This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published July 13-20.

Biomedical Sciences

Roadmap on the Use of Artificial Intelligence for Imaging of Vulnerable Atherosclerotic Plaque in Coronary Arteries. Föllmer, Bernhard, Michelle C. Williams, Damini Dey, Armin Arbab-Zadeh, Pál Maurovich-Horvat, Rick H. J. A. Volleberg, Daniel Rueckert, Julia A. Schnabel, David E. Newby, Marc R. Dweck, Giulio Guagliumi, Volkmar Falk, Aldo J. Vázquez Mézquita, Federico Biavati, Ivana Išgum, and Marc Dewey. Nature Reviews. Cardiology, July.

Reversal of Dual Epigenetic Repression of Non-Canonical Wnt-5a Normalises Diabetic Corneal Epithelial Wound Healing and Stem Cells. Shah, Ruchi, Tanya M. Spektor, Daniel J. Weisenberger, Hui Ding, Rameshwar Patil, Cynthia Amador, Xue-Ying Song, Steven T. Chun, Jake Inzalaco, Sue Turjman, Sean Ghiam, Jiho Jeong-Kim, Sasha Tolstoff, Sabina V. Yampolsky, Onkar B. Sawant, Yaron S. Rabinowitz, Ezra Maguen, Pedram Hamrah, Clive N. Svendsen, Mehrnoosh Saghizadeh, Julia Y. Ljubimova, Andrei A. Kramerov, and Alexander V. Ljubimov. Diabetologia, July.

Cancer

Disease Associations With Monoclonal Gammopathy of Undetermined Significance Can Only Be Evaluated Using Screened Cohorts: Results From the Population-Based IStopMM Study. Sigurbergsdóttir, Aðalbjörg Ýr, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Ingigerður Sverrisdóttir, Guðrún Ásta Sigurðardóttir, Brynjar Viðarsson, Páll Torfi Önundarson, Bjarni A. Agnarsson, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, Ísleifur Ólafsson, Ásdís Rósa Þórðardóttir, Gauti Kjartan Gíslason, Andri Ólafsson, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Ola Landgren, Thorvarður Jón Löve, and Sigurður Yngvi Kristinsson. Haematologica, July.

Cardiac Surgery

Commentary: The Potential Durability of Aortic Valve Repair in Children. Kim, Richard W. The Journal of Thoracic and Cardiovascular Surgery, July, S0022-5223(23)00609-8. 

Cardiology

Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation. Qian, Frank, Nathan Tintle, Paul N. Jensen, Rozenn N. Lemaitre, Fumiaki Imamura, Tobias Rudholm Feldreich, Sarah Oppeneer Nomura, Weihua Guan, Federica Laguzzi, Eunjung Kim, Jyrki K. Virtanen, Marinka Steur, Christian S. Bork, Yoichiro Hirakawa, Michelle L. O’Donoghue, Aleix Sala-Vila, Andres V. Ardisson Korat, Qi Sun, Eric B. Rimm, Bruce M. Psaty, Susan R. Heckbert, Nita G. Forouhi, Nicholas J. Wareham, Matti Marklund, Ulf Risérus, Lars Lind, Johan Ärnlöv, Parveen Garg, Michael Y. Tsai, James Pankow, Jeffrey R. Misialek, Bruna Gigante, Karin Leander, Julie A. Pester, Christine M. Albert, Maryam Kavousi, Arfan Ikram, Trudy Voortman, Erik B. Schmidt, Toshiharu Ninomiya, David A. Morrow, Antoni Bayés-Genís, James H. O’Keefe, Kwok Leung Ong, Jason H. Y. Wu, Dariush Mozaffarian, William S. Harris, David S. Siscovick, and Fatty Acids and Outcomes Research Consortium (FORCE). Journal of the American College of Cardiology 82 (4): 336–49.

Dealing With Nonproportional Hazards in Coronary Revascularization Studies. Godoy, Lucas C., Dennis T. Ko, Michael E. Farkouh, Baiju R. Shah, and Peter C. Austin. The Canadian Journal of Cardiology, July, S0828-282X(23)01521-0.

A Randomized Clinical Trial of Omega-3 Fatty Acid and Vitamin D Supplementation on Electrocardiographic Risk Profiles. Tikkanen, Jani T., Elsayed Z. Soliman, Julie Pester, Jacqueline S. Danik, Natalia Gomelskya, Trisha Copeland, I.-Min Lee, Julie E. Buring, JoAnn E. Manson, Nancy R. Cook, and Christine M. Albert. Scientific Reports 13 (1): 11454.

Novel Algorithms Improve Arrhythmia Detection Accuracy in Insertable Cardiac Monitors. Gopinathannair, Rakesh, Michael M. Shehata, Muhammad R. Afzal, Harish Manyam, Fujian Qu, Nima Badie, Fady Dawoud, Kyungmoo Ryu, Michael S. Katcher, and Dhanunjaya Lakkireddy. Journal of Cardiovascular Electrophysiology, July.

Early Optical Coherence Tomography Evaluation of Donor-Transmitted Atherosclerosis and Cardiac Allograft Vasculopathy: Insights From a Prospective, Single-Center Study. Takahashi, Tatsunori, Yuhei Kobayashi, Omar Saeed, Sasha Vukelic, Ulrich P. Jorde, Jooyoung Julia Shin, and Snehal R. Patel. The Journal of Heart and Lung Transplantation, July, S1053-2498(23)01937-X.

Impact of Complete Revascularization in the ISCHEMIA Trial. Stone, Gregg W., Ziad A. Ali, Sean M. O’Brien, Grace Rhodes, Philippe Genereux, Sripal Bangalore, Kreton Mavromatis, Jennifer Horst, Ovidiu Dressler, Kian Keong Poh, Ranjit K. Nath, Nagaraja Moorthy, Adam Witkowski, Sudhanshu K. Dwivedi, Olga Bockeria, Jiyan Chen, Paola E. P. Smanio, Michael H. Picard, Bernard R. Chaitman, Daniel S. Berman, Leslee J. Shaw, William E. Boden, Harvey D. White, Stephen E. Fremes, Yves Rosenberg, Harmony R. Reynolds, John A. Spertus, Judith S. Hochman, David J. Maron, and ISCHEMIA Research Group. Journal of the American College of Cardiology, July, S0735-1097(23)06031-X.

Redesigning the Future of Medicine. Liu, Linda, Shirlene Obuobi, and Martha Gulati. JAMA Network Open 6 (7): e2323831.

Artificial Intelligence in Ventricular Arrhythmias and Sudden Death. Holmström, Lauri, Frank Zijun Zhang, David Ouyang, Damini Dey, Piotr J. Slomka, and Sumeet S. Chugh. Arrhythmia & Electrophysiology Review 12: e17.

Computational Biomedicine

A Complete Workflow for High Throughput Human Single Skeletal Muscle Fiber Proteomics. Momenzadeh, Amanda, Yuming Jiang, Simion Kreimer, Laura E. Teigen, Carlos S. Zepeda, Ali Haghani, Mitra Mastali, Yang Song, Alexandre Hutton, Sarah J. Parker, Jennifer E. Van Eyk, Christopher W. Sundberg, and Jesse G. Meyer. Journal of the American Society for Mass Spectrometry, July.

Evaluation of European-Based Polygenic Risk Score for Breast Cancer in Ashkenazi Jewish Women in Israel. Levi, Hagai, Shai Carmi, Saharon Rosset, Rinat Yerushalmi, Aviad Zick, Tamar Yablonski-Peretz, BCAC Consortium, Qin Wang, Manjeet K. Bolla, Joe Dennis, Kyriaki Michailidou, Michael Lush, Ran Elkon, et al. Journal of Medical Genetics, July, jmg-2023-109185.

ChatGPT and Large Language Models in Academia: Opportunities and Challenges. Meyer, Jesse G., Ryan J. Urbanowicz, Patrick C. N. Martin, Karen O’Connor, Ruowang Li, Pei-Chen Peng, Tiffani J. Bright, Nicholas Tatonetti, Kyoung Jae Won, Graciela Gonzalez-Hernandez, and Jason H. Moore. BioData Mining 16 (1): 20.

Reasons for Discontinuation or Change of Selective Serotonin Reuptake Inhibitors in Online Drug Reviews. Golder, Su, Dominique Medaglio, Karen O’Connor, Sean Hennessy, Robert Gross, and Graciela Gonzalez Hernandez. JAMA Network Open 6 (7): e2323746.

Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases. Figlioli, Gisella, Amandine Billaud, Qin Wang, Manjeet K. Bolla, Joe Dennis, Michael Lush, Anders Kvist, Muriel A. Adank, Thomas U. Ahearn, Natalia N. Antonenkova, Päivi Auvinen, Sabine Behrens, Paolo Peterlongo, et al. Cancers 15 (13): 3313.

Emergency Medicine

Violence and Abuse: A Pandemic Within a Pandemic. Whiteman, Paula J., Wendy L. Macias-Konstantopoulos, Pryanka Relan, Anita Knopov, Megan L. Ranney, and M. D. Riviello. Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health 0 (0).

Medicine

Association between Physicians’ Geriatric Training and Patterns of End-of-Life Care Delivered to Persons With Dementia. Gotanda, Hiroshi, Jessica J. Zhang, David B. Reuben, Anne M. Walling, Haiyong Xu, Anupam B. Jena, Nate Gross, and Yusuke Tsugawa. Journal of the American Geriatrics Society, July.

Senescence of Alveolar Epithelial Progenitor Cells: A Critical Driver of Lung Fibrosis. Parimon, Tanyalak, Peter Chen, Barry R. Stripp, Jiurong Liang, Dianhua Jiang, Paul W. Noble, William C. Parks, and Changfu Yao. American Journal of Physiology. Cell Physiology, July.

Increasing Pancreatic Cancer Incidence in Young Women in the United States: A Population-Based Time-Trend Analysis, 2001-2018 - Reply. Abboud, Yazan, Gerardo Perrotta, and Srinivas Gaddam. Gastroenterology, July, S0016-5085(23)04781-9.

Association Between Severe Non-Adherence to Hydroxychloroquine and SLE Flares, Damage, and Mortality in 660 Patients From the SLICC Inception Cohort. Nguyen, Yann, Benoît Blanchet, Murray B. Urowitz, John G. Hanly, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Ann E. Clarke, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Graciela S. Alarcón, Ronald F. van Vollenhoven, Cynthia Aranow, Véronique Le Guern, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Søren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Jill Buyon, and Nathalie Costedoat-Chalumeau. Arthritis & Rheumatology (Hoboken, N.J.), July.

Young-GRAPPA (Y-GRAPPA) at the GRAPPA 2022 Annual Meeting: One Year in Y-GRAPPA. Where Do We Stand, Where Do We Go? Ayan, Gizem, Roxana Coras, Rachel Grynszpan, Sebastián Herrera, Hannah Jethwa, Hanna J. Johnsson, Dimitri L. F. Silva, Leonieke van Mens, Michelle L. M. Mulder, David Simon, Arani Vivekanantham, and Fabian Proft. The Journal of Rheumatology, July, jrheum.2023-0531.

Artificial Intelligence in Detecting Left Atrial Appendage Thrombus by Transthoracic Echocardiography and Clinical Features: The Left Atrial Thrombus on Transoesophageal Echocardiography (LATTEE) Registry. Pieszko, Konrad, Jaros?aw Hiczkiewicz, Katarzyna ?ojewska, Beata Uzi?b?o-?yczkowska, Pawe? Krzesi?ski, Monika Gawa?ko, Monika Budnik, Katarzyna Starzyk, Beata Wo?akowska-Kap?on, Ludmi?a Dani?owicz-Szymanowicz, Damian Kaufmann, Maciej Wójcik, Robert B?aszczyk, Katarzyna Mizia-Stec, Maciej Wybraniec, Katarzyna Kosmalska, Marcin Fija?kowski, Anna Szyma?ska, Miros?aw D?u?niewski, Micha? Kucio, Maciej Haberka, Karolina Kupczy?ska, B?a?ej Michalski, Anna Tomaszuk-Kazberuk, Katarzyna Wilk-?ledziewska, Renata Wachnicka-Truty, Marek Kozi?ski, Jacek Kwieci?ski, Rafa? Wolny, Ewa Kowalik, Iga Kolasa, Agnieszka Jurek, Jan Budzianowski, Pawe? Burchardt, Agnieszka Kap?on-Cie?licka, and Piotr J. Slomka. European Heart Journal, July, ehad431.

Revised Paradigm for Acute Pulmonary Embolism Prognostication and Treatment. Jiménez, David, Victor Tapson, Roger D. Yusen, Cecilia Becattini, Lisa Moores, Geoffrey D. Barnes, Manuel Monreal, Stavros Konstantinides, and Behnood Bikdeli. American Journal of Respiratory and Critical Care Medicine, July.

Patterns and Determinants of Pediatric Dermatologic Care in the United States: An Evaluation of the National Ambulatory Medical Care Survey From 2009 to 2015. Noveir, Sasan D., Ladan Afifi, Kevin A. Nguyen, Carol E. Cheng, and Daniel Q. Bach. Pediatric Dermatology, July.

Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes. Mahmood, Khalid, Minta Thomas, Conghui Qu, GECCO-CCFR Consortium, Li Hsu, Daniel D. Buchanan, and Ulrike Peters. Gastroenterology, July, S0016-5085(23)04770-4.

Serum Biomarkers of Nociceptive and Neuropathic Pain in Chronic Pancreatitis. Saloman, Jami L., Yan Li, Kimberly Stello, Wenhao Li, Shuang Li, Anna Evans Phillips, Kristen Hall, Evan L. Fogel, Santhi Swaroop Vege, Liang Li, Dana K. Andersen, William E. Fisher, Christopher E. Forsmark, Phil A. Hart, Stephen J. Pandol, Walter G. Park, Mark D. Topazian, Stephen K. Van Den Eeden, Jose Serrano, Darwin L. Conwell, Dhiraj Yadav, and Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). The Journal of Pain, July, S1526-5900(23)00472-8.

New Virus on the Block: Introducing Infection Control Processes for Mpox Patients in the Emergency Department During a Major Outbreak. Belandres, Corinne, Sharon Fawcett, Michael Ben-Aderet, Shawna Masih, MEGHAN Madhusudhan, and Jonathan Grein. American Journal of Infection Control, SI: 50th Annual Conference Abstracts, APIC 2023, 51 (7, Supplement): S6.

Candida Auris: A Team-Based Approach to Taming the Wild Yeast. Gaddam, Emily N., Wanda H. Jones, Julie Johnson Sharon Fawcett, MPH; Meghan Madhusudhan Raypon , Shawna Masih, MPH; Ryan, Deisy Contreras, Margie Morgan, Michael Ben-Aderet, and Jonathan Grein. American Journal of Infection Control, SI: 50th Annual Conference Abstracts, APIC 2023, 51 (7, Supplement): S2.

Feto-Placental Unit: From Development to Function. Covarrubias, Ambart, Macarena Aguilera-Olguín, Ivo Carrasco-Wong, Fabián Pardo, Pamela Díaz-Astudillo, and Sebastián San Martín. Advances in Experimental Medicine and Biology 1428: 1–29.

OBGYN

Polycystic Ovary Syndrome (PCOS) Does Not Impact Embryo Development Among High Responders. Willson, Bryn E., Amelia M. Schaub, Katherine Moran, Jessica L. Chan, Margareta D. Pisarska, and Erica T. Wang. Fertility and Sterility, 71st Annual Meeting of the Pacific Coast Reproductive Society, 120 (1, Supplement): e40–41.

Orthopaedics

Association Between TXA Use and HO Prevalence After Elbow Trauma Surgery: Commentary on an Article by Hang Liu, MD, et al.: ‘Association Between Tranexamic Acid Use and Heterotopic Ossification Prevalence After Elbow Trauma Surgery. A Propensity-Score-Matched Cohort Study.’ Itamura, John M., Brian K. Lee, and Ryan Dellamaggiora. The Journal of Bone and Joint Surgery. American Volume 105 (14): e37.

Rib-to-Spine and Rib-to-Pelvis Magnetically Controlled Growing Rods: Does the Law of Diminishing Returns Still Apply? Heyer, Jessica H., Jason B. Anari, Keith D. Baldwin, Stuart L. Mitchell, John M. Flynn, Wudbhav N. Sankar, Lindsay M. Andras, David L. Skaggs, John T. Smith, Scott J. Luhmann, Ishaan Swarup, Walter H. Truong, Jaysson T. Brooks, Ryan Fitzgerald, Ying Li, Pediatric Spine Study Group, and Patrick J. Cahill. Spine Deformity, July.

The Surgical Correction of Cavovarus Deformity in Charcot-Marie-Tooth Disease. Pfeffer, Glenn B., and Edward T. Haupt. The Journal of the American Academy of Orthopaedic Surgeons, July.

Pediatrics

Reconnecting, Recommitting, and Renewing. Klein, O. D. Journal of Dental Research, July, 220345231184211.

An Appreciation of a Giant in Orofacial Sciences Research-John Greenspan. Challacombe, S. J., and O. D. Klein. Journal of Dental Research, July, 220345231181536.

Radiation Oncology

Long-Term Outcomes of Chemoradiation for Muscle-Invasive Bladder Cancer in Noncystectomy Candidates. Final Results of NRG Oncology RTOG 0524-A Phase 1/2 Trial of Paclitaxel + Trastuzumab With Daily Radiation or Paclitaxel Alone With Daily Irradiation. Dahl, Douglas M., Theodore G. Karrison, M. Dror Michaelson, Huong T. Pham, Chin-Lee Wu, Gregory P. Swanson, William U. Shipley, Jacqueline Vuky, R. Jeffrey Lee, Anthony L. Zietman, Luis Souhami, Brian K. Chang, Richard L. Deming, John A. Ellerton, Howard M. Sandler, Joseph P. Rodgers, Felix Y. Feng, and Jason A. Efstathiou. European Urology Oncology, July, S2588-9311(23)00115-3.

Rehabilitation Medicine

Occupational Therapy Practice: Time From Stroke Onset to Outpatient Upper Limb Rehabilitation. Roberts, Pamela S., Debra Ouellette, Sara Benham, and Rachel Proffitt. OTJR: Occupation, Participation and Health, July, 15394492231183672.

Surgery

Impact of Postoperative Antibiotic Prophylaxis on Surgical Site Infections Rates After Mastectomy With Drains but Without Immediate Reconstruction: A Multicenter, Double-Blinded, Randomized Control Superiority Trial. Sattar, Abida K., Taleaa Masroor, Russell Seth Martins, Nida Zahid, Hania Shahzad, Rufina Soomro, Omema Saleem, Lubna M. Vohra, Sana Zeeshan, Muhammad Areeb Ashfaq, Irum Khan, Rida Nadeem, Nikhat Fatima, Ayisha Afzal Qureshi, Farin F. Amersi, and Syed Faisal Mahmood. Annals of Surgical Oncology, July.

Discordance in TME Specimen Grading in a Prospective Phase II Multicenter Rectal Cancer Trial: Are We Overestimating the Quality of Our Resections? Sylla, Patricia, Mariana Berho, Dana Sands, Alison Ricardo, Antoinette Bonaccorso, Erin Moshier, Elisabeth Hain, Riva Letchinger, John Marks, Mark Whiteford, Elisabeth Mclemore, Justin Maykel, Karim Alavi, Karen Zaghiyan, Sami Chadi, Sherief F. Shawki, Scott Steele, Alessio Pigazzi, Matthew Albert, Teresa DeBeche-Adams, Alexandros Polydorides, and Steven Wexner. Annals of Surgery, July.

Urology

Comparative Proteomic Profiling of Uric Acid, Ammonium Acid Urate, and Calcium-Based Kidney Stones. Khusid, Johnathan A., Alex Vasquez, Areeba S. Sadiq, Jennifer A. Stockert, Blair Gallante, Alan Yaghoubian, Roman Shimonov, Aryeh Stock, William Atallah, Natasha Kyprianou, Wei Yang, and Mantu Gupta. American Journal of Clinical and Experimental Urology 11 (3): 265–74.