This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Jan. 4-11.

Biomedical Sciences

Actionable Driver Events in Small Cell Lung Cancer. Gutiérrez, Mirian, Irene Zamora, Michael R. Freeman, Ignacio J. Encío, and Mirja Rotinen. International Journal of Molecular Sciences 25 (1): 105.

MRI/RNA-Seq-Based Radiogenomics and Artificial Intelligence for More Accurate Staging of Muscle-Invasive Bladder Cancer. Qureshi, Touseef Ahmad, Xingyu Chen, Yibin Xie, Kaoru Murakami, Toru Sakatani, Yuki Kita, Takashi Kobayashi, Makito Miyake, Simon R. V. Knott, Debiao Li, Charles J. Rosser, and Hideki Furuya. International Journal of Molecular Sciences 25 (1): 88.

Ethical Considerations of Digital Health Technology in Older Adult Care. Finco, M. G., Nabiel Mir, Gillian Gresham, and Megan Huisingh-Scheetz. The Lancet. Healthy Longevity 5 (1): e12–13.

Non-Electrocardiogram-Gated, Free-Breathing, Off-Resonance Reduced, High-Resolution, Whole-Heart Myocardial T2 * Mapping at 3 T Within 5 Min. Guan, Xingmin, Hsin-Jung Yang, Xinheng Zhang, Nan Wang, Hui Han, Richard Tang, Zhehao Hu, Khalid Youssef, Keyur Vora, Mayil S. Krishnam, Anthony G. Christodoulou, Debiao Li, Behzad Sharif, and Rohan Dharmakumar. Magnetic Resonance in Medicine, January.

Whole-Exome Sequencing of Nigerian Benign Prostatic Hyperplasia Reveals Increased Alterations in Apoptotic Pathways. White, Jason A., Ernest T. Kaninjing, Kayode A. Adeniji, Paul Jibrin, John O. Obafunwa, Chidiebere N. Ogo, Faruk Mohammed, Ademola Popoola, Omolara A. Fatiregun, Olabode P. Oluwole, Roland J. Thorpe, Balasubramanyam Karanam, Isra Elhussin, Stefan Ambs, Wei Tang, Melissa Davis, Paz Polak, Moray J. Campbell, Kathryn R. Brignole, Solomon O. Rotimi, Windy Dean-Colomb, Folake T. Odedina, and Clayton Yates. The Prostate, January.

Higher Noncalcified Plaque Volume Is Associated With Increased Plaque Vulnerability and Vascular Inflammation. Suzuki, Keishi, Daisuke Kinoshita, Haruhito Yuki, Takayuki Niida, Tomoyo Sugiyama, Taishi Yonetsu, Makoto Araki, Akihiro Nakajima, Lena Marie Seegers, Damini Dey, Hang Lee, Iris McNulty, Masamichi Takano, Tsunekazu Kakuta, Kyoichi Mizuno, and Ik-Kyung Jang. Circulation. Cardiovascular Imaging, January, e015769.

Cardiac Surgery

Interhospital Variation in Admissions Managed With Critical Care Therapies or Invasive Hemodynamic Monitoring in Tertiary Cardiac Intensive Care Units: An Analysis From the Critical Care Cardiology Trials Network Registry. Donnelly, Sarah, Christopher F. Barnett, Erin A. Bohula, Sunit-Preet Chaudhry, Meshe D. Chonde, Howard A. Cooper, Lori B. Daniels, Mark W. Dodson, Daniel Gerber, Michael J. Goldfarb, Jianping Guo, Michael C. Kontos, Shuangbo Liu, Adriana C. Luk, Venu Menon, Connor G. O’Brien, Alexander I. Papolos, Barbara A. Pisani, Brian J. Potter, Rajnish Prasad, Gregory Schnell, Kevin S. Shah, Lakshmi Sridharan, Derek Y. F. So, Jeffrey J. Teuteberg, Wayne J. Tymchak, Sammy Zakaria, Jason N. Katz, David A. Morrow, and Sean van Diepen. Circulation. Cardiovascular Quality and Outcomes, January, e010092.

Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics. Fenwick, Axel J., Vivek P. Jani, D. Brian Foster, Thomas E. Sharp, Traci T. Goodchild, Kyle LaPenna, Jake E. Doiron, David J. Lefer, Joseph A. Hill, David A. Kass, and Anthony Cammarato. Journal of the American Heart Association, January, e032037.

Cardiology

Coronary Vasospasm Causing Chest Pain in Early Postoperative Heart Transplantation. Le, Jonathan N., David H. Chang, Jon A. Kobashigawa, and Michelle M. Kittleson. JACC. Case Reports 28 (December): 102100.

Impact of the COVID-19 Pandemic on Global TAVR Activity: The COVID-TAVI Study. Armario, Xavier, Jennifer Carron, Andrew J. Simpkin, Mohamed Elhadi, Ciara Kennedy, Mohamed Abdel-Wahab, Sabine Bleiziffer, Thierry Lefèvre, Alexander Wolf, Thomas Pilgrim, Pedro A. Villablanca, Daniel J. Blackman, Darren Mylotte, et al. JACC. Cardiovascular Interventions, December, S1936-8798(23)01436-X.

Mavacamten Treatment for Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results From the MAVA-LTE Study, EXPLORER-LTE Cohort. Rader, Florian, Artur Or?ziak, Lubna Choudhury, Sara Saberi, David Fermin, Matthew T. Wheeler, Theodore P. Abraham, Pablo Garcia-Pavia, Donna R. Zwas, Ahmad Masri, Anjali Owens, Sheila M. Hegde, Tim Seidler, Shawna Fox, Ganesh Balaratnam, Amy J. Sehnert, and Iacopo Olivotto. JACC. Heart Failure 12 (1): 164–77.

Postural Orthostatic Tachycardia Syndrome After COVID-19 Vaccination. Teodorescu, Debbie Lin, Anxhela Kote, Jewel N. Reaso, Carine Rosenberg, Xiao Liu, Alan C. Kwan, Susan Cheng, and Peng-Sheng Chen. Heart Rhythm 21 (1): 74–81.

Incidence and Autopsy Rates for Sudden Cardiac Death in Northern Finland. Mäntyniemi, Lassi, Lasse Pakanen, Jani Tikkanen, Lauri Holmström, Jessica Hämaläinen, Laura Ruuska, Juha Vähätalo, Anette Haukilahti, Juha Perkiömäki, Heikki Huikuri, and Juhani Junttila. Heart Rhythm, January, S1547-5271(24)00004-3.

Moving Toward Point-of-Care Surgery in Ukraine: Testing an Ultra-Portable Operating Room in an Active War Zone. Lagazzi, Emanuele, Debbie Lin Teodorescu, Dias Argandykov, Michael Alexander Samotowka, and David Richard King. European Journal of Trauma and Emergency Surgery, January.

One- Versus Three-Month DAPT in Older Patients at High Bleeding Risk Undergoing PCI: Insights From the XIENCE Short DAPT Global Program. Sardella, Gennaro, Alessandro Spirito, Samantha Sartori, Dominick J. Angiolillo, Pascal Vranckx, Jose M. De la Torre Hernandez, Mitchell W. Krucoff, Sripal Bangalore, Deepak L. Bhatt, Gianluca Campo, Davide Cao, Bassem M. Chehab, James W. Choi, Yihan Feng, Junbo Ge, Katherine Godfrey, James Hermiller, Vijay Kunadian, Raj R. Makkar, Aziz Maksoud, Franz-Josef Neumann, Hector Picon, Shigeru Saito, Holger Thiele, Ralph Toelg, Olivier Varenne, Birgit Vogel, Yujie Zhou, Marco Valgimigli, Stephan Windecker, and Roxana Mehran. The American Journal of Cardiology, January, S0002-9149(24)00005-5.

The Role of Atrial Fibrosis for Atrial Fibrillation: Not Always Essential? Miguel-Dos-Santos, Rodrigo. Arquivos Brasileiros De Cardiologia 120 (10): e20230766.

Racial/Ethnic Disparities in Aortic Valve Replacement Among Medicare Beneficiaries in the United States, 2012-2019. Gupta, Aakriti, Makoto Mori, Yun Wang, Shubhadarshini G. Pawar, Torsten Vahl, Tamim Nazif, Oyere Onuma, Celina M. Yong, Rahul Sharma, Ajay J. Kirtane, John K. Forrest, Isaac George, Susheel Kodali, Joanna Chikwe, Arnar Geirsson, Raj Makkar, Martin B. Leon, and Harlan M. Krumholz. The American Journal of Medicine, January, S0002-9343(23)00804-5.

Precision of Echocardiographic Measurements. Pillai, Balakrishnan, Michael Salerno, Ingela Schnittger, Susan Cheng, and David Ouyang. Journal of the American Society of Echocardiography, January, S0894-7317(24)00001-4.

Pulmonary Hypertension Associated With Congenital Heart Disease. Venkatesh, Prashanth, and Erika Rosenzweig. Current Respiratory Medicine Reviews 19: 1–11.

Computational Biomedicine

Estimation of Age of Onset and Progression of Breast Cancer by Absolute Risk Dependent on Polygenic Risk Score and Other Risk Factors. Bhatt, Rikesh, Ardo van den Hout, Antonis C. Antoniou, Mitul Shah, Lorenzo Ficorella, Emily Steggall, Douglas F. Easton, Paul D. P. Pharoah, and Nora Pashayan. Cancer, January.

Estimating the Heritability of SARS-CoV-2 Susceptibility and COVID-19 Severity. Brown, Kathleen LaRow, Vijendra Ramlall, Michael Zietz, Undina Gisladottir, and Nicholas P. Tatonetti. Nature Communications 15 (1): 367.

Imaging

Relationship of Coronary Angiography-Derived Radial Wall Strain With Functional Significance, Plaque Morphology, and Clinical Outcomes. Yang, Seokhun, Zhiqing Wang, Sang-Hyeon Park, Huihong Hong, Chunming Li, Xun Liu, Lianglong Chen, Doyeon Hwang, Jinlong Zhang, Masahiro Hoshino, Taishi Yonetsu, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Bon-Kwon Koo, and Shengxian Tu. JACC. Cardiovascular Interventions 17 (1): 46–56.

ECG-Free Cine MRI With Data-Driven Clustering of Cardiac Motion for Quantification of Ventricular Function. Ming, Zhengyang, Arutyun Pogosyan, Chang Gao, Caroline M. Colbert, Holden H. Wu, J. Paul Finn, Dan Ruan, Peng Hu, Anthony G. Christodoulou, and Kim-Lien Nguyen. NMR in Biomedicine, January, e5091.

Medicine

Galectin-3 in Blood Serum and Lymphocytes as a Marker of Myocardial Damage in Patients With Arterial Hypertension and COVID-19. Pokrovska, Nataliia, Nataliia Denysenko, Iryna Fomenko, Helen Sklyarova, Andrii Basylevych, Eugene Sklyarov, Sandor G. Vari, and Lesya Kobylinska. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 22 (4): 250–60.

Are Prepubertal Gynaecomastia and Premature Thelarche Linked to Topical Lavender and Tea Tree Oil Use? Braunstein, Elsa W., and Glenn D. Braunstein. TouchREVIEWS in Endocrinology 19 (2): 60–68.

Interpretable Neural Architecture Search and Transfer Learning for Understanding CRISPR-Cas9 off-Target Enzymatic Reactions. Zhang, Zijun, Adam R. Lamson, Michael Shelley, and Olga Troyanskaya. Nature Computational Science 3 (12): 1056–66.

Genome-Wide Study Investigating Effector Genes and Polygenic Prediction for Kidney Function in Persons With Ancestry From Africa and the Americas. Hughes, Odessica, Amy R. Bentley, Charles E. Breeze, Francois Aguet, Xiaoguang Xu, Girish Nadkarni, Quan Sun, Bridget M. Lin, Thomas Gilliland, Mariah C. Meyer, Jiawen Du, Laura M. Raffield, Nora Franceschini, et al. Cell Genomics, December, 100468.

Assessment of the Psychosocial Impact of Pancreatic Cancer Surveillance in High-Risk Individuals. Anez-Bruzual, Isabel, Sarah Coughlin, Daniel Clay, Jordan Heiman, Michaela Dungan, Marina Weber, Christopher V. Almario, Galen Leung, Nuzhat A. Ahmad, Gregory G. Ginsberg, Michael L. Kochman, Kathleen D. Valverde, Jessica M. Long, and Bryson W. Katona. Cancers 16 (1): 86.

Effectiveness and Safety of Vedolizumab and Infliximab in Biologic-Naive Patients With Crohn’s Disease: Results From the EVOLVE Study. Mantzaris, Gerassimos J., Brian Bressler, Shashi Adsul, Michelle Luo, Chris Colby, Neil R. Brett, Sumit Saha, Pravin Kamble, Song Wang, and Andres Yarur. European Journal of Gastroenterology & Hepatology, December.

Cumulative Update of a Systematic Overview Evaluating Interventions Addressing Polypharmacy. Keller, Michelle S., Nabeel Qureshi, Allison M. Mays, Catherine A. Sarkisian, and Joshua M. Pevnick. JAMA Network Open 7 (1): e2350963.

Antiviral Therapy Utilization and 10-Year Outcomes in Resected Hepatitis B Virus- and Hepatitis C Virus-Related Hepatocellular Carcinoma. Huang, Daniel Q., Joseph K. Hoang, Rubayet Kamal, Pei-Chien Tsai, Hidenori Toyoda, Ming-Lun Yeh, Satoshi Yasuda, Jennifer Leong, Mayumi Maeda, Chung-Feng Huang, Dae Won Jun, Masatoshi Ishigami, Yasuhito Tanaka, Haruki Uojima, Eiichi Ogawa, Hiroshi Abe, Yao-Chun Hsu, Cheng-Hao Tseng, Manaf Alsudaney, Ju Dong Yang, Yoko Yoshimaru, Takanori Suzuki, Joanne K. Liu, Charles Landis, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Myron Schwartz, Yock Young Dan, Carlos Esquivel, Andrew Bonham, Ming-Lung Yu, and Mindie H. Nguyen. Journal of Clinical Oncology, January, JCO2300757.

Verteporfin Induces Lipid Peroxidation and Ferroptosis in Pancreatic Cancer Cells. Zhou, Wei, Adrian Lim, Omer Elmadbouh, Mouad Edderkaoui, Arsen Osipov, Angela Mathison, Raul Urrutia, Tao Liu, Qiang Wang, and Stephen J. Pandol. Free Radical Biology & Medicine, January, S0891-5849(24)00003-0.

Perspectives, Experiences, and Concerns With Cyclical Vomiting Syndrome: Insights From Online Targeted-Disease Forums. Khalil, Carine, Christopher V. Almario, Taylor Dupuy, Corey Arnold, Yaozhu J. Chen, and Brennan M. R. Spiegel. Neurogastroenterology and Motility, January, e14712.

Symptomatic Response to Antibiotics in Patients With Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-Analysis. Takakura, Will, Ali Rezaie, William D. Chey, Jiajing Wang, and Mark Pimentel. Journal of Neurogastroenterology and Motility 30 (1): 7–16.

Neurology

Palliative Care in Neuro-Oncology. Besbris, Jessica M., and Lynne P. Taylor. Seminars in Neurology, January.

Neurosurgery

Little Memory Editors Living Inside Your Brain. Zheng, Jie, Gordon Chen, Gabriel Kreiman, and Ueli Rutishauser. Frontiers for Young Minds 11: 968856.

OBGYN

ChatGPT Compared With Google Search and Healthcare Institution as Sources of Postoperative Patient Instructions After Gynecological Surgery. Meyer, Raanan, Kacey M. Hamilton, Mireille D. Truong, Kelly N. Wright, Matthew T. Siedhoff, Yoav Brezinov, and Gabriel Levin. BJOG: An International Journal of Obstetrics and Gynaecology, January.

Orthopaedics

Optimizing the Entry Point for Medullary Hip Screws. Huang, Kevin, Zachary A. Rockov, Lukas O. Foster, Jawad Najdawi, Abrianna S. Robles, and Geoffrey S. Marecek. The Journal of the American Academy of Orthopaedic Surgeons, January.

Pathology and Laboratory Medicine

CD70 Is Consistently Expressed in Primary and Metastatic Clear Cell Renal Cell Carcinoma. Huang, Rong Rong, Zhengshan Chen, Nils Kroeger, Allan Pantuck, Jonathan Said, Harriet M. Kluger, Brian Shuch, and Huihui Ye. Clinical Genitourinary Cancer, December, S1558-7673(23)00270-7.

Mark Wick Contributions to Pathology of the Mediastinum. Maluf, Horacio. Seminars in Diagnostic Pathology, January, S0740-2570(24)00005-4.

Markedly Increased Duodenal Villous Surface Apoptosis in Patients Taking Pre-Exposure Prophylaxis (PrEP) Against Human Immunodeficiency Virus. Hutchings, Danielle A., Brent K. Larson, Maha Guindi, and Kevin M. Waters. Histopathology, January.

Vascular Neoplasms With NFATC1/C2 Gene Alterations: Expanding the Clinicopathologic and Molecular Characteristics of a Distinct Entity. Dashti, Nooshin K., Raul Perret, Bonnie Balzer, Rana Naous, Michael Michal, Josephine K. Dermawan, and Cristina R. Antonescu. The American Journal of Surgical Pathology, January

Pediatrics

An Interactive Atlas of Three-Dimensional Syndromic Facial Morphology. Aponte, J. David, Jordan J. Bannister, Hanne Hoskens, Harold Matthews, Kaitlin Katsura, Cassidy Da Silva, Tim Cruz, Julie H. M. Pilz, Richard A. Spritz, Nils D. Forkert, Peter Claes, Francois P. Bernier, Ophir D. Klein, David C. Katz, and Benedikt Hallgrímsson. American Journal of Human Genetics 111 (1): 39–47.

Radiation Oncology

Single-Cell and Spatial Profiling Identify Three Response Trajectories to Pembrolizumab and Radiation Therapy in Triple Negative Breast Cancer. Shiao, Stephen L., Kenneth H. Gouin, Nathan Ing, Alice Ho, Reva Basho, Aagam Shah, Richard H. Mebane, David Zitser, Andrew Martinez, Natalie-Ya Mevises, Bassem Ben-Cheikh, Regina Henson, Monica Mita, Philomena McAndrew, Scott Karlan, Armando Giuliano, Alice Chung, Farin Amersi, Catherine Dang, Heather Richardson, Wonwoo Shon, Farnaz Dadmanesh, Michele Burnison, Amin Mirhadi, Zachary S. Zumsteg, Rachel Choi, Madison Davis, Joseph Lee, Dustin Rollins, Cynthia Martin, Negin H. Khameneh, Heather McArthur, and Simon R. V. Knott. Cancer Cell 42 (1): 70-84.e8.

Feasibility of Using a Transmission Ion Chamber for QA Tests of Medical Linear Accelerators. Farrokhkish, Makan, Andrew J. Veres, Luis E. Fong de Los Santos, John J. DeMarco, and Mohammad K. Islam. Journal of Applied Clinical Medical Physics, January, e14245. 

Prior Cancer and Risk of Monoclonal Gammopathy of Undetermined Significance: A Population-Based Study in Iceland and Sweden. Rögnvaldsson, Sæmundur, Sigrun Thorsteinsdóttir, Elisavet Syriopoulou, Ingigerdur Sverrisdottir, Ingemar Turesson, Elias Eythorsson, Jon Thorir Oskarsson, Thorir Einarsson Long, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni A. Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir, Thor Aspelund, Gauti Kjartan Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Magnus Bjorkholm, Ola Landgren, Thorvardur Jon Love, and Sigurdur Yngvi Kristinsson. Haematologica, January.

Surgery

Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer: A Narrative Review. Chen, Courtney, Monica Justo, and Alexandra Gangi. Chinese Clinical Oncology 12 (6): 68.

Robotic Navigational Bronchoscopy in a Thoracic Surgery Practice: Leveraging Technology in the Management of Pulmonary Nodules. Brownlee, Andrew R., Justin J. J. Watson, Akbarshakh Akhmerov, Shruthi Nammalwar, Qiudong Chen, Sevannah G. Soukiasian, and Harmik J. Soukiasian. JTCVS Open 16 (December): 1–6.

Reciprocal Regulation of Forkhead Box C1 and L1 Cell Adhesion Molecule Contributes to Triple-Negative Breast Cancer Progression. Zhang, Fan, Yue Xu, Jiediao Lin, Hongchao Pan, Armando E. Giuliano, Xiaojiang Cui, and Yukun Cui. Breast Cancer Research and Treatment, January.

Downstaging After Preoperative Chemoradiation for Locally Advanced Rectal Cancer Is Associated With Better Survival Than Pathologic Stage 0-1 Disease Treated With Upfront Surgery. Kasheri, Eli, Avo Artinyan, Kimberly Oka, Ruoyan Zhu, Natalie Seiser, Mihran Shirinian, Moshe Barnajian, Jason Cohen, Joshua Ellenhorn, and Yosef Nasseri. International Journal of Colorectal Disease 39 (1): 16.

Incidence and Outcomes of Simultaneous Thoracoabdominal Triple Organ Transplantation in the United States. Adjei, Michie A., Steven A. Wisel, Justin A. Steggerda, James Mirocha, Alisha Mavis, Carlos O. Esquivel, and Irene K. Kim. Transplantation Proceedings, January, S0041-1345(23)00767-4.

Facial Nerve Considerations for the Deep Plane Facelift and Neck Lift. Azizzadeh, Babak, and Richard J. Lu. Facial Plastic Surgery: FPS, January.

Urology

27-Hydroxycholesterol and DNA Damage Repair: Implication in Prostate Cancer. Galvan, Gloria Cecilia, Nadine A. Friedrich, Sanjay Das, James P. Daniels, Sara Pollan, Shweta Dambal, Ryusuke Suzuki, Sergio E. Sanders, Sungyong You, Hisashi Tanaka, Yeon-Joo Lee, Wei Yuan, Johann S. de Bono, Irina Vasilevskaya, Karen E. Knudsen, Michael R. Freeman, and Stephen J. Freedland. Frontiers in Oncology 13: 1251297.

Editorial Comment. Mitra, Anirban P. The Journal of Urology 211 (2): 252–53.