This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published May 11-18.

Biomedical Sciences

Microfluidic Organ-Chips and Stem Cell Models in the Fight Against COVID-19. Satta, Sandro, Sarah J. Rockwood, Kaidong Wang, Shaolei Wang, Maedeh Mozneb, Madelyn Arzt, Tzung K. Hsiai, and Arun Sharma. Circulation Research 132 (10): 1405–24.

Characterization of the Tilt (Tt) Phenotype in Drosophila Melanogaster. Houtman, Arno, Samuel Gruber, Hailey Reisert, Mina Amini, Caroline Fiore, Paula Gonzalez, Veronica Han, Aeva Jazic, Mie Kusupholnand, Max Miller, Jiung Nam, Ziqin Wang, Yang Yu, Peter Dong, Allen S. W. Oak, Arun Sharma, and Eric P. Spana. MicroPublication Biology.

Cardiology

Fitness Attenuates Long-Term Cardiovascular Outcomes in Women With Ischemic Heart Disease and Metabolic Syndrome. Quesada, Odayme, Marie Lauzon, Rae Buttle, Janet Wei, Nissi Suppogu, Galen Cook-Wiens, Steven E. Reis, Leslee J. Shaw, George Sopko, Eileen Handberg, Carl J. Pepine, and C. Noel Bairey Merz. American Journal of Preventive Cardiology 14 (June): 100498.

Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study. Holmstrom, Lauri, Ninad S. Chaudhary, Kotoka Nakamura, Harpriya Chugh, Audrey Uy-Evanado, Faye Norby, Ginger A. Metcalf, Vipin K. Menon, Bing Yu, Eric Boerwinkle, Sumeet S. Chugh, Zeynep Akdemir, and Evan P. Kransdorf. Circulation. Genomic and Precision Medicine, May, e004105.

Skin Sympathetic Nerve Activity and Nocturnal Blood Pressure Nondipping in Patients with Postural Orthostatic Tachycardia Syndrome. Liu, Xiao, Carine Rosenberg, Jewel N. Reaso, Andrew M. Lee, Joselyn Ricafrente, Joseph E. Ebinger, Lan S. Chen, Xiaochun Li, C. Noel Bairey Merz, Florian Rader, and Peng-Sheng Chen. Journal of Hypertension, May.

Soft Tissue Displacement for Detection of Left Ventricle Apical Dyskinesis With Transthoracic Echocardiography. Schwartz, Brandon H., Balaji K. Tamarappoo, Hezzy Shmueli, and Robert J. Siegel. The International Journal of Cardiovascular Imaging, May.

Three-Year Outcomes for Transcatheter Repair in Patients with Mitral Regurgitation from the CLASP Study. Spargias, Konstantinos, D. Scott Lim, Raj Makkar, Saibal Kar, Robert M. Kipperman, William W. O Neill, Martin K. C. Ng, Robert L. Smith, Neil P. Fam, Michael J. Rinaldi, Christopher O. Raffel, Darren L. Walters, Justin Levisay, Matteo Montorfano, Azeem Latib, John D. Carroll, Georg Nickenig, Stephan Windecker, Leo Marcoff, Gideon N. Cohen, Ulrich Schäfer, John G. Webb, and Molly Szerlip. Catheterization and Cardiovascular Interventions, May.

Intermediate-Term Outcomes of Complement Inhibition for Prevention of Antibody-Mediated Rejection in Immunologically High-Risk Heart Allograft Recipients. Coutance, Guillaume, Jon A. Kobashigawa, Evan Kransdorf, Alexandre Loupy, Eva Desiré, Michelle Kittleson, and Jignesh K. Patel. The Journal of Heart and Lung Transplantation, May, S1053-2498(23)01856-9.

Racial Disparities in Mortality Associated With Acute Myocardial Infarction and COVID-19 in the United States: A Nationwide Analysis. Muhyieddeen, Amer, Susan Cheng, Mamas A. Mamas, Dorian Beasley, Galen Cook Weins, and Martha Gulati. Current Problems in Cardiology, May, 101798.

Predictors of Arrhythmia During Pregnancy in Adults With Congenital Heart Disease. Venkatesh, Prashanth, Jeannette P. Lin, Amanda Nguyen, Joshua Rezkalla, and Jeremy P. Moore. International Journal of Cardiology, May, S0167-5273(23)00705-2.

Reply to Comment on ‘Detection and Management of HLA Sensitization in Candidates for Adult Heart Transplantation.’ DeFilippis, Ersilia M., Evan P. Kransdorf, Abhishek Jaiswal, Xiaohai Zhang, Jignesh Patel, Jon A. Kobashigawa, David A. Baran, and Michelle M. Kittleson. The Journal of Heart and Lung Transplantation, May, S1053-2498(23)01850-8.

Computational Biomedicine

Heterogeneity of Treatment Effects by Risk in Pulmonary Arterial Hypertension. Pan, Hao-Min, Robyn L. McClelland, Jude Moutchia, Dina H. Appleby, Jason S. Fritz, John H. Holmes, Jasleen Minhas, Harold I. Palevsky, Ryan J. Urbanowicz, Steven M. Kawut, and Nadine Al-Naamani. The European Respiratory Journal, May, 2300190.

Colorectal Cancer: Association Between Sociodemographic Variables and The Adherence To Cancer Screening. Kupper, Bruna Elisa Catin, Fabio Oliveira Ferreira, Wilson Toshihiko Nakagawa, Vinicius Fernando Calsavara, Thiago Celestino Chulam, Ademar Lopes, and Samuel Aguiar-Junior. Arquivos Brasileiros de Cirurgia Digestiva: ABCD = Brazilian Archives of Digestive Surgery 36: e1729.

Imaging

Coronary Volume to Left Ventricular Mass Ratio in Patients With Hypertension. Rosendael, Sophie E. van, Alexander R. van Rosendael, Jurrien H. Kuneman, Manesh R. Patel, Bjarne Linde Nørgaard, Timothy A. Fairbairn, Koen Nieman, Takashi Akasaka, Daniel S. Berman, Lynne M. Hurwitz Koweek, Gianluca Pontone, Tomohiro Kawasaki, Niels Peter Rønnow Sand, Jesper M. Jensen, Tetsuya Amano, Michael Poon, Kristian A. Øvrehus, Jeroen Sonck, Mark G. Rabbat, Campbell Rogers, Hitoshi Matsuo, Jonathon A. Leipsic, Nina Ajmone Marsan, J. Wouter Jukema, Jeroen J. Bax, Antti Saraste, and Juhani Knuuti. The American Journal of Cardiology, May, S0002-9149(23)00241-2.

Influence of Obesity on Coronary Artery Disease and Clinical Outcomes in the ADVANCE Registry. Lowenstern, Angela, Nicholas Ng, Hidenobu Takagi, Jennifer A. Rymer, Lynne M. Koweek, Pamela S. Douglas, Jessica M. Duran, Mark Rabbat, Gianluca Pontone, Timothy Fairbairn, Kavitha Chinnaiyan, Daniel S. Berman, Bernard De Bruyne, Jeroen J. Bax, Takashi Akasaka, Tetsuya Amano, Koen Nieman, Campbell Rogers, Hironori Kitabata, Niels P. R. Sand, Tomohiro Kawasaki, Sarah Mullen, Hitoshi Matsuo, Bjarne L. Norgaard, Manesh R. Patel, Jonathan Leipsic, and Melissa A. Daubert. Circulation. Cardiovascular Imaging 16 (5): e014850.

Sex and Age-Specific Interactions of Coronary Atherosclerotic Plaque Onset and Prognosis from Coronary Computed Tomography. Rosendael, Sophie E. van, A. Maxim Bax, Fay Y. Lin, Stephan Achenbach, Daniele Andreini, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin J. DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Jonathon A. Leipsic, Erica Maffei, Hugo Marques, Pedro de Araújo Gonçalves, Gianluca Pontone, Gilbert L. Raff, Ronen Rubinshtein, Todd C. Villines, Hyuk-Jae Chang, Daniel S. Berman, James K. Min, Jeroen J. Bax, Leslee J. Shaw, and Alexander R. van Rosendael. European Heart Journal. Cardiovascular Imaging, May, jead094.

Medicine

US Nationwide Insight Into All-Cause 30-Day Readmissions Following Inpatient Endoscopic Retrograde Cholangiopancreatography. Radadiya, Dhruvil, Kalpit Devani, Ashraf Ashhab, Polina Gaisinskaya, Paris Charilaou, Chakradhar Reddy, and Srinivas Gaddam. Journal of Clinical Gastroenterology 57 (5): 515.

Neighbourhood Social Deprivation and Risk of Prostate Cancer. Salmon, Charlotte, Amélie Quesnel-Vallée, Tracie A. Barnett, Andrea Benedetti, Marie-Soleil Cloutier, Geetanjali D. Datta, Yan Kestens, Belinda Nicolau, and Marie-Élise Parent. British Journal of Cancer, May.

Cholangiocarcinoma - Novel Biological Insights and Therapeutic Strategies. Ilyas, Sumera I., Silvia Affo, Lipika Goyal, Angela Lamarca, Gonzalo Sapisochin, Ju Dong Yang, and Gregory J. Gores. Nature Reviews. Clinical Oncology, May.

Inhibition of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) via DS-1040 to Accelerate Clot Lysis in Patients With Acute Pulmonary Embolism: A Randomized Phase Ib Study. Vanassche, Thomas, Rachel P. Rosovsky, Fares Moustafa, Harry R. Bu Ller, Annelise Segers, Indu Patel, Minggao Shi, Naoki Miyoshi, Venkatesh Mani, Zahi Fayad, Dominique Stephan, Jeannot Schmidt, Michael A. Grosso, Victor F. Tapson, Peter Verhamme, Menno V. Huisman, and DS-1040 Study Group. Journal of Thrombosis and Haemostasis: JTH, May, S1538-7836(23)00398-7.

Extracellular Vesicles in Fatty Liver Promote a Metastatic Tumor Microenvironment. Wang, Zhijun, So Yeon Kim, Wei Tu, Jieun Kim, Alexander Xu, Yoon Mee Yang, Michitaka Matsuda, Lien Reolizo, Takashi Tsuchiya, Sandrine Billet, Alexandra Gangi, Mazen Noureddin, Ben A. Falk, Sungjin Kim, Wei Fan, Mourad Tighiouart, Sungyong You, Michael S. Lewis, Stephen J. Pandol, Dolores Di Vizio, Akil Merchant, Edwin M. Posadas, Neil A. Bhowmick, Shelly C. Lu, and Ekihiro Seki. Cell Metabolism, May, S1550-4131(23)00140-7.

Small Extracellular Vesicles Derived From Four Dimensional-Culture of Mesenchymal Stem Cells Induce Alternatively Activated Macrophages by Upregulating IGFBP2/EGFR to Attenuate Inflammation in the Spinal Cord Injury of Rats. Wang, Junhua, Qingshuai Wei, Yue Yang, Mingtian Che, Yuanhuan Ma, Lizhi Peng, Haiyang Yu, Huijuan Shi, Guanheng He, Rongjie Wu, Ting Zeng, Xiang Zeng, and Wenbin Ma. Frontiers in Bioengineering and Biotechnology 11: 1146981.

Evaluation of Host Cellular Responses to Epstein-Barr Virus (EBV) in Adult Lung Transplant Patients With EBV-Associated Diseases. Zaffiri, Lorenzo, Joshua E. Messinger, Erika J. Bush, Janet S. Staats, Prekshaben Patel, Scott M. Palmer, Kent J. Weinhold, Laurie D. Snyder, and Micah A. Luftig. Journal of Medical Virology 95 (4): e28724.

Rising Incidence of Non-Cardia Gastric Cancer Among Young Women in the United States, 2000-2018: A Time-Trend Analysis Using the USCS Database. Oh, Janice, Yazan Abboud, Miguel Burch, Jun Gong, Kevin Waters, Jenan Ghaith, Yi Jiang, Kenneth Park, Quin Liu, Rabindra Watson, Simon K. Lo, and Srinivas Gaddam. Cancers 15 (8): 2283.

Impact of Delayed Transition off Intravenous Vasoactive Agents for Aortic Dissection on Intensive Care Unit Length of Stay. De Leon, Noelle, Gabriela Young, and Dexter Wimer. Journal of Thoracic Disease 15 (4): 1595–1604.

Neurology

Imaging Caveats to Consider When Screening for Thrombolysis in the Extended Time Window. Reyes, Dennys, Sabrena M. Ahmadi, Stuart Kieran, Nils H. Mueller-Kronast, Scott E. Blumenthal, Shlee S. Song, and Alexis N. Simpkins. Stroke, May.

Neurosurgery

Retinal Arterial A?40 Deposition Is Linked With Tight Junction Loss and Cerebral Amyloid Angiopathy in MCI and AD Patients. Shi, Haoshen, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Ousman Jallow, Krishna Mandalia, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Andrei A. Kramerov, Alexander V. Ljubimov, Debra Hawes, Carol A. Miller, Keith L. Black, Roxana O. Carare, and Maya Koronyo-Hamaoui. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, May.

Orthopaedics

Surgical Treatment of Shoulder Infection Following Rotator Cuff Repair. Stone, Michael A., Tyler W. Henry, Michael J. Gutman, Jason C. Ho, and Surena Namdari. The Archives of Bone and Joint Surgery 11 (2): 111–16.

Pathology

Demographics and Clinicopathologic Profile of Pulmonary Sarcomatoid Carcinoma With Survival Analysis and Genomic Landscape. Ullah, Asad, Asim Ahmed, Abdul Qahar Khan Yasinzai, Kue Tylor Lee, Israr Khan, Bina Asif, Imran Khan, Bisma Tareen, Kaleemullah Kakar, Gul Andam, Saleh Heneidi, Jaffar Khan, Hina Khan, Nabin R. Karki, Jaydira Del Rivero, and Nagla Abdel Karim. Cancers 15 (9): 2469.

Pediatrics 

De Novo Variants in GATAD2A in Individuals With a Neurodevelopmental Disorder: GATAD2A-Related Neurodevelopmental Disorder. Werren, Elizabeth A., Alba Guxholli, Natasha Jones, Matias Wagner, Iris Hannibal, Jorge L. Granadillo, Amanda V. Tyndall, Amanda Moccia, Ryan Kuehl, Kristin M. Levandoski, Debra L. Day-Salvatore, Marsha Wheeler, University of Washington Center for Mendelian Genomics, Jessica X. Chong, Michael J. Bamshad, A. Micheil Innes, Tyler Mark Pierson, Joel P. Mackay, Stephanie L. Bielas, and Donna M. Martin. HGG Advances 4 (3): 100198.

Psychiatry

Virtual Reality in the Management of Patients With Low Back and Neck Pain: A Retrospective Analysis of 82 People Treated Solely in the Metaverse. Orr, Eran, Tal Arbel, Miki Levy, Yaron Sela, Omer Weissberger, Omer Liran, and Jeremy Lewis. Archives of Physiotherapy 13 (1): 11.

Radiation Oncology

Beyond Diversity Toward Inclusion, Belonging, and Safety. Gibbs, Iris C., Geraldine Jacobson, Laura Dawson, Jeff M. Michalski, Howard Sandler, and Curtiland Deville. International Journal of Radiation Oncology, Biology, Physics 116 (2): 216–18.

Brachytherapy Training in India: Results From the GEC-ESTRO-India Survey. Mittal, Prachi, Supriya Chopra, Mitchell Kamrava, Rajesh Vashistha, Stefan Konrad, Surendra Senapati, Satyajit Pradhan, Vijay Anand Reddy, Daya Nand Sharma, Reena Engineer, Rajiv Sarin, Ashwini Budrukkar, Sushmita Ghoshal, Shyam Kishore Shrivastava, Jai Prakash Agarwal, and Alina Emiliana Sturdza. Brachytherapy, May, S1538-4721(23)00046-6.

Radical Cystectomy Versus Trimodality Therapy for Muscle-Invasive Bladder Cancer: A Multi-Institutional Propensity Score Matched and Weighted Analysis. Zlotta, Alexandre R., Leslie K. Ballas, Andrzej Niemierko, Katherine Lajkosz, Cynthia Kuk, Gus Miranda, Michael Drumm, Andrea Mari, Ethan Thio, Neil E. Fleshner, Girish S. Kulkarni, Michael A. S. Jewett, Robert G. Bristow, Charles Catton, Alejandro Berlin, Srikala S. Sridhar, Anne Schuckman, Adam S. Feldman, Matthew Wszolek, Douglas M. Dahl, Richard J. Lee, Philip J. Saylor, M. Dror Michaelson, David T. Miyamoto, Anthony Zietman, William Shipley, Peter Chung, Siamak Daneshmand, and Jason A. Efstathiou. The Lancet. Oncology, May, S1470-2045(23)00170-5.

Androgen Deprivation and Radiotherapy With or Without Docetaxel for Localized High-Risk Prostate Cancer: Long-Term Follow-up From the Randomized NRG Oncology RTOG 0521 Trial. Sartor, Oliver, Theodore G. Karrison, Howard M. Sandler, Leonard G. Gomella, Mahul Amin, James Purdy, Jeff M. Michalski, Mark G. Garzotto, Nadeem Pervez, Alexander G. Balogh, George B. Rodrigues, Luis Souhami, M. Neil Reaume, Scott G. Williams, Raquibul Hannan, Christopher U. Jones, Eric M. Horwitz, Joseph P. Rodgers, Felix Y. Feng, and Seth A. Rosenthal. European Urology, May, S0302-2838(23)02788-4.

Rehabilitation Medicine

A Perspective on a Precision Approach to Pain in Cancer; Moving Beyond Opioid Therapy. Chang, Philip, Lauren Julia Amaral, Arash Asher, Daniel Clauw, Bronwen Jones, Patricia Thompson, and Alix Sleight Warner. Disability and Rehabilitation, May, 1–10.

Surgery

The Effects of Obesity on Health Care Delivery. Velazquez, Amanda, and Caroline M. Apovian. Gastroenterology Clinics of North America 52 (2): 381–92.

One Anastomosis Gastric Bypass for Revisional Bariatric Surgery: Assessment of Short-Term Safety. Pivo, Sarah, Megan Jenkins, Christine Ren Fielding, Mirhee Kim, and Bradley Schwack. Obesity Surgery, May.

Frailty Among Total Hip and Knee Arthroplasty Recipients: Epidemiology and Propensity Score-Weighted Analysis of Effect on In-Hospital Postoperative Outcomes. Kuschner, Stuart H. The Journal of the American Academy of Orthopaedic Surgeons, May.

Preoperative Evaluations Before Transplantation-Essential Tools, Not Obstacles. Wisel, Steven A., Justin A. Steggerda, and Irene K. Kim. JAMA Internal Medicine, May. 

Incidence of Cancer and Role of Sentinel Lymph Node Biopsy in BRCA Mutation Carriers Undergoing Prophylactic Mastectomies. Fat, Shelby Chun, Christina Weed, Yasmina Samaha, Alice Chung, Marissa K. Boyle, Armando Giuliano, Edward Ray, and Farin Amersi. The American Surgeon, May, 31348231175498.

Pediatric Hyperthyroidism and Thyroid Eye Disease Management. Li, Joy, Juliana Austin, Raymond S. Douglas, and Sudha Nallasamy. Journal of AAPOS, May, S1091-8531(23)00090-3.

Genome-Wide Analysis of Palindrome Formation With Next-Generation Sequencing (GAPF-Seq) and a Bioinformatics Pipeline for Assessing De Novo Palindromes in Cancer Genomes. Murata, Michael M., Armando E. Giuliano, and Hisashi Tanaka. Methods in Molecular Biology (Clifton, N.J.) 2660: 13–22.

Urology

Stimulation of Antitumor Immunity by FoxP3-Targeting PROTAC. Wang, Yanping, Yi Zhang, Shengchen Su, Patrick Tamukong, Ramachandran Murali, and Hyung L. Kim. Biomedicine & Pharmacotherapy, 163 (May): 114871.

The Impact of Blue Light Cystoscopy Use Among Nonmuscle Invasive Bladder Cancer Patients in an Equal Access Setting: Implications on Recurrence and Time to Recurrence. Das, Sanjay, Lin Gu, Claire Trustram Eve, Joshua Parrish, Amanda M. De Hoedt, Chad McKee, William Aronson, Stephen J. Freedland, and Stephen B. Williams. Clinical Genitourinary Cancer, April, S1558-7673(23)00098-8.