This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published March 2 - March 9.

Anesthesiology

Combination Therapy With Simultaneous Delivery of Spinal Cord Stimulation Modalities: COMBO Randomized Controlled Trial. Wallace, Mark S., James M. North, Gregory M. Phillips, Aaron K. Calodney, James A. Scowcroft, Bindu U. Popat-Lewis, Jennifer M. Lee, Edward P. Washabaugh, Julio Paez, Robert B. Bolash, John Noles, Joseph Atallah, Binit Shah, Farshad M. Ahadian, Drew M. Trainor, Lilly Chen, and Roshini Jain. Pain Management, March.

Biomedical Sciences

Multiomics and Machine-Learning Identify Novel Transcriptional and Mutational Signatures in Amyotrophic Lateral Sclerosis. Catanese, Alberto, Sandeep Rajkumar, Daniel Sommer, Pegah Masrori, Nicole Hersmus, Philip Van Damme, Simon Witzel, Albert Ludolph, Ritchie Ho, Tobias M. Boeckers, and Medhanie Mulaw. Brain: A Journal of Neurology, March, awad075.

Peri-Coronary Adipose Tissue Is a Predictor of Stent Failure in Patients Undergoing Percutaneous Coronary Intervention. Nogic, Jason, Jiwon Kim, Jamie Layland, Kevin Cheng, Damini Dey, Dennis T. Wong, James D. Cameron, and Adam J. Brown. Cardiovascular Revascularization Medicine: Including Molecular Interventions, February, S1553-8389(23)00078-7.

Initial Recommendations for Performing, Benchmarking and Reporting Single-Cell Proteomics Experiments. Gatto, Laurent, Ruedi Aebersold, Juergen Cox, Vadim Demichev, Jason Derks, Edward Emmott, Alexander M. Franks, Alexander R. Ivanov, Ryan T. Kelly, Luke Khoury, Andrew Leduc, Michael J. MacCoss, Peter Nemes, David H. Perlman, Aleksandra A. Petelski, Christopher M. Rose, Erwin M. Schoof, Jennifer Van Eyk, Christophe Vanderaa, John R. Yates, and Nikolai Slavov. Nature Methods, March.

Coronary Inflammation and Plaque Vulnerability: A Coronary Computed Tomography and Optical Coherence Tomography Study. Yuki, Haruhito, Tomoyo Sugiyama, Keishi Suzuki, Daisuke Kinoshita, Takayuki Niida, Akihiro Nakajima, Makoto Araki, Damini Dey, Hang Lee, Iris McNulty, Sunao Nakamura, Tsunekazu Kakuta, and Ik-Kyung Jang. Circulation. Cardiovascular Imaging, March, e014959.

Cancer

Management of Infusion-Related Reactions (IRRs) in Patients Receiving Amivantamab in the CHRYSALIS Study. Park, Keunchil, Joshua K. Sabari, Eric B. Haura, Catherine A. Shu, Alexander Spira, Ravi Salgia, Karen L. Reckamp, Rachel E. Sanborn, Ramaswamy Govindan, Joshua M. Bauml, Joshua C. Curtin, John Xie, Amy Roshak, Patricia Lorenzini, Dawn Millington, Meena Thayu, Roland E. Knoblauch, and Byoung Chul Cho. Lung Cancer (Amsterdam, Netherlands) 178 (February): 166–71.

Melatonin Modulates the Warburg Effect and Alters the Morphology of Hepatocellular Carcinoma Cell Line Resulting in Reduced Viability and Migratory Potential. Cruz, Ellen Mayara Souza, Virginia Marcia Concato, Juliana Maria Bitencourt de Morais, Taylon Felipe Silva, Fabricio Seidy Ribeiro Inoue, Milena de Souza Cremer, Danielle Lazarin Bidóia, Rayanne Regina Beltrame Machado, Luiz Gustavo de Almeida Chuffa, Mário Sérgio Mantovani, Carolina Panis, Wander Rogério Pavanelli, and Fábio Rodrigues Ferreira Seiva. Life Sciences 319 (February): 121530.

Active Surveillance for Low-Risk Papillary Thyroid Carcinoma-Reply. Ho, Allen S., Wendy L. Sacks, and Zachary S. Zumsteg. JAMA Oncology, March.

Phase 1 Study to Determine the Safety and Dosing of Autologous PBMCs Modified to Present HPV16 Antigens (SQZ-PBMC-HPV) in HLA-A*02+ Patients With HPV16+ Solid Tumors. Jimeno, Antonio, Joaquina Baranda, Wade T. Iams, Jong Chul Park, Monica Mita, Michael S. Gordon, Matthew Taylor, Neesha Dhani, Alexis D. Leal, Prakash Neupane, Cathy Eng, Oladapo Yeku, Alain Mita, Justin C. Moser, Marcus Butler, Scott M. Loughhead, Julia Jennings, Nathan R. Miselis, Rui-Ru Ji, Nitya Nair, Martin Kornacker, Ricardo F. Zwirtes, Howard Bernstein, and Armon Sharei. Investigational New Drugs, March.

Loss of Anti-Spike Antibodies Following MRNA Vaccination for COVID-19 Among Patients With Multiple Myeloma. Stampfer, Samuel D., Sean Bujarski, Marissa-Skye Goldwater, Scott Jew, Bernard Regidor, Haiming Chen, Ning Xu, Mingjie Li, Eddie Fung, Regina Swift, Bethany Beatty, Shahrooz Eshaghian, and James R. Berenson. Cancer Reports (Hoboken, N.J.), March, e1803.

The 24-Hour Movement Paradigm: An Integrated Approach to the Measurement and Promotion of Daily Activity in Cancer Clinical Trials. Shirazipour, Celina H., Carolina Raines, Marcio A. Diniz, Sarah-Jeanne Salvy, Robert W. Haile, Stephen J. Freedland, Arash Asher, Jennifer R. Tomasone, and Gillian Gresham. Contemporary Clinical Trials Communications 32 (April): 101081.

Cardiology

Transcatheter Repair for Patients with Tricuspid Regurgitation. Sorajja, Paul, Brian Whisenant, Nadira Hamid, Hursh Naik, Raj Makkar, Peter Tadros, Matthew J. Price, Gagan Singh, Neil Fam, Saibal Kar, Jonathan G. Schwartz, Shamir Mehta, Richard Bae, Nishant Sekaran, Travis Warner, Moody Makar, George Zorn, Erin M. Spinner, Phillip M. Trusty, Raymond Benza, Ulrich Jorde, Patrick McCarthy, Vinod Thourani, Gilbert H. L. Tang, Rebecca T. Hahn, David H. Adams, and TRILUMINATE Pivotal Investigators. The New England Journal of Medicine, March.

The Protracted Path to Untethered Mechanical Circulatory Support: Always the Future or Reality Soon? Patel, Jignesh K. The British Journal of Cardiology 29 (3): 22.

Managing Patients With Moderate Aortic Stenosis. Stassen, Jan, See Hooi Ewe, Stephan M. Pio, Philippe Pibarot, Bjorn Redfors, Jonathon Leipsic, Philippe Genereux, Nicolas M. Van Mieghem, Jurrien H. Kuneman, Raj Makkar, Rebecca T. Hahn, David Playford, Nina Ajmone Marsan, Victoria Delgado, Ori Ben-Yehuda, Martin B. Leon, and Jeroen J. Bax. JACC. Cardiovascular Imaging, January, S1936-878X(22)00741-0.

Implications of Extra-Cardiac Disease in Patient Selection for Heart Transplantation: Considerations in Cardiac Amyloidosis. Punnoose, Lynn Raju, Hasan Siddiqi, Julie Rosenthal, Michelle Kittleson, Ronald Witteles, and Kevin Alexander. Cardiac Failure Review 9 (February): e01.

Can Artificial Intelligence Identify Physiologically ‘Old’ Hearts? Holmstrom, Lauri, and Sumeet S. Chugh. Mayo Clinic Proceedings 98 (3): 360–62.

Apparent Treatment Resistant Hypertension Associated Lifetime Cardiovascular Risk in a Longitudinal National Registry. Ebinger, Joseph E., Anni Kauko, FinnGen, Natalie A. Bello, Susan Cheng, and Teemu Niirranen. European Journal of Preventive Cardiology, March, zwad066.

The Evolving Use of Biomarkers in Heart Transplantation: Consensus of an Expert Panel. Kobashigawa, Jon, Shelley Hall, Palak Shah, Barry Fine, Phil Halloran, Annette M. Jackson, Kiran K. Khush, Kenneth B. Margulies, Maryam Mojarrad Sani, Jignesh K. Patel, Nikhil Patel, Eliot Peyster, and conference participants. American Journal of Transplantation, March, S1600-6135(23)00310-6.

2D-Echocardiographic Characterization of Dyspnea in Tricuspid Regurgitation. Visrodia, Parth, Louie Cao, Maulin Shah, Robert Naami, Joseph Ebinger, Florian Rader, Takahiro Shiota, Robert J. Siegel, and Sabah Skaf. Journal of the American College of Cardiology, ACC.23, 81 (8, Supplement): 1999.

Persistent Chest Pain at 5 Years: Predictors and Associated Outcomes Among Women With and Without Obstructive Coronary Artery Disease in the Women’s Ischemia Syndrome Evaluation (WISE). Obrutu, Okezi, Janet Wei, Martha Gulati, Steven E. Reis, Vera Bittner, Eileen M. Handberg, Galen Cook-Wiens, Carl J. Pepine, and C. Noel Bairey Merz. Journal of the American College of Cardiology, ACC.23, 81 (8, Supplement): 1161.

Temporal Trends in Persistent Chest Pain and Medication Use Among Women With and Without Obstructive Coronary Artery Disease in the Women’s Ischemia Syndrome Evaluation (WISE). Obrutu, Okezi, Janet Wei, Martha Gulati, Steven E. Reis, Vera Bittner, Eileen M. Handberg, Galen Cook-Wiens, Carl J. Pepine, and C. Noel Bairey Merz. Journal of the American College of Cardiology, ACC.23, 81 (8, Supplement): 1149.

Treatment of Late Paravalvular Regurgitation After Transcatheter Aortic Valve Implantation: Prognostic Implications. Landes, Uri, Aviram Hochstadt, Lisa Manevich, John G. Webb, Janarthanan Sathananthan, Horst Sievert, Kerstin Piayda, Martin B. Leon, Tamim M. Nazif, David Blusztein, David Hildick-Smith, Chris Pavitt, Holger Thiele, Mohamed Abdel-Wahab, Nicolas M. Van Mieghem, Rik Adrichem, Lars Sondergaard, Ole De Backer, Raj R. Makkar, Ofir Koren, Thomas Pilgrim, Taishi Okuno, Ran Kornowski, Pablo Codner, Ariel Finkelstein, Itamar Loewenstein, Israel Barbash, Amir Sharon, Federico De Marco, Matteo Montorfano, Nicola Buzzatti, Azeem Latib, Andrea Scotti, Won-Keun Kim, Christian Hamm, Luis Nombela Franco, Antonio Mangieri, Wolfgang H. Schoels, Marco Barbanti, Matjaz Bunc, Myriama Akodad, Ronen Rubinshtein, and Haim Danenberg. European Heart Journal, March, ehad146.

Imaging

Artificial Intelligence for Assessment of Epicardial Adipose Tissue on Coronary CT Angiography. Berman, Daniel S., and Andrew Lin. JACC. Cardiovascular Imaging, January, S1936-878X(22)00731-8.

Charcot-Marie-Tooth Disease of the Foot and Ankle: Imaging Features and Pathophysiology. Waldman, Leah E., Max P. Michalski, Joseph C. Giaconi, Glenn B. Pfeffer, and Thomas J. Learch. Radiographics: A Review Publication of the Radiological Society of North America, Inc 43 (4): e220114.

Medicine

Twenty-Year Analysis of Photobiomodulation Clinical Studies for Oral Mucositis: A Scoping Review. Kauark-Fontes, Elisa, Cesar Augusto Migliorati, Joel B. Epstein, Rene-Jean Bensadoun, Luiz Alcino Monteiro Gueiros, James Carroll, Luciana Maria Pedreira Ramalho, and Alan Roger Santos-Silva. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, December, S2212-4403(22)01307-4.

Etrasimod as Induction and Maintenance Therapy for Ulcerative Colitis (ELEVATE): Two Randomised, Double-Blind, Placebo-Controlled, Phase 3 Studies. Sandborn, William J., Séverine Vermeire, Laurent Peyrin-Biroulet, Marla C. Dubinsky, Julian Panes, Andres Yarur, Timothy Ritter, Filip Baert, Stefan Schreiber, Sheldon Sloan, Fabio Cataldi, Kevin Shan, Christopher J. Rabbat, Michael Chiorean, Douglas C. Wolf, Bruce E. Sands, Geert D’Haens, Silvio Danese, Martina Goetsch, and Brian G. Feagan. Lancet (London, England), March, S0140-6736(23)00061-2.

OPTN Required SARS-CoV-2 Lower Respiratory Testing for Lung Donors: Striking the Balance. Booker, Sarah E., Courtney Jett, Cole Fox, Judith A. Anesi, Gerald J. Berry, Kelly E. Dunn, Cynthia E. Fisher, Jason D. Goldman, Chak-Sum Ho, Michelle Kittleson, Dong Heun Lee, Deborah J. Levine, Charles C. Marboe, Gary Marklin, Carlos Martinez, Raymund R. Razonable, Marty T. Sellers, Sarah Taimur, Helen S. Te, Anil J. Trindade, R. Patrick Wood, Ann E. Woolley, Lorenzo Zaffiri, David K. Klassen, Marian G. Michaels, Stephanie M. Pouch, Lara Danziger-Isakov, and Ricardo M. La Hoz. Transplant Infectious Disease, March, e14048.

Exploring the Role of the Tumor Microenvironment in Refractory Pituitary Tumor Pathogenesis. Ben-Shlomo, Anat. Pituitary, March.

Irritable Bowel Syndrome Is Not Associated With an Increased Risk of Polyps and Colorectal Cancer: A Systematic Review and Meta-Analysis. Vichos, Theodoros, Ali Rezaie, Petros Vichos, Brooks Cash, and Mark Pimentel. Digestive Diseases and Sciences, March.

NAD-Elevating Interventions for Cardiometabolic Disease. Musi, Nicolas. The Journal of Clinical Endocrinology and Metabolism, March, dgad120.

Standard of Care Drugs Do Not Modulate Activity of Senescent Primary Human Lung Fibroblasts. Badaro-Garcia, Stephanie, Miriam S. Hohmann, Ana Lucia Coelho, Waldiceu A. Verri, and Cory M. Hogaboam. Scientific Reports 13 (1): 3654.

Type 2 Diabetes Complications Are Associated With Liver Fibrosis Independent of Hemoglobin A1c.Trivedi, Hirsh D., Qua Tran, Zachary Fricker, Michael P. Curry, Jonathan X. Li, and Michelle Lai. Annals of Hepatology, March, 101087.

Macrophage Fumarate Hydratase Restrains MtRNA-Mediated Interferon Production. Hooftman, Alexander, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado-Carrancio, Alva M. Casey, Hiran A. Prag, Ana S. H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander Von Kriegsheim, Michael P. Murphy, Caroline Jefferies, Christian Frezza, and Luke A. J. O’Neill. Nature, March.

NLRP12-Expressing Dendritic Cells Mediate Both Dissemination of Infection and Adaptive Immune Responses in Visceral Leishmaniasis. Valadares, Diogo Garcia, Owen Scott Clay, Yani Chen, Breanna Mary Scorza, Suzanne Louise Cassel, Fayyaz Shiraz Sutterwala, and Mary Edythe Wilson. IScience 26 (3): 106163.

Nursing

The Association Between Korean American Nurse and Primary Care Provider Burnout, Areas of Worklife, and Perceptions of Pandemic Experience: Cross-Sectional Study. Kim, Linda Y., Adrienne Martinez-Hollingworth, Harriet Aronow, Isa Caffe, Wenrui Xu, Christine Khanbijian, Mason Lee, Bernice Coleman, and Angela Jun. Asian/Pacific Island Nursing Journal 7 (March): e42490.

Orthopaedics

Adjacent Segment Impingement: A New Type of Adjacent Segment Disease?: A Report of 3 Cases. Skaggs, Kira F., Stephen Stephan, Tiffany G. Perry, and David L. Skaggs. JBJS Case Connector 12 (4).

Quadriceps Weakness Is Associated With Neuroplastic Changes Within Specific Corticospinal Pathways and Brain Areas After Anterior Cruciate Ligament Reconstruction: Theoretical Utility of Motor Imagery-Based Brain-Computer Interface Technology for Rehabilitation. Patel, Harsh H., Elyse J. Berlinberg, Benedict Nwachukwu, Riley J. Williams, Bert Mandelbaum, Konstantin Sonkin, and Brian Forsythe. Arthroscopy, Sports Medicine, and Rehabilitation 5 (1): e207–16.

Return to Sport After Arthroscopic Capsular Repair in Elite Baseball Players. Uffmann, William J., Neal S. ElAttrache, Keon Youssefzadeh, Andrew Carbone, and Orr Limpisvasti. Orthopaedic Journal of Sports Medicine 11 (2): 23259671231153144.

Patient-Reported Outcomes Are Similar in the First Two Years After Staged Versus Combined Hip Arthroscopy and Periacetabular Osteotomy for Hip Dysplasia. Orner, Caitlin A., Brittany E. Haws, John Reuter, Raymond Kenney, P. Christopher Cook, and Brian D. Giordano. Arthroscopy: The Journal of Arthroscopic & Related Surgery, March, S0749-8063(23)00197-4.

Pathology

Postoperative Polyp Scale (POPS): Development of a New Sinonasal Polyp Grading Scale. Wu, Arthur W., Akaber M. Halawi, Elisa A. Illing, Dennis M. Tang, Philip G. Chen, Edward C. Kuan, Jonathan Y. Ting, Daniel A. Norez, Stacey A. Kim, Dhruv Sharma, Douglas D. Reh, Sanjeet V. Rangarajan, Kent K. Lam, Randall A. Ow, J. Wesley Sublett, and Thomas S. Higgins. The Laryngoscope, March.

Successful Autologous Hematopoietic Stem Cell Transplants Using Salmonella Positive Products Collected From Asymptomatic Donors. Phou, Samantha, Ingrid Perez-Alvarez, Margie Morgan, Deisy A. Contreras, Michael Ben-Aderet, Emily Gaddam, Ronald Paquette, Robert Vescio, Samuel H. Pepkowitz, David R. Gibb, Rachel Zabner, and Ellen B. Klapper. Transfusion, March.

Radiation Oncology

Application of a Genetic Signature of Late GU Toxicity in SCIMITAR, a Post-Op SBRT Trial. Kishan, Amar U., Nicholas Marco, Ting Martin Ma, Michael L. Steinberg, Ankush Sachdeva, Minsong Cao, Leslie K. Ballas, Emily Rietdorf, Donatello Telesca, and Joanne B. Weidhaas. Clinical and Translational Radiation Oncology 39 (March): 100594.

Surgery

A Retrospective Evaluation of Changing Health Characteristics Amongst Deceased Organ Donors in the United States. Steggerda, Justin A., Daniela P. Ladner, Irene K. Kim, Steven A. Wisel, and Daniel Borja-Cacho. Transplantation Proceedings, March, S0041-1345(23)00036-2.

Analysis of Vein Grafting Versus Arteriovenous Loop in Microvascular Head and Neck Reconstruction: Multicenter Series of 36 Patients. Pak, Kaitlynne Y., Spencer R. Anderson, Tyler L. Langenfeld, Kenneth Tan, Allison Slijepcevic, Sunishka Wimalawansa, Yadranko Ducic, Mark K. Wax, and Sameep P. Kadakia. Head & Neck, March.

Functional Oculofacial Abstracts. Ali, Mohammad Javed, Francesco P. Bernardini, Aaron Savar, Alan A. McNab, and Hatem A. Tawfik. Ophthalmic Plastic and Reconstructive Surgery 39 (2): 201–2.