A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published July 20-27.

Biomedical Sciences

The Power of ‘Negative’ Experiments: Harry Goldblatt’s Pathway to Discovering How Renal Ischemia Causes Hypertension. Fine, Leon G. Kidney International 104 (2): 218–20.

Impact of Virtual Monoenergetic Levels on Coronary Plaque Volume Components Using Photon-Counting Computed Tomography. Vattay, Borbála, Bálint Szilveszter, Melinda Boussoussou, Milán Vecsey-Nagy, Andrew Lin, Gábor Konkoly, Anikó Kubovje, Florian Schwarz, Béla Merkely, Pál Maurovich-Horvat, Michelle C. Williams, Damini Dey, and Márton Kolossváry. European Radiology, July.

Proceedings of the NHLBI Workshop on Artificial Intelligence in Cardiovascular Imaging: Translation to Patient Care. Dey, Damini, Rima Arnaout, Sameer Antani, Aldo Badano, Louis Jacques, Huiqing Li, Tim Leiner, Edward Margerrison, Ravi Samala, Partho P. Sengupta, Sanjiv J. Shah, Piotr Slomka, Michelle C. Williams, W. Patricia Bandettini, and Vandana Sachdev. JACC. Cardiovascular Imaging, July, S1936-878X(23)00235-8.

Cancer

Applied Molecular-Based Quality Control of Biobanked Samples for Multi-Omics Approach. Michalska-Falkowska, Anna, Jacek Niklinski, Hartmut Juhl, Anetta Sulewska, Joanna Kisluk, Radoslaw Charkiewicz, Michal Ciborowski, Rodryg Ramlau, Robert Gryczka, Cezary Piwkowski, Miroslaw Kozlowski, Borys Miskiewicz, Przemyslaw Biecek, Karolina Wnorowska, Zofia Dzieciol-Anikiej, Karine Sargsyan, Wojciech Naumnik, Robert Mroz, and Joanna Reszec-Gielazyn. Cancers 15 (14): 3742.

Cardiac Surgery

Lung Transplantation Outcomes in Patients from Socioeconomically Distressed Communities. Malas, Jad, Qiudong Chen, Dominick Megna, Lorenzo Zaffiri, Reinaldo E. Rampolla, Natalia Egorova, Dominic Emerson, Pedro Catarino, Joanna Chikwe, and Michael E. Bowdish. The Journal of Heart and Lung Transplantation, July, S1053-2498(23)01938-1.

Cardiology

Detection of Left Ventricular Systolic Dysfunction from Electrocardiographic Images. Sangha, Veer, Arash A. Nargesi, Lovedeep S. Dhingra, Akshay Khunte, Bobak J. Mortazavi, Antônio H. Ribeiro, Evgeniya Banina, Oluwaseun Adeola, Nadish Garg, Cynthia A. Brandt, Edward J. Miller, Antonio Luiz J. Ribeiro, Eric J. Velazquez, Luana Giatti, Sandhi M. Barreto, Murilo Foppa, Neal Yuan, David Ouyang, Harlan M. Krumholz, and Rohan Khera. Circulation, July.

Newt A1 Cell-Derived Extracellular Vesicles Promote Mammalian Nerve Growth. Middleton, Ryan C., Ke Liao, Weixin Liu, Geoff de Couto, Nahuel Garcia, Travis Antes, Yizhou Wang, Di Wu, Xinling Li, Warren G. Tourtellotte, and Eduardo Marbán. Scientific Reports 13 (1): 11829.

Taking the Next Step in Cardiovascular Risk Reduction: Integrating Heart Failure & Peripheral Arterial Disease Prevention. Matasic, Daniel S., Roger S. Blumenthal, Gregg C. Fonarow, and Martha Gulati. American Heart Journal, July, S0002-8703(23)00176-X.

Aficamten for Drug-Refractory Severe Obstructive Hypertrophic Cardiomyopathy in Patients Receiving Disopyramide: REDWOOD-HCM Cohort 3. Owens, Anjali T., Ahmad Masri, Theodore P. Abraham, Lubna Choudhury, Florian Rader, John D. Symanski, Aslan T. Turer, Timothy C. Wong, Albree Tower-Rader, Caroline J. Coats, Michael A. Fifer, Iacopo Olivotto, Scott D. Solomon, Hugh C. Watkins, Stephen B. Heitner, Daniel L. Jacoby, Stuart Kupfer, Fady I. Malik, Lisa Meng, Regina Sohn, Amy Wohltman, Martin S. Maron, and REDWOOD-HCM Investigators. Journal of Cardiac Failure, July, S1071-9164(23)00261-0.

Underestimation of Intraprocedural Tricuspid Valve Pressure Gradient by Echocardiography in Patients Undergoing Tricuspid Transcatheter Edge-to-Edge Repair. Kuwajima, Ken, Shunsuke Kagawa, Takafumi Yamane, Hiroko Hasegawa, Moody Makar, Tarun Chakravarty, Raj R. Makkar, and Takahiro Shiota. Journal of Cardiothoracic and Vascular Anesthesia, July, S1053-0770(23)00417-2.

False Tendons in the Left Ventricle: Implications for Successful Ablation of Left Posterior Fascicular Tachycardias. Liu, Qiang, Yunhe Wang, Ashkan Ehdaie, Hui Cheng, Ruhong Jiang, Shiquan Chen, Yaxun Sun, Pei Zhang, Lu Yu, Xia Sheng, Jianwei Lin, Zuwen Zhang, Xu Zhou, Guosheng Fu, Michael Shehata, Chenyang Jiang, and Xunzhang Wang. JACC. Clinical Electrophysiology, June, S2405-500X(23)00350-X.

Fast Is Fine, But Accuracy Is Everything. Jilaihawi, Hasan. JACC. Cardiovascular Interventions, June, S1936-8798(23)00974-3.

Neural Remodeling After Myocardial Infarction: The Importance of Heterogeneity. Chen, Peng-Sheng, and Michael C. Fishbein. JACC. Clinical Electrophysiology, June, S2405-500X(23)00341-9.

Predicting the Risk of Iliofemoral Vascular Complication in Complex Transfemoral-TAVR Using New Generation Transcatheter Devices. Koren, Ofir, Vivek Patel, Yuval Tamir, Keita Koseki, Danon Kaewkes, Troy Sanders, Robert Naami, Edmund Naami, Daniel Eugene Cheng, Sharon Shalom Natanzon, Alon Shechter, Jeffrey Gornbein, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Hasan Jilaihawi, and Raj R. Makkar. Frontiers in Cardiovascular Medicine 10: 1167212

Case Report: Repeat Coronary Function Testing in Women with Ischemia and No Obstructive Coronary Artery Disease. Suppogu, Nissi, Benita Tjoe, Janet Wei, Jenna Maughan, Sandy Joung, Odayme Quesada, Chrisandra L. Shufelt, Bruce Samuels, Babak Azarbal, and C. Noel Bairey Merz. Frontiers in Cardiovascular Medicine 10: 1096265.

Computational Biomedicine

Risk of Metastasis in BRCA2 Carriers Diagnosed with Triple-Negative Breast Cancer. Moreno, Marcelo, Júlia Salles Oliveira, Rafael Canfield Brianese, Douglas Guedes de Castro, Solange Moraes Sanches, Giovana Tardin Torrezan, Karina Miranda Santiago, Marina De Brot, Vladmir Claudio Cordeiro de Lima, Fabiana Baroni Alves Makdissi, Jose Claudio Casali Da Rocha, Vinicius Fernando Calsavara, and Dirce Maria Carraro. Cancer Medicine, July.

Polygenic Scores in Cancer. Yang, Xin, Siddhartha Kar, Antonis C. Antoniou, and Paul D. P. Pharoah. Nature Reviews. Cancer, July.

Knowledge Graph Aids Comprehensive Explanation of Drug and Chemical Toxicity. Hao, Yun, Joseph D. Romano, and Jason H. Moore. CPT: Pharmacometrics & Systems Pharmacology, July.

Imaging

Standardized Medical Terminology for Cardiac Computed Tomography 2023 Update: An Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT), American Association of Physicists in Medicine (AAPM), American College of Radiology (ACR), North American Society for Cardiovascular Imaging (NASCI) and Radiological Society of North America (RSNA) with Endorsement by the Asian Society of Cardiovascular Imaging (ASCI), the European Association of Cardiovascular Imaging (EACI), and the European Society of Cardiovascular Radiology (ESCR). Koweek, Lynne, Stephan Achenbach, Daniel S. Berman, J. Jeffrey Carr, Ricardo C. Cury, Brian Ghoshhajra, Diana Litmanovich, Cynthia H. McCollough, Allen J. Taylor, Quynh A. Truong, Jia Wang, W. Guy Weigold, Armin Arbab-Zadeh, Suhny Abbara, and Marcus Y. Chen. Journal of Cardiovascular Computed Tomography, June, S1934-5925(23)00389-1.

Medicine

Pediatric Drug-Associated Pancreatitis Reveals Concomitant Risk Factors and Poor Reliability Of Causality Scoring: Report From INSPPIRE. Morinville, Veronique D., Sohail Z. Husain, Fuchenchu Wang, Gretchen A. Cress, Maisam Abu-El-Haija, Ankur Chugh, Elissa Downs, Kate Ellery, Douglas S. Fishman, Alvin Jay Freeman, Cheryl E. Gariepy, Matthew Giefer, Tanja Gonska, Quin Liu, Asim Maqbool, Jacob Mark, Brian Arthur Mcferron, Megha Mehta, Jaimie D. Nathan, Ken Ng, Chee Y. Ooi, Emily Perito, Wenly Ruan, Sarah Jane Schwarzenberg, Zachary M. Sellers, Jose Serrano, David M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark Lowe, Aliye Uc, and Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC). Journal of Pediatric Gastroenterology and Nutrition, July.

Temporal Trend of Mortality in Patients with Cirrhosis with Primary Biliary Cholangitis and Primary Sclerosing Cholangitis during the COVID-19 Pandemic. He, Xinyuan, Ning Gao, Fan Lv, Fengping Wu, Yi Liu, Lamei Li, Walid S. Ayoub, Yee Hui Yeo, and Fanpu Ji. Gut, July, gutjnl-2023-330271.

Recent Advances in the Management of Hepatocellular Carcinoma. Sankar, Kamya, Jun Gong, Arsen Osipov, Steven A. Miles, Kambiz Kosari, Nicholas N. Nissen, Andrew E. Hendifar, Ekaterina K. Koltsova, and Ju Dong Yang. Clinical and Molecular Hepatology, July.

Perspectives in Immunotherapy: Meeting Report from Immunotherapy Bridge (Naples, November 30th-December 1st, 2022). Ascierto, Paolo A., Antonio Avallone, Carlo Bifulco, Sergio Bracarda, Joshua D. Brody, Leisha A. Emens, Robert L. Ferris, Silvia C. Formenti, Omid Hamid, Douglas B. Johnson, Tomas Kirchhoff, Christopher A. Klebanoff, Gregory B. Lesinski, Anne Monette, Bart Neyns, Kunle Odunsi, Chrystal M. Paulos, Daniel J. Powell, Katayoun Rezvani, Brahm H. Segal, Nathan Singh, Ryan J. Sullivan, Bernard A. Fox, and Igor Puzanov. Journal of Translational Medicine 21 (1): 488.

Nursing

Geriatric Pain Protocol: Impact of Multimodal Pain Care for Elderly Orthopaedic Trauma Patients. Andujo, Paulina, Kelsey Yue, Karma McKelvey, Grant J. Dornan, and Kathleen Breda. Orthopedic Nursing 42 (4): 202–10.

OBGYN

Analysis of Sociodemographic Factors Affecting Ambulatory Surgical Center Discharge Patterns for Endometrial Cancer Hysterectomies. Wang, Stephanie M., Catherine Moore, Emma Keegan, Christopher Mayer, Ethan Litman, Kirsten Jh Das, Catherine Z. Wu, and Nicole P. Chappell. Journal of Minimally Invasive Gynecology, July, S1553-4650(23)00292-3.

Pathology

Capecitabine-Induced Gastrointestinal Injury Shows a Graft-Versus-Host Disease (GVHD)-like Pattern. Ojukwu, Kenechukwu, Brian K. Cox, Brent K. Larson, Maha Guindi, Kevin M. Waters, and Danielle A. Hutchings. The American Journal of Surgical Pathology, July.

Multifaceted Spindle Cell/Sclerosing Rhabdomyosarcoma with Role of Immunohistochemistry in Avoiding Misdiagnosis: A Multi-Institutional Study of 45 Distinct Tumors. Jain, Ekta, Gauri Munjal, Shivani Sharma, Zoya Brar, Nitin Bhardwaj, Aditi Dewan, Deepika Jain, Shilpy Jha, Anandi Lobo, Vipra Malik, Samriti Arora, Juhi Varshney, Arshi Beg, Nakul Y. Sampat, Anil V. Parwani, Bonnie Balzer, Monica Varma, Brijpal S. Yadav, Shailendra K. Sharma, Hena Paul Singh, Kamakhya Gogoi, Devendra Kumar, Vijinder Bhandari, Lalit M. Fulara, Arvind Kumar, Harish Singh, Munmun Bhattacharya, Mallika Dixit, and Sambit K. Mohanty. International Journal of Surgical Pathology, July, 10668969231188422.

Psychiatry

Virtual Reality in the Management of Stress and Anxiety Disorders: A Retrospective Analysis of 61 People Treated in the Metaverse. Orr, Eran, Tal Arbel, Miki Levy, Yaron Sela, Omer Weissberger, Omer Liran, and Jeremy Lewis. Heliyon 9 (7): e17870.

Surgery

B7-H3-Targeted CAR T Cell Activity Is Enhanced by Radiotherapy in Solid Cancers. Ventin, Marco, Giulia Cattaneo, Luke Maggs, Jingyu Jia, Shahrzad Arya, Soldano Ferrone, Xinhui Wang, and Cristina R. Ferrone. Frontiers in Oncology 13: 1193963.

Does Coffee Affect Bowel Recovery Following Minimally Invasive Colorectal Operations? A Three-Armed Randomized Controlled Trial. Nasseri, Yosef, Eli Kasheri, Kimberly Oka, Ruoyan Zhu, Abbas Smiley, Jason Cohen, Joshua Ellenhorn, and Moshe Barnajian. International Journal of Colorectal Disease 38 (1): 199.

Carpal Tunnel Syndrome: As Seen from the Perspective of the Patient. Blough, Christian L., Stuart H. Kuschner, Haben Berihun, Cassie C. Tseng, and David A. Kulber. Plastic and Reconstructive Surgery. Global Open 11 (7): e5146.

Autonomous Action and Cooperativity between the ONECUT2 Transcription Factor and Its 3’ Untranslated Region. Steadman, Kenneth, Sungyong You, Dustin V. Srinivas, Lila Mouakkad, Yiwu Yan, Minhyung Kim, Smrruthi V. Venugopal, Hisashi Tanaka, and Michael R. Freeman. Frontiers in Cell and Developmental Biology 11: 1206259.