This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published June 8-15. 

Anesthesiology

Longitudinal Comparative Analysis of Complications and Subsequent Interventions Following Stand-Alone Interspinous Spacers, Open Decompression, or Fusion for Lumbar Stenosis. Whang, Peter G., Oth Tran, and Howard L. Rosner. Advances in Therapy, June.

Biomedical Sciences

Pericoronary Adipose Tissue Density Is Increased in Patients With Recent Spontaneous Coronary Dissection. Wolny, Rafa? R., Jacek Kwieci?ski, Joanna Zalewska, Ilona Micha?owska, Mariusz Kruk, Cezary Kepka, Aleksander Prejbisz, Jerzy Pr?gowski, Alicja Chwa?a, Jaros?aw Skowro?ski, Agata Kobierska, Rados?aw Ciesielski, Andrzej Januszewicz, Adam Witkowski, David Adlam, Damini Dey, and Jacek K?dziela. Heart (British Cardiac Society), June, heartjnl-2023-322482.

Artificial Intelligence-Assisted Quantification of COVID-19 Pneumonia Burden From Computed Tomography Improves Prediction of Adverse Outcomes Over Visual Scoring Systems. Grodecki, Kajetan, Aditya Killekar, Judit Simon, Andrew Lin, Sebastien Cadet, Priscilla McElhinney, Cato Chan, Michelle C. Williams, Barry D. Pressman, Peter Julien, Debiao Li, Peter Chen, Nicola Gaibazzi, Udit Thakur, Elisabetta Mancini, Cecilia Agalbato, Jiro Munechika, Hidenari Matsumoto, Roberto Mene, Gianfranco Parati, Franco Cernigliaro, Nitesh Nerlekar, Camilla Torlasco, Gianluca Pontone, Pal Maurovich-Horvat, Piotr J. Slomka, and Damini Dey. The British Journal of Radiology, June, 20220180.

Racial and Ethnic Disparities in Treatment-Related Heart Disease Mortality Among US Breast Cancer Survivors. Vo, Jacqueline B., Cody Ramin, Wayne R. Lawrence, Ana Barac, Katherine L. Ho, Jongeun Rhee, Lene H. S. Veiga, and Amy Berrington de González. JNCI Cancer Spectrum 7 (2): pkad024.

Cancer

Expanding Genotype-Phenotype Correlations in FOXG1 Syndrome: Results From a Patient Registry. Brimble, Elise, Kathryn G. Reyes, Kopika Kuhathaas, Orrin Devinsky, Maura R. Z. Ruzhnikov, Xilma R. Ortiz-Gonzalez, Ingrid Scheffer, Nadia Bahi-Buisson, Heather Olson, and FOXG1 Research Foundation. Orphanet Journal of Rare Diseases 18 (1): 149.

Pertuzumab Plus Trastuzumab in Patients With Lung Cancer With ERBB2 Mutation or Amplification: Results From the Targeted Agent and Profiling Utilization Registry Study. Ganti, Apar K., Michael Rothe, Pam K. Mangat, Elizabeth Garrett-Mayer, Elie G. Dib, Herbert L. Duvivier, Eugene R. Ahn, Deepti Behl, Hossein Borghaei, Ani S. Balmanoukian, Anu Gaba, Rui Li, Kwabena Osei-Boateng, Ramya Thota, Gina N. Grantham, Abigail Gregory, Susan Halabi, and Richard L. Schilsky. JCO Precision Oncology 7 (June): e2300041.

Metabolic Reprograming of Exhausted Intratumoral CD8+ T-Cell Underlies Anti-Tumor Activity of SUMOylation Inhibitors in Large B Cell Lymphoma. Lownik, J., L. Milshteyn, A. L. Villamejor, and A. A. Merchant. Hematological Oncology 41 (S2): 277–277.

Cardiac Surgery

Long Term Outcomes and Anticoagulation in Mitral Valve Surgery - A Report From the Society of Thoracic Surgeons Database. Schwann, Thomas A., Andrew M. Vekstein, Daniel T. Engelman, Dylan Thibault, Joanna Chikwe, Milo Engoren, Mario Gaudino, Sreekanth Vemulapalli, Vinod Thourani, Gorav Ailawadi, Anthony Rousou, and Robert H. Habib. The Annals of Thoracic Surgery, June, S0003-4975(23)00585-4.

Clinical Outcomes of Different Revascularization Approaches for Patients With Multi-Vessel Coronary Artery Disease: A Network Meta-Analysis. Hasan, Syed Umar, Alina Pervez, Muhammad Wahdan Naseeb, Bakhtawar Saleem Rajput, Ariba Faheem, Irbaz Hameed, Michel Pompeu Sá, and M. Mujeeb Zubair. Perfusion, June, 2676591231182585.

Cardiology

Association of Beta-Blocker Therapy with Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease. Godoy, Lucas C., Michael E. Farkouh, Peter C. Austin, Baiju R. Shah, Feng Qiu, Cynthia A. Jackevicius, Harindra C. Wijeysundera, Harlan M. Krumholz, and Dennis T. Ko. Journal of the American College of Cardiology 81 (24): 2299–2311.

Left Ventricular Ejection Fraction and Long-Term Outcomes in Women Presenting With Signs and Symptoms of Ischaemia. Wu, Stephanie, Janet Wei, Marie Lauzon, Nissi Suppogu, Sheryl F. Kelsey, Steven E. Reis, Leslee J. Shaw, George Sopko, Eileen Handberg, Carl J. Pepine, and C. Noel Bairey Merz. Heart (British Cardiac Society), June, heartjnl-2023-322494.

Emerging Role of Scintigraphy Using Bone-Seeking Tracers for Diagnosis of Cardiac Amyloidosis: AJR Expert Panel Narrative Review. Slart, Riemer H. J. A., Wengen Chen, Alwin Tubben, Hendrea S. A. Tingen, Daniel R. Davies, Martha Grogan, Ashutosh D. Wechalekar, Michelle M. Kittleson, Louise E. J. Thomson, Piotr J. Slomka, Kshama Wechalekar, and Panithaya Chareonthaitawee. AJR. American Journal of Roentgenology, June.

Proteomics of Novel IPSC-Derived Vascular Endothelial Cells Reveal Extensive Similarity With an Immortalized Human Endothelial Cell Line. Ariyasinghe, Nethika Ruvini, Roberta de Souza Santos, Andrew Gross, Arwin Aghamaleky-Sarvestany, Simion Kreimer, Sarah J. Parker, and Dhruv Sareen. Physiological Genomics, June.

Ethnic Disparities in ST-Segment Elevation Myocardial Infarction Outcomes and Processes of Care in Patients With and Without Standard Modifiable Cardiovascular Risk Factors: A Nationwide Cohort Study. Weight, Nicholas, Saadiq Moledina, Louise Sun, Kristian Kragholm, Phillip Freeman, Carlos Diaz-Arocutipa, Mohamed Dafaalla, Martha Gulati, and Mamas A. Mamas. Angiology, June, 33197231182555.

High-Throughput Single-Cell Proteomic Analysis of Organ-Derived Heterogeneous Cell Populations by Nanoflow Dual-Trap Single-Column Liquid Chromatography. Kreimer, Simion, Aleksandra Binek, Blandine Chazarin, Jae Hyung Cho, Ali Haghani, Alexandre Hutton, Eduardo Marbán, Mitra Mastali, Jesse G. Meyer, Thassio Mesquita, Yang Song, Jennifer Van Eyk, and Sarah Parker. Analytical Chemistry, June.

Association Between Social Vulnerability Index and Mortality Following Acute Myocardial Infarction in the US Counties. Shaik, Ayesha, Muchi Ditah Chobufo, Karthik Gonuguntla, Neel Patel, Yasar Sattar, Harshith Thyagaturu, Dipesh Ludhwani, and Martha Gulati. Current Problems in Cardiology, June, 101854.

Saving Women’s Hearts: Improving Outcomes With Prevention & Policy. Gulati, Martha. American Journal of Preventive Cardiology 14 (June): 100504.

Antiarrhythmic Drug Therapy for Ventricular Arrhythmias: The Changing Role in the Modern Era. Cuk, Natasha, and Eric D. Braunstein. Cardiology 148 (2): 131–33.

Emergency Medicine

Characteristics of Patients Restrained in the Emergency Department and Evaluation for Disparities in Care. Stillman, Kaytlena, James Mirocha, Joel Geiderman, and Sam Torbati. Journal of Emergency Medicine 0 (0).

Medicine

Reciprocal Interactions Between Alveolar Progenitor Dysfunction and Aging Promote Lung Fibrosis. Liang, Jiurong, Guanling Huang, Xue Liu, Ningshan Liu, Forough Taghavifar, Kristy Dai, Changfu Yao, Nan Deng, Yizhou Wang, Peter Chen, Cory Hogaboam, Barry R. Stripp, William C. Parks, Paul W. Noble, and Dianhua Jiang. ELife 12 (June): e85415.

Reply to ‘Assessing the Accuracy of Responses by the Language Model ChatGPT to Questions Regarding Bariatric Surgery: A Critical Appraisal.’ Samaan, Jamil S., Yee Hui Yeo, Nithya Rajeev, Wee Han Ng, Nitin Srinivasan, and Kamran Samakar. Obesity Surgery, June.

The Novel SALT-M Score Predicts 1-Year Post-Transplant Mortality in Patients With Severe Acute-on-Chronic Liver Failure. Hernaez, Ruben, Constantine J. Karvellas, Yan Liu, Sophie-Caroline Sacleux, Saro Khemichian, Lance L. Stein, Kirti Shetty, Christina C. Lindenmeyer, Justin R. Boike, Douglas A. Simonetto, Robert S. Rahimi, Prasun K. Jalal, Manhal Izzy, Michael S. Kriss, Gene Y. Im, Ming V. Lin, Janice H. Jou, Brett E. Fortune, George Cholankeril, Alexander Kuo, Nadim Mahmud, Fasiha Kanwal, Faouzi Saliba, Vinay Sundaram, Thierry Artzner, Rajiv Jalan, and Multi-Organ Dysfunction and Evaluation for Liver Transplantation (MODEL) Consortium. Journal of Hepatology, June, S0168-8278(23)00403-8.

Defining Small Intestinal Bacterial Overgrowth by Culture and High Throughput Sequencing. Leite, Gabriela, Ali Rezaie, Ruchi Mathur, Gillian M. Barlow, Mohamad Rashid, Ava Hosseini, Jiajing Wang, Gonzalo Parodi, Maria Jesus Villanueva-Millan, Maritza Sanchez, Walter Morales, Stacy Weitsman, Mark Pimentel, and REIMAGINE Study Group. Clinical Gastroenterology and Hepatology, June, S1542-3565(23)00452-4.

Immunogenicity and Efficacy of Pembrolizumab and Doxorubicin in a Phase I Trial for Patients With Metastatic Triple-Negative Breast Cancer. Egelston, Colt A., Weihua Guo, Susan E. Yost, Xuan Ge, Jin Sun Lee, Paul H. Frankel, Yujie Cui, Christopher Ruel, Daniel Schmolze, Mireya Murga, Aileen Tang, Norma Martinez, Misagh Karimi, George Somlo, Peter P. Lee, James R. Waisman, and Yuan Yuan. Cancer Immunology, Immunotherapy: CII, June.

Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas. Yu, Ming, Kelly T. Carter, Kelsey K. Baker, Mary W. Redman, Ting Wang, Kathy Vickers, Christopher I. Li, Stacey A. Cohen, Mukta Krane, Jennifer Ose, Biljana Gigic, Jane C. Figueiredo, Adetunji T. Toriola, Erin M. Siegel, David Shibata, Martin Schneider, Cornelia M. Ulrich, Lynda Ann Dzubinski, Robert E. Schoen, and William M. Grady. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, June, EPI-22-1020.

Performance of Non-Invasive Tests and Histology for the Prediction of Clinical Outcomes in Patients With Non-Alcoholic Fatty Liver Disease: An Individual Participant Data Meta-Analysis. Mózes, Ferenc E., Jenny A. Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E. Stauber, Adriaan G. Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jérôme Boursier, LITMUS investigators, et al. The Lancet. Gastroenterology & Hepatology, June, S2468-1253(23)00141-3.

Stromal-Epithelial Interactions in Cancer Progression and Therapy Response. Thiruvalluvan, Manish, and Neil A. Bhowmick. Cancers 15 (11): 3014.

Plasma Metabolomics Predicts Chemotherapy Response in Advanced Pancreatic Cancer. Muranaka, Hayato, Andrew Hendifar, Arsen Osipov, Natalie Moshayedi, Veronica Placencio-Hickok, Nicholas Tatonetti, Aleksandr Stotland, Sarah Parker, Jennifer Van Eyk, Stephen J. Pandol, Neil A. Bhowmick, and Jun Gong. Cancers 15 (11): 3020.

Genome-Wide Association Study and Functional Characterization Identifies Candidate Genes for Insulin-Stimulated Glucose Uptake. Williamson, Alice, Dougall M. Norris, Xianyong Yin, K. Alaine Broadaway, Anne H. Moxley, Swarooparani Vadlamudi, Emma P. Wilson, Anne U. Jackson, Vasudha Ahuja, Mette K. Andersen, Zorayr Arzumanyan, Lori L. Bonnycastle, Claudia Langenberg, et al. Nature Genetics 55 (6): 973–83.

Alteration of Colonic Bacterial and Fungal Composition and Their Inter- and Intra-Kingdom Interaction in Patients With Adenomas With Low-Grade Dysplasia. Heng, Ding, Min Zhang, Yuhan Yuan, and Xinyun Qiu. Microorganisms 11 (5): 1327.

Neurosurgery

Intracranial Atherosclerosis Update for Neurointerventionalists. Alexander, Michael J., and Wengui Yu. Journal of Neurointerventional Surgery, June, jnis-2022-019628.

Orthopaedics

Standard versus Low-Dose Computed Tomography for Assessment of Acetabular Fracture Reduction Using Novel Step and Gap Measurement Technique. Robles, Abrianna S., Amit S. Piple, Donald J. DeSanto, Ashley Lamb, Stephen J. Gibbs, Nathanael D. Heckmann, and Geoffrey S. Marecek. European Journal of Orthopaedic Surgery & Traumatology: Orthopedie Traumatologie, June.

The Role of Relaxin in Anterior Cruciate Ligament Injuries: A Systematic Review. Berger, Garrett K., Zachary A. Rockov, Connor Byrne, Natasha E. Trentacosta, and Michael A. Stone. European Journal of Orthopaedic Surgery & Traumatology: Orthopedie Traumatologie, June.

How Do Surgeons Decide When to Treat Proximal Humerus Fractures With Operative versus Nonoperative Management? Reed, Logan A., Kevin A. Hao, David A. Patch, Joseph J. King, Catherine Fedorka, Jaimo Ahn, Jason A. Strelzow, Jonah Hebert-Davies, Milton T. M. Little, Peter C. Krause, Joseph P. Johnson, and Clay A. Spitler. European Journal of Orthopaedic Surgery & Traumatology: Orthopedie Traumatologie, June.

Pathology

Diagnostic Utility of GATA3 and ISL1 in Differentiating Neuroblastoma From Other Pediatric Malignant Small Round Blue Cell Tumors. Mohanty, Sambit K., Preeti Diwaker, Sourav K. Mishra, Shilpy Jha, Anandi Lobo, Saroj P. Panda, Shivani Sharma, Mohit Kumar, Samriti Arora, Vipra Mallik, Deepika Jain, Ekta Jain, Indranil Chakrabarti, Juhi Varshney, Arshi Beg, Mallika Dixit, Manas R. Baisakh, Subhasini Naik, Subrat K. Sahoo, Mahmut Akgul, Bonnie L. Balzer, Mahul B. Amin, and Anil V. Parwani. International Journal of Surgical Pathology, June, 10668969231177700.

Chordoma: Demographics and Survival Analysis With a Focus on Racial Disparities and the Role of Surgery, a U.S. Population-Based Study. Ullah, Asad, Guirshney Samarah Kenol, Kue Tylor Lee, Abdul Qahar Khan Yasinzai, Abdul Waheed, Bina Asif, Imran Khan, Hajra Sharif, Jaffar Khan, Saleh Heneidi, Nabin R. Karki, and Tamour Khan Tareen. Clinical & Translational Oncology, June, s12094-023-03227-0.

Metaplastic Breast Carcinoma in U.S. Population: Racial Disparities, Survival Benefit of Adjuvant Chemoradiation and Future Personalized Treatment With Genomic Landscape. Ullah, Asad, Jaffar Khan, Abdul Qahar Khan Yasinzai, Katharine Tracy, Tena Nguyen, Bisma Tareen, Andrea Agualimpia Garcia, Saleh Heneidi, and Sheila E. Segura. Cancers 15 (11): 2954.

Pediatrics

The Developmental Basis for Scaling of Mammalian Tooth Size. Christensen, Mona M., Outi Hallikas, Rishi Das Roy, Vilma Väänänen, Otto E. Stenberg, Teemu J. Häkkinen, Jean-Christophe François, Robert J. Asher, Ophir D. Klein, Martin Holzenberger, and Jukka Jernvall. Proceedings of the National Academy of Sciences of the United States of America 120 (25): e2300374120.

Radiation Oncology

Effect of Brachytherapy With External Beam Radiation Therapy Versus Brachytherapy Alone for Intermediate-Risk Prostate Cancer: NRG Oncology RTOG 0232 Randomized Clinical Trial. Michalski, Jeff M., Kathryn A. Winter, Bradley R. Prestidge, Martin G. Sanda, Mahul Amin, William S. Bice, Hiram A. Gay, Geoffrey S. Ibbott, Juanita M. Crook, Charles N. Catton, Adam Raben, Walter Bosch, David C. Beyer, Steven J. Frank, Michael A. Papagikos, Seth A. Rosenthal, H. Joseph Barthold, Mack Roach, Jennifer Moughan, and Howard M. Sandler. Journal of Clinical Oncology, June, JCO2201856.

Surgery

The Futility of Closed Chest Compressions After Trauma: A Multi-Institutional Study. Fierro, Nicole M., Navpreet K. Dhillon, Greigory Park, John Stupinski, Peter Drevets, Dennis J. Zheng, Areti Tillou, Chaiss Ugarte, Morgan Schellenberg, Erika Tay-Lasso, Jeffry Nahmias, Paige Parker, and Eric J. Ley. The Journal of Trauma and Acute Care Surgery, June.

Robotic Right Versus Left Colectomy for Colorectal Neoplasia: A Systemic Review and Meta-Analysis. Solis-Pazmino, Paola, Kimberly Oka, Kristina La, Orly Termeie, Oscar Ponce, Luis Figueroa, Antonio Weston, Mayara Machry, Jason Cohen, Moshe Barnajian, and Yosef Nasseri. Journal of Robotic Surgery, June.

New Traditional Chinese Medicine Supplement Reduces Pain Faster Than Conventional Pain Pills Alone: A Phase I/II Prospective, Double-Blinded Placebo-Controlled Randomized Trial. Hart, Kristel, Desmond Huynh, Cherin Oh, Charles Herndon, Negin Fadaee, Isabel Capati, Paul J. Turek, and Shirin Towfigh. The American Surgeon, June, 31348231183123.

Urology

Diabetes and Prostate Cancer Outcomes in Men With Nonmetastatic Castrate-Resistant Prostate Cancer: Results from the SEARCH Cohort. Sergeyev, Andrei, Lin Gu, Amanda M. De Hoedt, Christopher L. Amling, William J. Aronson, Matthew R. Cooperberg, Christopher J. Kane, Zachary Klaassen, Martha K. Terris, Lourdes Guerrios-Rivera, Stephen J. Freedland, and Ilona Csizmadi. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, June, EPI-22-1324.

Hemorrhagic Infarct Secondary to Vasculitis Presenting as Testicular Mass. Castaneda, Peris R., Daniel Luthringer, and Anirban P. Mitra. Urology, June, S0090-4295(23)00472-7.

Quality-of-Life Impact of Interstitial Cystitis and Other Pelvic Pain Syndromes. Cunningham, Andrew R., Lin Gu, Alexandra Dubinskaya, Amanda M. De Hoedt, Kamil E. Barbour, Jayoung Kim, Stephen J. Freedland, and Jennifer T. Anger. Frontiers in Pain Research (Lausanne, Switzerland) 4: 1149783.