This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 9 - Feb.16.

Biomedical Sciences

Large-Scale Differentiation of IPSC-Derived Motor Neurons From ALS and Control Subjects. Workman, Michael J., Ryan G. Lim, Jie Wu, Aaron Frank, Loren Ornelas, Lindsay Panther, Erick Galvez, Daniel Perez, Imara Meepe, Susan Lei, Viviana Valencia, Emilda Gomez, Chunyan Liu, Ruby Moran, Louis Pinedo, Stanislav Tsitkov, Ritchie Ho, Julia A. Kaye, Answer ALS Consortium, Terri Thompson, Jeffrey D. Rothstein, Steven Finkbeiner, Ernest Fraenkel, Dhruv Sareen, Leslie M. Thompson, and Clive N. Svendsen. Neuron, February, S0896-6273(23)00034-X.

Context-Specific Regulation of Extracellular Vesicle Biogenesis and Cargo Selection. Dixson, Andrew C., T. Renee Dawson, Dolores Di Vizio, and Alissa M. Weaver. Nature Reviews. Molecular Cell Biology, February.

Cancer

Increasing Pancreatic Cancer Incidence in Young Women in the US: A Population-Based Time-Trend Analysis, 2001-2018. Abboud, Yazan, Jamil S. Samaan, Janice Oh, Yi Jiang, Navkiran Randhawa, Daniel Lew, Jenan Ghaith, Pranav Pala, ChristineAnn Leyson, Rabindra Watson, Quin Liu, Kenneth Park, Shirley Paski, Arsen Osipov, Brent K. Larson, Andrew Hendifar, Katelyn Atkins, Nicholas N. Nissen, Debiao Li, Stephen J. Pandol, Simon K. Lo, and Srinivas Gaddam. Gastroenterology, January, S0016-5085(23)00055-0.

Pancreatic Cancer Incidence Trends by Race, Ethnicity, Age and Sex in the United States: A Population-Based Study, 2000-2018. Samaan, Jamil S., Yazan Abboud, Janice Oh, Yi Jiang, Rabindra Watson, Kenneth Park, Quin Liu, Katelyn Atkins, Andrew Hendifar, Jun Gong, Arsen Osipov, Debiao Li, Nicholas N. Nissen, Stephen J. Pandol, Simon K. Lo, and Srinivas Gaddam. Cancers 15 (3): 870.

Financial Toxicity: A Practical Review for Gynecologic Oncology Teams to Understand and Address Patient-Level Financial Burdens. Liang, Margaret I., Ross Harrison, Emeline M. Aviki, Katharine M. Esselen, Roni Nitecki, and Larissa Meyer. Gynecologic Oncology 170 (February): 317–27.

TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype. Tricarico, Rossella, Jozef Madzo, Gabrielle Scher, Maya Cohen, Jaroslav Jelinek, Shinji Maegawa, Rajeswari Nagarathinam, Carly Scher, Wen-Chi Chang, Emmanuelle Nicolas, Michael Slifker, Yan Zhou, Karthik Devarajan, Kathy Q. Cai, Tim Kwok, Pamela Nakajima, Jinfei Xu, Pietro Mancuso, Valentina Doneddu, Luigi Bagella, Riley Williams, Siddharth Balachandran, Nicholas Maskalenko, Kerry Campbell, Xueying Ma, Israel Cañadas, Julen Viana, Victor Moreno, Laura Valle, Sergei Grivennikov, Iuliia Peshkova, Natalia Kurilenko, Aleksandra Mazitova, Ekaterina Koltsova, Hayan Lee, Martin Walsh, Reuben Duttweiler, Johnathan R. Whetstine, Timothy J. Yen, Jean-Pierre Issa, and Alfonso Bellacosa. Gastroenterology, February, S0016-5085(23)00112-9.

Circulating Tumour DNA Analysis Predicts Relapse and Improves Risk Stratification in Primary Refractory Multiple Myeloma. Mithraprabhu, Sridurga, John Reynolds, Rose Turner, Hang Quach, Noemi Horvath, Ian Kerridge, Anna Kalff, Krystal Bergin, Jay Hocking, Flora Yuen, Tiffany Khong, Brian M. Durie, and Andrew Spencer. Blood Cancer Journal 13 (1): 25.

Safety and Management of Niraparib Monotherapy in Ovarian Cancer Clinical Trials. Monk, Bradley J., Antonio González-Martin, Lynn Buckley, Ursula A. Matulonis, B. J. Rimel, Xiaohua Wu, Kathleen N. Moore, and Mansoor R. Mirza. International Journal of Gynecological Cancer, February, ijgc–2022–004079.

Dual Kinase Inhibitor for EGFR Mutants and ErbB2 Limit Breast Cancer. Goel, Peeyush N., Hongtao Zhang, Ramachandran Murali, Cai Zheng, Mei Q. Ji, Angelica Patterson, Payal Grover, and Mark Greene. Biochemical and Biophysical Research Communications 651 (February): 39–46.

Measuring and Improving Quality of Colonoscopy for Colorectal Cancer Screening. Almario, Christopher V., Jaspreet Shergill, and Janice Oh. Techniques and Innovations in Gastrointestinal Endoscopy 24 (3): 269–83. 

Combining Cytotoxic Agents With Continuous Dose Levels in Seamless Phase I-II Clinical Trials. Jiménez, José L., and Mourad Tighiouart. Journal of the Royal Statistical Society. Series C, Applied Statistics71 (5): 1996–2013. 

Cardiology

Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection. Kwan, Alan C., Joseph E. Ebinger, Patrick Botting, Jesse Navarrette, Brian Claggett, and Susan Cheng. JAMA Network Open 6 (2): e2255965.

Current Challenges and Future Directions for Engineering Extracellular Vesicles for Heart, Lung, Blood and Sleep Diseases. Li, Guoping, Tianji Chen, James Dahlman, Lola Eniola-Adefeso, Ionita C. Ghiran, Peter Kurre, Wilbur A. Lam, Jennifer K. Lang, Eduardo Marbán, Pilar Martín, Stefan Momma, Malcolm Moos, Deborah J. Nelson, Robert L. Raffai, Xi Ren, Joost P. G. Sluijter, Shannon L. Stott, Gordana Vunjak-Novakovic, Nykia D. Walker, Zhenjia Wang, Kenneth W. Witwer, Phillip C. Yang, Martha S. Lundberg, Margaret J. Ochocinska, Renee Wong, Guofei Zhou, Stephen Y. Chan, Saumta Das, and Prithu Sundd. Journal of Extracellular Vesicles 12 (2): e12305.

Sex Differences in Contributors to Coronary Microvascular Dysfunction. Kwan, Alan C., Janet Wei, David Ouyang, Joseph E. Ebinger, C. Noel Bairey Merz, Daniel Berman, and Susan Cheng. Frontiers in Cardiovascular Medicine 10: 1085914.

Long-Term Adverse Outcomes in Black Women With Ischemia and No Obstructive Coronary Artery Disease: A Study of the WISE (Women’s Ischemia Syndrome Evaluation) Cohort. Luu, Judy M., Pankaj Malhotra, Galen Cook-Wiens, Carl J. Pepine, Eileen M. Handberg, Steven E. Reis, Nathaniel Reichek, Vera Bittner, Janet Wei, Sheryl F. Kelsey, Reddy Sailaja Marpuri, George Sopko, and C. Noel Bairey Merz. Circulation 147 (7): 617–19.

Hypertension Section Editors Series: Early Career Introduction and Update. Trask, Aaron J., Natalie A. Bello, Daniela Carnevale, Amy C. Arnold, and Stephanie W. Watts. Hypertension (Dallas, Tex.: 1979) 80 (3): 493–96.

Computational Biomedicine 

Pregex: Rule-Based Detection and Extraction of Twitter Data in Pregnancy. Klein, Ari Z., Shriya Kunatharaju, Karen O’Connor, and Graciela Gonzalez-Hernandez. Journal of Medical Internet Research 25 (February): e40569.

Single-Cell RNA-Sequencing Identifies Disease-Associated Oligodendrocytes in Male APP NL-G-F and 5XFAD Mice. Park, Hanseul, Byounggook Cho, Hongwon Kim, Takashi Saito, Takaomi C. Saido, Kyoung-Jae Won, and Jongpil Kim. Nature Communications 14 (1): 802.

Medicine

Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative Stress. Xu, Renfeng, Fan Wang, Zhenghong Zhang, Yan Zhang, Yedong Tang, Jingjing Bi, Congjian Shi, Defan Wang, Hongqin Yang, Zhengchao Wang, and Zonghao Tang. Oxidative Medicine and Cellular Longevity 2023: 4365895.

Protein Carbamylation and the Risk of ESKD in Patients With CKD. Kalim, Sahir, Sophia Zhao, Mengyao Tang, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, and Anders H. Berg. Journal of the American Society of Nephrology: JASN, January.

Understanding Interstitial Lung Diseases Associated With Connective Tissue Disease (CTD-ILD): Genetics, Cellular Pathophysiology, and Biologic Drivers. Cerro Chiang, Giuliana, and Tanyalak Parimon. International Journal of Molecular Sciences 24 (3): 2405.

Preventing Medication History Errors in High-Risk Patients: Impact of California Senate Bill 1254. Tu, Thanh, Sarah Stephens, Sarah Bajorek, Donna Leang, Daniel Nguyen, and Rita Shane. American Journal of Health-System Pharmacy: AJHP, February, zxad038.

Investigating Gene-Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits. Westerman, Kenneth E., Maura E. Walker, Sheila M. Gaynor, Jennifer Wesse, Daniel DiCorpo, Jiantao Ma, Alvaro Alonso, Stella Aslibekyan, Abigail S. Baldridge, Alain G. Bertoni, Mary L. Biggs, Jennifer A. Brody, Alisa K. Manning, et al. Diabetes, February, db220851.

Neurosurgery

Retinal Pathological Features and Proteome Signatures of Alzheimer’s Disease. Koronyo, Yosef, Altan Rentsendorj, Nazanin Mirzaei, Giovanna C. Regis, Julia Sheyn, Haoshen Shi, Ernesto Barron, Galen Cook-Wiens, Anthony R. Rodriguez, Rodrigo Medeiros, Joao A. Paulo, Veer B. Gupta, Andrei A. Kramerov, Alexander V. Ljubimov, Jennifer E. Van Eyk, Stuart L. Graham, Vivek K. Gupta, John M. Ringman, David R. Hinton, Carol A. Miller, Keith L. Black, Antonino Cattaneo, Giovanni Meli, Mehdi Mirzaei, Dieu-Trang Fuchs, and Maya Koronyo-Hamaoui. Acta Neuropathologica, February.

OBGYN

Using Potentially Preventable Severe Maternal Morbidity to Monitor Hospital Performance. Fridman, Moshe, Lisa M. Korst, David J. Reynen, Lisa A. Nicholas, Naomi Greene, Samia Saeb, Jennifer L. Troyan, and Kimberly D. Gregory. Joint Commission Journal on Quality and Patient Safety, November, S1553-7250(22)00272-0. 

Getting a Grip on Polycystic Ovary Syndrome. Jessica L. Chan, M. D., M. D. Katherine Moran, and M. D. Katherine Vanhise, Vol 68 No 02, 68 (February).

Orthopaedics

Rasch Calibration of the International Knee Documentation Committee Subjective Knee Form. Ryu, Seungho, Ryan Richardson, Adam C. Cady, Ashley Reeves, Madeline P. Casanova, and Russell T. Baker. Journal of Sport Rehabilitation, January, 1–8.

Pathology

Clinicopathological and Treatment Patterns of Combined Small-Cell Lung Carcinoma With Future Insight to Treatment: A Population-Based Study. Ullah, Asad, Omer Saeed, Nabin Raj Karki, Mya Goodbee, Abdul Qahar Khan Yasinzai, Abdul Waheed, Saleh Heneidi, Anish Thomas, Nagla Abdel Karim, Joyce Johnson, Jaydira Del Rivero, and Jaffar Khan. Journal of Clinical Medicine 12 (3): 991.

Two Distinct Pathogenic Pathways of Digital Papillary Adenocarcinoma - BRAF Mutation or Low-Risk HPV Infection. Bui, Chau M., Tatsiana Pukhalskaya, Bruce R. Smoller, Hatice Betul Zengin, Saleh Heneidi, Eric Vail, Elias Makhoul, and Bonnie Balzer. Journal of Cutaneous Pathology, February.

Progress in the Early Detection of Risk of End-Stage Kidney Disease in Diabetes at Last? Berg, Anders H., and David B. Sacks. Clinical Chemistry, February, hvac215.

Knockout of ACE-N Facilitates Improved Cardiac Function After Myocardial Infarction. Suhail, Hamid, Hongmei Peng, Jiang Xu, Hani N. Sabbah, Khalid Matrougui, Tang-Dong Liao, Pablo A. Ortiz, Kenneth E. Bernstein, and Nour-Eddine Rhaleb. Journal of Molecular and Cellular Cardiology Plus 3 (March): 100024.

Pediatrics

Sudden Cardiac Arrest During a Sedated Cardiac Magnetic Resonance Study in a Nonsyndromic Child With Evolving Supravalvar Aortic Stenosis Due to Familial ELN Mutation. Markush, Dor, Pedro A. Sanchez-Lara, Katheryn Grand, Robert Wong, and Ruchira Garg. Pediatric Cardiology, February.

Psychiatry

Hypnotic Medications as an Adjunct Treatment to Cognitive Behavioral Therapy for Insomnia. Barkopoulos, Paul, and Joshua Hyong-Jin Cho. Sleep Medicine Clinics 18 (1): 95–111.

Surgery

CX3CR1+ Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26. Moon, Hyung-Geun, Seung-Jae Kim, Ki-Hyun Kim, Young-Mee Kim, Jalees Rehman, Hyun Lee, Yi-Chien Wu, Steve Seung-Young Lee, John W. Christman, Steven J. Ackerman, Minhyung Kim, Sungyoung You, and Gye Young Park. American Journal of Respiratory and Critical Care Medicine, February.

Urology

Female Genitalia in Pornography: A Source of Labiaplasty Trends? Dubinskaya, Alexandra, and Jennifer T. Anger. The Journal of Sexual Medicine, January, qdac037.

Anatomic Maps of Erogenous Sensation and Pleasure in the Penis: Are There Difference Between Circumcised and Uncircumcised Men? Zaliznyak, Michael, Dylan Isaacson, Erin Duralde, Thomas W. Gaither, Aurash Naser-Tavakolian, Catherine Bresee, Jenna Stelmar, Nance Yuan, Kimberly Topp, and Maurice M. Garcia. The Journal of Sexual Medicine, January, qdac032.