This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Aug. 24-31.

Biomedical Sciences

Survival of the Fittest Glia. Moser, V. Alexandra, and Clive N. Svendsen. Nature Biotechnology, August.

Cancer

Helicase-Independent Function of RIG-I Against Murine Gammaherpesvirus 68 via Blocking the Nuclear Translocation of Viral Proteins. Xu, Yang, Guoli Hou, Qizhi Liu, Qiushi Zhang, Chun Li, Liang Hu, Xiaoying Chen, Rui Chen, Chengming Ding, Deliang Li, and Junhua Li. International Journal of Biological Macromolecules, August, 126527.

Comprehensive Analyses of Partially Methylated Domains and Differentially Methylated Regions in Esophageal Cancer Reveal Both Cell-Type- and Cancer-Specific Epigenetic Regulation. Zheng, Yueyuan, Benjamin Ziman, Allen S. Ho, Uttam K. Sinha, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, Benjamin P. Berman, and De-Chen Lin. Genome Biology 24 (1): 193.

Cardiac Surgery

Prognostic Significance of Hemodynamic Parameters in Patients With Cardiogenic Shock. Berg, David D., Gurleen Kaur, Erin A. Bohula, Vivian M. Baird-Zars, Carlos L. Alviar, Christopher F. Barnett, Gregory W. Barsness, James A. Burke, Sunit-Preet Chaudhry, Meshe Chonde, Howard A. Cooper, Lori B. Daniels, Mark W. Dodson, Daniel A. Gerber, Shahab Ghafghazi, Umesh K. Gidwani, Michael J. Goldfarb, Jianping Guo, Dustin Hillerson, Benjamin B. Kenigsberg, Ajar Kochar, Michael C. Kontos, Younghoon Kwon, Mathew S. Lopes, Daniel B. Loriaux, P. Elliott Miller, Connor G. O’Brien, Alexander I. Papolos, Siddharth M. Patel, Barbara A. Pisani, Brian J. Potter, Rajnish Prasad, Robert O. Rowsell, Kevin S. Shah, Shashank S. Sinha, Timothy D. Smith, Michael A. Solomon, Jeffrey J. Teuteberg, Andrea D. Thompson, Sammy Zakaria, Jason N. Katz, Sean van Diepen, and David A. Morrow. European Heart Journal. Acute Cardiovascular Care, August, zuad095.

Cardiology

The AHA/ACC/HFSA 2022 Heart Failure Guidelines: Changing the Focus to Heart Failure Prevention. Abovich, Arielle, Daniel S. Matasic, Rhanderson Cardoso, Chiadi E. Ndumele, Roger S. Blumenthal, Ron Blankstein, and Martha Gulati. American Journal of Preventive Cardiology 15 (September): 100527.

Technical Recommendations for Computed Tomography Guidance of Intervention in the Right Ventricular Outflow Tract: Native RVOT, Conduits, and Bioprosthetic Valves. Han, B. Kelly, Santiago Garcia, Jamil Aboulhosn, Phillip Blanke, Mary Hunt Martin, Evan Zahn, Andrew Crean, David Overman, C. Hamilton Craig, Kate Hanneman, Thomas Semple, and Aimee Armstrong. World Journal for Pediatric & Congenital Heart Surgery, August, 21501351231186896.

Hospital at Home as a Treatment Strategy for Worsening Heart Failure. Haywood, Hubert B., Gregg C. Fonarow, Muhammad Shahzeb Khan, Harriette G. C. Van Spall, Alanna A. Morris, Michael E. Nassif, Michelle M. Kittleson, Javed Butler, and Stephen J. Greene. Circulation. Heart Failure, August, e010456.

Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study. Hofmeyer, Mark, Garrie J. Haas, Elizabeth Jordan, Jinwen Cao, Evan Kransdorf, Gregory A. Ewald, Alanna A. Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia Garg, Barry H. Trachtenberg, Palak Shah, Salpy V. Pamboukian, Nancy K. Sweitzer, Matthew T. Wheeler, Jane E. Wilcox, Stuart Katz, Stephen Pan, Javier Jimenez, Frank Smart, Jessica Wang, Stephen S. Gottlieb, Daniel P. Judge, Charles K. Moore, Gordon S. Huggins, Daniel D. Kinnamon, Hanyu Ni, Ray E. Hershberger, and DCM Precision Medicine Study of the DCM Consortium. Circulation, August.

Warning Symptoms Associated With Imminent Sudden Cardiac Arrest: A Population-Based Case-Control Study With External Validation. Reinier, Kyndaron, Bernadine Dizon, Harpriya Chugh, Ziana Bhanji, Madison Seifer, Arayik Sargsyan, Audrey Uy-Evanado, Faye L. Norby, Kotoka Nakamura, Katy Hadduck, Daniel Shepherd, Tristan Grogan, David Elashoff, Jonathan Jui, Angelo Salvucci, and Sumeet S. Chugh. The Lancet. Digital Health, August, S2589-7500(23)00147-4.

Risk Stratification of Sudden Cardiac Death: A Review. Tfelt-Hansen, Jacob, Rodrigue Garcia, Christine Albert, Jose Merino, Andrew Krahn, Eloi Marijon, Cristina Basso, Arthur A. M. Wilde, and Kristina Hermann Haugaa. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology 25 (8): euad203.

The Lancet Commission to Reduce the Global Burden of Sudden Cardiac Death: A Call for Multidisciplinary Action. Marijon, Eloi, Kumar Narayanan, Karen Smith, Sérgio Barra, Cristina Basso, Marieke T. Blom, Lia Crotti, Andre D’Avila, Rajat Deo, Florence Dumas, Anastase Dzudie, Audrey Farrugia, Kaitlyn Greeley, Gerhard Hindricks, Wei Hua, Jodie Ingles, Taku Iwami, Juhani Junttila, Rudolph W. Koster, Jean-Benoît Le Polain De Waroux, Theresa M. Olasveengen, Marcus E. H. Ong, Michael Papadakis, Comilla Sasson, Sang Do Shin, Hung-Fat Tse, Zian Tseng, Christian Van Der Werf, Fredrik Folke, Christine M. Albert, and Bo Gregers Winkel. Lancet (London, England), August, S0140-6736(23)00875-9.

Sex Differences in Prevalence and Prognosis of Steatotic Liver Disease Phenotypes: Biological Sex Matters. Ji, Hongwei, Susan Cheng, and Heart-Liver Axis Research Collaboration. Journal of Hepatology, August, S0168-8278(23)05066-3.

Dual-Organ Transplantation: Indications, Evaluation, and Outcomes for Heart-Kidney and Heart-Liver Transplantation: A Scientific Statement From the American Heart Association. Kittleson, Michelle M., Kavita Sharma, Daniel C. Brennan, Xingxing S. Cheng, Sheryl L. Chow, Monica Colvin, Adam D. DeVore, Shannon M. Dunlay, Meg Fraser, Jacqueline Garonzik-Wang, Prateeti Khazanie, Kevin M. Korenblat, Duc T. Pham, and American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology; Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Council on Lifelong Congenital Heart Disease and Heart Health in the Young. Circulation 148 (7): 622–36.

The ABC of Heart Transplantation-Part 1: Indication, Eligibility, Donor Selection, and Surgical Technique. Masarone, Daniele, Michelle M. Kittleson, Luigi Falco, Maria L. Martucci, Dario Catapano, Benedetta Brescia, Andrea Petraio, Marisa De Feo, and Giuseppe Pacileo. Journal of Clinical Medicine 12 (16): 5217.

Imaging

Making Fair Comparisons: The Potency and Necessity of Combining Myocardial Perfusion Imaging and CAC Scanning. Berman, Daniel S. Journal of Nuclear, August.

Medicine

The Landscape of Alterations From 1407 Ultra-Rare Sarcomas From the AACR GENIE Database: Clinical Implications. Denu, Ryan A., Justin T. Moyers, Mohamed A. Gouda, Anthony Conley, Alexander J. Lazar, and Vivek Subbiah. Clinical Cancer Research, August, CCR-23-0876.

Pilot Study to Define Criteria for Pituitary Tumors Centers of Excellence (PTCOE): Results of an Audit of Leading International Centers. Giustina, A., M. M. Uygur, S. Frara, A. Barkan, N. R. Biermasz, P. Chanson, P. Freda, M. Gadelha, U. B. Kaiser, S. Lamberts, E. Laws, L. B. Nachtigall, V. Popovic, M. Reincke, C. Strasburger, A. J. van der Lely, J. a. H. Wass, S. Melmed, and F. F. Casanueva. Pituitary, August.

Genome-Wide Interaction Analysis of Folate for Colorectal Cancer Risk. Bouras, Emmanouil, Andre E. Kim, Yi Lin, John Morrison, Mengmeng Du, Demetrius Albanes, Elizabeth L. Barry, James W. Baurley, Sonja I. Berndt, Stephanie A. Bien, Timothy D. Bishop, Hermann Brenner, Konstantinos K. Tsilidis, et al. The American Journal of Clinical Nutrition, August, S0002-9165(23)66108-8.

Immune Checkpoint Inhibitors for Child-Pugh Class B Advanced Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. Xie, Enrui, Yee Hui Yeo, Bernhard Scheiner, Yue Zhang, Atsushi Hiraoka, Xinxing Tantai, Petros Fessas, Tiago de Castro, Antonio D’Alessio, Claudia Angela Maria Fulgenzi, Shuo Xu, Hong-Ming Tsai, Swetha Kambhampati, Wenjun Wang, Bridget P. Keenan, Xu Gao, Zixuan Xing, Matthias Pinter, Yih-Jyh Lin, Zhanjun Guo, Arndt Vogel, Takaaki Tanaka, Hsin-Yu Kuo, Robin K. Kelley, Masatoshi Kudo, Ju Dong Yang, David J. Pinato, and Fanpu Ji. JAMA Oncology, August, e233284.

Identifying Implementation Factors for the Development, Operation, and Sustainment of Ambulatory Care Pharmacy Programs: A Qualitative Study. Qureshi, Nabeel, and Michelle S. Keller. Journal of General Internal Medicine, August.

Focused Ultrasound, an Emerging Tool for Atherosclerosis Treatment: A Comprehensive Review. Imtiaz, Cynthia, Muhammad Awais Farooqi, Theophilus Bhatti, Jooho Lee, Ramsha Moin, Chul Ung Kang, and Hafiz Muhammad Umer Farooqi. Life (Basel, Switzerland) 13 (8): 1783.

Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis. Buchynskyi, Mykhailo, Valentyn Oksenych, Iryna Kamyshna, Sandor G. Vari, and Aleksandr Kamyshnyi. Viruses 15 (8): 1724.

Near-Peer Supervision in Primary Care: Bringing Teaching Teams From the Wards to the Clinic. Chen, Katherine L., Stanley E. Yuan, Elizabeth K. Asfaw, Myung Shin Sim, Gifty-Maria J. Ntim, Mina W. Ma, and Antonio M. Pessegueiro. Journal of Graduate Medical Education 15 (4): 481–87.

OBGYN

Care Delivery for Patients With Leiomyomas: Failures, Real-Life Experiences, Analysis of Barriers, and Proposed Restorative Remedies. Lerner, Veronica T., Nicole M. Donnellan, Mathew T. Siedhoff, Mireille D. Truong, and Cara R. King. Health Equity 7 (1): 439–52.

Orthopaedics

The Incidence of Subclinical Infection in Patients Undergoing Revision Shoulder Stabilization Surgery: A Retrospective Chart Review. Malige, Ajith, Isaac Manuputy, Alexandra Boyd, Richard Michelin, and John M. Itamura. Journal of Shoulder and Elbow Surgery, August, S1058-2746(23)00610-9.

Pathology

Impact of Diabetic Lesions on Pathology, Treatment and Outcomes of Glomerular Diseases. Kim, Young Ho, Manish K. Saha, Yichun Hu, Srikar Kumar, Caroline J. Poulton, Susan L. Hogan, Patrick Nachman, J. Charles Jennette, Cynthia C. Nast, and Amy K. Mottl. Kidney360, August.

Pediatrics

Epithelial TNF Controls Cell Differentiation and CFTR Activity to Maintain Intestinal Mucin Homeostasis. Reyes, Efren A., David Castillo-Azofeifa, Jérémie Rispal, Tomas Wald, Rachel K. Zwick, Brisa Palikuqi, Angela Mujukian, Shervin Rabizadeh, Alexander R. Gupta, James M. Gardner, Dario Boffelli, Zev J. Gartner, and Ophir D. Klein. The Journal of Clinical Investigation, August, e163591.

Characterization of the Prenatal Renal Phenotype Associated With 17q12, HNF1B, Microdeletions. Verscaj, Courtney P., Frances Velez-Bartolomei, Ethan Bodle, Katie Chan, Michael J. Lyons, Willa Thorson, Wen-Hann Tan, Nancy Rodig, John M. Graham, Angela Peron, Fabiola Quintero-Rivera, Elaine H. Zackai, Mary Ann Thomas, Cathy A. Stevens, Margaret P. Adam, Lynne M. Bird, Marilyn C. Jones, and Dena R. Matalon. Prenatal Diagnosis, August.

Editorial: Targeting Gut Microbiota Modulation by Dietary Supplementation to Improve Metabolic Diseases. Sheng, Lili, Xiaojiao Zheng, Lin Shi, and Prasant Kumar Jena. Frontiers in Microbiology 14: 1260520.

Surgery

Reply to Letter to the Editor: Should There Be a Definite Place for Grade in the Next TNM Staging System for (Major) Salivary Gland Malignancies? Ho, Allen S., Michael Luu, Bonnie L. Balzer, and Zachary S. Zumsteg. Head & Neck, August.

Long-Term Outcomes of Tuberous Sclerosis Complex-Associated Non-Functional Pancreatic Neuroendocrine Tumors: Should We Be More Conservative? Arya, Shahrzad, Marco Ventin, Martina Nebbia, Carlos Fernandez-Del Castillo, Gabriella Lionetto, Motaz Qadan, Keith D. Lillemoe, Vikram Deshpande, Onofrio A. Catalano, Elizabeth A. Thiele, and Cristina R. Ferrone. Annals of Surgical Oncology, August.

Extreme Limb Salvage: The Thin SCIP Flap for Distal Amputation Coverage in Highly Comorbid Patients. Salibian, Ara A., Mark A. Swerdlow, Katelyn Kondra, and Ketan M. Patel. Plastic and Reconstructive Surgery, August.

Sex-Based Differences in Inguinal Hernia Factors. Pivo, Sarah, Desmond Huynh, Cherin Oh, and Shirin Towfigh. Surgical Endoscopy, August.

Laryngeal Manifestations of the Human Monkeypox Virus. Hsue, Victor B., Kaitlynne Pak, Estelle Viaud-Murat, Martin L. Hopp, and Anca M. Barbu. The Laryngoscope, August.

De-Implementation of Low-Value Care for Women 70 Years of Age or Older With Low-Risk Breast Cancer During the COVID-19 Pandemic. Wang, Ton, Christina Weed, Joshua Tseng, Alice Chung, Marissa K. Boyle, Farin Amersi, Jaswinder Jutla, Amin Mirhadi, and Armando E. Giuliano. Annals of Surgical Oncology, August.

Comment on: Oncological Outcomes after Transanal Total Mesorectal Excision for Rectal Cancer. Gachabayov, Mahir, Roberto Bergamaschi, Hans Wasmuth, Arne Faerden, Mirkhalig Javadov, Fabio Cianchi, Yosef Nasseri, Moshe Barnajian, Dorin E. Popa, and Hanjoo Lee. The British Journal of Surgery, August, znad260.

Watchful Waiting After Radiological Guided Drainage of Intra-Abdominal Abscess in Patients With Crohn’s Disease Might Be Associated With Increased Rates of Stoma Construction. El-Hussuna, Alaa, Casper Steenholdt, Mette Louise Merrild Karer, Natasja Nyggard Uldall Nielsen, Angela Mujukian, Phillip R. Fleshner, Igors Iesalnieks, Nir Horesh, Uri Kopylov, Harel Jacoby, Haider Mahmoud Al-Qaisi, Francesco Colombo, Gianluca M. Sampietro, Marco V. Marino, Mark Ellebæk, Nina Sørensen, Valerio Celentano, Nikhil Ladwa, Janindra Warusavitarne, Gianluca Pellino, Aurang Zeb, Francesca Di Candido, Luis Hurtado-Pardo, Matteo Frasson, Lumir Kunovsky, Ali Yalcinkaya, Sandra Alonso, Miguel Pera, Cristina Antón Rodríguez, Ana-Minaya Bravo, Alvaro Garcia Granero, Ozan Can Tatar, Antonino Spinelli, and Niels Qvist. Crohn’s & Colitis 360 5 (3): otad038.

Urology

Plain Language Summary: Does the Amount of Time It Takes for Prostate-Specific Antigen to Double Affect How Long Men With Nonmetastatic Castration-Resistant Prostate Cancer Live and Their Healthcare Costs? Freedland, Stephen J., Krishnan Ramaswamy, Ahong Huang, Rickard Sandin, Neil M. Schultz, Nora Janjan, and Daniel J. George. Future Oncology (London, England), August.