This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published April 6-13. 

Cancer

Diagnostic Assessment (Imaging) and Staging of Laryngeal Cancer. Itamura, Kyohei, Victor B. Hsue, Anca M. Barbu, and Michelle M. Chen. Otolaryngologic Clinics of North America 56 (2): 215–31.

Pertuzumab Plus Trastuzumab in Patients With Endometrial Cancer With ERBB2/3 Amplification, Overexpression, or Mutation: Results From the TAPUR Study. Ahn, Eugene R., Michael Rothe, Pam K. Mangat, Elizabeth Garrett-Mayer, Hussein M. Ali-Ahmad, John Chan, Michael L. Maitland, Sapna R. Patel, Zachary Reese, Ani S. Balmanoukian, Charles W. Drescher, Rui Li, Apostolia M. Tsimberidou, Charles A. Leath, Raegan O’Lone, Gina N. Grantham, Susan Halabi, and Richard L. Schilsky. JCO Precision Oncology 7 (April): e2200609.

Development of an Artificial Intelligence-Derived Histologic Signature Associated With Adjuvant Gemcitabine Treatment Outcomes in Pancreatic Cancer. Nimgaonkar, Vivek, Viswesh Krishna, Vrishab Krishna, Ekin Tiu, Anirudh Joshi, Damir Vrabac, Hriday Bhambhvani, Katelyn Smith, Julia S. Johansen, Shalini Makawita, Benjamin Musher, Arnav Mehta, Andrew Hendifar, Zev Wainberg, Davendra Sohal, Christos Fountzilas, Aatur Singhi, Pranav Rajpurkar, and Eric A. Collisson. Cell Reports. Medicine, April, 101013.

Association of Polycystic Ovary Syndrome With Pancreatic Cancer. Levin, Gabriel, and Raanan Meyer. JAMA Oncology, April.

Impact of Obesity on Chemotherapy Dosing of Carboplatin and Survival of Women With Ovarian Cancer. Martin, Alexandra L., Christelle M. Colin-Leitzinger, Sweta K. Sinha, Jing-Yi Chern, and Lauren C. Peres. British Journal of Cancer, April.

Patterns of Care and Outcomes of Risk Reducing Surgery in Women With Pathogenic Variants in Non-BRCA and Lynch Syndrome Ovarian Cancer Susceptibility Genes. Schwartz, Zachary P., Andrew J. Li, Christine S. Walsh, B. J. Rimel, Monica M. Alvarado, Scott E. Lentz, and Ilana Cass. Gynecologic Oncology173 (April): 1–7.

Phase I Trial of Ipatasertib Plus Carboplatin, Carboplatin/Paclitaxel, or Capecitabine and Atezolizumab in Metastatic Triple-Negative Breast Cancer. Yuan, Yuan, Susan E. Yost, Yujie Cui, Christopher Ruel, Mireya Murga, Aileen Tang, Norma Martinez, Daniel Schmolze, James Waisman, Niki Patel, Lalit Vora, Lusine Tumyan, Mari Bozoghlanian, Daphne Stewart, and Paul H. Frankel. The Oncologist, April, oyad026.

Signalling Inhibition by Ponatinib Disrupts Productive Alternative Lengthening of Telomeres (ALT). Kusuma, Frances Karla, Aishvaryaa Prabhu, Galen Tieo, Syed Moiz Ahmed, Pushkar Dakle, Wai Khang Yong, Elina Pathak, Vikas Madan, Yan Yi Jiang, Wai Leong Tam, Dennis Kappei, Peter Dröge, H. Phillip Koeffler, and Maya Jeitany. Nature Communications 14 (1): 1919.

Associations of Life Course Obesity With Endometrial Cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2). Harvey, Summer V., Nicolas Wentzensen, Kimberly Bertrand, Amanda Black, Louise A. Brinton, Chu Chen, Laura Costas, Luigino Dal Maso, Immaculata De Vivo, Mengmeng Du, Montserrat Garcia-Closas, Marc T. Goodman, Jessica Gorzelitz, Lisa Johnson, James V. Lacey, Linda Liao, Loren Lipworth, Jolanta Lissowska, Anthony B. Miller, Kelli O’Connell, Tracy A. O’Mara, Xiao Ou, Julie R. Palmer, Alpa V. Patel, Sonia Paytubi, Beatriz Pelegrina, Stacey Petruzella, Anna Prizment, Thomas Rohan, Sven Sandin, Veronica Wendy Setiawan, Rashmi Sinha, Britton Trabert, Penelope M. Webb, Lynne R. Wilkens, Wanghong Xu, Hannah P. Yang, Wei Zheng, and Megan A. Clarke. International Journal of Epidemiology, April, dyad046.

A Modeling Study to Estimate Prostate Cancer-Specific Mortality on Active Surveillance for Men With Favorable Intermediate-Risk Prostate Cancer: Results From the SEARCH Cohort. Kuhlmann, Paige K., Taofik Oyekunle, Zachary Klaassen, Christopher L. Amling, William J. Aronson, Matthew R. Cooperberg, Christopher J. Kane, Martha K. Terris, and Stephen J. Freedland. Cancer Medicine, April.

Application of Mendelian Randomization to Explore the Causal Role of the Human Gut Microbiome in Colorectal Cancer. Hatcher, Charlie, George Richenberg, Samuel Waterson, Long H. Nguyen, Amit D. Joshi, Robert Carreras-Torres, Victor Moreno, Andrew T. Chan, Marc Gunter, Yi Lin, Conghui Qu, Mingyang Song, Graham Casey, Jane C. Figueiredo, Stephen B. Gruber, Jochen Hampe, Heather Hampel, Mark A. Jenkins, Temitope O. Keku, Ulrike Peters, Catherine M. Tangen, Anna H. Wu, David A. Hughes, Malte C. Rühlemann, Jeroen Raes, Nicholas J. Timpson, and Kaitlin H. Wade. Scientific Reports 13 (1): 5968.

Management of Patients With Pancreatic Cancer Using the ‘Right Track’ Model. Rosenzweig, Allison, Jordan Berlin, Suresh Chari, Hedy Kindler, Lynn Matrisian, Allison Mayoral, Jeannine Mills, Nicholas Nissen, Vincent Picozzi, Fatima Zelada-Arenas, and Jason Fleming. The Oncologist, April, oyad080.

Cardiac Surgery 

Donation After Circulatory Death Heart Procurement Strategy Impacts Utilization and Outcomes of Concurrently Procured Abdominal Organs. Thomas, Jason, Qiudong Chen, Amy Roach, Stanley Wolfe, Asishana A. Osho, Vinay Sundaram, Steven A. Wisel, Dominick Megna, Dominic Emerson, Lawrence Czer, Fardad Esmailian, Joanna Chikwe, Irene Kim, and Pedro Catarino. The Journal of Heart and Lung Transplantation, February, S1053-2498(23)01546-2.

Left Atrial Appendage Closure During Mitral Repair in Patients Without Atrial Fibrillation. Chikwe, Joanna, Amy Roach, Dominic Emerson, Qiudong Chen, Georgina Rowe, George Gill, Achille Peiris, Danny Ramzy, Wen Cheng, Natalia Egorova, and Alfredo Trento. The Journal of Thoracic and Cardiovascular Surgery, April, S0022-5223(23)00262-3.

Simultaneous Heart-Kidney Transplant in Patients With Borderline Estimated Glomerular Filtration Rate Without Dialysis Dependency. Chen, Qiudong, Jad Malas, Kevin Gianaris, Gabriel Esmailian, Dominic Emerson, Dominick Megna, Pedro Catarino, Lawrence Czer, Michael E. Bowdish, Joanna Chikwe, Jignesh Patel, Jon Kobashigawa, and Fardad Esmailian. Clinical Transplantation, April, e14986.

Cardiology

Impaired Tolerance to the Autoantigen LL-37 in Acute Coronary Syndrome. Chernomordik, Fernando, Bojan Cercek, Jianchang Zhou, Xiaoning Zhao, Nicole Wai Man Lio, Kuang-Yuh Chyu, Prediman K. Shah, and Paul C. Dimayuga. Frontiers in Immunology 14: 1113904.

Left Ventricular Morphologic Progression in Apical Hypertrophic Cardiomyopathy. Lee, Mirae, Alon Shechter, Donghee Han, Long-Co Nguyen, Min Sun Kim, Daniel S. Berman, Florian Rader, and Robert J. Siegel. International Journal of Cardiology, April, S0167-5273(23)00519-3.

Sex-Specific Differences in the Genetic and Environmental Effects on Cardiac Phenotypic Variation Assessed by Echocardiography. Lin, Honghuang, Alan C. Kwan, Cecilia Castro-Diehl, Meghan I. Short, Vanessa Xanthakis, Ibrahim M. Yola, Gerran Salto, Gary F. Mitchell, Martin G. Larson, Ramachandran S. Vasan, and Susan Cheng. Scientific Reports 13 (1): 5786.

High-Field Asymmetric Waveform Ion Mobility Spectrometry: Practical Alternative for Cardiac Proteome Sample Processing. Ai, Lizhuo, Aleksandra Binek, Simion Kreimer, Matthew Ayres, Aleksandr Stotland, and Jennifer E. Van Eyk. Journal of Proteome Research, April.

Aberrant Activation of TCL1A Promotes Stem Cell Expansion in Clonal Haematopoiesis. Weinstock, Joshua S., Jayakrishnan Gopakumar, Bala Bharathi Burugula, Md Mesbah Uddin, Nikolaus Jahn, Julia A. Belk, Hind Bouzid, Bence Daniel, Zhuang Miao, Nghi Ly, Taralynn M. Mack, Sofia E. Luna, Siddhartha Jaiswal, et al. Nature, April.

Computational Biomedicine

Evidence of Epistasis in Regions of Long-Range Linkage Disequilibrium Across Five Complex Diseases in the UK Biobank and EMERGE Datasets. Singhal, Pankhuri, Yogasudha Veturi, Scott M. Dudek, Anastasia Lucas, Alex Frase, Kristel van Steen, Steven J. Schrodi, David Fasel, Chunhua Weng, Rion Pendergrass, Daniel J. Schaid, Iftikhar J. Kullo, Ozan Dikilitas, Patrick M. A. Sleiman, Hakon Hakonarson, Jason H. Moore, Scott M. Williams, Marylyn D. Ritchie, and Shefali S. Verma. American Journal of Human Genetics 110 (4): 575–91.

Automated Quantitative Trait Locus Analysis (AutoQTL). Freda, Philip J., Attri Ghosh, Elizabeth Zhang, Tianhao Luo, Apurva S. Chitre, Oksana Polesskaya, Celine L. St Pierre, Jianjun Gao, Connor D. Martin, Hao Chen, Angel G. Garcia-Martinez, Tengfei Wang, Wenyan Han, Keita Ishiwari, Paul Meyer, Alexander Lamparelli, Christopher P. King, Abraham A. Palmer, Ruowang Li, and Jason H. Moore. BioData Mining 16 (1): 14.

Medicine

Challenges and Approaches to High-Level Isolation Unit Staffing and Just-in-Time Training: A Meeting Report. Herstein, Jocelyn J., Katie Stern, Jade Flinn, Jennifer A. Garland, Abigail E. Lowe, and Lauren M. Sauer. Open Forum Infectious Diseases 10 (4): ofad152.

Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor-Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials. Self, Wesley H., Matthew S. Shotwell, Kevin W. Gibbs, Marjolein de Wit, D. Clark Files, Michelle Harkins, Kristin M. Hudock, Lisa H. Merck, Ari Moskowitz, Krystle D. Apodaca, Aaron Barksdale, Basmah Safdar, Ali Javaheri, Jeffrey M. Sturek, Harry Schrager, Nicole Iovine, Brian Tiffany, Ivor S. Douglas, Joseph Levitt, Laurence W. Busse, Adit A. Ginde, Samuel M. Brown, David N. Hager, Katherine Boyle, Abhijit Duggal, Akram Khan, Michael Lanspa, Peter Chen, Michael Puskarich, Derek Vonderhaar, Lokesh Venkateshaiah, Nina Gentile, Yves Rosenberg, James Troendle, Amanda J. Bistran-Hall, Josh DeClercq, Robert Lavieri, Meghan Morrison Joly, Michael Orr, Jill Pulley, Todd W. Rice, Jonathan S. Schildcrout, Matthew W. Semler, Li Wang, Gordon R. Bernard, Sean P. Collins, and ACTIV-4 Host Tissue Investigators. JAMA 329 (14): 1170–82.

Scleroderma: Best Approaches to Patient Care. Weisman, Michael H. Rheumatic Diseases Clinics of North America 49 (2): xvii–xviii.

Neurosurgery

Oscillatory and Aperiodic Neuronal Activity in Working Memory Following Anesthesia. Lendner, Janna D., Ulrich Harler, Jonathan Daume, Andreas K. Engel, Christian Zöllner, Till R. Schneider, and Marlene Fischer. Clinical Neurophysiology, 150 (March): 79–88.

OBGYN

Twitter Gynecologic Surgery Journal Club: Impact on Citation Scores and Social Media Attention.Meyer, Raanan, Sadikah Behbehani, Kaylee Brooks, Cristobal R. Valero, Courtney Fox, Alyssa N. Small Layne, Meenal Misal, Peter R. Movilla, Jacob K. Lauer, Adriana J. Wong, Kathleen Ackert, and Mireille Truong. Journal of Minimally Invasive Gynecology, April, S1553-4650(23)00152-8.

Orthopaedics

Lumbar Sympathetic Chain Tract and Mobility of Oblique Lumbar Interbody Fusion Approach: A Cadaveric Study. Itthipanichpong, Thun, Teerachat Tanasansomboon, Nonn Jaruthien, Somjet Jenvorapoj, Weerasak Singhatanadgige, Wicharn Yingsakmongkol, and Worawat Limthongkul. World Neurosurgery, April, S1878-8750(23)00491-6.

Comparative Outcome of Lidocaine Versus Bupivacaine for Cervical Medial Branch Block (CMBB) in Chronic Cervical Facet Arthropathy: A Randomized Double-Blind Study. Pasuhirunnikorn, Porntipa, Teerachat Tanasansomboon, Weerasak Singhatanadgige, Wicharn Yingsakmongkol, and Pornpan Chalermkitpanit. World Neurosurgery, April, S1878-8750(23)00478-3.

Pathology

A Compensatory RNase E Variation Increases Iron Piracy and Virulence in Multidrug-Resistant Pseudomonas Aeruginosa During Macrophage Infection. Vaillancourt, Mylene, Anna Clara Milesi Galdino, Sam P. Limsuwannarot, Diana Celedonio, Elizabeth Dimitrova, Matthew Broerman, Catherine Bresee, Yohei Doi, Janet S. Lee, William C. Parks, and Peter Jorth. PLoS Pathogens 19 (4): e1010942.

Pediatrics

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: Common Inflammatory Pathways of Two Distinct Diseases. Rivas, Magali Noval, and Moshe Arditi. Rheumatic Disease Clinics 0 (0).

Precise Modulation of Transcription Factor Levels Identifies Features Underlying Dosage Sensitivity. Naqvi, Sahin, Seungsoo Kim, Hanne Hoskens, Harold S. Matthews, Richard A. Spritz, Ophir D. Klein, Benedikt Hallgrímsson, Tomek Swigut, Peter Claes, Jonathan K. Pritchard, and Joanna Wysocka. Nature Genetics, April.

Radiation Oncology 

3D Printing in Brachytherapy: A Systematic Review of Gynecological Applications. Fahimian, Benjamin P., Wu Liu, Lawrie Skinner, Amy S. Yu, Tiffany Phillips, Jennifer M. Steers, John DeMarco, Benedick A. Fraass, and Mitchell Kamrava. Brachytherapy, April, S1538-4721(23)00008-9.

Surgery

ADMs and Synthetic Meshes Improve Implant-Based Breast Reconstruction Aesthetics, but at What Cost? Samaha, Yasmina, Jiaxi Chen, and Edward C. Ray. Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS 80 (March): 178–81.

Improving the Accuracy of Maxillary Sinus Balloon Dilation Using Virtual Reality Navigation: A Proof-of-Concept Study. Tang, Dennis M., Kevin Grafmiller, Satyan B. Sreenath, Arthur Wu, William C. Yao, and Raj Sindwani. American Journal of Rhinology & Allergy, March, 19458924231164844.

Targeted Hypoglossal Nerve Stimulation for Patients With Obstructive Sleep Apnea: A Randomized Clinical Trial. Schwartz, Alan R., Ofer Jacobowitz, David W. Eisele, Samuel A. Mickelson, Mitchell B. Miller, Arie Oliven, Victor Certal, Martin L. Hopp, David H. Winslow, Tod C. Huntley, Nathan E. Nachlas, Luu V. Pham, M. Boyd Gillespie, Brian H. Weeks, Eric G. Lovett, John Shen, Atul Malhotra, and Joachim T. Maurer. JAMA Otolaryngology-- Head & Neck Surgery, April, e230161.

From Bench to Bedside-When Dreams Become Reality. Tang, Dennis M. American Journal of Rhinology & Allergy 37 (3): 245–46.