chuwen Liu, M. Andrea Azcarate-Peril, Miguel A. Simancas-Pallares, Poojan Shrestha, Alena Orlenko, Jeannie Ginnis, Kari E. North, Andrea G. Ferreira Zandona, Apoena Aguiar Ribeiro, Di Wu, and Hyun Koo. Nature Communications 14 (1): 2919.

Associations Between Mother’s Depressive Symptoms during Pregnancy and Newborn’s Brain Functional Connectivity. Na, Xiaoxu, Charles M. Glasier, Aline Andres, Jayne Bellando, Haitao Chen, Wei Gao, Luke W. Livingston, Thomas M. Badger, and Xiawei Ou. Cerebral Cortex (New York, N.Y.: 1991), May, bhad176.

Applying a Radiation Therapy Volume Analysis Pipeline to Determine the Utility of Spectroscopic MRI-Guided Adaptive Radiation Therapy for Glioblastoma. Trivedi, Anuradha G., Su Hyun Kim, Karthik K. Ramesh, Alexander S. Giuffrida, Brent D. Weinberg, Eric A. Mellon, Lawrence R. Kleinberg, Peter B. Barker, Hui Han, Hui-Kuo G. Shu, Hyunsuk Shim, and Eduard Schreibmann. Tomography (Ann Arbor, Mich.) 9 (3): 1052–61.

Cardiac Surgery

How Times Have Changed; a Contemporary Perspective on a Long-Term Study of Thoracoscopic Surgical Ablation. Sertic, Federico, and Armin Kiankhooy. The Annals of Thoracic Surgery, May, S0003-4975(23)00503-9.

Cardiology

Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives. Ni, Hanyu, Elizabeth Jordan, Daniel D. Kinnamon, Jinwen Cao, Garrie J. Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A. Ewald, Alanna A. Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia Garg, Barry H. Trachtenberg, Palak Shah, Salpy V. Pamboukian, Nancy K. Sweitzer, Matthew T. Wheeler, Jane E. Wilcox, Stuart Katz, Stephen Pan, Javier Jimenez, Daniel P. Fishbein, Frank Smart, Jessica Wang, Stephen S. Gottlieb, Daniel P. Judge, Charles K. Moore, Gordon S. Huggins, Ray E. Hershberger, and DCM Precision Medicine Study of the DCM Consortium. Journal of the American College of Cardiology 81 (21): 2059–71.

Trends in Ambulatory Blood Pressure Monitoring in Five High-Volume Medical Centers. Juraschek, Stephen P., Natalie A. Bello, Alexander R. Chang, Jennifer L. Cluett, Karen Griffin, Alan Hinderliter, Kenneth Mukamal, Long Ngo, Ruth-Alma N. Turkson-Ocran, Raven Voora, and Wanpen Vongpatanasin. Hypertension (Dallas, Tex.: 1979), May.

Safety and Efficacy of Empagliflozin and Diuretic Use in Patients With Heart Failure and Preserved Ejection Fraction: A Post Hoc Analysis of the EMPEROR-Preserved Trial. Butler, Javed, Muhammad Shariq Usman, Gerasimos Filippatos, João Pedro Ferreira, Michael Böhm, Martina Brueckmann, James L. Januzzi, Sanjay Kaul, Ileana L. Piña, Piotr Ponikowski, Michele Senni, Mikhail Sumin, Subodh Verma, Liliana Zaremba-Pechmann, Stuart J. Pocock, Milton Packer, and Stefan Anker. JAMA Cardiology, May.

Transcatheter Mitral Valve Repair for Degenerative Mitral Regurgitation. Makkar, Raj R., Joanna Chikwe, Tarun Chakravarty, Qiudong Chen, Patrick T. O’Gara, Marc Gillinov, Michael J. Mack, Andrew Vekstein, Dhairya Patel, Amanda Lee Stebbins, Annetine C. Gelijns, Moody Makar, Deepak L. Bhatt, Samir Kapadia, Sreekanth Vemulapalli, and Martin B. Leon. JAMA 329 (20): 1778–88.

Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study. Miller, Eliza C., Anni Kauko, Sarah E. Tom, Hannele Laivuori, Teemu Niiranen, Natalie A. Bello, and FinnGen Investigators. Stroke, May.

Impact of High Implantation of Transcatheter Aortic Valve on Subsequent Conduction Disturbances and Coronary Access. Ochiai, Tomoki, Futoshi Yamanaka, Koki Shishido, Noriaki Moriyama, Ikki Komatsu, Hiroaki Yokoyama, Hirokazu Miyashita, Daisuke Sato, Yoichi Sugiyama, Takahiro Hayashi, Takayoshi Yamashita, Kazuki Tobita, Takashi Matsumoto, Shingo Mizuno, Yutaka Tanaka, Masato Murakami, Saeko Takahashi, Raj Makkar, and Shigeru Saito. JACC. Cardiovascular Interventions 16 (10): 1192–1204.

Effects of Elective Coronary Revascularization vs Medical Therapy Alone on Noncardiac Mortality: A Meta-Analysis. Navarese, Eliano P., Alexandra J. Lansky, Michael E. Farkouh, Klaudyna Grzelakowska, Marc P. Bonaca, Diana A. Gorog, Paolo Raggi, Malte Kelm, Brandon Yeo, Julia Umi?ska, Nick Curzen, Jacek Kubica, William Wijns, and Dean J. Kereiakes. JACC. Cardiovascular Interventions 16 (10): 1144–56.

Contemporary Use of Sodium-Glucose Cotransporter-2 Inhibitor Therapy Among Patients Hospitalized for Heart Failure With Reduced Ejection Fraction in the US: The Get With the Guidelines-Heart Failure Registry. Pierce, Jacob B., Muthiah Vaduganathan, Gregg C. Fonarow, Uchechukwu Ikeaba, Karen Chiswell, Javed Butler, Adam D. DeVore, Paul A. Heidenreich, Joanna C. Huang, Michelle M. Kittleson, Karen E. Joynt Maddox, Karthik K. Linganathan, James J. McDermott, Anjali Tiku Owens, Pamela N. Peterson, Scott D. Solomon, Orly Vardeny, Clyde W. Yancy, and Stephen J. Greene. JAMA Cardiology, May, e231266.

Left Bundle Branch Area Pacing Versus Biventricular Pacing as Initial Strategy for Cardiac Resynchronization. Diaz, Juan Carlos, William H. Sauer, Mauricio Duque, Bruce A. Koplan, Eric D. Braunstein, Jorge Eduardo Marín, Julian Aristizabal, Cesar Daniel Niño, Oriana Bastidas, Juan Manuel Martinez, Carolina Hoyos, Carlos D. Matos, Nestor Lopez-Cabanillas, Nathaniel A. Steiger, Sunil Kapur, Thomas M. Tadros, David T. Martin, Paul C. Zei, Usha B. Tedrow, and Jorge E. Romero. JACC. Clinical Electrophysiology, May, S2405-500X(23)00268-2.

Temporal Trends in Incidence and Survival from Sudden Cardiac Arrest Manifesting with Shockable and Nonshockable Rhythms: A 16-Year Prospective Study in a Large US Community. Holmstrom, Lauri, Harpriya Chugh, Audrey Uy-Evanado, Jonathan Jui, Kyndaron Reinier, and Sumeet S. Chugh. Annals of Emergency Medicine, May, S0196-0644(23)00269-X.

Beta 2-Microglobulin: Case Report of a Rare Cause of Cardiac Amyloidosis. Haslett, Jack J., Jignesh K. Patel, and Michelle M. Kittleson. European Heart Journal. Case Reports 7 (5): ytad239.

Imaging

Diagnostic Accuracy of Bone Scintigraphy Imaging for Transthyretin Cardiac Amyloidosis: Systematic Review and Meta-Analysis. Ahluwalia, Nanki, Golnaz Roshankar, Logan Draycott, Victor Jimenez-Zepeda, Nowell Fine, Denise Chan, Donghee Han, and Robert J. H. Miller. Journal of Nuclear Cardiology, May.

Medicine

Effectiveness of HCC Surveillance Programs Using Multitarget Blood Test: A Modeling Study. Chhatwal, Jagpreet, Sumeyye Samur, Ju Dong Yang, Lewis R. Roberts, Mindie H. Nguyen, A. Burak Ozbay, Turgay Ayer, Neehar D. Parikh, and Amit G. Singal. Hepatology Communications 7 (6): e0146.

American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Chang, Lin, William D. Chey, Aamer Imdad, Christopher V. Almario, Adil E. Bharucha, Susan Diem, Katarina B. Greer, Brian Hanson, Lucinda A. Harris, Cynthia Ko, M. Hassan Murad, Amit Patel, Eric D. Shah, Anthony J. Lembo, and Shahnaz Sultan. Gastroenterology 164 (7): 1086–1106.

Folate Intake and Ovarian Cancer Risk among Women With Endometriosis: A Case-Control Study From the Ovarian Cancer Association Consortium. Gersekowski, Kate, Torukiri I. Ibiebele, Jennifer A. Doherty, Holly R. Harris, Marc T. Goodman, Kathryn L. Terry, Anna H. Wu, Elisa V. Bandera, Bo Qin, Jue-Sheng Ong, Jonathan P. Tyrer, Suzanne C. Dixon-Suen, Francesmary Modugno, Harvey A. Risch, and Penelope M. Webb. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, May, EPI-23-0121.

Magnetic Resonance Elastography-Based Prediction Model for Hepatic Decompensation in NAFLD; a Multi-Center Cohort Study. Kim, Beom Kyung, Jaclyn Bergstrom, Rohan Loomba, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Emily Truong, Ju Dong Yang, Mazen Noureddin, Alina M. Allen, Rohit Loomba, and Veeral Ajmera. Hepatology (Baltimore, Md.), May.

Content Validation of a Daily Patient-Reported Outcome Measure for Assessing Symptoms in Patients With Small Intestinal Bacterial Overgrowth. Durgam, Neha, Ankur A. Dashputre, Olga Moshkovich, Ali Rezaie, Nicholas Martinez, Pedram Enayati, James Stansbury, and George Joseph. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, May.

Systemic Lupus Erythematosus Women With Lupus Nephritis in Pregnancy Therapeutic Challenge (SWITCH): The Systemic Lupus International Collaborating Clinics Experience. Lee, Joo-Young E., Arielle Mendel, Anca Askanase, Sang-Cheol Bae, Jill P. Buyon, Ann Elaine Clarke, Nathalie Costedoat-Chalumeau, Paul R. Fortin, Dafna D. Gladman, Rosalind Ramsey-Goldman, John G. Hanly, Murat Inanç, David Alan Isenberg, Anselm Mak, Marta Mosca, Michelle Petri, Anisur Rahman, Jorge Sanchez-Guerrero, Murray Urowitz, Daniel J. Wallace, Sasha Bernatsky, and Évelyne Vinet. Annals of the Rheumatic Diseases, May, ard-2023-224197.

Prognostic Value of Circulating Mitochondrial DNA in Prostate Cancer and Underlying Mechanism. Borah, Supriya, Rajeev Mishra, Sananda Dey, Surabhi Suchanti, Neil A. Bhowmick, Biplab Giri, and Subhash Haldar. Mitochondrion, May, S1567-7249(23)00041-7.

Patients With Inflammatory Bowel Diseases and Higher Visceral Adipose Tissue Burden May Benefit from Higher Infliximab Concentrations to Achieve Remission. Yarur, Andres J., Maria T. Abreu, Parakkal Deepak, Poonam Beniwal-Patel, Konstantinos Papamichail, Byron Vaughn, Alexandra Bruss, Shaina Sekhri, Andrea Moosreiner, Phillip Gu, William Kennedy, Marla Dubinsky, Adam Cheifetz, and Gil Y. Melmed. The American Journal of Gastroenterology, May.

Generation of Isogenic and Homozygous MEN1 Mutant Cell Lines From Patient-Derived IPSCs Using CRISPR/Cas9. Even-Zohar, Naomi, Derya Metin-Armagan, Anat Ben-Shlomo, Dhruv Sareen, and Shlomo Melmed. Stem Cell Research 69 (May): 103124.

Immunotherapy for Deficient Mismatch Repair (DMMR) Pancreatic Ductal Adenocarcinoma. Ebia, Matthew I., Megan P. Hitchins, and Andrew E. Hendifar. Journal of Gastrointestinal Oncology 14 (2): 1175–77.

Associations of Psychological Wellbeing With COVID-19 Hospitalization and Mortality in Adults Aged 50 Years or Older From 25 European Countries and Israel. Wang, Wenjun, Jingjing Wang, Juanjuan Shi, Yaping Li, Xin Zhang, Fengping Wu, Yikai Wang, Jia Li, Miao Hao, Xiongtao Liu, Song Zhai, Yuan Wang, Ning Gao, Yan Tian, Rui Lu, Yee Hui Yeo, Xiaoli Jia, Fanpu Ji, and Shuangsuo Dang. Frontiers in Public Health 11: 1124915.

Neurology

Global Synergistic Actions to Improve Brain Health for Human Development. Owolabi, Mayowa O., Matilde Leonardi, Claudio Bassetti, Joke Jaarsma, Tadeusz Hawrot, Akintomiwa I. Makanjuola, Rajinder K. Dhamija, Wuwei Feng, Volker Straub, Jennifer Camaradou, David W. Dodick, Rosita Sunna, Franco Servadei, et al. Nature Reviews. Neurology, May, 1–13.

OBGYN

Exploring the Use of ChatGPT in OBGYN: A Bibliometric Analysis of the First ChatGPT-Related Publications. Levin, Gabriel, Yoav Brezinov, and Raanan Meyer. Archives of Gynecology and Obstetrics, May.

Gender Leadership in Gynecologic Oncology Professional Societies Worldwide. Cohen, Adiel, Roie Alter, Raanan Meyer, Paul-Adrien Guigue, and Gabriel Levin. International Journal of Gynaecology and Obstetrics, May.

Evaluating Open Access Publication and Research Impact in Gynecologic Oncology. Levin, Gabriel, Ross Harrison, Jonathan Ledermann, Raanan Meyer, Robert L. Coleman, and Pedro T. Ramirez. International Journal of Gynecological Cancer, May, ijgc–2023–004460.

Tyrosine Kinase Inhibitor Toxicities: A Society of Gynecologic Oncology Review and Recommendations. Rimel, Bobbie J., Erin K. Crane, June Hou, John Nakayama, Jennifer MacDonald, Kathleen Lutz, Vicky Makker, and Roisin E. O’Cearbhaill. Gynecologic Oncology 174 (May): 148–56.

Outcomes Following Extracorporeal Membrane Oxygenation for Severe COVID-19 in Pregnancy or Post Partum. Byrne, John J., Amir A. Shamshirsaz, Alison G. Cahill, Mark A. Turrentine, Angela R. Seasely, Joe Eid, Caroline E. Rouse, Michael Richley, Nandini Raghuraman, Mariam Naqvi, Yasser Y. El-Sayed, Martina L. Badell, CeCe Cheng, James Liu, Emily H. Adhikari, Soha S. Patel, Erika R. O’Neil, and Patrick S. Ramsey. JAMA Network Open 6 (5): e2314678.

Orthopaedics

Optimizing the Entry Point for Reconstruction Nailing of the Femur. Robles, Abrianna S., Jawad J. Najdawi, Juntian Wang, Zachary A. Rockov, Harin B. Parikh, Milton T. M. Little, and Geoffrey S. Marecek. The Journal of the American Academy of Orthopaedic Surgeons, May.

Pathology

EGR4 Is Critical for Cell-Fate Determination and Phenotypic Maintenance of Geniculate Ganglion Neurons Underlying Sweet and Umami Taste. Dutta Banik, Debarghya, Louis J. Martin, Tao Tang, Jonathan Soboloff, Warren G. Tourtellotte, and Brian A. Pierchala. Proceedings of the National Academy of Sciences of the United States of America 120 (22): e2217595120.

Measurement of Blood Viscoelasticity Using Thromboelastography. Volod, Oksana, and Alice Runge. Methods in Molecular Biology (Clifton, N.J.) 2663: 709–24.

The Quantra System: System Description and Protocols for Measurements. Volod, Oksana, and Francesco Viola. Methods in Molecular Biology (Clifton, N.J.) 2663: 743–61.

The TEG 6s System: System Description and Protocol for Measurements. Volod, Oksana, and Alice Runge. Methods in Molecular Biology (Clifton, N.J.) 2663: 735–42.

The TEG 5000 System: System Description and Protocol for Measurements. Volod, Oksana, and Alice Runge. Methods in Molecular Biology (Clifton, N.J.) 2663: 725–33.

Surgery

When Critically Ill Patients With Decision Making Capacity and No Further Therapeutic Options Request Indefinite Life Support. Batten, Jason N., Elizabeth Dzeng, Stuart Finder, Jacob A. Blythe, and Michael Nurok. The American Journal of Bioethics: AJOB 23 (6): 21–23.

Ostial Patency Measurements After Endoscopic Sphenoidotomies and Frontal Sinusotomies. Wu, Arthur W., Dhruv Sharma, Elisa A. Illing, Jonathan Y. Ting, Missael Vasquez, Kolin Rubel, Dennis M. Tang, and Thomas S. Higgins. The Annals of Otology, Rhinology, and Laryngology, May, 34894231173483.

Non-Muscle-Invasive Bladder Cancer Molecular Subtypes Predict Differential Response to Intravesical Bacillus Calmette-Guérin. Jong, Florus C. de, Teemu D. Laajala, Robert F. Hoedemaeker, Kimberley R. Jordan, Angelique C. J. van der Made, Egbert R. Boevé, Deric K. E. van der Schoot, Bart Nieuwkamer, Emiel A. M. Janssen, Tokameh Mahmoudi, Joost L. Boormans, Dan Theodorescu, James C. Costello, and Tahlita C. M. Zuiverloon. Science Translational Medicine 15 (697): eabn4118.

Management of Perianal Crohn’s Disease - AJG. Parian, Alyssa M., Megan Obi, Phillip Fleshner, and David A. Schwartz. The American Journal of Gastroenterology, May.

A Single Center Experience with Bilateral Wilms Tumor. Chen, Stephanie Y., William Gh Lee, Eric Laifman, Shale J. Mack, Shengmei Zhou, and Eugene S. Kim. The American Surgeon, May, 31348231175446.

Understanding Ultrarare Adverse Events - Lessons Learned from a Twelve-Year Review of Intraoperative Deaths at an Academic Medical Center. Cohen, Tara N., Falisha F. Kanji, Andrew S. Wang, Edward G. Seferian, Harry C. Sax, and Bruce L. Gewertz. American Journal of Surgery, May, S0002-9610(23)00199-X.

Microsurgery in Oncoplastic Breast Reconstruction. Salibian, Ara A., and Ketan M. Patel. Gland Surgery 12 (4): 527–34.

Urology

Prostate Cancer Is Not Just a Man’s Concern - the Use of PSA Screening in Transgender Women. Nik-Ahd, Farnoosh, Jennifer T. Anger, Matthew R. Cooperberg, and Stephen J. Freedland. Nature Reviews. Urology, May.

The Streaming Web-Based Exercise at Home Study for Breast and Prostate Cancer Survivors: A Feasibility Study Protocol. Shirazipour, Celina H., Rachel M. Ruggieri-Bacani, Laura Lockshon, Christopher Waring, Aubrey Jarman, Novalyn Cruz, Catherine Bresee, Angela J. Fong, Pao-Hwa Lin, Gillian Gresham, Arash Asher, and Stephen J. Freedland. Methods and Protocols 6 (3): 51.