This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published June 29-July 6. 

Biomedical Sciences

Artificial Intelligence in Cardiovascular Imaging: Enhancing Image Analysis and Risk Stratification. Lin, Andrew, Konrad Pieszko, Caroline Park, Katarzyna Ignor, Michelle C. Williams, Piotr Slomka, and Damini Dey. BJR Open 5 (1): 20220021.

Cancer

TROPION-Breast01: Datopotamab Deruxtecan vs Chemotherapy in Pre-Treated Inoperable or Metastatic HR+/HER2- Breast Cancer. Bardia, Aditya, Komal Jhaveri, Kevin Kalinsky, Sonia Pernas, Junji Tsurutani, Binghe Xu, Erika Hamilton, Seock-Ah Im, Zbigniew Nowecki, Joohyuk Sohn, Michelino De Laurentiis, Noelia Martínez Jañez, Barbara Adamo, Keun Seok Lee, Kyung Hae Jung, Gábor Rubovszky, Ling-Ming Tseng, Yen-Shen Lu, Yuan Yuan, Micah J. Maxwell, Vincent Haddad, Sabrina S. Khan, Hope S. Rugo, and Barbara Pistilli. Future Oncology (London, England), June.

Phase I/II Trial of Carboplatin, Nab-Paclitaxel, and Pembrolizumab for Advanced Non-Small Cell Lung Cancer: Hoosier Cancer Research Network LUN13-175. Gentzler, Ryan D., Nisha A. Mohindra, Shadia I. Jalal, Karen L. Reckamp, Richard D. Hall, Nasser H. Hanna, Young Kwang Chae, Marianna Koczywas, Irene B. Helenowski, and Jyoti D. Patel. The Oncologist, June, oyad180.

Cardiac Surgery

Socioeconomic Disparities in Mid-Term Outcomes After Repair for Degenerative Mitral Regurgitation. Malas, Jad, Qiudong Chen, Dominic Emerson, George Gill, Georgina Rowe, Natalia Egorova, Alfredo Trento, Joanna Chikwe, and Michael E. Bowdish. The Journal of Thoracic and Cardiovascular Surgery, June, S0022-5223(23)00534-2.

STS National Databases - Irreplaceable Tool for High-Impact Research. Chen, Qiudong, and Michael E. Bowdish. The Annals of Thoracic Surgery, June, S0003-4975(23)00669-0.

Cardiology

Assessment of a 60-Biomarker Health Surveillance Panel (HSP) on Whole Blood From Remote Sampling Devices by Targeted LC/MRM-MS and Discovery DIA-MS Analysis. Whelan, Stephen A., Nathan Hendricks, Zachary L. Dwight, Qin Fu, Annie Moradian, Jennifer E. Van Eyk, and Susan M. Mockus. Analytical Chemistry, June.

Diagnosed Gonorrhea Among Privately Insured Women: Analysis of United States Claims Data. Groene, Emily A., Faye L. Norby, Anne A. Eaton, Susan M. Mason, Eva A. Enns, Shalini Kulasingam, and David M. Vock. Journal of Women’s Health (2002), June.

Cardiomuscular Biomarkers in the Diagnosis and Prognostication of Immune Checkpoint Inhibitor Myocarditis. Lehmann, Lorenz H., Markus B. Heckmann, Guillaume Bailly, Daniel Finke, Adrien Procureur, John R. Power, Frederic Stein, Marie Bretagne, Stephane Ederhy, Charlotte Fenioux, Omar Hamwy, Elisa Funck-Brentano, Emanuela Romano, Laurence Pieroni, Jan Münster, Yves Allenbach, Céline Anquetil, Sarah Leonard-Louis, Nicolas L. Palaskas, Salim S. Hayek, Hugo A. Katus, Evangelos Giannitsis, Norbert Frey, Ziya Kaya, Javid Moslehi, Edi Prifti, Joe-Elie Salem, and International ICI-Myocarditis Registry Contributors. Circulation, June.

Complex Calculus -Older Donors for Older Heart Transplant Recipients? Nikolova, Andriana P., and Jon A. Kobashigawa. The Annals of Thoracic Surgery, June, S0003-4975(23)00617-3.

Outcomes of SAPIEN 3 Transcatheter Aortic Valve Replacement Compared With Surgical Valve Replacement in Intermediate-Risk Patients. Madhavan, Mahesh V., Susheel K. Kodali, Vinod H. Thourani, Raj Makkar, Michael J. Mack, Samir Kapadia, John G. Webb, David J. Cohen, Howard C. Herrmann, Mathew Williams, Kevin Greason, Philippe Pibarot, Rebecca T. Hahn, Wael Jaber, Ke Xu, Maria Alu, Craig R. Smith, and Martin B. Leon. Journal of the American College of Cardiology 82 (2): 109–23.

Three-Vessel Coronary Infusion of Cardiosphere-Derived Cells for the Treatment of Heart Failure With Preserved Ejection Fraction in a Pre-Clinical Pig Model. Gallet, Romain, Jin-Bo Su, Daphné Corboz, Paul-Matthieu Chiaroni, Alain Bizé, Jianping Dai, Mathieu Panel, Pierre Boucher, Gaëtan Pallot, Juliette Brehat, Lucien Sambin, Guillaume Thery, Nadir Mouri, Aurélien de Pommereau, Pierre Denormandie, Stéphane Germain, Alain Lacampagne, Emmanuel Teiger, Eduardo Marbán, and Bijan Ghaleh. Basic Research in Cardiology 118 (1): 26.

Impacts of Exercise Interventions on Inflammatory Markers and Vascular Adhesion Molecules in Patients with Heart Failure: A Meta-Analysis of RCTs. Malandish, Abbas, Asma Karimi, Mahdi Naderi, Niloufar Ghadamyari, and Martha Gulati. CJC Open 5 (6): 429–53.

Clinical Profiles, Outcomes, and Sex Differences of Patients With STEMI: Findings From the NORIN-STEMI Registry. Qamar, Arman, Kirtipal Bhatia, Sameer Arora, Michael Hendrickson, Puneet Gupta, Amber Fatima, Girish Mp, Ankit Bansal, Vishal Batra, Mark J. Ricciardi, Cindy L. Grines, Jamal Yusuf, Saibal Mukhopadhyay, Sidney C. Smith, Sanjay Tyagi, Deepak L. Bhatt, Martha Gulati, and Mohit D. Gupta. JACC. Asia 3 (3): 431–42.

Computational Biomedicine

Automatically Identifying Self-Reports of COVID-19 Diagnosis on Twitter: An Annotated Data Set, Deep Neural Network Classifiers, and a Large-Scale Cohort. Klein, Ari Z., Shriya Kunatharaju, Karen O’Connor, and Graciela Gonzalez-Hernandez. Journal of Medical Internet Research 25 (July): e46484.

Emergency Medicine

A Multicenter Retrospective Cohort Study to Characterize Patients Hospitalized With MIS-A and COVID-19 in the United States, 2020-2021. Melgar, Michael, Joseph Y. Abrams, Shana Godfred-Cato, Ami B. Shah, Amit Garg, Andrew Strunk, Mangala Narasimhan, Jonathan Koptyev, Alexandra Norden, David Musheyev, Fahmida Rashid, Rachel Tannenbaum, Rosa M. Estrada-Y-Martin, Bela Patel, Siddharth Karanth, Chad J. Achenbach, Gavin T. Hall, Sara M. Hockney, Matthew Caputo, Lilian M. Abbo, Laura Beauchamps, Stephen B. Morris, Renzo O. Cifuentes, Annabelle de St Maurice, Douglas S. Bell, Kavitha K. Prabaker, Fernando J. Sanz Vidorreta, Evan Bryant, David K. Cohen, Rohith Mohan, Christopher P. Libby, Spencer SooHoo, Tristel J. Domingo, Angela P. Campbell, and Ermias D. Belay. Clinical Infectious Diseases, June, ciad374.

Medicine

Evolution of Symptoms After Ustekinumab Induction Therapy in Patients With Crohn’s Disease. Colombel, Jean-Frederic, Bruce E. Sands, Christopher Gasink, Benjamin Yeager, Omoniyi J. Adedokun, James Izanec, Tony Ma, Long-Long Gao, Scott D. Lee, Stephan R. Targan, Subrata Ghosh, Stephen B. Hanauer, and William J. Sandborn. Clinical Gastroenterology and Hepatology June, S1542-3565(23)00499-8.

Evaluating Demographic Representation in Clinical Trials: Use of the Adaptive Coronavirus Disease 2019 Treatment Trial (ACTT) as a Test Case. Ortega-Villa, Ana M., Noreen A. Hynes, Corri B. Levine, Katherine Yang, Zanthia Wiley, Nikolaus Jilg, Jing Wang, Jennifer A. Whitaker, Christopher J. Colombo, Seema U. Nayak, Hannah Jang Kim, Nicole M. Iovine, Dilek Ince, Stuart H. Cohen, Adam J. Langer, Jonathan M. Wortham, Robert L. Atmar, Hana M. El Sahly, Mamta K. Jain, Aneesh K. Mehta, Cameron R. Wolfe, Carlos A. Gomez, Tatiana Beresnev, Richard A. Mularski, Catharine I. Paules, Andre C. Kalil, Angela R. Branche, Annie Luetkemeyer, Barry S. Zingman, Jocelyn Voell, Michael Whitaker, Michelle S. Harkins, Richard T. Davey, Robert Grossberg, Sarah L. George, Victor Tapson, William R. Short, Varduhi Ghazaryan, Constance A. Benson, Lori E. Dodd, Daniel A. Sweeney, and Kay M. Tomashek. Open Forum Infectious Diseases 10 (6): ofad290.

Medication-Related Osteonecrosis of the Jaw: Successful Medical Management of Complex Maxillary Alveolus With Sinus Involvement. Epstein, Joel B., Praveen R. Arany, Susan E. Yost, and Yuan Yuan. Case Reports in Oncology 16 (1): 397–413.

Revisiting VH1 Phosphatase at the Time of Monkeypox: Back to the Spotlight. Bottini, Angel, Diana R. D. C. G. Pacheco, Fabio L. Forti, and Nunzio Bottini. Biochemical Society Transactions, July, BST20200408.

Barriers to Implementing the Kidney Disease Outcomes Quality Initiative End-Stage Kidney Disease Life Plan Guideline. Keller, Michelle S., Christine Mavilian, Keaton L. Altom, Kevin F. Erickson, Laura M. Drudi, and Karen Woo. Journal of General Internal Medicine, July.

Clustering of Phosphatase RPTP? Promotes Src Signaling and the Arthritogenic Action of Synovial Fibroblasts. Sendo, Sho, William B. Kiosses, Shen Yang, Dennis J. Wu, Daniel W. K. Lee, Lin Liu, Yael Aschner, Allison J. Vela, Gregory P. Downey, Eugenio Santelli, and Nunzio Bottini. Science Signaling 16 (792): eabn8668.

Pancreatic Diffuse Large B-Cell Lymphoma in the US Population. Ullah, Asad, Kue T. Lee, Kali Malham, Abdul Qahar Khan Yasinzai, Bisma Tareen, Dara Lopes, Agha Wali, Luis Velasquez Zarate, Abdul Waheed, Maya Wiest, Resham Hakim, Marjan Khan, Bina Asif, Nikhil Patel, Sahar Hakim, Kaleemullah Kakar, Saleh Heneidi, Nabin R. Karki, and Feroze Sidhwa. Cureus 15 (6): e39862.

Evaluation of Frailty Measures and Short-Term Outcomes After Lung Transplantation. Swaminathan, Aparna C., Alec McConnell, Sarah Peskoe, Mustafa R. Bashir, Erika Bush Buckley, Courtney W. Frankel, Daniel J. Turner, Patrick J. Smith, Lorenzo Zaffiri, Lianne G. Singer, and Laurie D. Snyder. Chest, January, S0012-3692(23)00121-6.

Editorial: Application of Nanotechnology in Diagnosis and/or Therapy of Non-Small Cell Lung Cancer. Shen, Qinglin, Ling Peng, Yi Zhang, and Ruoxiang Wang. Frontiers in Oncology 13: 1234727.

Neurology

MAPK/MAK/MRK Overlapping Kinase (MOK) Controls Microglial Inflammatory/Type-I IFN Responses via Brd4 and Is Involved in ALS. Pérez-Cabello, Jesús A., Lucía Silvera-Carrasco, Jaime M. Franco, Vivian Capilla-González, Alexandros Armaos, María Gómez-Lima, Raquel García-García, Xin Wen Yap, Magdalena Leal-Lasarte, Deepti Lall, Robert H. Baloh, Salvador Martínez, Yoshihiko Miyata, Gian G. Tartaglia, Ritwick Sawarkar, Mario García-Domínguez, David Pozo, and Cintia Roodveldt. Proceedings of the National Academy of Sciences of the United States of America 120 (28): e2302143120.

Neurosurgery

Spontaneous Absorption of Osteophytic Calcification Associated With Chronic Dural Tear and Ventral Spinal CSF Leak. Rohatgi, Varun K., Matthew S. Robbins, Wouter I. Schievink, and J. Levi Chazen. The Neuroradiology Journal, June, 19714009231187360.

Nursing

Nursing Practice and Equitable Nursing Care - ClinicalKey for Nursing. Astasio, Jennifer, Akai Khalsa, Reanton Grana, and Linda Kim. Accessed July 6.

OBGYN

The Association of Black Race With Receipt of Hysterectomy and Survival in Low-Risk Endometrial Cancer. Taylor, Kristin N., Andrew Li, Michael Manuel, Bobbie Jo Rimel, and Kenneth H. Kim. Gynecologic Oncology 175 (June): 156–62.

Orthopaedics

Orthopaedic Advances: Use of Three-Dimensional Metallic Implants for Reconstruction of Critical Bone Defects After Trauma. Westrick, Edward R., Mitchell Bernstein, Milton T. Little, Geoffrey S. Marecek, and John A. Scolaro. The Journal of the American Academy of Orthopaedic Surgeons, June.

On-Field and Pitch-Side Assessment of Sports Concussion in Collision Sports: An Expert Consensus Statement Using the Modified Delphi Technique. Hohmann, Erik, Paul Bloomfield, Jiri Dvorak, Ruben Echemendia, Rachel M. Frank, Janesh Ganda, Leigh Gordon, Louis Holtzhausen, Alan Kourie, Jerome Mampane, Michael Makdissi, Jon Patricios, Elizabeth Pieroth, Margot Putukian, Dina C. Janse van Rensburg, Pierre Viviers, Vernon Williams, and Jean de Wilde. Arthroscopy: The Journal of Arthroscopic & Related Surgery, June, S0749-8063(23)00487-5.

Perioperative Intravenous Nefopam on Pain Management and Ambulation After Open Spine Surgery: A Randomized Double-Blind Controlled Study. Chalermkitpanit, Pornpan, Wicharn Yingsakmongkol, Worawat Limthongkul, Teerachat Tanasansomboon, Patt Pannangpetch, Nattapat Tangchitcharoen, and Weerasak Singhatanadgige. Asian Spine Journal, July.

Pathology

Post-Transplant Lymphoproliferative Disorder (PTLD) in the US Population: Demographics, Treatment Characteristics, and Survival Analysis. Ullah, Asad, Kue T. Lee, Kali Malham, Abdul Qahar Khan Yasinzai, Imran Khan, Bina Asif, Abdul Waheed, Saleh Heneidi, Nabin R. Karki, and Feroze Sidhwa. Cureus 15 (5): e39777.

Radiation Oncology

Early Endpoints in High-Risk Localized Prostate Cancer: Exploratory Analysis of Three Radiation Therapy Oncology Group Phase 3 Studies. Feng, Felix, Branko Miladinovic, Ke Zhang, James J. Dignam, Daniel Wang, Margaret Yu, and Howard Sandler. European Urology, June, S0302-2838(23)02876-2.

Surgery

Proof-of-Concept and Randomized, Placebo-Controlled Trials of an Fcrn Inhibitor, Batoclimab, for Thyroid Eye Disease. Kahaly, George J., Peter J. Dolman, Jan Wolf, Bert C. Giers, Heike M. Elflein, Amy P. Jain, Ashok Srinivasan, Lubomir Hadjiiski, David Jordan, Elizabeth A. Bradley, Marius N. Stan, Anja Eckstein, Susanne Pitz, Christian Vorländer, Sara T. Wester, John Nguyen, Nancy Tucker, Marco Sales-Sanz, Steven E. Feldon, Christine C. Nelson, Isabelle Hardy, Maravillas Abia-Serrano, Philip Tedeschi, Jonathan M. Janes, Jing Xu, Peter Vue, William L. Macias, and Raymond S. Douglas. The Journal of Clinical Endocrinology and Metabolism, June, dgad381.

Editorial: Considerations in the Surgical Management of HPV-Positive Oropharyngeal Squamous Cell Carcinoma. Mallen-St Clair, Jon, and Ryan K. Orosco. Frontiers in Oncology 13: 1205525.

Diagnosis and Management of Traumatic Rectal Injury: A Western Trauma Association Critical Decisions Algorithm. Schellenberg, Morgan, Sarah Koller, Marc de Moya, Laura J. Moore, Carlos V. R. Brown, Jennifer L. Hartwell, Kenji Inaba, Eric J. Ley, Natasha Keric, Kimberly A. Peck, Charles J. Fox, Nelson G. Rosen, Jordan A. Weinberg, Raul Coimbra, and Matthew J. Martin. The Journal of Trauma and Acute Care Surgery, July.

Drug Overdose and Cardiovascular Deaths Among Deceased Organ Donors: Implications for Donor Utilization and Data Reporting. Adjei, Michie A., Steven A. Wisel, Irene K. Kim, and Justin A. Steggerda. Annals of Transplantation 28 (July): e940255.

Urology

Are Associations between Obesity and Prostate Cancer Outcomes Following Radical Prostatectomy the Same in Smokers and Non-Smokers? Results From the SEARCH Cohort. Liu, Ivy T., Lin Gu, Amanda M. De Hoedt, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane, Zachary Klaassen, Martha K. Terris, Lourdes Guerrios-Rivera, Adriana C. Vidal, William J. Aronson, Stephen J. Freedland, and Ilona Csizmadi. Cancer Causes & Control: CCC, July.

Can Vaginal Lactobacillus Suppositories Help Reduce Urinary Tract Infections? Shoureshi, Poone S., Clarissa Niino, and Karyn S. Eilber. International Urogynecology Journal, July.