This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Jan. 26 - Feb. 2. 

Anesthesiology

Associations of an Eye-Tracking Task and Pupillary Metrics With Age and ASA Physical Status Score in a Preoperative Cohort. Papangelou, Alexander, David W. Boorman, Milad Sharifpour, Haresh P. Patel, Tuan Cassim, and Paul S. García. Journal of Clinical Monitoring and Computing, January, 1–9.

ASRA Pain Medicine Consensus Guidelines on the Management of the Perioperative Patient on Cannabis and Cannabinoids. Shah, Shalini, Eric S. Schwenk, Rakesh V. Sondekoppam, Hance Clarke, Mark Zakowski, Rachel S. Rzasa-Lynn, Brent Yeung, Kate Nicholson, Gary Schwartz, W. Michael Hooten, Mark Wallace, Eugene R. Viscusi, and Samer Narouze. Regional Anesthesia and Pain Medicine 48 (3): 97–117.

Biomedical Sciences

Altered Static and Dynamic Functional Network Connectivity in Post-Stroke Cognitive Impairment. Yue, Xipeng, Ziqiang Li, Ying Li, Jiahuan Gao, Hui Han, Ge Zhang, Xiaochen Li, Yu Shen, Wei Wei, Yan Bai, Jiapei Xie, Zhi Luo, Xianchang Zhang, and Meiyun Wang. Neuroscience Letters, January, 137097.

Cancer

Prostate Cancer Extracellular Vesicle Digital Scoring Assay - a Rapid Noninvasive Approach for Quantification of Disease-Relevant MRNAs. Wang, Jasmine J., Na Sun, Yi-Te Lee, Minhyung Kim, Tatyana Vagner, Krizia Rohena-Rivera, Zhili Wang, Zijing Chen, Ryan Y. Zhang, Junseok Lee, Ceng Zhang, Hubert Tang, Josephine Widjaja, Tiffany X. Zhang, Dongping Qi, Pai-Chi Teng, Yu Jen Jan, Kuan-Chu Hou, Candace Hamann, Howard M. Sandler, Timothy J. Daskivich, Daniel J. Luthringer, Neil A. Bhowmick, Renjun Pei, Sungyong You, Dolores Di Vizio, Hsian-Rong Tseng, Jie-Fu Chen, Yazhen Zhu, and Edwin M. Posadas. Nano Today 48 (February): 101746.

Dosimetric Parameters and Radiotherapy Simulation Methods Used in Preclinical Studies of Radiation Damage to the Dentition: A Systematic Review. Pedroso, Caique Mariano, Ana Gabriela Costa Normando, Maria Eduarda Pérez-de-Oliveira, Natália Rangel Palmier, Eliete Neves Silva Guerra, Joel B. Epstein, Marcio Ajudarte Lopes, Ana Carolina Prado Ribeiro, Thaís Bianca Brandão, Rene-Jean Bensadoun, Gustavo Nader Marta, Mario Fernando de Goes, and Alan Roger Santos-Silva. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, December, S2212-4403(22)01301-3.

A Prospective Clinical Trial to Evaluate the Performance of a Multi-Analyte Blood Test for Early Detection of Hepatocellular Carcinoma Among at-Risk Patients With Liver Cirrhosis: The CLiMB Study. Roy, Dhruvajyoti, Jianfeng Xu, David J. Taggart, Max A. Gallant, Kisha Bush, Octavia Reed, Arshia Akhtar, Ju Dong Yang, Mindie Nguyen, Wei Li, and Richard A. Van Etten. Journal of Clinical Oncology 41 (4_suppl): TPS617–TPS617.

Molecular Characterization and Clinical Outcomes of Pancreatic Neuroendocrine Tumors (PNENs) Harboring PAK4-NAMPT Alterations. Azar, Ibrahim, Nishant Gandhi, Misako Nagasaka, Jun Gong, Bassel Nazha, Khalil Choucair, Moh’d M. Khushman, Heloisa P. Soares, Wafik S. El-Deiry, Philip Agop Philip, Emil Lou, Alex Patrick Farrell, Jeffrey Swensen, Matthew James Oberley, Jim Abraham, Chadi Nabhan, Sanjay Goel, Wolfgang Michael Korn, Anthony Frank Shields, and Asfar S. Azmi. Journal of Clinical Oncology 41 (4_suppl): 649–649.

Pertuzumab plus Trastuzumab (P+T) in Patients (Pts) With Biliary Tract Cancer (BTC) With ERBB2/3 Amplification (Amp), Overexpression (Oe), or Mutation (Mut): Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study. Cannon, Timothy Lewis, Michael Rothe, Elizabeth Garrett-Mayer, Vi Kien Chiu, Jimmy J. Hwang, Namrata Vijayvergia, Olatunji B. Alese, Elie G. Dib, Herbert Leon Duvivier, Kelsey Klute, Vaibhav Sahai, Eugene R Ahn, Deepti Behl, Sarah Sinclair, Ramya Thota, Walter John Urba, Eddy Shih-Hsin Yang, Gina N. Grantham, Susan Halabi, and Richard L. Schilsky. Journal of Clinical Oncology 41 (4_suppl): 546–546.

Plasma Central Carbon Metabolite Changes Associated With KRAS Mutation and Circulating Tumor DNA (CtDNA) Status in Colorectal Cancer (CRC). Kim, Daniel Myung, Francesca Paola Aguirre, Alexandra Gangi, Rocio Alvarez, Lisa Zhou, Johanna ten Hoeve, Yi Jou Liao, Thomas Graeber, Andrew Eugene Hendifar, Arsen Osipov, Kamya Sankar, May Thet Cho, Anser Abbas, John Davelaar, Megan Philippa Hitchins, and Jun Gong. Journal of Clinical Oncology 41 (4_suppl): 181–181.

Factors Associated With Unrecognized Cirrhosis in Patients With Hepatocellular Carcinoma. Lee, Yi-Te, Mohammad Karim, Hye Chung Kum, Sulki Park, Nicole E. Rich, Mazen Noureddin, Amit G. Singal, and Ju Dong Yang. Clinical and Molecular Hepatology, February.

Telehealth Utilization Among Occupational Therapists in Oncology: Results From a National Survey. Sleight, Alix G., Caroline M. Klein, Alexandra E. Feldman, and Leah I. Stein Duker. OTJR: Occupation, Participation and Health, February, 15394492221148984.

Randomized Clinical Trial of Tissue Equivalent Bolus Prescription in Postmastectomy Radiotherapy Stratified by Skin Involvement Status. Sapienza, Lucas Gomes, Maria Aparecida Conte Maia, Maria José Leite Gomes, André Mattar, Glauco Baiocchi, and Vinicius Fernando Calsavara. Clinical and Translational Radiation Oncology 39 (March): 100570.

Cardiology

Sex-Related Differences in Eicosanoid Levels in Chronic Thromboembolic Pulmonary Hypertension. Alotaibi, Mona, Timothy Fernandes, Amber B. Tang, Gino Alberto Magalang, Jeramie D. Watrous, Tao Long, Victor Pretorius, Michael Madani, Nick H. Kim, Mohit Jain, and Susan Cheng. American Journal of Respiratory Cell and Molecular Biology 68 (2): 228–31.

Multimodal Deep Learning Enhances Diagnostic Precision in Left Ventricular Hypertrophy. Soto, Jessica Torres, J. Weston Hughes, Pablo Amador Sanchez, Marco Perez, David Ouyang, and Euan A. Ashley. European Heart Journal. Digital Health 3 (3): 380–89.

Assessment and Management of Allosensitization Following Heart Transplant in Adults. Jaiswal, Abhishek, Jennifer Bell, Ersilia M. DeFilippis, Evan P. Kransdorf, Jignesh Patel, Jon A. Kobashigawa, Michelle M. Kittleson, and David A. Baran. The Journal of Heart and Lung Transplantation, December, S1053-2498(22)02258-6.

Gender Disparities in Cardiac Surgery Trials: Leadership, Authorship, and Patient Enrollment. Soletti, Giovanni Jr, Roberto Perezgrovas-Olaria, Arnaldo Dimagli, Lamia Harik, Lisa Rong, C. Noel Bairey Merz, Mohamed Rahouma, Sigrid E. Sandner, Annetine C. Gelijns, and Mario Gaudino. The Annals of Thoracic Surgery, January, S0003-4975(23)00040-1.

Multi-Ancestry Transcriptome-Wide Association Analyses Yield Insights into Tobacco Use Biology and Drug Repurposing. Chen, Fang, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D. D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Dajiang J. Liu, et al. Nature Genetics, January.

Current and Future Applications of Artificial Intelligence in Cardiac CT. Joshi, Mugdha, Diana Patricia Melo, David Ouyang, Piotr J. Slomka, Michelle C. Williams, and Damini Dey. Current Cardiology Reports, January.

Patient-Centered Insights and Biases Regarding Cardiologists Via Online Review Platform Analysis. Mark, Erica, Mackenzi Oswald, Priyanka Kundar, and Martha Gulati. Journal of the American Heart Association, January, e027405.

Transcatheter Edge-to-Edge Repair in Patients With Anatomically Complex Degenerative Mitral Regurgitation. Hausleiter, Jörg, D. Scott Lim, Linda D. Gillam, Firas Zahr, Scott Chadderdon, Andrew N. Rassi, Raj Makkar, Scott Goldman, Volker Rudolph, James Hermiller, Robert M. Kipperman, Abhijeet Dhoble, Richard Smalling, Azeem Latib, Susheel K. Kodali, Mohamad Lazkani, Joseph Choo, Philipp Lurz, William W. O’Neill, Roger Laham, Josep Rodés-Cabau, Saibal Kar, Niklas Schofer, Brian Whisenant, Ignacio Inglessis-Azuaje, Stephan Baldus, Samir Kapadia, Konstantinos Koulogiannis, Leo Marcoff, Robert L. Smith, and PASCAL IID Registry Investigators. Journal of the American College of Cardiology 81 (5): 431–42.

Emergency Medicine

Implementation of a Regional Extracorporeal Membrane Oxygenation Program for Refractory Ventricular Fibrillation Out-of-Hospital Cardiac Arrest. Bosson, Nichole, Clayton Kazan, Stephen Sanko, Tiffany Abramson, Marc Eckstein, David Eisner, Joel Geiderman, Walid Ghurabi, Vadim Gudzenko, Anil Mehra, Sam Torbati, Atilla Uner, Marianne Gausche-Hill, and David Shavelle. Resuscitation, January, 109711.

Imaging

Relationship Between Coronary High-Intensity Plaques on T1-Weighted Imaging by Cardiovascular Magnetic Resonance and Vulnerable Plaque Features by Near-Infrared Spectroscopy and Intravascular Ultrasound: A Prospective Cohort Study. Fukase, Tatsuya, Tomotaka Dohi, Shinichiro Fujimoto, Ryota Nishio, Yui O. Nozaki, Ayako Kudo, Mitsuhiro Takeuchi, Norihito Takahashi, Yuichi Chikata, Hirohisa Endo, Yuko O. Kawaguchi, Shinichiro Doi, Hiroki Nishiyama, Makoto Hiki, Iwao Okai, Hiroshi Iwata, Takayuki Yokoyama, Shinya Okazaki, Katsumi Miyauchi, Hiroyuki Daida, Debiao Li, Yibin Xie, and Tohru Minamino. Journal of Cardiovascular Magnetic Resonance 25 (1): 4.

Medicine

Practical Strategies for Ensuring Safety of Medication Overrides From Automated Dispensing Cabinets. Youmbi, Karen V., Amisha Arya, Ashley Conger, Domini Hood, Jennifer Mai, Sheetal Patel-House, and Michelle Then. Journal of the American Pharmacists Association 63 (1): 193–97.

Professional Networking at Gastroenterology Scientific Meetings: A Trainee’s Practical Guide. Sleiman, Joseph, Nikki Duong, Elizabeth S. Aby, Daniela Guerrero Vinsard, Rashmi Advani, and Mohammad Bilal. Digestive Diseases and Sciences 68 (1): 24–28.

Central Lung Gene Expression Associates With Myofibroblast Features in Idiopathic Pulmonary Fibrosis. Huang, Yong, Rob Guzy, Shwu-Fan Ma, Catherine A. Bonham, Jonathan Jou, Jefree J. Schulte, John S. Kim, Andrew J. Barros, Milena S. Espindola, Aliya N. Husain, Cory M. Hogaboam, Anne I. Sperling, and Imre Noth. BMJ Open Respiratory Research 10 (1): e001391.

Obinutuzumab Effectively Depletes Key B-Cell Subsets in Blood and Tissue in End-Stage Renal Disease Patients. Looney, Cary M., Aaron Schroeder, Erica Tavares, Jay Garg, Thomas Schindler, Flavio Vincenti, Robert R. Redfield, Stanley C. Jordan, Stephan Busque, E. Steve Woodle, Jared Khan, Jeffrey Eastham, Sandrine Micallef, Cary D. Austin, and Alyssa Morimoto. Transplantation Direct 9 (2): e1436.

Neurosurgery

Neurophysiological Mechanisms of Error Monitoring in Human and Non-Human Primates. Fu, Zhongzheng, Amirsaman Sajad, Steven P. Errington, Jeffrey D. Schall, and Ueli Rutishauser. Nature Reviews. Neuroscience, January. https://doi.org/10.1038/s41583-022-00670-w.

Fluid Restriction Reduces Delayed Hyponatremia and Hospital Readmissions After Transsphenoidal Surgery. Cooper, Odelia, Rita Lis, Vivien Bonert, Artak Labadzhyan, Ning-Ai Liu, Anat Ben-Shlomo, Vladimir Ljubimov, Viktoria Krutikova, and Adam N. Mamelak. The Journal of Clinical Endocrinology and Metabolism, February, dgad066.

OBGYN

Racial and Ethnic Disparities in Polycystic Ovary Syndrome. VanHise, Katherine, Erica T. Wang, Keith Norris, Ricardo Azziz, Margareta D. Pisarska, and Jessica L. Chan. Fertility and Sterility, January, S0015-0282(23)00069-9.

Pathology

A Case of Digital Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Fusion. Bui, Chau M., Manita Chaum, and Bonnie Balzer. Cureus 14 (12): e33179.

Pseudomyogenic Hemangioendothelioma: A Case of a Solitary Lesion With a Very Indolent Clinical Course. Gant, Tayler, Chau M. Bui, Earl Brien, and Bonnie Balzer. Cureus 14 (12): e33172.

Liver Fibrosis: The Good, the Bad and the Patchy - an Update. Guindi, Maha. Human Pathology, January, S0046-8177(23)00014-X.

Storage Differentially Impacts Alloimmunization to Distinct Red Cell Antigens Following Transfusion in Mice. Maier, Cheryl L., Ryan P. Jajosky, Seema R. Patel, Hans P. Verkerke, Megan D. Fuller, Jerry William Allen, Patricia E. Zerra, Ross M. Fasano, Satheesh Chonat, Cassandra D. Josephson, David R. Gibb, Stephanie C. Eisenbarth, C. John Luckey, Krystalyn E. Hudson, Jeanne E. Hendrickson, Connie M. Arthur, and Sean R. Stowell. Transfusion, January.

Pediatrics

The Genomic Landscape of Short Tandem Repeats Across Multiple Ancestries. Vijayaraghavan, Prashanth, Sergey Batalov, Yan Ding, Erica Sanford, Stephen F. Kingsmore, David Dimmock, Charlotte Hobbs, and Matthew Bainbridge. PloS One 18 (1): e0279430.

Radiation Oncology

Analysis of a Biopsy-Based Genomic Classifier in High-Risk Prostate Cancer: Meta-Analysis of the NRG Oncology/RTOG 9202, 9413, and 9902 Phase III Randomized Trials. Nguyen, Paul L., Huei-Chung Rebecca Huang, Daniel E. Spratt, Elai Davicioni, Howard M. Sandler, William U. Shipley, Jason A. Efstathiou, Jeffry P. Simko, Alan Pollack, Adam P. Dicker, Mack Roach, Seth A. Rosenthal, Kenneth L. Zeitzer, Lucas C. Mendez, Alan C. Hartford, William A. Hall, Anand B. Desai, Rachel A. Rabinovitch, Christopher A. Peters, Joseph P. Rodgers, Phuoc Tran, and Felix Y. Feng. International Journal of Radiation Oncology, Biology, Physics, December, S0360-3016(22)03688-4.

Embracing a Future of Progress in Gynecologic Brachytherapy. Harkenrider, Matthew M., and Mitchell Kamrava. Brachytherapy 22 (1): 6–8.

Knowledge and Understanding of Radiation Therapy Among Breast Cancer Patients From Culturally Diverse Backgrounds at a Safety-Net Hospital. Vassantachart, April, Omar Ragab, Kimberly Miller, Derrick Lock, Julia Stal, Shelly X. Bian, Julie Jang, Croix Fossum, Hye Ri Han, Shahil Mehta, Karen Cheng, and Leslie K. Ballas. International Journal of Radiation Oncology, Biology, Physics, January, S0360-3016(23)00077-9.

Surgery

A Review of Midface Aging. Ugradar, Shoaib, Jane S. Kim, and Guy Massry. Ophthalmic Plastic and Reconstructive Surgery, December.

Efficacy of Anal Sphincter Division During Fistulotomy in Anal Fissure Associated Fistula. Adams, Evan D., James M. Mirocha, Phillip R. Fleshner, and Karen N. Zaghiyan. Diseases of the Colon and Rectum, January.

Permanent Section Margin Concordance After Mohs Micrographic Surgery With Immunohistochemistry for Invasive Melanoma and Melanoma in Situ: A Retrospective Dual-Center Analysis. Young, Jade N., Tuyet A. Nguyen, S. Caleb Freeman, Emma Hill, Mariah Johnson, Nima Gharavi, Anna Bar, and Justin Leitenberger. Journal of the American Academy of Dermatology, January, S0190-9622(23)00141-X.

Feasibility of Opioid-Free Surgery for Inflammatory Bowel Disease. Truong, Adam, Lucille Yao, Phillip R. Fleshner, and Karen N. Zaghiyan. Colorectal Disease, January.

Change in Lacrimal Gland Volume and Aqueous Tear Production Following Treatment With Teprotumumab. Ugradar, Shoaib, Erin Zimmerman, Emanuil Parunakian, Julia Kang, Kimberly Cockerham, and Raymond S. Douglas. Clinical & Experimental Ophthalmology, February.

The Management of Lumps, Bumps and Contour Irregularities of the Lower Eyelid and Cheek After Poor Outcome Fat Transfer. Ugradar, Shoaib, Yao Wang, Amy Patel, John B. Holds, Raymond Douglas, and Guy Massry. Aesthetic Surgery Journal, February, sjad025.

Urology

The Utility of Radiologic and Symptomatic Surveillance After Minimally-Invasive Adult Pyeloplasty. Castaneda, Peris R., Emma Bethel, Henry Valora-Tapia, J. Stuart Wolf, Bahaa S. Malaeb, Yooni Blair, and Sapan N. Ambani. Urology, January, S0090-4295(23)00056-0.