This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published April 27-May 4.

Biomedical Sciences

The Tox Gene Encodes Two Proteins with Distinct and Shared Roles in Gene Regulation. Yeckes, Alyson R., Aaron R. Victor, Zheng Zhu, Meena Narayanan, Bharani Srinivasan, Bethany Bruce, and Jonathan Kaye. Journal of Immunology (Baltimore, Md.: 1950), April, ji2200659.

Peptidoglycan-Induced Modulation of Metabolic and Inflammatory Responses. Wolf, Andrea J. Immunometabolism (Cobham (Surrey, England)) 5 (2): e00024.

Risk of Second Primary Cancer among Women in the Kaiser Permanente Breast Cancer Survivors Cohort. Ramin, Cody, Lene H. S. Veiga, Jacqueline B. Vo, Rochelle E. Curtis, Clara Bodelon, Erin J. Aiello Bowles, Diana S. M. Buist, Sheila Weinmann, Heather Spencer Feigelson, Gretchen L. Gierach, and Amy Berrington de Gonzalez. Breast Cancer Research: BCR 25 (1): 50.

Identification and Characterization of the Wilms Tumor Cancer Stem Cell. Petrosyan, Astgik, Valentina Villani, Paola Aguiari, Matthew E. Thornton, Yizhou Wang, Alex Rajewski, Shengmei Zhou, Paolo Cravedi, Brendan H. Grubbs, Roger E. De Filippo, Sargis Sedrakyan, Kevin V. Lemley, Marie Csete, Stefano Da Sacco, and Laura Perin. Advanced Science (Weinheim, Baden-Wurttemberg, Germany), April, e2206787.

Cancer

Time-Varying Model of Engagement With Digital Self Reporting: Evidence From Smoking Cessation Longitudinal Studies. Sobolev, Michael, Aditi Anand, John J. Dziak, Lindsey N. Potter, Cho Y. Lam, David W. Wetter, and Inbal Nahum-Shani. Frontiers in Digital Health 5: 1144081.

Cardiac Surgery

Risk of Prolonged Ischaemic Time Linked to Use of Cardio-Pulmonary Bypass during Implantation for Lung Transplantation in the United Kingdom. Mehew, Jennifer Dawn, Rachel Hogg, Stephen Clark, Karthik Santhanakrishnan, Pedro Catarino, Jorge Mascaro, Ulrich Stock, and John Dark. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation, April, S1053-2498(23)01845-4.

Cardiology

Increased Rehospitalization in Young Women With Acute Myocardial Infarction at 1 Year: Adding Insult to Infarct. Gulati, Martha, Jessica N. Holtzman, and Gurleen Kaur. Journal of the American College of Cardiology 81 (18): 1807–9.

1-Year Outcomes of Transcatheter Tricuspid Valve Repair. Kodali, Susheel K., Rebecca T. Hahn, Charles J. Davidson, Akhil Narang, Adam Greenbaum, Patrick Gleason, Samir Kapadia, Rhonda Miyasaka, Firas Zahr, Scott Chadderdon, Robert L. Smith, Paul Grayburn, Robert M. Kipperman, Leo Marcoff, Brian Whisenant, Mike Gonzales, Raj Makkar, Moody Makar, William O’Neill, Dee Dee Wang, William A. Gray, Sandra Abramson, James Hermiller, Lucas Mitchel, D. Scott Lim, Dale Fowler, Mathew Williams, Sorin V. Pislaru, Abdellaziz Dahou, Michael J. Mack, Martin B. Leon, and Mackram F. Eleid. Journal of the American College of Cardiology 81 (18): 1766–76.

Repeat Mitral Transcatheter Edge-to-Edge Repair for Recurrent Significant Mitral Regurgitation. Shechter, Alon, Mirae Lee, Danon Kaewkes, Ofir Koren, Sabah Skaf, Tarun Chakravarty, Keita Koseki, Vivek Patel, Raj R. Makkar, and Robert J. Siegel. Journal of the American Heart Association 12 (9): e028654.

Reckoning with Race in Sports Cardiology: A Call to Action. Grant, Aubrey, Sheela Krishan, Merije Chukumerije, James Sawalla Guseh, and Jonathan H. Kim. British Journal of Sports Medicine, May, bjsports-2022-106553.

Artificial Intelligence Using a Deep Learning Versus Expert Computed Tomography Human Reading in Calcium Score and Coronary Artery Calcium Data and Reporting System Classification. Aldana-Bitar, Jairo, Geoffrey W. Cho, Lauren Anderson, Daniel W. Karlsberg, Venkat S. Manubolu, Dhiran Verghese, Luay Hussein, Matthew J. Budoff, and Ronald P. Karlsberg. Coronary Artery Disease, May.

The Genetic Determinants of Recurrent Somatic Mutations in 43,693 Blood Genomes. Weinstock, Joshua S., Cecelia A. Laurie, Jai G. Broome, Kent D. Taylor, Xiuqing Guo, Alan R. Shuldiner, Jeffrey R. O’Connell, Joshua P. Lewis, Eric Boerwinkle, Kathleen C. Barnes, Nathalie Chami, Eimear E. Kenny, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, et al. Science Advances 9 (17): eabm4945.

Obesity and Atrial Fibrillation: Prevalence, Pathogenesis, and Prognosis. Middeldorp, Melissa E., Suraya H. Kamsani, and Prashanthan Sanders. Progress in Cardiovascular Diseases, April, S0033-0620(23)00040-3.

A Heart-Healthy Diet for Cardiovascular Disease Prevention: Where Are We Now? Diab, Alaa, L. Nedda Dastmalchi, Martha Gulati, and Erin D. Michos. Vascular Health and Risk Management 19: 237–53.

Reply to the Editor - The Promising Future of Remote Monitoring for Cardiac Implantable Electronic Devices. Middeldorp, Melissa E., and Prashanthan Sanders. Heart Rhythm O2 4 (4): 288–89.

Computational Biomedicine

HLA Amino Acid Mismatch-Based Risk Stratification of Kidney Allograft Failure Using a Novel Machine Learning Algorithm. Dasariraju, Satvik, Loren Gragert, Grace L. Wager, Keith McCullough, Nicholas K. Brown, Malek Kamoun, and Ryan J. Urbanowicz. Journal of Biomedical Informatics, April, 104374.

Medicine

Heterozygous Midnolin Knockout Attenuates Severity of Nonalcoholic Fatty Liver Disease in Mice Fed a Western-Style Diet High in Fat, Cholesterol, and Fructose. Kweon, Soo-Mi, Jose Irimia-Dominguez, Gayeoun Kim, Patrick T. Fueger, Kinji Asahina, Keith K. Lai, Daniela S. Allende, Quincy R. Lai, Chih-Hong Lou, Walter M. Tsark, Ju Dong Yang, Dominic S. Ng, Ju-Seog Lee, Patrick Tso, Wendong Huang, and Keane K. Y. Lai. American Journal of Physiology. Gastrointestinal and Liver Physiology, May.

Evaluation of Oncology Infusion Pharmacy Practices: A Nationwide Survey. Boyd, A. M., C. Sue, A. Khandoobhai, B. Vinson, H. Shaikh, S. Sorenson, V. Patel, B. Snyder, C. Bondarenk, Y. Koukounas, M. Earl, and M. Jenkins. Journal of Oncology Pharmacy Practice: Official Publication of the International Society of Oncology Pharmacy Practitioners, April, 10781552231170358.

Multicentered Evaluation of Palliative Care Pharmacists’ Interventions and Outcomes in California (Sci240). Naidu, Dharma, Kasey L. Malotte, and Rabia Atayee. Journal of Pain and Symptom Management 65 (5): e661–62.

Multidisciplinary Care for Patients With HCC: A Systematic Review and Meta-Analysis. Seif El Dahan, Karim, Annika Reczek, Darine Daher, Nicole E. Rich, Ju Dong Yang, David Hsiehchen, Hao Zhu, Madhukar S. Patel, Maria Del Pilar Bayona Molano, Nina Sanford, Purva Gopal, Neehar D. Parikh, Adam C. Yopp, and Amit G. Singal. Hepatology Communications 7 (5): e0143.

Isolated Esophageal Lichen Planus Causing Pseudoachalasia. Lim, Jane, and Ali Rezaie. Digestive Diseases and Sciences, April.

Improved Inference for MCP-Mod Approach Using Time-to-Event Endpoints With Small Sample Sizes. Diniz, Márcio A., Diego I. Gallardo, and Tiago M. Magalhães. Pharmaceutical Statistics, April.

Reply to: Type 2 Diabetes Complications Are Associated With Liver Fibrosis Independent of Hemoglobin A1c. Trivedi, Hirsh D., and Michelle Lai. Annals of Hepatology, April, 101114.

An Individual Patient Data Meta-Analysis to Determine Cut-Offs for and Confounders of NAFLD-Fibrosis Staging With Magnetic Resonance Elastography. Liang, Jia-Xu, Javier Ampuero, Hao Niu, Kento Imajo, Mazen Noureddin, Jaideep Behari, Dae Ho Lee, Richard L. Ehman, Fredrik Rorsman, Johan Vessby, Juan R. Lacalle, Ferenc E. Mózes, Michael Pavlides, Quentin M. Anstee, Stephen A. Harrison, Javier Castell, Rohit Loomba, Manuel Romero-Gómez, and LITMUS Consortium Investigators. Journal of Hepatology, April, S0168-8278(23)00312-4.

Identification and Characterization of the Wilms Tumor Cancer Stem Cell. Petrosyan, Astgik, Valentina Villani, Paola Aguiari, Matthew E. Thornton, Yizhou Wang, Alex Rajewski, Shengmei Zhou, Paolo Cravedi, Brendan H. Grubbs, Roger E. De Filippo, Sargis Sedrakyan, Kevin V. Lemley, Marie Csete, Stefano Da Sacco, and Laura Perin. Advanced Science (Weinheim, Baden-Wurttemberg, Germany), April, e2206787.

Machine Learning Versus Regression for Prediction of Sporadic Pancreatic Cancer. Chen, Wansu, Botao Zhou, Christie Y. Jeon, Fagen Xie, Yu-Chen Lin, Rebecca K. Butler, Yichen Zhou, Tiffany Q. Luong, Eva Lustigova, Joseph R. Pisegna, and Bechien U. Wu. Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], April, S1424-3903(23)00103-5.

Assessing the Accuracy of Responses by the Language Model ChatGPT to Questions Regarding Bariatric Surgery. Samaan, Jamil S., Yee Hui Yeo, Nithya Rajeev, Lauren Hawley, Stuart Abel, Wee Han Ng, Nitin Srinivasan, Justin Park, Miguel Burch, Rabindra Watson, Omer Liran, and Kamran Samakar. Obesity Surgery, April.

Does the Addition of Mutations of CTNNB1 S45F to Clinical Factors Allow Prediction of Local Recurrence in Patients With a Desmoid Tumor? A Local Recurrence Risk Model. Pinto, Fabio F. E., Celso A. L. Mello, Suely A. Nakagawa, Wu Tu Chung, Giovana T. Torrezan, Bruna D. F. Barros, Isabela W. Cunha, Vinícius F. Calsavara, Dirce M. Carraro, and Ademar Lopes. Clinical Orthopaedics and Related Research, April.

Predictive Biomarkers for Immune-Checkpoint Inhibitor Treatment Response in Patients With Hepatocellular Carcinoma. Ji, Jun Ho, Sang Yun Ha, Danbi Lee, Kamya Sankar, Ekaterina K. Koltsova, Ghassan K. Abou-Alfa, and Ju Dong Yang. International Journal of Molecular Sciences 24 (8): 7640.

Neurology

Careers in Telestroke: Toward a Virtual and Tangible Purpose. Jagolino-Cole, Amanda L., Alicia M. Zha, Navdeep Sangha, Shlee S. Song, and Jennifer J. Majersik. Stroke 54 (5): e220–23.

An Innovative Phase 2 Proof-of-Concept Trial Design to Evaluate SAR445088, a Monoclonal Antibody Targeting Complement C1s in Chronic Inflammatory Demyelinating Polyneuropathy. Querol, Luis, Richard A. Lewis, Hans-Peter Hartung, Pieter A. Van Doorn, Erik Wallstroem, Xiaodong Luo, Miguel Alonso-Alonso, Nazem Atassi, and Richard A. C. Hughes. Journal of the Peripheral Nervous System: JPNS, April.

Nursing

Aligning the Nursing Professional Development Practitioner Role With the Scope and Standards. Moreno, Janette V., Anita Girard, David R. Marshall, and Margo B. Minissian. Journal for Nurses in Professional Development 39 (3): 182.

Diversity, Equity, Inclusion, and Belonging: A Role for Us All. Foster-Smith, Rhonda R., Nicole Mitchell, and Maria L. Bobo. Nursing Management 54 (5): 40–47.

OBGYN

ChatGPT-Written OBGYN Abstracts Fool Practitioners. Levin, Gabriel, Raanan Meyer, Amber Yasmeen, Bowen Young, Paul-Adien Guige, Tomer Bar-Noy, Angela Tatar, Olga Perelstein, and Yoav Brezinov. American Journal of Obstetrics & Gynecology MFM, April, 100993.

Orthopaedics

Higher Complication Rate in COVID-19 Recovered Patients Undergoing Primary Total Joint Arthroplasty. Lee, Anderson, Caleb Durst, Kevin Rezzadeh, Sean Rajaee, Brad Penenberg, and Justin Than. The Journal of Arthroplasty, April, S0883-5403(23)00399-6.

Midcarpal Instability. Rabinovich, Remy V., Omar F. Rahman, Matthew H. Nasra, Daniel B. Polatsch, and Steven Beldner. The Journal of the American Academy of Orthopaedic Surgeons, April.

Pathology

Investigate the Possibility of Using Phosphorescence in Clinical Oncology as an Early Prognostic Test in Detecting Brain Carcinogenesis. Vinnyk, Yuriy O., Igor A. Kryvoruchko, Valeriy V. Boyko, Yulia V. Ivanova, Svetlana Gramatiuk, and Karine Sargsyan. Journal of Fluorescence, April.

Radiation Oncology 

Genomic Classifier Performance in Intermediate-Risk Prostate Cancer: Results from NRG Oncology/RTOG 0126 Randomized Phase III Trial. Spratt, Daniel E., Vinnie Y. T. Liu, Jeff Michalski, Elai Davicioni, Alejandro Berlin, Jeff M. Simko, Jason A. Efstathiou, Phuoc T. Tran, Howard M. Sandler, William A. Hall, Darby Js Thompson, Matthew B. Parliament, Ian S. Dayes, Rohann Jonathan Mark Correa, John M. Robertson, Elizabeth M. Gore, Desiree E. Doncals, Eric Vigneault, Luis Souhami, Theodore G. Karrison, and Felix Y. Feng. International Journal of Radiation Oncology, Biology, Physics, May, S0360-3016(23)00371-1.

Dose-Escalated Radiation Alone or in Combination with Short-Term Total Androgen Suppression for Intermediate-Risk Prostate Cancer: Patient-Reported Outcomes From NRG/Radiation Therapy Oncology Group 0815 Randomized Trial. Movsas, Benjamin, Joseph P. Rodgers, Mohamed A. Elshaikh, Alvaro A. Martinez, Gerard C. Morton, Daniel J. Krauss, Di Yan, Deborah E. Citrin, Bruce W. Hershatter, Jeff M. Michalski, Rodney J. Ellis, Vivek S. Kavadi, Elizabeth M. Gore, Gary S. Gustafson, Craig A. Schulz, Vikram M. Velker, Adam C. Olson, Fabio L. Cury, Michael A. Papagikos, Theodore G. Karrison, Howard M. Sandler, and Deborah W. Bruner. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, April, JCO2202389.

IA Pulmonary Vein Atlas for Radiotherapy Planning. Walls, Gerard M., Conor McCann, Peter Ball, Katelyn M. Atkins, Raymond H. Mak, Ahmed Bedair, Jolyne O’Hare, Jonathan McAleese, Claire Harrison, Karen A. Tumelty, Cathryn Crockett, Sarah-Louise Black, Catherine Nelson, John O’Connor, Alan R. Hounsell, Conor K. McGarry, Karl T. Butterworth, Aidan J. Cole, Suneil Jain, and Gerard G. Hanna. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, April, 109680.

Rehabilitation Medicine

A 6-Week Program to Strengthen Resiliency Among Women with Metastatic Cancer: A Randomized Clinical Trial. Asher, Arash, Celina H. Shirazipour, Jessica M. Capaldi, Sungjin Kim, Marcio Diniz, Bronwen Jones, and Jeffrey Wertheimer. The Oncologist, April, oyad091.

Surgery

The Evolving Use of Magnets in Surgery: Biomedical Considerations and a Review of Their Current Applications. Lee, William G., Lauren L. Evans, Sidney M. Johnson, and Russell K. Woo. Bioengineering (Basel, Switzerland) 10 (4): 442.

Urology

Prostate Cancer in Transgender Women in the Veterans Affairs Health System, 2000-2022. Nik-Ahd, Farnoosh, Amanda De Hoedt, Christi Butler, Jennifer T. Anger, Peter R. Carroll, Matthew R. Cooperberg, and Stephen J. Freedland. JAMA, April, e236028.