This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published March 16 - 23.

Biomedical Sciences

Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders. Alex, Ann M., Claudia Buss, Elysia Poggi Davis, Gustavo de Los Campos, Kirsten A. Donald, Damien A. Fair, Nadine Gaab, Wei Gao, John H. Gilmore, Jessica B. Girault, Karen Grewen, Nynke A. Groenewold, Benjamin L. Hankin, Jonathan Ipser, Shreya Kapoor, Pilyoung Kim, Weili Lin, Shan Luo, Elizabeth S. Norton, Thomas G. O’Connor, Joseph Piven, Anqi Qiu, Jerod M. Rasmussen, Michael A. Skeide, Dan J. Stein, Martin A. Styner, Paul M. Thompson, Laurie Wakschlag, Rebecca Knickmeyer, and ENIGMA ORIGINs group. Biological Psychiatry, January, S0006-3223(23)00040-9.

Axial Shear Rate: A Hemorheological Factor for Erythrocyte Aggregation Under Womersley Flow in an Elastic Vessel Based on Numerical Simulation. Lee, Cheong-Ah, Hafiz Muhammad Umer Farooqi, and Dong-Guk Paeng. Computers in Biology and Medicine 157 (March): 106767.

The Journal of Cardiovascular Computed Tomography: A Year in Review: 2022. Pontone, Gianluca, Saima Mushtaq, Subhi J. Al’Aref, Daniele Andreini, Andrea Baggiano, Arzu Canan, Joao L. Cavalcante, Anjali Chelliah, Marcus Chen, Andrew Choi, Dey Damini, Carlo Nicola De Cecco, Kanwal M. Farooqi, Maros Ferencik, Gudrun Feuchtner, Harvey Hecht, Heidi Gransar, Márton Kolossváry, Jonathon Leipsic, Michael T. Lu, Mohamed Marwan, Ming-Yen Ng, Pál Maurovich-Horvat, Prashant Nagpal, Ed Nicol, Jonathan Weir-McCall, Seamus P. Whelton, Michelle C. Williams, Anna Reid, Timothy A. Fairbairn, Todd Villines, Rosemarie Vliegenthart, and Armin Arbab-Zadeh. Journal of Cardiovascular Computed Tomography, March, S1934-5925(23)00086-2.

MFN1 Augmentation Prevents Retinal Degeneration in a Charcot-Marie-Tooth Type 2A Mouse Model. Shahin, Saba, Bin Lu, Yueqin Zhou, Hui Xu, Jason Chetsawang, Robert H. Baloh, and Shaomei Wang. IScience 26 (3): 106270.

Cancer

Dietary Omega-3 Fatty Acids and Endometrial Cancer Risk in the Epidemiology of Endometrial Cancer Consortium: An Individual-Participant Meta-Analysis. Brasky, Theodore M., Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O’Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O’Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-Ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, and Marian L. Neuhouser. Gynecologic Oncology 169 (February): 137–46.

The Molecular Consequences of Androgen Activity in the Human Breast. Raths, Florian, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T. Tilley, Theresa E. Hickey, Bo Wang, Armando E. Giuliano, Shikha Bose, Hani Goodarzi, Edward C. Ray, Xiaojiang Cui, and Simon R. V. Knott. Cell Genomics 3 (3): 100272.

Neoadjuvant Therapy for Pancreatic Cancer. Springfeld, Christoph, Cristina R. Ferrone, Matthew H. G. Katz, Philip A. Philip, Theodore S. Hong, Thilo Hackert, Markus W. Büchler, and John Neoptolemos. Nature Reviews. Clinical Oncology, March.

CS-ICCA; A New Clinically Based Staging System for Intrahepatic Cholangiocarcinoma: Establishment and External Validation. Lozada Mel, Maria E., Ning Zhang Nz, Weidong Jin Wj, Nicha Wongjarupong Nw, Ju Dong Yang Jdy, Molly M. Petersen Mmp, Kritika Prasai Kp, Dominic O. Amakye Doa, William S. Harmsen Wsh, Sushant Chaudhary Sc, Oliver Bathe Ob, Mitesh Borad Mb, Tushar C. Patel Tcp, Gregory J. Gores Gjg, Terry M. Therneau Tmt, and Lewis R. Roberts Lrr. The American Journal of Gastroenterology, March.

Novel Prognostic Staging System for Patients With De Novo Metastatic Breast Cancer. Plichta, Jennifer K., Samantha M. Thomas, Daniel F. Hayes, Mariana Chavez-MacGregor, Kimberly Allison, Jennifer de Los Santos, Amy M. Fowler, Armando E. Giuliano, Priyanka Sharma, Benjamin D. Smith, Elizabeth van Eycken, Stephen B. Edge, and Gabriel N. Hortobagyi. Journal of Clinical Oncology, March, JCO2202222.

P53 and Ovarian Carcinoma Survival: An Ovarian Tumor Tissue Analysis Consortium Study. Köbel, Martin, Eun-Young Kang, Ashley Weir, Peter F. Rambau, Cheng-Han Lee, Gregg S. Nelson, Prafull Ghatage, Nicola S. Meagher, Marjorie J. Riggan, Jennifer Alsop, Michael S. Anglesio, Matthias W. Beckmann, James D. Brenton, et al. The Journal of Pathology. Clinical Research, March.

Age-Related Differences in Employment, Insurance, and Financial Hardship among Colorectal Cancer Patients: A Report from the ColoCare Study. Berghuijs, Karely M. van Thiel, Heydon K. Kaddas, Gillian Trujillo, Gazelle Rouhani, Amy Chevrier, Jennifer Ose, David Shibata, Adetunji T. Toriola, Jane C. Figueiredo, Anita R. Peoples, Christopher I. Li, Sheetal Hardikar, Erin M. Siegel, Biljana Gigic, Martin Schneider, Cornelia M. Ulrich, and Anne C. Kirchhoff. Journal of Cancer Survivorship: Research and Practice, March.

Editorial Comment. Das, Sanjay, Jun Gong, and Stephen J. Freedland. The Journal of Urology, March, 101097JU000000000000337001.

TOPAZ-1: A New Standard of Care for Advanced Biliary Tract Cancers? Ebia, Matthew I., Kamya Sankar, Arsen Osipov, Andrew E. Hendifar, and Jun Gong. Immunotherapy, March.

Cardiac Surgery

Outcomes of Extremely Prolonged (> 50 d) Venovenous Extracorporeal Membrane Oxygenation Support. Malas, Jad, Qiudong Chen, Tao Shen, Dominic Emerson, Tyler Gunn, Dominick Megna, Pedro Catarino, Michael Nurok, Michael Bowdish, Joanna Chikwe, Susan Cheng, Joseph Ebinger, and Abirami Kumaresan. Critical Care Medicine, March.

The Boundaries of Professionalism in Surgery. Prager, Richard L., Robbin G. Cohen, G. Michael Deeb, William O. Cooper, and Robert M. Sade. The Annals of Thoracic Surgery, March, S0003-4975(23)00290-4.

Cardiology

Vitamin D Metabolite Ratio and Coronary Artery Calcification in the Multi-Ethnic Study of Atherosclerosis. Ginsberg, Charles, Andrew N. Hoofnagle, Ronit Katz, Jonathan H. Cheng, Simon Hsu, Matthew J. Budoff, Deborah M. Kado, Bryan Kestenbaum, David S. Siscovick, Erin D. Michos, Joachim H. Ix, and Ian H. de Boer. Circulation. Cardiovascular Imaging 16 (3): e015055.

Association of Abnormal P-Wave Parameters With Brain Mri Morphology: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). Reyes, Jorge L., Faye L. Norby, Yuekai Ji, Wendy Wang, Romil Parikh, Michael J. Zhang, Niki C. Oldenburg, Pamela L. Lutsey, Clifford R. Jack, Michelle Johansen, Rebecca F. Gottesman, Josef Coresh, Thomas Mosley, Elsayed Z. Soliman, Alvaro Alonso, and Lin Yee Chen. Pacing and Clinical Electrophysiology: PACE, March.

Effectiveness of the Family Heart Talk Communication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial. Kinnamon, Daniel D., Elizabeth Jordan, Garrie J. Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A. Ewald, Alanna A. Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia Garg, Barry H. Trachtenberg, Palak Shah, Salpy V. Pamboukian, Nancy K. Sweitzer, Matthew T. Wheeler, Jane E. Wilcox, Stuart Katz, Stephen Pan, Javier Jimenez, Keith D. Aaronson, Daniel P. Fishbein, Frank Smart, Jessica Wang, Stephen S. Gottlieb, Daniel P. Judge, Charles K. Moore, Jonathan O. Mead, Gordon S. Huggins, Hanyu Ni, Wylie Burke, Ray E. Hershberger, and DCM (Dilated Cardiomyopathy) Precision Medicine Study of the DCM Consortium. Circulation, March.

Computational Biomedicine

Genetics and Precision Health: The Ecological Fallacy and Artificial Intelligence Solutions. Williams, Scott M., and Jason H. Moore. BioData Mining 16 (1): 9.

Emergency Medicine

Civility in the Emergency Department. Geiderman, Joel M., and Catherine A. Marco. The American Journal of Emergency Medicine, March, S0735-6757(23)00121-3.

Physicians’ Moral Duties During Pandemics. Iserson, Kenneth V., Arthur R. Derse, John C. Moskop, and Joel M. Geiderman. Journal of Emergency Medicine.

Imaging

Assessment of Lifestyle-Related Risk Factors Enhances the Effectiveness of Cardiac Stress Testing. Rozanski, Alan, Sakul Sakul, Jagat Narula, Seth Uretsky, Carl J. Lavie, and Daniel Berman. Progress in Cardiovascular Diseases, March, S0033-0620(23)00029-4.

Medicine

Barriers and Facilitators to Interhospital Transfer of Acute Pulmonary Embolism: An Inductive Qualitative Analysis. DeBerry, Jacob, Parth Rali, Michael McDaniel, Christopher Kabrhel, Rachel Rosovsky, Roman Melamed, Oren Friedman, Jean M. Elwing, Vijay Balasubramanian, Sandeep Sahay, Eduardo Bossone, Mary Jo S. Farmer, Andrew J. P. Klein, Megan E. Hamm, Charles B. Ross, and Belinda N. Rivera-Lebron. Frontiers in Medicine 10: 1080342.

Impact of Gut-Peripheral Nervous System Axis on the Development of Diabetic Neuropathy. Mázala-de-Oliveira, Thalita, Yago Amigo Pinho Jannini de Sá, and Vinicius de Frias Carvalho. Memorias Do Instituto Oswaldo Cruz 118: e220197.

Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis. Liu, Xue, Kristy Dai, Xuexi Zhang, Guanling Huang, Heather Lynn, Anas Rabata, Jiurong Liang, Paul W. Noble, and Dianhua Jiang. American Journal of Respiratory Cell and Molecular Biology, March.

Interleukin-10 Knockout Mice Do Not Reliably Exhibit Macroscopic Inflammation: A Natural History Endoscopic Surveillance Study. Kim, Seung Young, Jae Ho Park, Gabriela Leite, Mark Pimentel, and Ali Rezaie. Digestive Diseases and Sciences, March.

Assessing the Performance of ChatGPT in Answering Questions Regarding Cirrhosis and Hepatocellular Carcinoma. Yeo, Yee Hui, Jamil S. Samaan, Wee Han Ng, Peng-Sheng Ting, Hirsh Trivedi, Aarshi Vipani, Walid Ayoub, Ju Dong Yang, Omer Liran, Brennan Spiegel, and Alexander Kuo. Clinical and Molecular Hepatology, March.

Screening and Management of PTLD. Zaffiri, Lorenzo, and Eileen T. Chambers. Transplantation, March.

Hyaluronan in Liver Fibrosis: Basic Mechanisms, Clinical Implications, and Therapeutic Targets. Kim, Jieun, and Ekihiro Seki. Hepatology Communications 7 (4): e0083.

Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Mastracci, Teresa L., Minoti Apte, Laufey T. Amundadottir, Alexandra Alvarsson, Steven Artandi, Melena D. Bellin, Ernesto Bernal-Mizrachi, Alejandro Caicedo, Martha Campbell-Thompson, Zobeida Cruz-Monserrate, Abdelfattah El Ouaamari, Kyle J. Gaulton, Andrea Geisz, Mark O. Goodarzi, Manami Hara, Rebecca L. Hull-Meichle, Alexander Kleger, Alison P. Klein, Janel L. Kopp, Rohit N. Kulkarni, Mandar D. Muzumdar, Anjaparavanda P. Naren, Scott A. Oakes, Søren S. Olesen, Edward A. Phelps, Alvin C. Powers, Cherie L. Stabler, Temel Tirkes, David C. Whitcomb, Dhiraj Yadav, Jing Yong, Norann A. Zaghloul, Stephen J. Pandol, and Maike Sander. Diabetes 72 (4): 433–48. 

Neurology

Neuropathy Due to Bi-Allelic SH3TC2 Variants: Genotype-Phenotype Correlation and Natural History. Rehbein, Tyler, Tong Tong Wu, Simona Treidler, Davide Pareyson, Richard Lewis, Sabrina W. Yum, Brett A. McCray, Sindhu Ramchandren, Joshua Burns, Jun Li, Richard S. Finkel, Steven S. Scherer, Stephan Zuchner, Michael E. Shy, Mary M. Reilly, David N. Herrmann, and Inherited Neuropathy Consortium-Rare Diseases Clinical Research Network (INC-RDCRN). Brain: A Journal of Neurology, March, awad095.

OBGYN

Anatomy of the Ureter and Applications During Gynecologic Surgery. Meyer, R., R. Schneyer, K. Hamilton, K. Wright, M. T. Siedhoff, and M. Truong. American Journal of Obstetrics and Gynecology, Society of Gynecologic Surgeons 49th Annual Scientific Meeting, 228 (3, Supplement): S949–50.

Child-Free by Choice: Providing Permanent Contraception to a Nulliparous Population. Caron, J., S. Torna, and N. Schimmoeller. American Journal of Obstetrics and Gynecology, Society of Gynecologic Surgeons 49th Annual Scientific Meeting, 228 (3, Supplement): S916.

Ovarian Transposition for Posterior Cul-de-Sac Access: A Case Report Video Abstract. Niino, C. A., K. Hamilton, L. Tholemeier, M. T. Siedhoff, M. D. Truong, and K. Wright. American Journal of Obstetrics and Gynecology, Society of Gynecologic Surgeons 49th Annual Scientific Meeting, 228 (3, Supplement): S933.

Racial and Gender Representation Trends Among National Obstetrics and Gynecology Society Leadership. Hamilton, K. M., N. Konate, R. Meyer, G. Jasmine, K. Wright, M. T. Siedhoff, S. A. Scheib, and M. Truong. American Journal of Obstetrics and Gynecology, Society of Gynecologic Surgeons 49th Annual Scientific Meeting, 228 (3, Supplement): S859.

Rectal Endometrioma Resection. Hamilton, K. M., K. Moran, C. Liao, M. Truong, K. Wright, and M. T. Siedhoff. American Journal of Obstetrics and Gynecology, Society of Gynecologic Surgeons 49th Annual Scientific Meeting, 228 (3, Supplement): S950.

Telemedicine Improves Visit Efficiency in Minimally Invasive Gynecologic Surgery Practice. Niino, C. A., L. Tholemeier, R. Meyer, M. T. Siedhoff, K. Wright, and M. Truong. American Journal of Obstetrics and Gynecology, Society of Gynecologic Surgeons 49th Annual Scientific Meeting, 228 (3, Supplement): S913–14.

The Red Bag Problem: Our Unsustainable Future in the Operating Room. Niino, C. A., C. S. John, and K. Wright. American Journal of Obstetrics and Gynecology, Society of Gynecologic Surgeons 49th Annual Scientific Meeting, 228 (3, Supplement): S799.

Twitter Gynecologic Surgery Journal Club: Impact on Social Media Attention and Citation Scores. Meyer, R., S. Behbehani, K. Brooks, C. G. Rodríguez Valero, C. Fox, A. Small Layne, M. Misal, P. R. Movilla, J. K. Lauer, A. Wong, K. Ackert, and M. Truong. American Journal of Obstetrics and Gynecology, Society of Gynecologic Surgeons 49th Annual Scientific Meeting, 228 (3, Supplement): S828–29.

Identifying ChatGPT-Written OBGYN Abstracts Using a Simple Tool. Levin, Gabriel, Raanan Meyer, Eva Kadoch, and Yoav Brezinov. American Journal of Obstetrics & Gynecology MFM, March, 100936.

Orthopaedics

Integration of Collaborative Care Model Ameliorates Population Level COVID-19 Pandemic-Related Depressive Symptoms Among Orthopaedic Clinic Patient Population in US Major Metropolitan Area. Lindsey, Caryn, Grant J. Dornan, and Karma McKelvey. Current Orthopaedic Practice, May, 10.1097/BCO.0000000000001204.

Building Consensus for the Medical Management of Children With Moderate and Severe Acute Spinal Cord Injury: A Modified Delphi Study. CreveCoeur, Travis S., Nikita G. Alexiades, Christopher M. Bonfield, Douglas L. Brockmeyer, Samuel R. Browd, Jason Chu, Anthony A. Figaji, Mari L. Groves, Todd C. Hankinson, David H. Harter, Steven W. Hwang, Andrew Jea, Steven G. Kernie, Jeffrey R. Leonard, Jonathan E. Martin, Matthew E. Oetgen, Alexander K. Powers, Curtis J. Rozzelle, David L. Skaggs, Jennifer M. Strahle, John C. Wellons, Michael G. Vitale, and Richard C. E. Anderson. Journal of Neurosurgery. Spine, March, 1–14.

Deformity Angular Ratio Is Associated With Neuromonitoring Changes Without a Vertebral Column Resection: Spinal Deformity Is More Influential than Type of Surgery. Illingworth, Kenneth D., Ali A. Siddiqui, David L. Skaggs, and Lindsay M. Andras. Spine Deformity, March.

Pathology

Characteristics of Renal Intravascular Large B-Cell Lymphoma. Rastogi, Prerna, Audai Alrwashdeh, Tiffany Caza, Mercury Lin, Mohammad Obeidat, Gabriel Giannini, Chris Larsen, and Dao-Fu Dai. Kidney International Reports 8 (3): 575–83.

CARD-Only Proteins Regulate in Vivo Inflammasome Responses and Ameliorate Gout. Devi, Savita, Mohanalaxmi Indramohan, Elisabeth Jäger, Jessica Carriere, Lan H. Chu, Lucia de Almeida, David R. Greaves, Christian Stehlik, and Andrea Dorfleutner. Cell Reports 42 (3): 112265.

Pediatrics

Automated Prioritization of Sick Newborns for Whole Genome Sequencing Using Clinical Natural Language Processing and Machine Learning. Peterson, Bennet, Edgar Javier Hernandez, Charlotte Hobbs, Sabrina Malone Jenkins, Barry Moore, Edwin Rosales, Samuel Zoucha, Erica Sanford, Matthew N. Bainbridge, Erwin Frise, Albert Oriol, Luca Brunelli, Stephen F. Kingsmore, and Mark Yandell. Genome Medicine 15 (1): 18.

Surgery

Cochlear Ossification After Vestibular Schwannoma Surgery: A Temporal Bone Study. Itamura, Kyohei, Alexander Geerardyn, Archana Podury, Ivan A. Lopez, Yu-Tung Wong, Akira Ishiyama, Alicia M. Quesnel, and Mia E. Miller. Otolaryngology--Head and Neck Surgery, January.

Creatinine Clearance May Predict Goal Enoxaparin Dose in Trauma. Park, Greigory, Navpreet K. Dhillon, Nicole M. Fierro, Peter Drevets, John Stupinski, and Eric J. Ley. Journal of the American College of Surgeons, March. https://doi.org/10.1097/XCS.000000000000068.

Urology

Residency Graduates Should Not Be Expected to Perform Hypospadias Repair Without Fellowship Training: Results from a Survey of SPU Membership. Masterson, John M., Michael Zaliznyak, Peris R. Castaneda, Aurash Naser-Tavakolian, and Andrew L. Freedman. Journal of Pediatric Urology, March, S1477-5131(23)00069-4.