This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published March 30-April 6.

Biomedical Sciences

Entropic Analysis of Antigen-Specific CDR3 Domains Identifies Essential Binding Motifs Shared by CDR3s With Different Antigen Specificities. Xu, Alexander M., William Chour, Diana C. DeLucia, Yapeng Su, Ana Jimena Pavlovitch-Bedzyk, Rachel Ng, Yusuf Rasheed, Mark M. Davis, John K. Lee, and James R. Heath. Cell Systems, March, S2405-4712(23)00057-1.

Functional Neural Network Connectivity at 3 Months Predicts Infant-Mother Dyadic Flexibility During Play at 6 Months. Li, Xiaomei, Haitao Chen, Yannan Hu, Ryan J. Larsen, Bradley P. Sutton, Nancy L. McElwain, and Wei Gao. Cerebral Cortex (New York, N.Y.: 1991), April, bhad117.

Cancer

Belzutifan plus Cabozantinib for Patients With Advanced Clear Cell Renal Cell Carcinoma Previously Treated With Immunotherapy: An Open-Label, Single-Arm, Phase 2 Study. Choueiri, Toni K., David F. McDermott, Jaime Merchan, Todd M. Bauer, Robert Figlin, Elisabeth I. Heath, M. Dror Michaelson, Edward Arrowsmith, Anishka D’Souza, Song Zhao, Ananya Roy, Rodolfo Perini, Donna Vickery, and Scott S. Tykodi. The Lancet. Oncology, March, S1470-2045(23)00097-9.

Can High-Intensity Interval Training Impact Tumor Suppression and Inflammatory Response in Prostate Cancer Survivors? Gresham, Gillian, Carolina Raines, Arash Asher, Stephen J. Freedland, Celina H. Shirazipour, and Alix G. Sleight. Prostate Cancer and Prostatic Diseases, March.

Association of Literature Metrics in Gynecologic Oncology With Country Classification by Income Level. Levin, Gabriel, Rene Pareja, Ross Harrison, Pedro T. Ramirez, and Raanan Meyer. International Journal of Gynecological Cancer, March, ijgc–2023–004380.

Brief Report: High Levels of CD47 Expression in Thymic Epithelial Tumors. Sun, Thomas Yang, Brandon Nguyen, Simon B. Chen, Yasodha Natkunam, Sukhmani Padda, Matt van de Rijn, Robert West, Joel W. Neal, Heather Wakelee, and Jonathan W. Riess. JTO Clinical and Research Reports 4 (4): 100498.

Advances in Endocrine Therapy for Hormone Receptor-Positive Advanced Breast Cancer. Ziyeh, Sharvina, Lauren Wong, and Reva K. Basho. Current Oncology Reports, April.

Associations of Combined Physical Activity and Body Mass Index Groups With Colorectal Cancer Survival Outcomes. Himbert, Caroline, Jennifer Ose, Biljana Gigic, Richard Viskochil, Kelly Santuci, Tengda Lin, Anjelica Ashworth, Jessica N. Cohan, Courtney L. Scaife, Jolanta Jedrzkiewicz, Victoria Damerell, Katelyn M. Atkins, Jun Gong, Matthew G. Mutch, Corey Bernadt, Seth Felder, Julian Sanchez, Stacey A. Cohen, Mukta K. Krane, Nathan Hinkle, Elizabeth Wood, Anita R. Peoples, Jane C. Figueiredo, Adetunji T. Toriola, Erin M. Siegel, Christopher I. Li, David Shibata, Kenneth Boucher, June L. Round, Alexis B. Ulrich, Martin Schneider, Lyen C. Huang, Sheetal Hardikar, and Cornelia M. Ulrich. BMC Cancer 23 (1): 300.

Avocados: A Recipe for Good Guacamole or Lower Cancer Risk? Galván, Gloria Cecilia, and Stephen J. Freedland. Cancer Prevention Research (Philadelphia, Pa.) 16 (4): 187–89.

Cardiology

Blinded, Randomized Trial of Sonographer Versus AI Cardiac Function Assessment. He, Bryan, Alan C. Kwan, Jae Hyung Cho, Neal Yuan, Charles Pollick, Takahiro Shiota, Joseph Ebinger, Natalie A. Bello, Janet Wei, Kiranbir Josan, Grant Duffy, Melvin Jujjavarapu, Robert Siegel, Susan Cheng, James Y. Zou, and David Ouyang. Nature, April.

Deep Learning-Enabled Analysis of Medical Images Identifies Cardiac Sphericity as an Early Marker of Cardiomyopathy and Related Outcomes. Vukadinovic, Milos, Alan C. Kwan, Victoria Yuan, Michael Salerno, Daniel C. Lee, Christine M. Albert, Susan Cheng, Debiao Li, David Ouyang, and Shoa L. Clarke. Med (New York, N.Y.), March, S2666-6340(23)00069-7.

Dealing With Calcification in the Coronary Arteries. Aldana-Bitar, Jairo, Ronald P. Karlsberg, and Matthew J. Budoff. Expert Review of Cardiovascular Therapy, March, 1–4.

Transforming Growth Factor-? Analysis of the VANISH Trial Cohort. Kim, Yuri, Mitra Mastali, Jennifer E. Van Eyk, E. John Orav, Christoffer R. Vissing, Sharlene M. Day, Anna Axelsson Raja, Mark W. Russell, Kenneth Zahka, Harry M. Lever, Alexandre C. Pereira, Anne M. Murphy, Charles Canter, Richard G. Bach, Matthew T. Wheeler, Joseph W. Rossano, Anjali T. Owens, Henning Bundgaard, Lee Benson, Luisa Mestroni, Matthew R. G. Taylor, Amit R. Patel, Ivan Wilmot, Philip Thrush, Jonathan H. Soslow, Jason R. Becker, Christine E. Seidman, Carolyn Y. Ho, and VANISH Investigators. Circulation. Heart Failure, March, e010314.

How to Approach HLA Sensitization in Heart Transplant Candidates. Rao, Roopa A., Evan P. Kransdorf, Jignesh K. Patel, Jon A. Kobashigawa, and Michelle M. Kittleson. JACC. Heart Failure 11 (4): 469–75.

Heart Failure With Reduced Ejection Fraction: What’s New in the 2022 Guideline? Kittleson, Michelle M. Cleveland Clinic Journal of Medicine 90 (4): 215–20.

ROMA-Women: Innovative Approaches for the First Cardiac Surgery Trial in Women. Gaudino, Mario, Stephen E. Fremes, Roxana Mehran, Noel Bairey Merz, and ROMA-Women Steering Committee and Investigators. Circulation, April.

The Genetic Determinants of Aortic Distention. Pirruccello, James P., Joel T. Rämö, Seung Hoan Choi, Mark D. Chaffin, Shinwan Kany, Mahan Nekoui, Elizabeth L. Chou, Sean J. Jurgens, Samuel F. Friedman, Dejan Juric, James R. Stone, Puneet Batra, Kenney Ng, Anthony A. Philippakis, Mark E. Lindsay, and Patrick T. Ellinor. Journal of the American College of Cardiology 81 (14): 1320–35.

*The Importance of Low-Density Lipoprotein Cholesterol Measurement and Control as Performance Measures: A Joint Clinical Perspective From the National Lipid Association and the American Society for Preventive Cardiology. Virani, Salim S., Karen Aspry, Dave L. Dixon, Keith C. Ferdinand, Paul A. Heidenreich, Elizabeth J. Jackson, Terry A. Jacobson, Janice L. McAlister, David R. Neff, Martha Gulati, and Christie M. Ballantyne. Journal of Clinical Lipidology 17 (2): 208–18.

*The Importance of Low-Density Lipoprotein Cholesterol Measurement and Control as Performance Measures: A Joint Clinical Perspective From the National Lipid Association and the American Society for Preventive Cardiology. Virani, Salim S., Karen Aspry, Dave L. Dixon, Keith C. Ferdinand, Paul A. Heidenreich, Elizabeth J. Jackson, Terry A. Jacobson, Janice L. McAlister, David R. Neff, Martha Gulati, and Christie M. Ballantyne. American Journal of Preventive Cardiology 13 (March): 100472.

*These were simultaneously published guidelines from the National Lipid Association and the American Society for Preventive Cardiology.

Imaging

Evaluation of California Non-Comprehensive Death File Against National Death Index. Chen, Xi, Rebekah Park, Cecilia Hurtado, Heidi Gransar, Brian Tep, Romalisa Miranda-Peats, Spencer L. Soohoo, Alan Rozanski, and Daniel S. Berman. Dialogues in Health 1 (December).

Medicine

Stress-Associated Weight Gain, Fibromyalgia Symptoms, Cardiometabolic Markers, and Human Growth Hormone Suppression Respond to an Amino Acid Supplement Blend: Results of a Prospective, Cohort Study. Pekarovics, Susan, Adam Beres, Colleen Kelly, Sonja K. Billes, and Amy L. Heaton. Frontiers in Endocrinology 14: 1053692.

Machine Learning Models for NAFLD/NASH and Cirrhosis Diagnosis and Staging: Accuracy and Routine Variables Are the Success Keys. Chang, Devon, Emily Truong, and Mazen Noureddin. Hepatology (Baltimore, Md.), January.

Long Term Recovery of Right Ventricular Function After Treatment of Intermediate and High Risk Pulmonary Emboli. Matusov, Yuri, Maidah Yaqoob, Anya Karumanchi, H. Gabriel Lipshutz, Suhail Dohad, Jonathan Steinberger, Angelena Lopez, Siddharth Singh, Victor F. Tapson, and Oren Friedman. Thrombosis Research 225 (March): 57–62.

Efficacy and Safety of Advanced Therapies for Moderately to Severely Active Ulcerative Colitis at Induction and Maintenance: An Indirect Treatment Comparison Using Bayesian Network Meta-Analysis. Panaccione, Remo, Eric B. Collins, Gil Y. Melmed, Severine Vermeire, Silvio Danese, Peter D. R. Higgins, Christina S. Kwon, Wen Zhou, Dapo Ilo, Dolly Sharma, Yuri Sanchez Gonzalez, and Si-Tien Wang. Crohn’s & Colitis 360 5 (2): otad009.

DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury. Shimodaira, Yosuke, Shyam K. More, Hussein Hamade, Anna Y. Blackwood, Jay P. Abraham, Lisa S. Thomas, Jordan H. Miller, Dalton T. Stamps, Sofi L. Castanon, Noam Jacob, Connie W. Y Ha, Suzanne Devkota, David Q. Shih, Stephan R. Targan, and Kathrin S. Michelsen. Cellular and Molecular Gastroenterology and Hepatology, April, S2352-345X(23)00048-6.

Neurosurgery

Adolescent Headache Due to Congenital Pelvic/Sacral Vascular Malformation. Schievink, Wouter I., Marcel M. Maya, and Alexandra J. Borst. Annals of Neurology, March.

Intraoperative Neuromonitoring in Spine Surgery: Large Database Analysis of Cost-Effectiveness. Ament, Jared D., Alyssa Leon, Kee D. Kim, J. Patrick Johnson, and Amir Vokshoor. North American Spine Society Journal 14 (June): 100206.

Orthopaedics

Phosphaturic Mesenchymal Tumor-Induced Osteomalacia Masquerading as an Orthopedic Polytrauma Patient: A Case Report and Review of the Literature. Robles, Abrianna S., Zachary A. Rockov, Earl W. Brien, and Milton Thomas Michael Little. Journal of Orthopaedic Case Reports 12 (11): 28–33.

Concave and Convex Growth Do Not Differ Over Tethered Vertebral Segments, Even With Open Tri-Radiate Cartilage. Farivar, Daniel, Stefan Parent, Firoz Miyanji, Michael J. Heffernan, Ron El-Hawary, A. Noelle Larson, Lindsay M. Andras, Pediatric Spine Study Group, and David L. Skaggs. Spine Deformity, April.

Pediatrics

Functional Effects of Disease-Associated Variants Reveal That the S1-M1 Linker of the NMDA Receptor Critically Controls Channel Opening. Xie, Lingling, Miranda J. McDaniel, Riley E. Perszyk, Sukhan Kim, Gerarda Cappuccio, Kevin A. Shapiro, Beatriz Muñoz-Cabello, Pedro A. Sanchez-Lara, Katheryn Grand, Jing Zhang, Kelsey A. Nocilla, Rehan Sheikh, Lluis Armengol, Roberta Romano, Tyler Mark Pierson, Hongjie Yuan, Scott J. Myers, and Stephen F. Traynelis. Cellular and Molecular Life Sciences: CMLS 80 (4): 110.

Radiation Oncology

A Single-Institution Retrospective Study of Three-Fraction HDR Accelerated Partial Breast Irradiation. Chung, Eric M., Anthony T. Nguyen, Amin Mirhadi, Jennifer M. Steers, Tiffany Phillips, Katelyn M. Atkins, Michele Burnison, Stephen L. Shiao, and Mitchell Kamrava. Brachytherapy, March, S1538-4721(23)00027-2.

Rehabilitation Medicine

Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke. Liew, Sook-Lei, Nicolas Schweighofer, James H. Cole, Artemis Zavaliangos-Petropulu, Bethany P. Lo, Laura K. M. Han, Tim Hahn, Lianne Schmaal, Miranda R. Donnelly, Jessica N. Jeong, Zhizhuo Wang, Aisha Abdullah, Paul M. Thompson, et al. Neurology, April, 10.1212/WNL.0000000000207219.

Surgery

Frontal Ethmoid Mucocele: An Unusual Postoperative Complication. Schenck, Nicholas L., Sarah A. Ustrell, and Zhiheng Chen. OTO Open 7 (1): e26.

Multilayer Outperforms Single-Layer Slide Scanning in AI-Based Classification of Whole Slide Images With Low-Burden Acid-Fast Mycobacteria (AFB). Nurzynska, Karolina, Dalin Li, Ann E. Walts, and Arkadiusz Gertych. Computer Methods and Programs in Biomedicine 234 (March): 107518.