This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published March 23-30.

Biomedical Sciences

Sex Differences in Resting State Functional Connectivity Across the First Two Years of Life. Fenske, Sonja J., Janelle Liu, Haitao Chen, Marcio A. Diniz, Rebecca L. Stephens, Emil Cornea, John H. Gilmore, and Wei Gao. Developmental Cognitive Neuroscience 60 (March): 101235.

Cancer

Ad Hoc Analysis of the Phase III ENGOT-OV16/NOVA Study: Niraparib Efficacy in Germline BRCA Wild-Type Recurrent Ovarian Cancer With Homologous Recombination Repair Defects. Mirza, Mansoor Raza, Gabriel Lindahl, Sven Mahner, Andrés Redondo, Michel Fabbro, Bobbie J. Rimel, Jørn Herrstedt, Amit M. Oza, Ulrich Canzler, Jonathan S. Berek, Antonio González-Martín, Phillipe Follana, Rosemary Lord, Masoud Azodi, Kasey Estenson, Zebin Wang, Yong Li, Divya Gupta, Ursula Matulonis, and Bin Feng. Cancer Research Communications 2 (11): 1436–44.

Targeting Glutamine Metabolism in Prostate Cancer. Bhowmick, Neil, Edwin Posadas, Leigh Ellis, Stephen J. Freedland, Dolores Di Vizio, Michael R. Freeman, Dan Theodorescu, Robert Figlin, and Jun Gong. Frontiers in Bioscience (Elite Edition) 15 (1): 2.

IMAGE-Seq and You Shall Find. Chute, John P., and Joshua P. Sasine. Nature Methods, March.

Incidence and Prognostic Impact of HER2-Positivity Loss After Dual HER2-Directed Neoadjuvant Therapy for HER2+ Breast Cancer. LeVee, Alexis, Kellie Spector, Brigid Larkin, Felipe Dezem, Jasmine Plummer, Farnaz Dadmanesh, Sujata Patil, and Heather L. McArthur. Cancer Medicine, March.

Local Recurrence After Breast-Conserving Therapy in Patients With Multiple Ipsilateral Breast Cancer: Results From ACOSOG Z11102 (Alliance). Boughey, Judy C., Kari M. Rosenkranz, Karla V. Ballman, Linda McCall, Bruce G. Haffty, Laurie W. Cuttino, Charlotte D. Kubicky, Huong T. Le-Petross, Armando E. Giuliano, Kimberly J. Van Zee, Kelly K. Hunt, Olwen M. Hahn, Lisa A. Carey, and Ann H. Partridge. Journal of Clinical Oncology, March, JCO2202553.

Cardiac Surgery

Bridging With Surgically Placed Microaxial Left Ventricular Assist Devices: A High-Volume Center Experience. Gill, George, Georgina Rowe, Qiudong Chen, Jad Malas, Jason Thomas, Achille Peiris, Robert Cole, Joanna Chikwe, Dominick Megna, and Dominic Emerson. European Journal of Cardio-Thoracic Surgery, March, ezad116.

Unequal Treatment: An Introduction to The Annals Reprint Collection. Chikwe, Joanna. The Annals of Thoracic Surgery 115 (4): e87–88

Cardiology

Depression Symptom Patterns as Predictors of Metabolic Syndrome and Cardiac Events in Symptomatic Women With Suspected Myocardial Ischemia: The Women’s Ischemia Syndrome Evaluation (WISE and WISE-CVD) Projects. Virzi, Nicole E., David S. Krantz, Vera A. Bittner, C. Noel Bairey Merz, Steven E. Reis, Eileen M. Handberg, Carl J. Pepine, Viola Vaccarino, and Thomas Rutledge. Heart and Mind (Mumbai, India) 6 (4): 254–61.

Autoimmune Disease and Risk of Postpartum Venous Thromboembolism. Walker, Rob F., Neil A. Zakai, Susan M. Mason, Richard F. MacLehose, Faye L. Norby, Line H. Evensen, Alvaro Alonso, and Pamela L. Lutsey. Research and Practice in Thrombosis and Haemostasis 7 (2): 100091.

Dupilumab Inhibits Vascular Leakage of Blood Proteins into Atopic Dermatitis Skin. Leung, Donald Y. M., Robert Bissonnette, Simion Kreimer, Evgeny Berdyshev, Shantanu Bafna, Taras Lyubchenko, Brittany N. Richers, Shannon Garcia, Marco Ramirez-Gama, Clifton F. Hall, Olivia Xiao, Patricia Taylor, Mark Boguniewicz, Noah A. Levit, Inoncent Agueusop, Annie Zhang, and Elena Goleva. The Journal of Allergy and Clinical Immunology. In Practice, March, S2213-2198(23)00304-5.

Associations Between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC). Wang, Shuo, Guillaume C. Onyeaghala, Nathan Pankratz, Heather H. Nelson, Bharat Thyagarajan, Weihong Tang, Faye L. Norby, Chinenye Ugoji, Corinne E. Joshu, Christian R. Gomez, David J. Couper, Josef Coresh, Elizabeth A. Platz, and Anna E. Prizment. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, March, EPI-22-1113.

Sudden Cardiac Arrest During the COVID-19 Pandemic: A Two-Year Prospective Evaluation in a North American Community. Chugh, Harpriya S., Arayik Sargsyan, Kotoka Nakamura, Audrey Uy-Evanado, Bernadine Dizon, Faye L. Norby, Christopher Young, Katy Hadduck, Jonathan Jui, Daniel Shepherd, Angelo Salvucci, Sumeet S. Chugh, and Kyndaron Reinier. Heart Rhythm, March, S1547-5271(23)00327-2.

Association of Blood Pressure Variability With Endothelin-1 by Menopause Status Among Black Women: Findings From the Jackson Heart Study. Rethy, Leah, Vincenzo B. Polsinelli, Paul Muntner, Natalie A. Bello, and Jordana B. Cohen. Journal of Human Hypertension, March.

Guidelines and Principles for the Care of the Cardiothoracic Transplant Patient in the Intensive Care Unit. Nurok, Michael, Mark E. Nunnally, Michael O’Connor, Richard N. Pierson, David A. Baran, Michael D. Harper, Darren Malinoski, Aly El Banayosy, Abiodun Orija, Shelley Hall, Jeffrey D. Edelman, Thoralf M. Sundt, Deborah Levine, Jon Kobashigawa, and David Nelson. Clinical Transplantation, March, e14978.

30-Day Clinical Outcomes of a Self-Expanding Transcatheter Aortic Valve: The International PORTICO NG Study. Reardon, Michael J., Bassem Chehab, Dave Smith, Antony S. Walton, Stephen G. Worthley, Ganesh Manoharan, Ibrahim Sultan, Gerald Yong, Katherine Harrington, Paul Mahoney, Neal Kleiman, Raj R. Makkar, Gregory Fontana, Augustin DeLago, Ravi K. Ramana, Nicholas Bates, and Lars Søndergaard. JACC. Cardiovascular Interventions 16 (6): 681–89.

With Current Safety and Efficacy Data, Should Statins Be Made Available as Nonprescription Over-the-Counter Drugs? Mehta, Anurag, Dave L. Dixon, Anum Saeed, Michael S. Kelly, Martha Gulati, Michael D. Shapiro, Laurence S. Sperling, and Salim S. Virani. Current Cardiology Reports, March.

Medicine

A Randomized Controlled Trial of Presatovir for Respiratory Syncytial Virus After Lung Transplant. Gottlieb, Jens, Fernando Torres, Tarik Haddad, Gundeep Dhillon, Daniel F. Dilling, Christiane Knoop, Reinaldo Rampolla, Rajat Walia, Vivek Ahya, Romain Kessler, Marie Budev, Claus Neurohr, Allan R. Glanville, Robert Jordan, Danielle Porter, Matt McKevitt, Polina German, Ying Guo, Jason W. Chien, Timothy R. Watkins, and Martin R. Zamora. The Journal of Heart and Lung Transplantation, February, S1053-2498(23)00034-7.

Patients With Acute-on-Chronic Liver Failure Have Greater Healthcare Resource Utilization After Liver Transplantation. Sundaram, Vinay, Christina C. Lindenmeyer, Kirti Shetty, Robert S. Rahimi, Atef Al-Attar, Gianina Flocco, Brett E. Fortune, Cynthia Gong, Suryanarayana Challa, Haripriya Maddur, Janice H. Jou, Michael Kriss, Lance L. Stein, Alex H. Xiao, Ross H. Vyhmeister, Ellen W. Green, Braidie Campbell, Andrew J. Piscitello, William Cranford, Josh Levitsky, Constantine J. Karvellas, and Multi-Organ Dysfunction and Evaluation for Liver Transplantation (MODEL) Consortium. Clinical Gastroenterology and Hepatology, 21 (3): 704-712.e3.

Prevalence of Small Intestinal Bacterial Overgrowth Syndrome in Patients With Non-Alcoholic Fatty Liver Disease/Non-Alcoholic Steatohepatitis: A Cross-Sectional Study. Gkolfakis, Paraskevas, Georgios Tziatzios, Gabriela Leite, Ioannis S. Papanikolaou, Elias Xirouchakis, Ioannis G. Panayiotides, Athanasios Karageorgos, Maria Jesus Millan, Ruchi Mathur, Stacy Weitsman, George D. Dimitriadis, Evangelos J. Giamarellos-Bourboulis, Mark Pimentel, and Konstantinos Triantafyllou. Microorganisms 11 (3): 723.

Anti-Vinculin Antibodies in Systemic Sclerosis: Associations With Slow Gastric Transit and Extra-Intestinal Clinical Phenotype. Herrán, María, Brittany L. Adler, Jamie Perin, Walter Morales, Mark Pimentel, and Zsuzsanna H. McMahan. Arthritis Care & Research, March.

Rituximab Versus Azathioprine for Maintenance of Remission for Patients With ANCA-Associated Vasculitis and Relapsing Disease: An International Randomised Controlled Trial. Smith, Rona M., Rachel B. Jones, Ulrich Specks, Simon Bond, Marianna Nodale, Reem Al-Jayyousi, Jacqueline Andrews, Annette Bruchfeld, Brian Camilleri, Simon Carette, Chee Kay Cheung, Vimal Derebail, Tim Doulton, Alastair Ferraro, Lindsy Forbess, Shouichi Fujimoto, Shunsuke Furuta, Ora Gewurz-Singer, Lorraine Harper, Toshiko Ito-Ihara, Nader Khalidi, Rainer Klocke, Curry Koening, Yoshinori Komagata, Carol Langford, Peter Lanyon, Raashid Luqmani, Carol McAlear, Larry W. Moreland, Kim Mynard, Patrick Nachman, Christian Pagnoux, Chen Au Peh, Charles Pusey, Dwarakanathan Ranganathan, Rennie L. Rhee, Robert Spiera, Antoine G. Sreih, Vladamir Tesar, Giles Walters, Caroline Wroe, David Jayne, Peter A. Merkel, and RITAZAREM co-investigators. Annals of the Rheumatic Diseases, March, ard-2022-223559.

Evidence for Virus-Mediated Oncogenesis in Bladder Cancers Arising in Solid Organ Transplant Recipients. Starrett, Gabriel J., Kelly Yu, Yelena Golubeva, Petra Lenz, Mary L. Piaskowski, David Petersen, Michael Dean, Ajay Israni, Brenda Y. Hernandez, Thomas C. Tucker, Iona Cheng, Lou Gonsalves, Cyllene R. Morris, Shehnaz K. Hussain, Charles F. Lynch, Reuben S. Harris, Ludmila Prokunina-Olsson, Paul S. Meltzer, Christopher B. Buck, and Eric A. Engels. ELife 12 (March): e82690.

Persistent SARS-CoV-2-Specific Immune Defects in Kidney Transplant Recipients Following Third MRNA Vaccine Doses. Werbel, William A., Andrew H. Karaba, Teresa Po-Yu Chiang, Allan B. Massie, Diane M. Brown, Natasha Watson, Maggie Chahoud, Elizabeth A. Thompson, Aileen C. Johnson, Robin K. Avery, Willa V. Cochran, Daniel Warren, Tao Liang, Miguel Fribourg, Christopher Huerta, Hady Samaha, Sabra L. Klein, Maria P. Bettinotti, William A. Clarke, Ioannis Sitaras, Nadine Rouphael, Andrea L. Cox, Justin R. Bailey, Andrew Pekosz, Aaron A. R. Tobian, Christine M. Durand, Nancy D. Bridges, Christian P. Larsen, Peter S. Heeger, Dorry L. Segev, and CPAT investigators. American Journal of Transplantation, March, S1600-6135(23)00357-X.

Numerous Gastric Nodules in a Leukaemia Patient. Bahdi, Firas, Samer Alkassis, Michael S. Lewis, Monica El-Masry, Anthony Bejjani, and Jennifer M. Kolb. Gut, March, gutjnl-2023-329699.

Economic Burden Related to Fistulas or Strictures Among Commercially Insured Patients With Crohn’s Disease in the United States. Fan, Yanni, Ling Zhang, Monik C. Jiménez, Rhonda L. Bohn, Jennifer S. Thompson, Kimberly G. Brodovicz, Stephani Gray, and Gil Y. Melmed. Journal of Managed Care & Specialty Pharmacy 29 (4): 400–408.

MicroRNA-449a Reduces Growth Hormone-Stimulated Senescent Cell Burden Through PI3K-MTOR Signaling. Noureddine, Sarah, Jia Nie, Augusto Schneider, Vinal Menon, Zoubeida Fliesen, Joseph Dhahbi, Berta Victoria, Jeremiah Oyer, Liza Robles-Carrillo, Allancer Divino De Carvalho Nunes, Sarah Ashiqueali, Artur Janusz, Alicja Copik, Paul D. Robbins, Nicolas Musi, and Michal M. Masternak. Proceedings of the National Academy of Sciences of the United States of America 120 (14): e2213207120.

Neurosurgery

Neurons in Human Pre-Supplementary Motor Area Encode Key Computations for Value-Based Choice. Aquino, Tomas G., Jeffrey Cockburn, Adam N. Mamelak, Ueli Rutishauser, and John P. O’Doherty. Nature Human Behaviour, March.

OBGYN

KRAS Mutations and Endometriosis Burden of Disease. Orr, Natasha L., Arianne Albert, Yang Doris Liu, Amy Lum, JooYoon Hong, Catalina L. Ionescu, Janine Senz, Tayyebeh M. Nazeran, Anna F. Lee, Heather Noga, Kate Lawrenson, Catherine Allaire, Christina Williams, Mohamed A. Bedaiwy, Michael S. Anglesio, and Paul J. Yong. The Journal of Pathology. Clinical Research, March.

Orthopaedics

IPSC-Derived Tenocytes Seeded on Microgrooved 3D Printed Scaffolds for Achilles Tendon Regeneration. Kaneda, Giselle, Julie L. Chan, Chloe M. Castaneda, Angela Papalamprou, Julia Sheyn, Oksana Shelest, Dave Huang, Nadine Kluser, Victoria Yu, Gian C. Ignacio, Arkadiusz Gertych, Ryu Yoshida, Melodie Metzger, Wafa Tawackoli, Andrea Vernengo, and Dmitriy Sheyn. Journal of Orthopaedic Research, March.

Harmonization and Standardization of Nucleus Pulposus Cell Extraction and Culture Methods. Basatvat, Shaghayegh, Frances C. Bach, Marcos N. Barcellona, Abbie L. Binch, Conor T. Buckley, Brian Bueno, Nadeen O. Chahine, Ana Chee, Laura B. Creemers, Stefan Dudli, Bailey Fearing, Stephen J. Ferguson, Christine L. Le Maitre, et al. JOR Spine 6 (1): e1238.

Over 90% Percent of Childhood BCG Vaccine-Induced Keloids in Japan Occur in Women. Noishiki, Chikage, Yoshiaki Hayasaka, Ryu Yoshida, and Rei Ogawa. Dermatology and Therapy, March, 1–11.

Pathology

Pocket ACEs: Discovering New Function Within an Old Player. Leong, Matthew, Xiaomo Li, and Manita Chaum. Frontiers in Physiology 14: 1151908.

Glycogenic Hepatopathy Is Associated With Type 1 Diabetes Mellitus in Only a Minority of Cases in a Contemporary Adult Population. Cox, Brian K., Maha Guindi, Danielle Hutchings, Stacey A. Kim, Kevin M. Waters, and Brent K. Larson. Annals of Diagnostic Pathology 64 (March): 152130.

Supporting Biomarker-Driven Therapies in Oncology: A Genomic Testing Cost Calculator. Stenzinger, Albrecht, Brian Cuffel, Noman Paracha, Eric Vail, Jesus Garcia-Foncillas, Clifford Goodman, Ulrik Lassen, Gilles Vassal, and Sean D. Sullivan. The Oncologist, March, oyad005.

Pharmacologic Improvement of CFTR Function Rapidly Decreases Sputum Pathogen Density but Lung Infections Generally Persist. Nichols, David P., Sarah J. Morgan, Michelle Skalland, Anh T. Vo, Jill M. Van Dalfsen, Sachinkumar Bp Singh, Wendy Ni, Lucas R. Hoffman, Kailee McGeer, Sonya L. Heltshe, John P. Clancy, Steven M. Rowe, Peter K. Jorth, and Pradeep K. Singh. The Journal of Clinical Investigation, March, e167957.

Pediatrics

Impact of Trainee Involvement on Pediatric ERCP Procedures: Results From the Pediatric ERCP Initiative. Gupta, Rekha, Racha Khalaf, John Morrison, Ernest Amankwah, Wenly Ruan, Douglas S. Fishman, Bradley A. Barth, Quin Y. Liu, Matthew Giefer, Kyung Mo Kim, Mercedes Martinez, Luigi Dall’oglio, Filippo Torroni, Paola De Angelis, Simona Faraci, Sam Bitton, Kulwinder Dua, Steven Werlin, Roberto Gugig, Clifton Huang, Petar Mamula, J. Antonio Quiros, Yuhua Zheng, Travis Piester, Amit Grover, Victor L. Fox, Michael Wilsey, and David M. Troendle. Journal of Pediatric Gastroenterology and Nutrition, March.

Radiation Oncology

The Effect of Dose Gradients on Gamma Comparison Insensitivity in Patient Specific QA Comparisons. Steers, Jennifer M., and Benedick A. Fraass. Medical Physics, March.

Surgery

Stability Determination of Intact Humanin-G With Characterizations of Oxidation and Dimerization Patterns. Ozgul, Mustafa, Anthony B. Nesburn, Nader Nasralla, Benjamin Katz, Enes Taylan, Baruch D. Kuppermann, and Maria Cristina Kenney. Biomolecules 13 (3): 515.

Impact of Smoking on Donor Site Following Rectus Flap Harvest for Head and Neck Reconstruction. Reece, Mac Kenzie, Tyler L. Langenfeld, Kaitlynne Y. Pak, Mark K. Wax, Kenneth Tan, Allison Slijepcevic, Dan Petrisor, Mohamedkazim Alwani, R. Michael Johnson, Yadranko Ducic, and Sameep P. Kadakia. American Journal of Otolaryngology 44 (4): 103847.

Diagnostic Accuracy of Two Manual Muscle Testing Scales for Identifying Upper Extremity Nerve Transfer Candidates in Children With Acute Flaccid Myelitis. Werner, Julie M., Jordan Wlodarczyk, and Mitchel Seruya. Plastic and Reconstructive Surgery, March.