This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published June 15-22.

Biomedical Sciences

Hexokinase Dissociation From Mitochondria Promotes Oligomerization of VDAC That Facilitates NLRP3 Inflammasome Assembly and Activation. Baik, Sung Hoon, V. Krishnan Ramanujan, Courtney Becker, Sarah Fett, David M. Underhill, and Andrea J. Wolf. Science Immunology 8 (84): eade7652.

Influence of Cusp Morphology and Sex on Quantitative Valve Composition in Severe Aortic Stenosis. Patel, Kush P., Andrew Lin, Niraj Kumar, Giulia Esposito, Kajetan Grodecki, Guy Lloyd, Anthony Mathur, Andreas Baumbach, Michael J. Mullen, Michelle C. Williams, David E. Newby, Thomas A. Treibel, Marc R. Dweck, and Damini Dey. European Heart Journal. Cardiovascular Imaging, June, jead142.

Associations Between Infant Amygdala Functional Connectivity and Social Engagement Following a Stressor: A Preliminary Investigation. Hu, Yannan, Haitao Chen, Xiaomei Li, Ryan J. Larsen, Bradley P. Sutton, Wei Gao, and Nancy L. McElwain. Developmental Science, June, e13418.

Editorial: Simultaneous Multiparametric and Multidimensional Cardiovascular Magnetic Resonance Imaging. Radjenovic, Aleksandra, and Anthony G. Christodoulou. Frontiers in Cardiovascular Medicine 10: 1205994.

Cancer

Y Chromosome Loss in Cancer Drives Growth by Evasion of Adaptive Immunity. Abdel-Hafiz, Hany A., Johanna M. Schafer, Xingyu Chen, Tong Xiao, Timothy D. Gauntner, Zihai Li, and Dan Theodorescu. Nature, June.

A Phase Ib Trial of Pembrolizumab Plus Paclitaxel or Flat-Dose Capecitabine in 1st/2nd Line Metastatic Triple-Negative Breast Cancer. Page, David B., Joanna Pucilowska, Brie Chun, Isaac Kim, Katherine Sanchez, Nicole Moxon, Staci Mellinger, Yaping Wu, Yoshinobu Koguchi, Valerie Conrad, William L. Redmond, Maritza Martel, Zhaoyu Sun, Mary B. Campbell, Alison Conlin, Anupama Acheson, Reva Basho, Philomena McAndrew, Mary El-Masry, Dorothy Park, Laura Bennetts, Robert S. Seitz, Tyler J. Nielsen, Kimberly McGregor, Venkatesh Rajamanickam, Brady Bernard, Walter J. Urba, and Heather L. McArthur. NPJ Breast Cancer 9 (1): 53.

HER2-Targeted Antibody-Drug Conjugates for Breast Cancer: Ancestry and Dose Adjustment for Thrombocytopenia. Rainone, Michael, Carolyn E. Behrendt, Saro Kasparian, Tina Nguyen, Mina S. Sedrak, Sayeh Lavasani, Daphne B. Stewart, Yuan Yuan, Joanne E. Mortimer, James R. Waisman, Niki Patel, and Vinod Pullarkat. Breast Cancer (Tokyo, Japan), June.

Neoadjuvant Talazoparib in Patients With Germline BRCA1/2 Mutation-Positive, Early-Stage Triple-Negative Breast Cancer: Results of a Phase II Study. Litton, Jennifer K., J. Thaddeus Beck, Jason M. Jones, Jay Andersen, Joanne L. Blum, Lida A. Mina, Raymond Brig, Michael Danso, Yuan Yuan, Antonello Abbattista, Kay Noonan, Alexander Niyazov, Jayeta Chakrabarti, Akos Czibere, William F. Symmans, and Melinda L. Telli. The Oncologist, June, oyad139.

Cardiac Surgery

The American Association for Thoracic Surgery 2023 Expert Consensus Document: Adult Cardiac Transplantation Utilizing Donors After Circulatory Death. Schroder, Jacob N., Sarah Scheuer, Pedro Catarino, Arthur Caplan, Scott C. Silvestry, Valluvan Jeevanandam, Stephen Large, Ashish Shah, Peter MacDonald, Mark S. Slaughter, Yoshifumi Naka, and Carmelo A. Milano. The Journal of Thoracic and Cardiovascular Surgery, June, S0022-5223(23)00252-0.

Cardiology

Coronary Microvascular Dysfunction: What Clinicians and Investigators Should Know. Marano, Paul, Janet Wei, and C. Noel Bairey Merz. Current Atherosclerosis Reports, June.

ROMA:Women - a Trial Dedicated to Women to Improve Coronary Bypass Outcomes. Gaudino, Mario, C. Noel Bairey Merz, Sigrid Sandner, Ruth Masterson Creber, Karla V. Ballman, Sean M. O’Brien, Lamia Harik, Roberto Perezgrovas-Olaria, Roxana Mehran, Monika M. Safford, and Stephen E. Fremes. The Journal of Thoracic and Cardiovascular Surgery, June, S0022-5223(23)00525-1.

Autoimmune Rheumatic Diseases in Women With Coronary Microvascular Dysfunction: A Report From the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) Project. Chen, Melanie T., Joseph Chang, Ashley S. Manchanda, Galen Cook-Wiens, Chrisandra L. Shufelt, R. David Anderson, John W. Petersen, Dhaval R. Naik, Louise E. J. Thomson, Daniel S. Berman, Eileen M. Handberg, Carl J. Pepine, C. Noel Bairey Merz, and Janet Wei. Frontiers in Cardiovascular Medicine 10: 1155914.

Medicine

The Role of Imaging in Diagnosis and Monitoring of Large Vessel Vasculitis. Horomanski, Audra, and Lindsy J. Forbess. Rheumatic Diseases Clinics of North America 49 (3): 489–504.

Intravenous Aviptadil and Remdesivir for Treatment of COVID-19-Associated Hypoxaemic Respiratory Failure in the USA (TESICO): A Randomised, Placebo-Controlled Trial. Brown, Samuel M., Christina E. Barkauskas, Birgit Grund, Shweta Sharma, Andrew N. Phillips, Lindsay Leither, Ithan D. Peltan, Michael Lanspa, Daniel L. Gilstrap, Ahmad Mourad, Kathleen Lane, Jeremy R. Beitler, Christine Wenner, et al. The Lancet Respiratory Medicine 0 (0).

Timing and Setting of Billed Advance Care Planning Among Medicare Decedents in 2017-2019. Gotanda, Hiroshi, Anne M. Walling, Jessica J. Zhang, Haiyong Xu, and Yusuke Tsugawa. Journal of the American Geriatrics Society, June.

Thrombopoietin Receptor Agonists for Thrombocytopenia Secondary to HER2-Targeted Antibody Drug Conjugates. Rainone, Michael, Saro Kasparian, Tina Nguyen, Neel Talwar, Yuan Yuan, Matthew Mei, Joanne E. Mortimer, James R. Waisman, Niki Patel, and Vinod Pullarkat. The Oncologist, June, oyad185.

Prevalence and Burden of Illness of Rome IV Chronic Idiopathic Constipation, Opioid-Induced Constipation, and Opioid-Exacerbated Constipation in the United States. Liang, Jeff, Christopher V. Almario, William D. Chey, Carolyn S. Higgins, and Brennan M. R. Spiegel. The American Journal of Gastroenterology, June.

Pharmacokinetics, Efficacy, and Safety of a SARS-CoV-2 Antibody Treatment in Pediatric Participants: An Open-Label Addendum of a Placebo-Controlled, Randomized Phase 2/3 Trial. Upadhyaya, Himanshu P., Jenny Y. Chien, Amanda J. Long, Martin S. Bohm, Nicole L. Kallewaard, Lisa F. Macpherson, Dipak R. Patel, Matthew M. Hufford, Constance J. Krull, Jocelyn Y. Ang, Peter Chen, William J. Muller, Jeffrey A. Potts, Timothy Quinn, Mark Williams, and BLAZE-1 Investigators. Infectious Diseases and Therapy, June.

Letter to the Editor: ‘Hook’ (Prozone) Effect in Sars-Cov-2 Anti-Spike Binding Antibody Levels Following Vaccination, Infection, or Monoclonal Antibody in Solid Organ Transplant Recipients. Abedon, Aura T., Teresa P. Y. Chiang, Andrew H. Karaba, Jennifer L. Alejo, Margaret Chahoud, Casey Hussey, Jessica F. Lopes, Sarah Hussain, Christian P. Larsen, Christine M. Durand, Peter S. Heeger, Dorry L. Segev, William A. Clarke, and William A. Werbel. Clinical Transplantation, June, e15044.

Targeting the PRC2-Dependent Epigenetic Program Alleviates Urinary Tract Infections. Guo, Chunming, Mingyi Zhao, Xinbing Sui, Zarine Balsara, Songhui Zhai, Michael Ahdoot, Yingsheng Zhang, Christa M. Lam, Ping Zhu, and Xue Li. IScience 26 (6): 106925.

Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop. Espinoza, Sara E., Sundeep Khosla, Joseph A. Baur, Rafael de Cabo, and Nicolas Musi. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 78 (Supplement_1): 53–60.

Benefits of Nature-Based Walking for Breast Cancer Survivors. Shirazipour, Celina H., Carolina Raines, Eileen Liu, Rachel M. Ruggieri, Jessica M. Capaldi, Bianca Luna-Lupercio, Marcio A. Diniz, Gillian Gresham, Neil Bhowmick, Robert W. Haile, and Arash Asher. BMJ Open 13 (6): e071041.

Cluster-Randomized Comparative Effectiveness Trial of Physician-Directed Clinical Decision Support vs. Patient-Directed Education to Promote Appropriate Use of Opioids for Chronic Pain. Spiegel, Brennan M. R., Garth Fuller, Xiaoyu Liu, Taylor Dupuy, Tom Norris, Roger Bolus, Rebecca Gale, Itai Danovitch, Sam Eberlein, Alma Jusufagic, Teryl Nuckols, and Penney Cowan. The Journal of Pain, June, S1526-5900(23)00436-4.

Neurosurgery

Response to Letter to the Editor: Demographic Predictors of Treatment and Complications for Adult Spinal Deformity: An Analysis of the National Inpatient Sample. Brown, Nolan J., Julian L. Gendreau, Shane Shahrestani, Luis D. Diaz-Aguilar, and Martin H. Pham. Clinical Neurology and Neurosurgery 231 (May): 107805.

Osteopontin Depletion in Macrophages Perturbs Proteostasis via Regulating UCHL1-UPS Axis and Mitochondria-Mediated Apoptosis. Rentsendorj, Altan, Koen Raedschelders, Dieu-Trang Fuchs, Julia Sheyn, Vineet Vaibhav, Rebecca A. Porritt, Haoshen Shi, Jargalsaikhan Dagvadorj, Juliana de Freitas Germano, Yosef Koronyo, Moshe Arditi, Keith L. Black, Bhakta Prasad Gaire, Jennifer E. Van Eyk, and Maya Koronyo-Hamaoui. Frontiers in Immunology 14: 1155935.

OBGYN

Risk Factors for Major Complications Following Minimally Invasive Surgeries for Endometriosis in the United States. Meyer, Raanan, Matthew Siedhoff, Mireille Truong, Kacey Hamilton, Shannon Fan, Gabriel Levin, Moshe Barnajian, Yosef Nasseri, and Kelly Wright. Journal of Minimally Invasive Gynecology, June, S1553-4650(23)00235-2.

Orthopaedics

Lumbar Discectomy With Bone-Anchored Annular Closure Device in Patients With Large Annular Defects: One-Year Results. Nunley, Pierce, K. Brandon Strenge, Kade Huntsman, Hyun Bae, Christian DiPaola, R. T. Allen, Andrew Shaw, Rick C. Sasso, Ali Araghi, Blake Staub, Selby Chen, Laura C. Shum, and Michael Musacchio. Cureus 15 (6): e40195.

Return to Play After Thumb Ulnar Collateral Ligament Injuries Managed Surgically in Athletes-A Systematic Review. Allahabadi, Sachin, Jeffrey W. Kwong, Nirav K. Pandya, Steven S. Shin, Igor Immerman, and Nicolas H. Lee. Journal of Hand Surgery Global Online 5 (3): 349–57.

Pathology

Claudin-4 Expression in the Distinction of Mammary and Extramammary Paget Disease From Morphologic Mimics: Diagnostic Utility and Pitfalls. Bui, Chau M., Bonnie L. Balzer, and Wonwoo Shon. The American Journal of Dermatopathology, June.

Pediatrics

The Role of Trained Immunity in COVID-19: Lessons for the Next Pandemic. Netea, Mihai G., Athanasios Ziogas, Christine Stabell Benn, Evangelos J. Giamarellos-Bourboulis, Leo A. B. Joosten, Moshe Arditi, Konstantin Chumakov, Reinout van Crevel, Robert Gallo, Peter Aaby, and Jos W. M. van der Meer. Cell Host & Microbe 31 (6): 890–901.

Psychiatry

The Impact of Psilocybin on Patients Experiencing Psychiatric Symptoms: A Systematic Review of Randomized Clinical Trials. IsHak WW, Garcia P, Pearl R, Dang R, Williams C, Totlani J, Danovitch, I. Innovations in Clinical Neuroscience 20(4-6) (June): 39–48.

Rehabilitation Medicine

Palliative Care Education in US Physical Medicine and Rehabilitation Residency Programs: Current Practices, Perceived Needs, and Barriers. Yeh, Jonathan C., Leena Ambady, Ryan Lewis, Ambereen K. Mehta, Arash Asher, Vishwa S. Raj, and Jessica P. Engle. Journal of Palliative Medicine, June.

Inpatient Rehabilitation for Acute Presentations of Motor Functional Neurological Disorder (FND): A Retrospective Cohort Study. Polich, Ginger, Stacey Zalanowski, Julie Maney Lewis, Sarah Sugarman, Kanella Christopulos, Caitlin Hebb, David L. Perez, Gaston Baslet, Priyanca Shah, and Seth Herman. American Journal of Physical Medicine & Rehabilitation, June.

Surgery

Pediatric Emergency Resuscitative Thoracotomy: A Western Trauma Association, Pediatric Trauma Society, and Eastern Association for the Surgery of Trauma Collaborative Critical Decisions Algorithm. Martin, Matthew J., Karen J. Brasel, Carlos V. R. Brown, Jennifer L. Hartwell, Marc de Moya, Kenji Inaba, Eric J. Ley, Ernest E. Moore, Kimberly A. Peck, Anne G. Rizzo, Nelson G. Rosen, Jordan A. Weinberg, Raul Coimbra, Marie Crandall, Kaushik Mukherjee, Romeo Ignacio, Shannon Longshore, Katherine T. Flynn-O’Brien, Grace Ng, Leigh Selesner, and Mubeen Jafri. The Journal of Trauma and Acute Care Surgery, June.

Creatinine Clearance Predicts the Goal Enoxaparin Dose in Traumatic Brain Injury. Park, Greigory, Navpreet K. Dhillon, Nicole M. Fierro, Peter Drevets, John Stupinski, and Eric J. Ley. The Journal of Trauma and Acute Care Surgery, June.

Metastasectomy in Stage IV Melanoma: How and When Should We Employ It? Faries, Mark B., and Michael Lowe. Annals of Surgical Oncology, June.

Breast Conservation Surgery and Mastectomy Have Similar Locoregional Recurrence Following Neoadjuvant Chemotherapy: Results From 1,462 Patients on the Prospective, Randomized I-SPY2 Trial. Mukhtar, Rita A., Harrison Chau, Hannah Woriax, Mara Piltin, Gretchen Ahrendt, Julia Tchou, Hongmei Yu, Qian Ding, Catherine Lu Dugan, Jori Sheade, Angelena Crown, Michael Carr, Jasmine Wong, Jennifer Son, Rachel Yang, Theresa Chan, Alicia Terando, Michael Alvarado, Cheryl Ewing, Jennifer Tonneson, Nina Tamirisa, Rebekah Gould, Puneet Singh, Constantine Godellas, Kelsey Larson, Akiko Chiba, Roshni Rao, Candice Sauder, Lauren Postlewait, Marie Catherine Lee, William Fraser Symmans, Laura J. Esserman, Judy C. Boughey, and ISPY-2 Locoregional Working Group. Annals of Surgery, June.

Inadequate Venous Thromboembolism Chemoprophylaxis Is Associated With Higher Venous Thromboembolism Rates Among Trauma Patients With Epidurals. Dhillon, Navpreet K., Tobias Muniz, Nicole M. Fierro, Anaar E. Siletz, Juliet Alexander, Chidinma Ikonte, Russell Mason, and Eric J. Ley. The Journal of Surgical Research 291 (June): 1–6.

Capacity Assessment Tool to Promote Capacity Building in Global Orthopaedic Surgical Outreach. Shapiro, Lauren M., Jessica Welch, Chelsea Leversedge, Julie A. Katarincic, Fraser J. Leversedge, George S. M. Dyer, Scott H. Kozin, Paige M. Fox, Meghan McCullough, Bruce Agins, and Robin N. Kamal. The Journal of Bone and Joint Surgery. American Volume, June.

Demands of Surgical Teams in Robotic-Assisted Surgery: An Assessment of Intraoperative Workload Within Different Surgical Specialties. Zamudio, Jennifer, Jeffrey Woodward, Falisha F. Kanji, Jennifer T. Anger, Ken Catchpole, and Tara N. Cohen. American Journal of Surgery, June, S0002-9610(23)00263-5.

The Impact of Virtual Reality on the Patients and Providers Experience in Wide-Awake, Local-Only Hand Surgery. McCullough, Meghan, Thomas F. Osborne, Caitlin Rawlins, Robert J. Reitz, Paige M. Fox, and Catherine Curtin. Journal of Hand Surgery Global Online 5 (3): 290–93.

Predictive Factors of First-Time Failure on the American Board of Colorectal Surgery Certifying and Qualifying Examinations. Fair, Lucas, Benjamin Gough, Neil Hyman, Brian Bello, Randolph Steinhagen, Robert Cleary, Matthew Ziegler, Dipen Maun, Phillip Fleshner, Gerald Ogola, Katerina Wells, Warren Lichliter, James Fleshman, and Alessandro Fichera. Proceedings (Baylor University. Medical Center) 36 (4): 483–89.

Antithrombin III Levels in Critically Ill Surgical Patients: Do They Correlate With VTE? Bhatti, Umar F., Navpreet K. Dhillon, Russell Mason, Andrew Wang, Yassar M. Hashim, Galinos Barmparas, and Eric J. Ley. Trauma Surgery & Acute Care Open 8 (1): e001009.