This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Dec. 1-Dec. 8.

Anesthesiology

Superficial Parasternal Intercostal Plane Blocks (SPIB) With Buprenorphine, Magnesium, and Bupivacaine for Management of Pain in Coronary Artery Bypass Grafting. Krishnan, Sandeep, Ronak Desai, Peter Paik, Adam Cassella, Jon Lucaj, Farhad Ghoddoussi, Joffer Hakim, Charles Schwartz, Timothy Leicht, and Kinjal Patel. Cureus 14 (11): e30964.

Cancer

Phase I Study Evaluating Glesatinib (MGCD265), An Inhibitor of MET and AXL, in Patients With Non-Small Cell Lung Cancer and Other Advanced Solid Tumors. Kollmannsberger, Christian, Herbert Hurwitz, Lyudmila Bazhenova, Byoung Chul Cho, David Hong, Keunchil Park, Karen L. Reckamp, Sunil Sharma, Hirak Der-Torossian, James G. Christensen, Demiana Faltaos, Diane Potvin, Vanessa Tassell, Richard Chao, and Geoffrey I. Shapiro. Targeted Oncology, December.

Natural Product Preferentially Targets Redox and Metabolic Adaptations and Aberrantly Active STAT3 to Inhibit Breast Tumor Growth in Vivo. Zhu, Yinsong, Peibin Yue, Cody F. Dickinson, Justin K. Yang, Kyrstin Datanagan, Ning Zhai, Yi Zhang, Gabriella Miklossy, Francisco Lopez-Tapia, Marcus A. Tius, and James Turkson. Cell Death & Disease 13 (12): 1022.

Cardiac Surgery

Clopidogrel Resistance: Barrier to Effective Antiplatelet Therapy After Off-Pump Coronary Artery Bypass Grafting. Chen, Qiudong, and Michael E. Bowdish. The Annals of Thoracic Surgery, November, S0003-4975(22)01496-5.

The Importance of Randomized Clinical Trials for Contemporary Surgically Implanted Biological Heart Valves. Bowdish, Michael E., and Qiudong Chen. The Annals of Thoracic Surgery, November, S0003-4975(22)01504-1.

Sex Disparities in Failure to Rescue After Cardiac Surgery in California and New York. Alabbadi, Sundos, Georgina Rowe, George Gill, Ageliki Vouyouka, Joanna Chikwe, and Natalia Egorova. Circulation. Cardiovascular Quality and Outcomes, December, e009050.

Cardiology

US Severe Acute Respiratory Syndrome Coronavirus 2 Epsilon Variant: Highly Transmissible but With an Adjusted Muted Host T-Cell Response. Plummer, Jasmine T., Deisy Contreras, Wenjuan Zhang, Aleksandra Binek, Ruan Zhang, Felipe Dezem, Stephanie S. Chen, Brian D. Davis, Jorge Sincuir Martinez, Aleksandr Stotland, Simion Kreimer, Elias Makhoul, Saleh Heneidi, Celeste Eno, Bongha Shin, Anders H. Berg, Susan Cheng, CORALE Study Group, Stanley C. Jordan, Eric Vail, Jennifer E. Van Eyk, and Margie A. Morgan. Clinical Infectious Diseases 75 (11): 1940–49.

A Discovery-Based Proteomics Approach Identifies Protein Disulphide Isomerase (PDIA1) as a Biomarker of ? Cell Stress in Type 1 Diabetes. Syed, Farooq, Divya Singhal, Koen Raedschelders, Preethi Krishnan, Robert N. Bone, Madeline R. McLaughlin, Jennifer E. Van Eyk, Raghavendra G. Mirmira, Mei-Ling Yang, Mark J. Mamula, Huanmei Wu, Xiaowen Liu, and Carmella Evans-Molina. EBioMedicine 87 (December): 104379.

A Proteomic Approach for Investigating the Pleiotropic Effects of Statins in the Atherosclerosis Risk in Communities (ARIC) Study. Bohn, Bruno, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, and Ryan T. Demmer. Journal of Proteomics, December, 104788.

2-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients With Annular Calcification, Rings, and Bioprostheses. Eleid, Mackram F., Dee Dee Wang, Amit Pursnani, Susheel K. Kodali, Issac George, Igor Palacios, Hyde Russell, Raj R. Makkar, Saibal Kar, Lowell F. Satler, Vivek Rajagopal, George Dangas, Gilbert H. L. Tang, James M. McCabe, Brian K. Whisenant, Kenith Fang, Tatiana Kaptzan, Bradley Lewis, Pamela Douglas, Rebecca Hahn, Jeremy Thaden, Jae K. Oh, Martin Leon, William O’Neill, Charanjit S. Rihal, and Mayra E. Guerrero. Journal of the American College of Cardiology 80 (23): 2171–83.

Implementation of an Electronic Health Records-Based Safe Contrast Limit for Preventing Contrast-Associated Acute Kidney Injury After Percutaneous Coronary Intervention. Yuan, Neal, Justin Zhang, Rakan Khaki, Derek Leong, Chandrashekhar Bhoopalam, Steven W. Tabak, Yaron Elad, Joshua M. Pevnick, Susan Cheng, and Joseph E. Ebinger. Circulation. Cardiovascular Quality and Outcomes, December, e009235.

Emergency Medicine

Patient and Visit Characteristics Associated With Physical Restraint Use in the Emergency Department. Walia, Harbir, Lue-Yen S. Tucker, Raj N. Manickam, Mamata V. Kene, Adam L. Sharp, Carl T. Berdahl, and Matthew E. Hirschtritt. The Permanente Journal, December, 1–9.

Medicine

Gravity and the Gut: A Hypothesis of Irritable Bowel Syndrome. Spiegel, Brennan. The American Journal of Gastroenterology 117 (12): 1933–47.

Clinical Biology of the Pituitary Adenoma. Melmed, Shlomo, Ursula B. Kaiser, M. Beatriz Lopes, Jerome Bertherat, Luis V. Syro, Gerald Raverot, Martin Reincke, Gudmundur Johannsson, Albert Beckers, Maria Fleseriu, Andrea Giustina, John A. H. Wass, and Ken K. Y. Ho. Endocrine Reviews 43 (6): 1003–37.

Optimizing Reliability of Real-Time Sonographic Examination and Scoring of Joint Synovitis in Rheumatoid Arthritis. Ranganath, Veena K., Ami Ben-Artzi, Jenny Brook, Yosra Suliman, Astrid Floegel-Shetty, Thasia Woodworth, Mihaela Taylor, Laurie A. Ramrattan, David Elashoff, and Gurjit S. Kaeley. Cureus14 (11): e31030.

Type 2 Diabetes and the Microbiome. Barlow, Gillian M, and Ruchi Mathur. Journal of the Endocrine Society, November, bvac184.

Importance of IL-6 Inhibition in Prevention and Treatment of Antibody-Mediated Rejection in Kidney Allografts. Jordan, Stanley C., Noriko Ammerman, Edmund Huang, and Ashley Vo. American Journal of Transplantation 22 Suppl 4 (December): 28–37.

Culture Impact on the Transcriptomic Programs of Primary and IPSC-Derived Human Alveolar Type 2 Cells. Alysandratos, Konstantinos-Dionysios, Carolina Garcia-de-Alba, Changfu Yao, Patrizia Pessina, Jessie Huang, Carlos Villacorta-Martin, Olivia T. Hix, Kasey Minakin, Claire L. Burgess, Pushpinder Bawa, Aditi Murthy, Bindu Konda, Michael F. Beers, Barry R. Stripp, Carla F. Kim, and Darrell N. Kotton. JCI Insight, December, e158937.

Interface Bonding Behavior and Failure Mechanism of Joining Tribaloy T-800/AISI 4140 via Laser Engineered Net Shaping. Kim, Hoyeol, Manikanta Grandhi, Zhichao Liu, Israt Zarin Era, and Hongchao Zhang. Optics & Laser Technology 156 (December): 108620.

Peripheral-Dominant Liver Fibrosis and Tumor Distribution in a Mouse Model of Congestive Hepatopathy. Kawai, Hironari, Yosuke Osawa, Tomoyuki Tsunoda, Michitaka Matsuda, Miku Okawara, Yuzuru Sakamoto, Tomonari Shimagaki, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Hiroyoshi Doi, Taizo Mori, Taiji Yamazoe, Sachiyo Yoshio, Tadashi Okamura, Masaya Sugiyama, Daisuke Okuzaki, Haruki Komatsu, Ayano Inui, Katsuhiko Yanaga, Toru Ikegami, and Tatsuya Kanto. Hepatology Research, December.

A 5-Year Retrospective, Observational Study Assessing Rheumatoid Arthritis Disease Outcome Measures to Characterize Systemic Lupus Erythematosus Burden in the USA. Bell, Christopher F., Shirley P. Huang, Louise H. Yu, Maral DerSarkissian, Guillaume Germain, Andrew L. Concoff, Carlyne M. Averell, Bernard Rubin, Yuqian M. Gu, Mei Sheng Duh, and Daniel J. Wallace. Rheumatology and Therapy, December.

Placebo Adverse Events in Non-Alcoholic Steatohepatitis Clinical Trials: A Pooled Analysis of 2,944 Participants. Tay, Phoebe Wen Lin, Cheng Han Ng, Snow Yunni Lin, Yip Han Chin, Jieling Xiao, Wen Hui Lim, Sze Yinn Lim, Clarissa Elysia Fu, Kai En Chan, Jingxuan Quek, Darren Jun Hao Tan, Nicholas Chew, Nicholas Syn, Taisei Keitoku, Nobuharu Tamaki, Mohammad Shadab Siddiqui, Mazen Noureddin, Mark Muthiah, Daniel Q. Huang, and Rohit Loomba. The American Journal of Gastroenterology, November.

OBGYN

Association Between Diagnosed Perinatal Mood and Anxiety Disorders and Adverse Perinatal Outcomes. Accortt, Eynav, James Mirocha, Susan Jackman, Mary Coussons-Read, Christine Dunkel Schetter, and Calvin Hobel. The Journal of Maternal-Fetal & Neonatal Medicine 35 (25): 9066–70.

Residency Training in Gynecologic Surgery: Where Do We Go From Here? Wright, Kelly N., Mireille Truong, and Matthew T. Siedhoff. Journal of Gynecologic Surgery 38 (6): 375–78.

Orthopaedics

Trust but Verify: Discordance in Opioid Reporting Between the Electronic Medical Record and a Statewide Database. Pujari, Amit, Mili Patel, Aria Darbandi, John Garlich, Milton Little, and Carol Lin. Cureus14 (11): e31027.

Multi-Group Invariance Testing of the Knee Injury Osteoarthritis Outcome Score for Joint Replacement Scale. Allred, Caleb, Ashley J. Reeves, Madeline P. Casanova, Adam C. Cady, and Russell T. Baker. Osteoarthritis and Cartilage Open 4 (4): 100296.

Ambulatory Surgery Centers Significantly Decrease Total Health Care Expenditures in Primary Anterior Cruciate Ligament Reconstruction. Tiao, Justin, Kevin Wang, Andrew D. Carbone, Michael Herrera, Nicole Zubizarreta, James N. Gladstone, Alexis C. Colvin, and Shawn G. Anthony. The American Journal of Sports Medicine, December, 3635465221136542.

Pediatrics

Risk of Paediatric Multisystem Inflammatory Syndrome (PIMS-TS) During the SARS-CoV-2 Alpha and Delta Variant Waves: National Observational and Modelling Study, 2020–21, England. Shingleton, Joseph, Lucy Burton, Hannah E. Williams, Thomas J. R. Finnie, Emma Bennett, Paul Birrell, Simon Kenny, Tiffany Watson-Koszel, Russell Viner, Moshe Arditi, Daniela DeAngelis, Nick Gent, and Shamez N. Ladhani. Frontiers in Pediatrics 10.

Surgery

Recovery After Thyroid and Parathyroid Surgery: How Do Our Patients Really Feel? Lee, William G., Jessica E. Gosnell, Wen T. Shen, Quan-Yang Duh, Insoo Suh, and Yufei Chen. The Journal of Surgical Research 283 (December): 764–70.

Long vs Short Acting Testosterone Treatments: A Look at the Risks. Gurayah, Aaron A., Alexandra Dullea, Alexander Weber, John M. Masterson, Kajal Khodamoradi, Arslan I. Mohamed, and Ranjith Ramasamy. Urology, November, S0090-4295(22)00991-8.

Endolymphatic Hydrops in the Setting of Vestibular Schwannoma: A Temporal Bone Study. Wong, Yu-Tung, Ivan A. Lopez, Helena Wichova, Akira Ishiyama, and Mia E. Miller. Otology & Neurotology, 10.1097/MAO.0000000000003754. Accessed December 2.