This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Jan. 5 - Jan.12.

Anesthesiology

A Survey of Intensive Care Unit Models in Cardiothoracic Transplantation at High-Volume Centers. Nurok, Michael, Mark Nunnally, George Gill, Michael O’Connor, Michael Harper, Jeffrey Edelman, Abiodun Orija, Aly El Banayosy, Darren Malinoski, Thor Sundt, David Baran, Deborah Levine, Shelley Hall, Jon Kobashigawa, and David Nelson. Clinical Transplantation, January, e14911.

Biomedical Sciences

NeuroLINCS Proteomics: Defining Human-Derived IPSC Proteomes and Protein Signatures of Pluripotency. Matlock, Andrea D., Vineet Vaibhav, Ronald Holewinski, Vidya Venkatraman, Victoria Dardov, Danica-Mae Manalo, Brandon Shelley, Loren Ornelas, Maria Banuelos, Berhan Mandefro, Renan Escalante-Chong, Jonathan Li, Steve Finkbeiner, Ernest Fraenkel, Jeffrey Rothstein, Leslie Thompson, Dhruv Sareen, Clive N. Svendsen, NIH NeuroLINCS Consortium, and Jennifer E. Van Eyk. Scientific Data 10 (1): 24.

Pericoronary Adipose Tissue CT Attenuation in Coronary Artery Plaque Inflammation. Yu, Xinming, Simona Botezatu, Evangelos Tzolos, Damini Dey, and Jacek Kwiecinski. Heart (British Cardiac Society), January, heartjnl-2022-321158.

Coronary Low-Attenuation Plaque and High-Sensitivity Cardiac Troponin. Meah, Mohammed N., Ryan Wereski, Anda Bularga, Edwin J. R. van Beek, Marc R. Dweck, Nicholas L. Mills, David E. Newby, Damini Dey, Michelle Claire Williams, and Kuan Ken Lee. Heart (British Cardiac Society), January, heartjnl-2022-321867.

Cancer

Efficacy and Safety of Lifileucel, a One-Time Autologous Tumor-Infiltrating Lymphocyte (TIL) Cell Therapy, in Patients With Advanced Melanoma After Progression on Immune Checkpoint Inhibitors and Targeted Therapies: Pooled Analysis of Consecutive Cohorts of the C-144-01 Study. Chesney, Jason, Karl D. Lewis, Harriet Kluger, Omid Hamid, Eric Whitman, Sajeve Thomas, Martin Wermke, Mike Cusnir, Evidio Domingo-Musibay, Giao Q. Phan, John M. Kirkwood, Jessica C. Hassel, Marlana Orloff, James Larkin, Jeffrey Weber, Andrew J. S. Furness, Nikhil I. Khushalani, Theresa Medina, Michael E. Egger, Friedrich Graf Finckenstein, Madan Jagasia, Parameswaran Hari, Giri Sulur, Wen Shi, Xiao Wu, and Amod Sarnaik. Journal for Immunotherapy of Cancer 10 (12): e005755.

Investigation of Rare Non-Coding Variants in Familial Multiple Myeloma. Niazi, Yasmeen, Nagarajan Paramasivam, Joanna Blocka, Abhishek Kumar, Stefanie Huhn, Matthias Schlesner, Niels Weinhold, Rolf Sijmons, Mirjam De Jong, Brian Durie, Hartmut Goldschmidt, Kari Hemminki, and Asta Försti. Cells 12 (1): 96.

Large Cancer Pedigree Involving Multiple Cancer Genes Including Likely Digenic MSH2 and MSH6 Lynch Syndrome (LS) and an Instance of Recombinational Rescue from LS. Vogelaar, Ingrid P., Stephanie Greer, Fan Wang, GiWon Shin, Billy Lau, Yajing Hu, Sigurdis Haraldsdottir, Rocio Alvarez, Dennis Hazelett, Peter Nguyen, Francesca P. Aguirre, Maha Guindi, Andrew Hendifar, Jessica Balcom, Anna Leininger, Beth Fairbank, Hanlee Ji, and Megan P. Hitchins. Cancers 15 (1): 228.

Comparison of Computed Tomography Response Criteria After Chemoembolization of Hepatic Carcinoma in Dogs. Rogatko, Cleo, Chick Weisse, Tobias Schwarz, Allyson Berent, and Marcio Diniz. Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire 87 (1): 74–81.

A Parish-Based Multilevel Cluster Randomized Controlled Trial to Reduce Stigma and Mental Health Treatment Disparities Among Latino Communities. Wong, Eunice C., Kathryn P. Derose, Vanessa N. Torres, Mario O. Martinez, Bing Han, and Melen Vue. Contemporary Clinical Trials, January, 107080.

Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort. Su, Yu-Ru, Lori C. Sakoda, Jihyoun Jeon, Minta Thomas, Yi Lin, Jennifer L. Schneider, Natalia Udaltsova, Jeffrey K. Lee, Iris Lansdorp-Vogelaar, Elisabeth F. P. Peterse, Ann G. Zauber, Jiayin Zheng, Li Hsu, et al. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, January, EPI-22-0817.

Contextual Influences Across the Cancer Control Continuum. Datta, Geetanjali D., and Hazel B. Nichols. JNCI Cancer Spectrum, January, pkac089.

Post-Traumatic Stress Symptoms, Post-Traumatic Stress Disorder, and Post-Traumatic Growth Among Cancer Survivors: A Systematic Scoping Review of Interventions. Capaldi, Jessica M., Julia Shabanian, Laurel B. Finster, Arash Asher, Jeffrey C. Wertheimer, Bradley J. Zebrack, and Celina H. Shirazipour. Health Psychology Review, January, 1–34.

Cardiac Surgery

The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2022 Update on Outcomes and Research. Kim, Karen M., Arman Arghami, Robert Habib, Mani A. Daneshmand, Niharika Parsons, Zouheir Elhalabi, Carole Krohn, Vinod Thourani, and Michael E. Bowdish. The Annals of Thoracic Surgery, January, S0003-4975(23)00008-5.

ESC/EACTS vs. ACC/AHA Guidelines for the Management of Severe Aortic Stenosis. Lee, Grace, Joanna Chikwe, Milan Milojevic, Harindra C. Wijeysundera, Giuseppe Biondi-Zoccai, Marcus Flather, Mario F. L. Gaudino, Stephen E. Fremes, and Derrick Y. Tam. European Heart Journal, January, ehac803.

Cardiac Surgery

First-Line Catheter Ablation for Paroxysmal Atrial Fibrillation - Have We Reached the Tipping Point? Sandhu, Roopinder K., and Christine M. Albert. The New England Journal of Medicine 388 (2): 177–78.

Long-Term Durability of Antibody Responses After SARS-CoV-2 Vaccination and Influencing Factors. Ebinger, Joseph E., Sandy Y. Joung, Minhao Wang, Yunxian Liu, John C. Prostko, Edwin C. Frias, James L. Stewart, Jonathan Braun, Dermot P. B. McGovern, Gil Y. Melmed, Stanley C. Jordan, Brian L. Claggett, Kimia Sobhani, and Susan Cheng. Journal of Internal Medicine, January.

Late Bleeding Following TAVR in Japan: An Important Cause of Mortality. Jilaihawi, Hasan. JACC. Asia 2 (5): 633–34.

Detection and Management of HLA Sensitization in Candidates for Adult Heart Transplantation. DeFilippis, Ersilia M., Evan P. Kransdorf, Abhishek Jaiswal, Xiaohai Zhang, Jignesh Patel, Jon A. Kobashigawa, David A. Baran, and Michelle M. Kittleson. The Journal of Heart and Lung Transplantation, December, S1053-2498(22)02274-4.

A Roadmap to Reinvigorating Training Pathways Focused on the Care of Patients With Heart Failure: Shifting from Failure to Function. Blumer, Vanessa, Michelle M. Kittleson, John R. Teerlink, Mark H. Drazner, Mary N. Walsh, Eiran Z. Gorodeski, Robert J. Mentz, and Anuradha Lala. Journal of Cardiac Failure, December, S1071-9164(22)01249-0.

Pregnancy Outcomes in Women With Elevated and Stage I Blood Pressures After 20 Weeks Gestation. Parra, Natalia, Sbaa Syeda, Yijia Zhang, Uma M. Reddy, Natalie Bello, Nikolas Bletnisky, and Whitney A. Booker. American Journal of Obstetrics and Gynecology, SMFM 43rd Annual Meeting: The Pregnancy Meeting, 228 (1, Supplement): S711–12.

President’s Page: The Re-Emergence of Prevention in the Forefront of Cardiology. Gulati, Martha. American Journal of Preventive Cardiology, January, 100458.

Diet Modification Reverses Diastolic Dysfunction in Rats With Heart Failure and Preserved Ejection Fraction. Kim, Myung Yoon, Isabelle Pellot, Catherine Bresee, Asma Nawaz, Mario Fournier, Jae Hyung Cho, and Eugenio Cingolani. Journal of Molecular and Cellular Cardiology Plus, January, 100031.

Racial and Ethnic Disparities in Hypertension: Barriers and Opportunities to Improve Blood Pressure Control. Abrahamowicz, Aleksandra A., Joseph Ebinger, Seamus P. Whelton, Yvonne Commodore-Mensah, and Eugene Yang. Current Cardiology Reports, January.

High Cardiomyocyte Diversity in Human Early Prenatal Heart Development. Sylvén, Christer, Eva Wärdell, Agneta Månsson-Broberg, Eugenio Cingolani, Konstantinos Ampatzis, Ludvig Larsson, Åsa Björklund, and Stefania Giacomello. IScience 26 (1): 105857.

Increased in Vivo Perpetuation of Whole-Heart Ventricular Arrhythmia in Heterozygous Na+/Ca2+ Exchanger Knockout Mice. Bögeholz, Nils, Vincent Knappe, Paul Pauls, Jan S. Schulte, Joshua I. Goldhaber, Frank U. Müller, Georg Nickenig, Lars Eckardt, Jan W. Schrickel, and Thomas Beiert. International Journal of Cardiology. Heart & Vasculature 44 (February): 101168.

Imaging

Imaging Subclinical Coronary Atherosclerosis to Guide Lipid Management, Are We There Yet? Piña, Pamela, Daniel Lorenzatti, Rita Paula, Jonathan Daich, Aldo L. Schenone, Carlos Gongora, Mario J. Garcia, Michael J. Blaha, Matthew J. Budoff, Daniel S. Berman, Salim S. Virani, and Leandro Slipczuk. American Journal of Preventive Cardiology 13 (March): 100451.

Medicine

Medication Reconciliation to Support Pharmacogenomics Implementation. Mosley, Scott A., and Joshua M. Pevnick. Annals of Translational Medicine 10 (23): 1258.

Real-Time Transcription Polymerase Chain Reaction Cycle Threshold Values as Criteria for Utilization of Incidental COVID-19 Positive Lung Donors. Hwang, Josephine, Alexander Yuen, Joshua Rhoades, Darina Barnes, Phillip Zakowski, Dominick J. Megna, Pedro Catarino, Lorenzo Zaffiri, and Reinaldo Rampolla. The Journal of Heart and Lung Transplantation, December, S1053-2498(22)02272-0.

ENAMPT/TLR4 Inflammatory Cascade Activation Is a Key Contributor to SLE Lung Vasculitis and Alveolar Hemorrhage. Tumurkhuu, Gantsetseg, Nancy G. Casanova, Carrie L. Kempf, Duygu Ercan Laguna, Sara M. Camp, Jargalsaikhan Dagvadorj, Jin H. Song, Vivian Reyes Hernon, Cristina Travelli, Erica N. Montano, Jeong Min Yu, Mariko Ishimori, Daniel J. Wallace, Saad Sammani, Caroline Jefferies, and Joe G. N. Garcia. Journal of Translational Autoimmunity 6: 100181.

The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods. Mauck, Matthew C., Jeffrey Lotz, Matthew A. Psioda, Timothy S. Carey, Daniel J. Clauw, Sharmila Majumdar, William S. Marras, Nam Vo, Ayleen Aylward, Anna Hoffmeyer, Patricia Zheng, Anastasia Ivanova, Micah McCumber, Christiane Carson, Kevin J. Anstrom, Anton E. Bowden, Diane Dalton, Leslie Derr, Jonathan Dufour, Aaron J. Fields, Julie Fritz, Afton L. Hassett, Steven E. Harte, Trisha F. Hue, Roland Krug, Marco L. Loggia, Prasath Mageswaran, Samuel A. McLean, Ulrike H. Mitchell, Conor O’Neill, Valentina Pedoia, David Adam Quirk, Daniel I. Rhon, Viola Rieke, Lubdha Shah, Gwendolyn Sowa, Brennan Spiegel, Ajay D. Wasan, Hsiao-Ying Monica Wey, and Lisa LaVange. Pain Medicine (Malden, Mass.), January, pnac202.

Quality Metrics for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging: An ASNC Information Statement. Hage, Fadi G., Andrew J. Einstein, Karthikeyan Ananthasubramaniam, Jamieson M. Bourque, James Case, E. Gordon DePuey, Robert C. Hendel, Milena J. Henzlova, Nishant R. Shah, Brian G. Abbott, Wael Al Jaroudi, Nathan Better, Rami Doukky, W. Lane Duvall, Saurabh Malhotra, Robert Pagnanelli, Amalia Peix, Eliana Reyes, Ibrahim M. Saeed, Rupa M. Sanghani, Piotr J. Slomka, Randall C. Thompson, Vikas Veeranna, Kim A. Williams, and David E. Winchester. Journal of Nuclear Cardiology, January.

Neurosurgery

Activated T Cell Therapy Targeting Glioblastoma Cancer Stem Cells. Miyaguchi, Ken, Hongqiang Wang, Keith L. Black, Stephen L. Shiao, Rongfu Wang, and John S. Yu. Scientific Reports 13 (1): 196.

OBGYN

Single-Cell Transcriptomic Analysis of Endometriosis. Fonseca, Marcos A. S., Marcela Haro, Kelly N. Wright, Xianzhi Lin, Forough Abbasi, Jennifer Sun, Lourdes Hernandez, Natasha L. Orr, Jooyoon Hong, Yunhee Choi-Kuaea, Horacio M. Maluf, Bonnie L. Balzer, Aaron Fishburn, Ryan Hickey, Ilana Cass, Helen S. Goodridge, Mireille Truong, Yemin Wang, Margareta D. Pisarska, Huy Q. Dinh, Amal El-Naggar, David G. Huntsman, Michael S. Anglesio, Marc T. Goodman, Fabiola Medeiros, Matthew Siedhoff, and Kate Lawrenson. Nature Genetics, January.

Postthrombotic Syndrome and Chronic Pulmonary Embolism After Obstetric Venous Thromboembolism. O’Shaugnessy, Fergal, Shravya Govindappagari, Yongmei Huang, Sbaa K. Syeda, Mary E. D’Alton, Jason D. Wright, and Alexander M. Friedman. American Journal of Perinatology 40 (01): 022–024.

Association between Acceptance of Routine Pregnancy Vaccinations and COVID-19 Vaccine Uptake. Ha, Laura, Candace Levian, Anna Hirsch, Naomi Greene, Ilona Goldfarb, and Mariam Naqvi. American Journal of Obstetrics and Gynecology, SMFM 43rd Annual Meeting: The Pregnancy Meeting, 228 (1, Supplement): S514–15.

Association Between in Vitro Fertilization and Preterm Birth Among Very Advanced Maternal Age Parturients. Newman, Rachel A., Tania Esakoff, Candace Levian, Sarah Smithson, and Mariam Naqvi. American Journal of Obstetrics and Gynecology, SMFM 43rd Annual Meeting: The Pregnancy Meeting, 228 (1, Supplement): S564–65.

Automated Clinical Decision Support Eliminates Racial Disparities in Aspirin Recommendation. Wong, Melissa S., Samira Torna, Matthew Wells, and Kimberly D. Gregory. American Journal of Obstetrics and Gynecology, SMFM 43rd Annual Meeting: The Pregnancy Meeting, 228 (1, Supplement): S699–700.

Gestational Age Variations in Indications for Primary Cesarean Delivery in Very Advanced Maternal Aged Women. Smithson, Sarah, Rachel A. Newman, Candace Levian, and Tania Esakoff. American Journal of Obstetrics and Gynecology, SMFM 43rd Annual Meeting: The Pregnancy Meeting, 228 (1, Supplement): S734–35.

Increased Peripartum Bleeding Complications in Very Advanced Maternal Age Patients Who Conceive via In-Vitro Fertilization. Newman, Rachel A., Mariam Naqvi, Candace Levian, Sarah Smithson, and Tania Esakoff. American Journal of Obstetrics and Gynecology, SMFM 43rd Annual Meeting: The Pregnancy Meeting, 228 (1, Supplement): S563–64.

Racial and Ethnic Differences in Anemia Correction During Pregnancy. Newman, Rachel A., Richard Burwick, and Mariam Naqvi. American Journal of Obstetrics and Gynecology, SMFM 43rd Annual Meeting: The Pregnancy Meeting, 228 (1, Supplement): S563.

Resolving Placenta Accreta Spectrum Biology With Spatial Transcriptomics. Jeong, Anhyo, Jina Kim, Ophelia Yin, Deborah Krakow, Hsian-Rong Tseng, Yazhen Zhu, Sungyong You, and Yalda Afshar. American Journal of Obstetrics and Gynecology, SMFM 43rd Annual Meeting: The Pregnancy Meeting, 228 (1, Supplement): S68–69.

Orthopaedics

Clean or Dirty? A Systematic Review of Splash Basin Use and Its Infectious Potential in Orthopaedic Surgery. Rezzadeh, Kevin, Harin Parikh, Isabella Guanche, Eytan Debbi, Sean Rajaee, Ran Schwarzkopf, and Guy Paiement. The Iowa Orthopaedic Journal 42 (2): 82–89.

Accuracy of Pain Tolerance Self-Assessment Versus Objective Pressure Sensitivity. Haupt, Edward T., Giselle M. Porter, Timothy Charlton, and David Thordarson. The Journal of the American Academy of Orthopaedic Surgeons, January.

Pathology

Familial Duodenal Somatostatinomatosis Not Associated With a Known Genetic Syndrome. Yu, Run, Jianyu Rao, Jing Zhai, J. Randolph Hecht, and Joseph R. Pisegna. Pancreas 51 (8): 1056–60.

Mucoepidermoid Carcinoma of the Salivary Gland: Demographics and Comparative Analysis in U.S. Children and Adults With Future Perspective of Management. Ullah, Asad, Jaffar Khan, Abdul Waheed, Nabin Raj Karki, Mya Goodbee, Abdul Qahar Khan Yasinzai, Bisma Tareen, Agha Wali, Khaleel Ahmad Khan, Muhammad Samsoor Zarak, Israr Khan, Andrea Agualimpia Garcia, Adil Khan, Marjan Khan, Sana Jogezai, Junaid Ahmad, Luis Velasquez Zarate, Nikhil Patel, Nagla Abdel Karim, and Saleh Heneidi. Cancers 15 (1): 250.

Single-Cell Profiling Identifies ACE+ Granuloma Macrophages as a Nonpermissive Niche for Intracellular Bacteria During Persistent Salmonella Infection. Pham, Trung H. M., Yuan Xue, Susan M. Brewer, Kenneth E. Bernstein, Stephen R. Quake, and Denise M. Monack. Science Advances 9 (1): eadd4333.

Pediatrics

Vignette Research Methodology: An Essential Tool for Quality Improvement Collaboratives. Payton, Kurlen S. E., and Jeffrey B. Gould. Healthcare (Basel, Switzerland) 11 (1): 7.

Harnessing Synthetic Biology to Engineer Organoids and Tissues. Trentesaux, Coralie, Toshimichi Yamada, Ophir D. Klein, and Wendell A. Lim. Cell Stem Cell 30 (1): 10–19.

Surgery

Impact of TEVAR Timing on Outcomes After Uncomplicated Type B Aortic Dissection in the SVS VQI Post-Approval Project for Dissection. Beck, Adam W., Grace Wang, Joseph V. Lombardi, Rodney White, Mark F. Fillinger, John A. Kern, Jack L. Cronenwett, Richard P. Cambria, Ali Azizzadeh, and TEVAR for Dissection Post-approval Project Steering Committee and Participants. Journal of Vascular Surgery, January, S0741-5214(22)02735-5.

Simultaneous Thoracic and Abdominal Donation After Circulatory Death Organ Recovery: The Abdominal Surgeon’s Perspective. Thiessen, Carrie, Steven A. Wisel, and Garrett R. Roll. Current Opinion in Organ Transplantation, January.

Interwoven Nitinol Stents for the Treatment of Infrainguinal Peripheral Arterial Disease. Sadri, Lili, Eileen Lu, and Donald T. Baril. The Journal of Cardiovascular Surgery, January.

ONECUT2 Regulates RANKL-Dependent Enterocyte and Microfold Cell Differentiation in the Small Intestine; a Multi-Omics Study. Luna Velez, Maria V., Hannah K. Neikes, Rebecca R. Snabel, Yarah Quint, Chen Qian, Aniek Martens, Gert Jan C. Veenstra, Michael R. Freeman, Simon J. van Heeringen, and Michiel Vermeulen. Nucleic Acids Research, January, gkac1236.

High Complication Rate After Early Ileostomy Closure: Early Termination of the Short Versus Long Interval to Loop Ileostomy Reversal After Pouch Surgery Randomized Trial. Vogel, Jon D., Phillip R. Fleshner, Stefan D. Holubar, Vitaliy Y. Poylin, Scott E. Regenbogen, Brandon C. Chapman, Evangelos Messaris, Matthew G. Mutch, and Neil H. Hyman. Diseases of the Colon and Rectum 66 (2): 253–61.