This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published June 1-8.

Anesthesiology

The Theory of Oxygen Hemoglobin Association. Chou, Henry, and Chihjen Lee. Bio Systems, June, 104932.

Biomedical Sciences

Clinical Quantitative Coronary Artery Stenosis and Coronary Atherosclerosis Imaging: A Consensus Statement From the Quantitative Cardiovascular Imaging Study Group. Mézquita, Aldo J. Vázquez, Federico Biavati, Volkmar Falk, Hatem Alkadhi, Reza Hajhosseiny, Pál Maurovich-Horvat, Robert Manka, Sebastian Kozerke, Matthias Stuber, Thorsten Derlin, Keith M. Channon, Ivana Išgum, Adriaan Coenen, Bernhard Foellmer, Damini Dey, Rick H. J. A. Volleberg, Felix G. Meinel, Marc R. Dweck, Jan J. Piek, Tim van de Hoef, Ulf Landmesser, Giulio Guagliumi, Andreas A. Giannopoulos, René M. Botnar, Ramzi Khamis, Michelle C. Williams, David E. Newby, and Marc Dewey. Nature Reviews. Cardiology, June.

A Cisplatin Conjugate With Tumor Cell Specificity Exhibits Antitumor Effects in Renal Cancer Models. Mrdenovic, Stefan, Yanping Wang, Lijuan Yin, Gina Chia-Yi Chu, Yan Ou, Michael S. Lewis, Marija Heffer, Edwin M. Posadas, Haiyen E. Zhau, Leland W. K. Chung, Mouad Edderkaoui, Stephen J. Pandol, Ruoxiang Wang, and Yi Zhang. BMC Cancer 23 (1): 499.

Tetracycline-Inducible and Reversible Stable Gene Expression in Human IPSC-Derived Neural Progenitors and in the Postnatal Mouse Brain. Linesch, Paul W., Aslam Abbasi Akhtar, and Joshua J. Breunig. Current Protocols 3 (6): e792.

Computed Tomography-Based Pericoronary Adipose Tissue Attenuation in Patients Undergoing TAVR: A Novel Method for Risk Assessment. Steyer, Alexandra, Silvia Mas-Peiro, David M. Leistner, Valentina O. Puntmann, Eike Nagel, Damini Dey, Markus Goeller, Vitali Koch, Christian Booz, Thomas J. Vogl, and Simon S. Martin. Frontiers in Cardiovascular Medicine 10: 1192093.

Cancer

Tebentafusp in Combination With Durvalumab and/or Tremelimumab in Patients with Metastatic Cutaneous Melanoma: A Phase 1 Study. Hamid, Omid, Jessica C. Hassel, Alexander N. Shoushtari, Friedegund Meier, Todd M. Bauer, April K. S. Salama, John M. Kirkwood, Paolo A. Ascierto, Paul C. Lorigan, Cornelia Mauch, Marlana Orloff, Thomas R. Jeffry Evans, Chris Holland, Ramakrishna Edukulla, Shaad E. Abedin, and Mark R. Middleton. Journal for Immunotherapy of Cancer 11 (6): e006747.

A Cancer Care Desert: Living in Between the Urban and Rural and the Case for Defining Semirural Regions. Finster, Laurel J., Sarah J. Salvy, and Robert W. Haile. Frontiers in Oncology 13: 1204821.

Cardiac Surgery

Transplantation Outcomes With Donor Hearts After Circulatory Death. Schroder, Jacob N., Chetan B. Patel, Adam D. DeVore, Benjamin S. Bryner, Sarah Casalinova, Ashish Shah, Jason W. Smith, Amy G. Fiedler, Mani Daneshmand, Scott Silvestry, Arnar Geirsson, Victor Pretorius, David L. Joyce, John Y. Um, Fardad Esmailian, Koji Takeda, Karol Mudy, Yasuhiro Shudo, Christopher T. Salerno, Si M. Pham, Daniel J. Goldstein, Jonathan Philpott, John Dunning, Lucian Lozonschi, Gregory S. Couper, Hari Reddy Mallidi, Michael M. Givertz, Duc Thinh Pham, Andrew W. Shaffer, Masashi Kai, Mohammed A. Quader, Tarek Absi, Tamer S. Attia, Bassam Shukrallah, Ben C. Sun, Maryjane Farr, Mandeep R. Mehra, Joren C. Madsen, Carmelo A. Milano, and David A. D’Alessandro. The New England Journal of Medicine 388 (23): 2121–31.

Cardiology

Role of Glucagon-Like Peptide-1 Receptor Agonists in Achieving Weight Loss and Improving Cardiovascular Outcomes in People With Overweight and Obesity. Michos, Erin D., Francisco Lopez-Jimenez, and Martha Gulati. Journal of the American Heart Association, June, e029282

Evolving Management of Low-Density Lipoprotein Cholesterol: A Personalized Approach to Preventing Atherosclerotic Cardiovascular Disease Across the Risk Continuum. Wilkinson, Michael J., Norman E. Lepor, and Erin D. Michos. Journal of the American Heart Association 12 (11): e028892.

Transcatheter Edge-to-Edge Repair for Chronic Functional Mitral Regurgitation in Patients With Very Severe Left Ventricular Dysfunction. Shechter, Alon, Ofir Koren, Sabah Skaf, Moody Makar, Tarun Chakravarty, Keita Koseki, Danon Kaewkes, Aum Solanki, Vivek Patel, Raj R. Makkar, and Robert J. Siegel. American Heart Journal, June, S0002-8703(23)00138-2.

Adverse Pregnancy Outcomes and Future Metabolic Syndrome. Ehrenthal, Deborah B., Rebecca B. McNeil, Emma G. Crenshaw, C. Noel Bairey Merz, William A. Grobman, Corette B. Parker, Philip Greenland, Victoria L. Pemberton, Phyllis C. Zee, Christina M. Scifres, LuAnn Polito, and George Saade. Journal of Women’s Health, June.

Association Between Calculated Panel Reactive Antibody and Waitlist Outcomes in the 2018 Heart Allocation System. DeFilippis, Ersilia M., Ziyu Ji, Maria Masotti, Valmiki Maharaj, Tamas Alexy, Michelle M. Kittleson, and Rebecca Cogswell. The Journal of Heart and Lung Transplantation, May, S1053-2498(23)01874-0.

Ischemic and Nonischemic Heart Failure After Pregnancy-Induced Hypertension: Another Piece of the Puzzle. Bello, Natalie A. JACC. Heart Failure, May, S2213-1779(23)00228-7.

New Approaches to Reduce Recurrent PCI: To Angioplasty and Beyond Sabouret, Pierre, Stéphane Manzo-Silberman, Mirvat Alasnag, Marinos Fysekidis, Martha Gulati, Giuseppe Galati, Luigi Spadafora, Maciej Banach, Giuseppe Biondi-Zoccai, and Deepak L. Bhatt. European Heart Journal Open 3 (3): oead049.

Cardiac Computed Tomography Angiography Anatomical Characterization of Patients Screened for a Dedicated Transfemoral Transcatheter Valve System for Primary Aortic Regurgitation. Gogia, Shawnbir, Torsten P. Vahl, Vinod H. Thourani, Pradeep K. Yadav, Isaac George, Susheel K. Kodali, Nadira Hamid, Lauren Ranard, Tiffany Chen, Mitsuaki Matsumura, Akiko Maehara, Hendrik Treede, Stephan Baldus, David Daniels, Brett C. Sheridan, Firas Zahr, Mark J. Russo, James M. McCabe, Stanley J. Chetcuti, Martin B. Leon, Raj R. Makkar, and Omar K. Khalique. Structural Heart: The Journal of the Heart Team 7 (3): 100164.

Low-Intensity vs. High-Intensity Antithrombotic Therapy After Transcatheter Aortic Valve Replacement: Meta-Analysis of Randomized Controlled Trials. Chakravarty, Tarun, Derek Leong, Angelo de la Rosa, Neel Bhardwaj, and Raj R. Makkar. Structural Heart: The Journal of the Heart Team 7 (2): 100133.

Long-Term Outcomes of Randomized Controlled Trials Comparing Percutaneous Left Atrial Appendage Closure to Oral Anticoagulation for Nonvalvular Atrial Fibrillation: A Meta-Analysis. Madhavan, Mahesh V., James P. Howard, Michael I. Brener, Caroline Der Nigoghossian, Shmuel Chen, Raj Makkar, Pavel Osmancik, Vivek Y. Reddy, David R. Holmes, Gregg W. Stone, Martin B. Leon, and Yousif Ahmad. Structural Heart: The Journal of the Heart Team 7 (1): 100096.

Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future. Ahmad, Yousif, Mahesh V. Madhavan, Suzanne J. Baron, John K. Forrest, Michael A. Borger, Jonathon A. Leipsic, João L. Cavalcante, Dee Dee Wang, Patrick McCarthy, Molly Szerlip, Samir Kapadia, Raj Makkar, Michael J. Mack, Martin B. Leon, and David J. Cohen. Structural Heart: The Journal of the Heart Team 7 (1): 100102.

Imaging

Cardiac Computed Tomography for Quantification of Myocardial Extracellular Volume Fraction: A Systematic Review and Meta-Analysis. Han, Donghee, Andrew Lin, Keiichiro Kuronuma, Heidi Gransar, Damini Dey, John D. Friedman, Daniel S. Berman, and Balaji K. Tamarappoo. JACC. Cardiovascular Imaging, May, S1936-878X(23)00188-2.

Medicine

IgA Determines Bacterial Composition in the Gut. Gupta, Suman, Sneh Lata Gupta, Aashima Singh, Neelam Oswal, Vineeta Bal, Satyajit Rath, Anna George, and Srijani Basu. Crohn’s & Colitis 360 5 (3): otad030.

A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients With Advanced Solid Tumors. Bauer, Todd M., Kathleen N. Moore, Janet S. Rader, Fiona Simpkins, Alain C. Mita, J. Thaddeus Beck, Lowell Hart, Quincy Chu, Amit Oza, Anna V. Tinker, Esteban Rodrigo Imedio, Sanjeev Kumar, Ganesh Mugundu, Suzanne Jenkins, Juliann Chmielecki, Suzanne Jones, David Spigel, and Siqing Fu. Targeted Oncology, June.

Identification of Iatrogenic Perforation in Paediatric Gastrointestinal Endoscopy. Ledder, Oren, Marek Woynarowski, Diana Kami?ska, Izabella ?azowska-Przeorek, Stanislaw Pieczarkowski, Claudio Romano, Raffi Lev-Tzion, Magdalena Holon, Andreia Nita, Anna Rybak, El?bieta Jarocka-Cyrta, Bartosz Korczowski, Elzbieta Czkwianianc, Iva Hojsak, Anna Szaflarska-Pop?awska, Bruno Hauser, Isabelle Scheers, Shishu Sharma, Salvatore Oliva, Raoul Furlano, Christos Tzivinikos, Quin Y. Liu, Matthew Giefer, Petar Mamula, Andrew Grossman, Judith Kelsen, Brian Edelstein, Matthieu Antoine, Mike Thomson, and Matjaž Homan. Journal of Pediatric Gastroenterology and Nutrition, June.

Corrigendum to ‘Prognostic Value of Circulating Mitochondrial DNA in Prostate Cancer and Underlying Mechanism’ [Mitochondrion 71 (2023) 40-49]. Borah, Supriya, Rajeev Mishra, Sananda Dey, Surabhi Suchanti, Neil A. Bhowmick, Biplab Giri, and Subhash Haldar. Mitochondrion 71 (June): 63.

NFYA Promotes Malignant Behavior of Triple-Negative Breast Cancer in Mice through the Regulation of Lipid Metabolism. Okada, Nobuhiro, Chihiro Ueki, Masahiro Shimazaki, Goki Tsujimoto, Susumu Kohno, Hayato Muranaka, Kiyotsugu Yoshikawa, and Chiaki Takahashi. Communications Biology 6 (1): 596.

Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease. Khrom, Michelle, Dalin Li, Takeo Naito, Ho-Su Lee, Gregory J. Botwin, Alka A. Potdar, Gabrielle Boucher, NIDDK Inflammatory Bowel Disease Genetics Consortium, International Inflammatory Bowel Disease Genetics Consortium, Shaohong Yang, Emebet Mengesha, Shishir Dube, Kyuyoung Song, Dermot P. B. McGovern, and Talin Haritunians. Inflammatory Bowel Diseases, June, izad089.

In Vivo and in Vitro Models to Study Liver Fibrosis: Mechanisms and Limitations. Lee, Young-Sun, and Ekihiro Seki. Cellular and Molecular Gastroenterology and Hepatology, June, S2352-345X(23)00107-8.

Economic and Humanistic Burden Among Medicare-Aged Women With Fragility Fracture in the United States. Teigland, Christie, Zulkarnain Pulungan, Jill Schinkel, Barnabie C. Agatep, Eric J. Yeh, Michele McDermott, Stuart L. Silverman, and E. Michael Lewiecki. Journal of the American Medical Directors Association, June, S1525-8610(23)00421-8.

Coronavirus Disease 2019 (COVID-19) Infection Prevention Practices That Exceed Centers for Disease Control and Prevention (CDC) Guidance: Balancing Extra Caution Against Impediments to Care. Gohil, Shruti K., Edward Septimus, Kenneth E. Sands, Eunice Jackie Blanchard, Julia Moody, Annabelle de St Maurice, Deborah Yokoe, Jennie Kwon, Jonathan Grein, Stuart Cohen, Daniel Uslan, Milind Vasudev, Amarah Mauricio, Shannon Mabalot, Micaela H. Coady, Selsebil Sljivo, Kimberly Smith, Brandon Carver, Russell Poland, Jonathan Perlin, Richard Platt, Susan S. Huang, and Centers for Disease Control and Prevention Epicenters Program. Infection Control and Hospital Epidemiology, June, 1–4.

Causal Relationship Between Smoking Marijuana and Gynecomastia Remains Unproven. Braunstein, Glenn D. Radiology 307 (5): e223046.

Best Practices for Ultrasound-Guided Synovial Biopsy in the United States. Ben-Artzi, Ami, Diane L. Horowitz, Arthur M. Mandelin, and Darren Tabechian. Best Practice & Research. Clinical Rheumatology, May, 101834.

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. Thaweethai, Tanayott, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce Levy, Grace A. McComsey, Lisa McCorkell, Girish N. Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A. Walker, Caitlin A. Selvaggi, RECOVER Consortium, et al. JAMA, May, e238823.

Main-Duct Intraductal Papillary Mucinous Neoplasm Complicated by a Pancreaticogastric Fistula and a Pancreaticocholedocal Fistula. Patel, Sarvanand, Umaima Al Salmi, and Khalid Al Shamousi. Cureus 15 (5): e38502.

Race and Socioeconomic Status: Interlinked Drivers of Sleep Health Disparities. Rojanapairat, Oragun, Abigail Beggs, Michelle Zeidler, and Bharati Prasad. Health Equity 7 (1): 307–11.

Neurology

Genetic Analysis and Natural History of Charcot-Marie-Tooth Disease CMTX1 Due to GJB1 Variants. Record, Christopher J., Mariola Skorupinska, Matilde Laura, Alexander M. Rossor, Davide Pareyson, Chiara Pisciotta, Shawna M. E. Feely, Thomas E. Lloyd, Rita Horvath, Reza Sadjadi, David N. Herrmann, Jun Li, David Walk, Sabrina W. Yum, Richard A. Lewis, John Day, Joshua Burns, Richard S. Finkel, Mario A. Saporta, Sindhu Ramchandren, Michael D. Weiss, Gyula Acsadi, Vera Fridman, Francesco Muntoni, Roy Poh, James M. Polke, Stephan Zuchner, Michael E. Shy, Steven S. Scherer, Mary M. Reilly, and Inherited Neuropathies Consortium - Rare Disease Clinical Research Network. Brain: A Journal of Neurology, June, awad187.

Timing and Predictors of Recanalization After Anticoagulation in Cerebral Venous Thrombosis. Salehi Omran, Setareh, Liqi Shu, Allison Chang, Neal S. Parikh, Adeel S. Zubair, Alexis N. Simpkins, Mirjam R. Heldner, Arsany Hakim, Sami Al Kasab, Thanh Nguyen, Piers Klein, Eric D. Goldstein, Maria Cristina Vedovati, Maurizio Paciaroni, David S. Liebeskind, Shadi Yaghi, and Shawna Cutting. Journal of Stroke 25 (2): 291–98.

Nursing

Sensory Adaptations to Improve Physiological and Behavioral Distress During Dental Visits in Autistic Children: A Randomized Crossover Trial. Stein Duker, Leah I., Dominique H. Como, Caitlin Jolette, Cheryl Vigen, Cynthia L. Gong, Marian E. Williams, José C. Polido, Lucía I. Floríndez-Cox, and Sharon A. Cermak. JAMA Network Open 6 (6): e2316346.

Orthopaedics

The Effects of Sport, Setting, and Demographics on Sunscreen Use and Education in Young Athletes. Zaslow, Tracy, Akash R. Patel, Rachel Coel, Mia J. Katzel, and Tishya A. L. Wren. Research in Sports Medicine (Print), June, 1–9.

Pathology

EGF Receptor-Dependent TLR7 Signaling in Macrophages Promotes Glomerular Injury in Crescentic Glomerulonephritis. Tatsumoto, Narihito, Suguru Saito, Ian R. Rifkin, Ramon G. Bonegio, Daniel N. Leal, Ganes C. Sen, Moshe Arditi, and Michifumi Yamashita. Laboratory Investigation; a Journal of Technical Methods and Pathology, May, 100190.

Pediatrics

Epidural Analgesia Is Associated With Reduced Inpatient Opioid Consumption and Length of Stay After Wilms Tumor Resection. Chen, Stephanie Y., Eric Laifman, Shale J. Mack, Shengmei Zhou, James E. Stein, and Eugene S. Kim. The Journal of Surgical Research 290 (May): 141–46.

Platelets Exacerbate Cardiovascular Inflammation in a Murine Model of Kawasaki Disease Vasculitis. Kocatürk, Begüm, Youngho Lee, Nobuyuki Nosaka, Masanori Abe, Daisy Martinon, Malcolm E. Lane, Debbie Moreira, Shuang Chen, Michael C. Fishbein, Rebecca A. Porritt, Bernardo S. Franklin, Magali Noval Rivas, and Moshe Arditi. JCI Insight, June, e169855.

High Prevalence of Hepatitis A and B Nonimmunity in Pediatric Liver Transplant Recipients. St Maurice, Annabelle de, G. Ng, C. Aryasomayajula, A. Liman, S. V. McDiarmid, R. S. Venick, and Laura Wozniak. Clinical Transplantation, June, e15035.

Radiation Oncology

Chronic Antigen in Solid Tumors Drives a Distinct Program of T Cell Residence. Gavil, Noah V., Milcah C. Scott, Eyob Weyu, Olivia C. Smith, Stephen D. O’Flanagan, Sathi Wijeyesinghe, Sahar Lotfi-Emran, Stephen L. Shiao, Vaiva Vezys, and David Masopust. Science Immunology 8 (84): eadd5976.

Surgery

End-to-End Stapled Technique for Kono-S Anastomosis. Adams, E. D., K. N. Zaghiyan, and P. R. Fleshner. Techniques in Coloproctology, June.

Contemporary Cancer Program Practice Profile Report Compliance Rates for Gastric Cancer: A National Cancer Database Analysis. Russo, Ashley, Joshua Tseng, Timothy DiPeri, Eric Pletcher, Jaewon Lee, Courtney Chen, Monica Justo, Allen Razavi, Jun Gong, Kaitlyn Atkins, Miguel Burch, and Alexandra Gangi. The American Surgeon, June, 31348231180931.

Management and Outcomes of Wilms Tumor With Suprarenal Intravascular Extension: A Pediatric Surgical Oncology Research Collaborative Study. Naik-Mathuria, Bindi, Alan F. Utria, Peter F. Ehrlich, Jennifer H. Aldrink, Andrew J. Murphy, Timothy Lautz, Roshni Dasgupta, Scott S. Short, Harold N. Lovvorn, Eugene S. Kim, Erica Newman, Dave R. Lal, Barrie S. Rich, Nelson Piché, Zachary J. Kastenberg, Marcus M. Malek, Richard D. Glick, Robin T. Petroze, Stephanie F. Polites, Richard Whitlock, Elizabeth Alore, Pattamon Sutthatarn, Stephanie Y. Chen, Shannon Wong-Michalak, Rodrigo Lp Romao, Ameer Al-Hadidi, Nathan S. Rubalcava, John P. Marquart, Hailey Gainer, Mike Johnson, Chloe Boehmer, Hannah Rinehardt, Natashia M. Seemann, Jacob Davidson, Valerie Polcz, Sarah B. Lund, Katlyn G. McKay, Hernan Correa, and David H. Rothstein. Annals of Surgery, June.

Anastomotic Leak Rates After Repair of Mesenteric Bucket-Handle Injuries: A Multi-Center Retrospective Cohort Study. Dhanasekara, Chathurika S., Brianna Marschke, Erin Morris, Bryan S. Bashrum, Kripa Shrestha, Robyn Richmond, Sharmila Dissanaike, Ara Ko, Lakshika Tennakoon, Eric M. Campion, Frank C. Wood, Maggie Brandt, Grace Ng, Justin Regner, Stacey L. Keith, Michelle K. Mcnutt, Heather Kregel, Rajesh Gandhi, Thomas Schroeppel, Daniel R. Margulies, Yassar Hashim, Joseph Herrold, Mallory Goetz, LeRone Simpson, and Doan Xuan-Lan. American Journal of Surgery, May, S0002-9610(23)00218-0.

Defining Sexual Dimorphism in Masculinizing Chest Surgery Using 3-Dimensional Imaging. Azadgoli, Beina, Yasmina Samaha, Jiaxi Chen, and Edward Ray. Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS 83 (April): 32–41.

Planning an Escape: Considerations for the Development of Applied Escape Rooms. Doherty, Shawn M., Andrew C. Griggs, Elizabeth H. Lazzara, Joseph R. Keebler, Bruce L. Gewertz, and Tara N. Cohen. Simulation & Gaming 54 (2): 150–66.