In 2023, Cedars-Sinai’s top researchers led world-class investigations into new ways of understanding the most challenging conditions, and our experienced clinicians provided the highest-quality patient-centered care while encouraging the next generation of physician-leaders.
Our highly specialized neurology and neurosurgery teams make such strides only when we join forces. Our strength lies in our multidisciplinary collaborations with one another and with the brilliant minds across our institution.
We are proud of our recognitions and rejoice in our results—and we remain focused on the future. We continually strive to improve outcomes, expand access and further the research that improves patients’ lives. This year, we have achieved deeper and more refined knowledge in our efforts to:
At Cedars-Sinai, our every endeavor aims to evolve and improve our understanding of neurological disease and disability. With awe and anticipation, we look forward to the coming year and to establishing new partnerships that will propel us even further forward.
Chair, Department of Neurosurgery
Ruth and Lawrence Harvey Chair in Neuroscience
Professor of Neurosurgery
Chair, Department of Neurology
Women’s Guild Distinguished Chair in Neurology
Professor of Neurology
This report features photographs of astronomical objects captured with the aid of powerful telescopes. The Crescent Nebula, an ever-evolving clump of gas and interstellar matter located about 5,000 light-years from Earth, is featured on the cover of the printed annual report and resembles an illuminated human brain.
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The Neurocritical Care Fellowship Program at Cedars-Sinai was among the first of its kind in the nation to be accredited by the Accreditation Council for Graduate Medical Education. Five highly motivated physicians in the two-year fellowship gain experience in advanced research and clinical care.
Clinicians and researchers at the Cedars-Sinai Board of Governors Regenerative Medicine Institute, in collaboration with the departments of Neurology and Neurosurgery, have demonstrated for the first time the safety and viability of spinal cord injections of specialized stem cells engineered to secrete a growth factor known to protect neurons. The findings were published in the peer-reviewed journal Nature Medicine. A follow-up Phase I/II trial will determine the safety and efficacy of stem cell injections in the motor cortex.
Researchers from the Center for Neural Science and Medicine at Cedars-Sinai were the first to identify, using single-neuron recordings, specific roles of the ventromedial prefrontal cortex and pre-supplementary motor area in planning and decision-making. Their study was published in the peer-reviewed journal Nature Human Behavior.
Cedars-Sinai investigators participated in a multicenter study that distinguished distinct clinical markers of impaired awareness during focal to bilateral tonic-clonic seizures from those observed during focal impaired awareness seizures. The findings were published in the peer-reviewed journal Brain.
Cedars-Sinai investigators studying ocular indicators of neurodegenerative disorders performed the most extensive analysis of retinal changes directly related to brain and cognitive changes in patients with Alzheimer’s disease. The study was published in the peer-reviewed journal Acta Neuropathologica.
The researchers also identified blood vessel abnormalities in the retina that correlate with the accumulation of vascular amyloid-beta in the brain. The findings, published in the peer-reviewed journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, could inform new, noninvasive strategies for early diagnosis and disease monitoring.
Cedars-Sinai received more than $30 million in philanthropic gifts to support memory disorders research, including $3 million from the Universal Sunlight Foundation to establish a neuropathology core at the Jona Goldrich Center for Alzheimer’s and Memory Disorders at Cedars-Sinai.
The American Heart Association and American Stroke Association selected Nestor Gonzalez, MD, director of Cedars-Sinai’s Neurovascular Laboratory and a world-leading expert in moyamoya disease, as chair of the international writing committee for the groups’ Science Advisory and Coordinating Committee. A roadmap for future investigation into the condition was published in the peer-reviewed journal Stroke.
Scientists at the Cedars-Sinai Neuroimaging Research Program have demonstrated the utility of incorporating the central vein sign in the diagnosis of multiple sclerosis. The viewpoint was published in the peer-reviewed journal JAMA Neurology.
Cedars-Sinai investigators continue to strengthen the body of evidence supporting use of tenecteplase for stroke treatment. A large, multinational study published in the peer-reviewed journal JAMA Neurology found patients who were treated with tenecteplase suffered fewer stroke-related complications than patients who received alteplase.
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